How to conduct forced degradation study?

ICH guidelines emphasize the importance of conducting forced degradation studies, but provided only very general and limited information on the experimental stress conditions. This video will help you to understand forced degradation to much deeper level.

[@PG12333]

What is mass balance in FD study and how it is calculate

[@LearnValue]

Plus or minus 5% is acceptable

[@mitalipereira446]

Sir,
Please make video on finding LOD and LOQ of method

[@rajeshpudi8795]

Linearity and sample concentration chapter available

[@hanumantgare1891]

Very nice presentation and explain in very easy language.
Thanku so much sir for your efforts.

[@rahulgunjal663]

Sir kindly make video on mass balance calculation in fd

[@krish_krish354]

While conducting acid hydrolysis sample with hcl added. With this diluent added and kept in oven for degradation.
Diluent added means how much should add before keeping in oven for hydrolysis.
Can anyone reply please

[@pharmagrowthhub3083]

The volume of diluent should be sufficient to solubalize your analyte before you proceed degradation

[@krish_krish354]

@@pharmagrowthhub3083 if suppose sample and HCl only added no other diluent added before keeping in oven.
after taken out from oven neutralize with NaOH and make up with diluent.
This way of doing foreced degradation right or wrong.

[@rohinikumar7065]

Nice presentation sir and make video on what are facts effecting mass balance failure and solutions

[@krish_krish354]

If the compound melting point or boiling point near 45 degree can we conduct acid or base hydrolysis at 80 c

[@mrinmoysarkar4133]

Thanks a lot sir...it's really informative ♥️♥️🙏🙏

[@manishkharkwal6106]

Ur presentation was good.
Please check as for evaluating purity / spectra in FD, PDA detectors required not UV.
But overall content was good.
Thanks for sharing

[@sameer_shindeshinde3674]

Ur content is good so don't show advertising in between video, it disturb during learning.....

[@ankushthakur213]

Stability indicating method meaning?

[@prashantpandit7806]

Superbly Explained...👍🏻

[@supriyabhamare06]

How to select drugs for FDS study

[@mohdazeemuddin8353]

Hi sir
This is Azeem
My Question is
We have controlled Nitrite content in water NMT 0.03ppm
Secondary amine is there
Nitrosamine is possible pls suggest
Provide the guideline

[@verans7152]

Thanks sir

[@ShikshanAcademy]

Pls put pdf

[@rohitkhade4060]

How to perform normal phase force degradation study

[@krish_krish354]

For themal degradation dry method sample alone heated. For wet method with sampl wt will be added

[@modernmogli5155]

Sir what software is this you are using , its very nice way to explain

[@rahulchadha6795]

Is it possible to do FD on UV methods?

[@madhavikatta2150]

Well explained sir thank you 😊

[@PG12333]

Sir please make videos on process validation

[@pankajshah1084]

Nice video sir, very useful

[@sanketdalvi2942]

Thanks sir....,❤️

[@kishordangat684]

Good presentation

[@jnaniashok]

Excellent..

[@krish_krish354]

Degradation 5_20 or 5_30 in other video of yours I saw 5_30 which is correct

[@pharmagrowthhub3083]

5-20% is more relevant and accurate, though there is no as such regulatory reference available.

[@krish_krish354]

@@pharmagrowthhub3083 thank you

[@krish_krish354]

@@pharmagrowthhub3083 what are regulatory guidelines using for a method validation. Not only ICHQ2R1 and R2. Other than