Thank God for science, My Ajovy injections have greatly reduced my migraine frequency in the last 6 months. Absolute game changer that has really improved my life. Cool to see how they explain CGRP
Thank your for helping me understand a bit more about my disease. I am currently prescribed propanolol (prevention) + zomiltriptal-Napeoxen (during). Best
Does any one else hallucinate when they have migraines see things no one else sees and hear things that arent there. Im getting to a point where i would rather die than to keep going through it its so hard suffering right now
The oral meds are no good if you don't catch it in time because your stomach shuts down and then you vomit, so in the end you just have to go through the majority of the pain. Usually I end up lying in a funny looking awkward position until I find a way I can lay to reduce the pain enough to fall asleep... Yes, I had one last night ☹️
My old roommate used to roll some socks into tight balls, throw them in the freezer, then put them over her eyes with a headband to hold them in place. Actually works very well for some pain relief. Hardly a treatment for migraines but it does help.
yes you must do it early. but worst thing is they only give you 3 or 6 triptan's a month. and sometimes it's hard to accurately gauge if early pain, or throbing sensation is truly going to be a migraine but you don't want to risk it. so you spend your 3 triptans and run out. either way it's guaranteed you will suffer, by taking it too late or by not having it when you need it
When I get a migraine I hit it with 50mg diphenhydramine every 2 hours up to 300mg, 1000mg of Tylenol every 2 hours up to 4000mg, two doses of 50mg of Sumatriptan across 2 hours up to 100mg, and an extra 25mg of Metoprolol if my systolic blood pressure is 140 or higher. I have developed tolerance for the diphenhydramine over a few years since my doctor had me take it to offset the effects of other medications and help with sleep disorders. My blood pressure is normally controlled very well with 50mg/day Metoprolol (around 120/80 +-15) but I have noticed that sometimes my blood pressure goes up during migraines for some reason. I once went to the ER with the worst migraine of my life and my blood pressure was 199/110 but that was before starting Metoprolol. That extra 25mg of Metoprolol after significant acute pain has started makes the difference between beating the migraine and getting stuck with it for the next couple days.
mimi isah Basic Botox (even cosmetic) plus memantine 20-30mg has done wonders and unlocked a new freedom in life without harmful longterm potential as others. Positive cosmetic and brain side effects.
Nice video. Beta blockers are also used for migraine according to my textbook, maybe because they block beta 2 receptors on blood vessels preventing vasodilation ?
Eletriptan works perfectly for me but I have to take also Gravol, for the vomit and nausea.... those two work very well. The pain lasts for about 2-3 hours while without medicactión it lasts 12 hours with intense vomiting. I rather die seriously when I dont take medication.
Sir, it is said that drugs like Propranolol , atenolol (beta blockers) act as prophylactic treatment for migraine. However they cause vasodilation .. So how does it prophylactically treat migraine? (Which is caused DUE to cerebral vasodilation)..
Perhaps the membrane stabilization helps the migraine prophylaxis. Usually the trigger event in migraine is ischaemia, so prophylactic agents are vasodilators which prevent the ischaemia and thus the migraine.. The drugs used for acute management are vasoconstrictor s like triptans
I was wondering the same thing.. on drugs for migaine prophylaxis and their moa....so it's due to vasoconstriction of cerebral blood vessels due to beta 2 ....and membrane stabilizing properties?
...😔yeah... increasing vision problems were my signal that I was in for essentially sort of a neurological-earthquake lasting around *_*seven_** hours. Sht like that usually happened to me in between when I was 13 to 18. 😖😳🥴🤢😵💫🤮
I have two distinctive types of migrane: migrain on left-sided brain and migraine on right-sided brain. All are triggered by hungers (lacking of sleep and stress is a catalyst) and easily prevented by high-sugar, high-caffein food intake. My left-sided brain paint can be treated by Paracetamol (found in common flu medicine or panadol). But that treatment has no effect on right-sided brain paint. Until now, I still don't know why. The only effective way of treatment for acute right-sided migraine is a big cup of coffee with much sweetened condensed milk. It kills the migraine in just 01 hour =)) Hope that one day I could found the cause of this problem haha. Actually, it impacts a lot on my effort to lose weight. I just can not reduce sugar partake, otherwise, a migraine will be triggered.
It’s related to the pro inflammatory effect of the neuropeptides that are released during a migraine. The Inflammation caused by these leads to vasodilation and pain.
![[ LIVE ] Rank เล่นแต่แครี่ ยาวๆถึง 100ดาว “วันนี้มีกิจกรรมลุ้นรับสกินมาบอกต่อ โก๋แก่ช็อกโกบอล x ROV”](http://i.ytimg.com/vi/5NNgkhWj57Y/mqdefault.jpg)
Love these, especially the illustrations. Helps me "visualize" what textbooks like Robbins tries to explain.
Is this channel underrated.? Whyy?
Thanks for the wonderful explaination! Keep adding such videos ❤
Thank God for science,
My Ajovy injections have greatly reduced my migraine frequency in the last 6 months. Absolute game changer that has really improved my life. Cool to see how they explain CGRP
Thank your for helping me understand a bit more about my disease.
I am currently prescribed propanolol (prevention) + zomiltriptal-Napeoxen (during).
Best
Does any one else hallucinate when they have migraines see things no one else sees and hear things that arent there. Im getting to a point where i would rather die than to keep going through it its so hard suffering right now
Such a wholesome video. Kudos!
Excellent and easy explanation.... Thank you so much sir 😍
Excellent migraine tutorial.. love the visuals 😚
The oral meds are no good if you don't catch it in time because your stomach shuts down and then you vomit, so in the end you just have to go through the majority of the pain.
Usually I end up lying in a funny looking awkward position until I find a way I can lay to reduce the pain enough to fall asleep...
Yes, I had one last night ☹️
My old roommate used to roll some socks into tight balls, throw them in the freezer, then put them over her eyes with a headband to hold them in place. Actually works very well for some pain relief. Hardly a treatment for migraines but it does help.
yes you must do it early. but worst thing is they only give you 3 or 6 triptan's a month. and sometimes it's hard to accurately gauge if early pain, or throbing sensation is truly going to be a migraine but you don't want to risk it. so you spend your 3 triptans and run out. either way it's guaranteed you will suffer, by taking it too late or by not having it when you need it
You should try getting the nasal spray version if you can, lifesaver for me
Thank you for this wonderful explanation 👍🏽👍🏽👍🏽
Love the way you siplify
Amazing video!
Can you do a video on preventatives? Love your content man
very elucidating. thank you.
Thank you! Excellent video
you deserve more views!
Very well explained , wanted to know the MOA of sumatriptan as migraine concept was difficult to understand.
But this video made them easy
Great video, very helpful
Excellent work done!
Highly appreciated!!! May Allah bless you more.
thank you so much! very helpful🥹✨️
It's nice n informative
Very Informative
Good explanation, great visuals!
Much appreciated!
Im a med student and i have migraines :( but this was helpful thank you so much
sorry about that 💗
Kinda part of being a med student 😆😆
@@kwesikwansakennedy2196 for real
Could you please make a video on migraine prophylaxis drugs..and .thank you for your videos so far...sir
good video,thank you!
When I get a migraine I hit it with 50mg diphenhydramine every 2 hours up to 300mg, 1000mg of Tylenol every 2 hours up to 4000mg, two doses of 50mg of Sumatriptan across 2 hours up to 100mg, and an extra 25mg of Metoprolol if my systolic blood pressure is 140 or higher. I have developed tolerance for the diphenhydramine over a few years since my doctor had me take it to offset the effects of other medications and help with sleep disorders. My blood pressure is normally controlled very well with 50mg/day Metoprolol (around 120/80 +-15) but I have noticed that sometimes my blood pressure goes up during migraines for some reason. I once went to the ER with the worst migraine of my life and my blood pressure was 199/110 but that was before starting Metoprolol. That extra 25mg of Metoprolol after significant acute pain has started makes the difference between beating the migraine and getting stuck with it for the next couple days.
Great info thanks
I experienced migraines for almost 4 years I almost ask God to end my life than in that situation😭
Try Amitriptyline! It’s been a game changer for me. Consult your doctor
So what medicines u have taken please help me too my brother have also so painful headache whole day not in condition to talk
Seriously migraine needs a cure,its worse than heartbreak,i will choose death over it..so sad
mimi isah Basic Botox (even cosmetic) plus memantine 20-30mg has done wonders and unlocked a new freedom in life without harmful longterm potential as others. Positive cosmetic and brain side effects.
@@user-ih1om5vm9j what about just botox without memantine? Asking as a long-time sufferer of migraines.
Try yoga! It will play wonders!
Ginger powder in water can work sometimes or Niacin!
Thank you so much
Thx!
Thank you
thanks
thanks for the visuals. this helps me understand aura as a person who experience migraines without aura. well done!
this is so useful
Nice video. Beta blockers are also used for migraine according to my textbook, maybe because they block beta 2 receptors on blood vessels preventing vasodilation ?
2nd most predominant adrenergic receptor on vessels is beta-2. So blocking of that gives some cerebral vasoconstriction.
cov-19 caused a shortage of zolmitriptan in my region, somehow. it's been difficult two months.
thank you sooo much
this was super informative!
I gave my presentation and thank you. Do you have a reference citation
Eletriptan works perfectly for me but I have to take also Gravol, for the vomit and nausea.... those two work very well. The pain lasts for about 2-3 hours while without medicactión it lasts 12 hours with intense vomiting. I rather die seriously when I dont take medication.
What is the main trigger of your migraine? And what side of brain (left, right) does your migraines are usually on?
Water
Light
Depth
Those drug names are hard to pronounce, how do you crank out all those big words? Excellent video
I just use www.pronouncekiwi.com/ to learn the pronunciation.
Sir, it is said that drugs like Propranolol , atenolol (beta blockers) act as prophylactic treatment for migraine. However they cause vasodilation .. So how does it prophylactically treat migraine? (Which is caused DUE to cerebral vasodilation)..
Blocking beta-2 receptors on the cerebral vessels leads to vasoconstriction.
@@physiopathopharmaco4190 ohh alright sir thank you ♥️
Perhaps the membrane stabilization helps the migraine prophylaxis. Usually the trigger event in migraine is ischaemia, so prophylactic agents are vasodilators which prevent the ischaemia and thus the migraine..
The drugs used for acute management are vasoconstrictor s like triptans
I was wondering the same thing.. on drugs for migaine prophylaxis and their moa....so it's due to vasoconstriction of cerebral blood vessels due to beta 2 ....and membrane stabilizing properties?
Thanks
...😔yeah... increasing vision problems were my signal that I was in for essentially sort of a neurological-earthquake lasting around *_*seven_** hours. Sht like that usually happened to me in between when I was 13 to 18. 😖😳🥴🤢😵💫🤮
I have two distinctive types of migrane: migrain on left-sided brain and migraine on right-sided brain. All are triggered by hungers (lacking of sleep and stress is a catalyst) and easily prevented by high-sugar, high-caffein food intake.
My left-sided brain paint can be treated by Paracetamol (found in common flu medicine or panadol).
But that treatment has no effect on right-sided brain paint. Until now, I still don't know why. The only effective way of treatment for acute right-sided migraine is a big cup of coffee with much sweetened condensed milk. It kills the migraine in just 01 hour =))
Hope that one day I could found the cause of this problem haha. Actually, it impacts a lot on my effort to lose weight. I just can not reduce sugar partake, otherwise, a migraine will be triggered.
How did you manage to identify your catalysts? For me, it never seems clear what triggers my migraines.
Good Presentation
Thank you
excellent
Thank you! Cheers!
nice
Why Beta blockers used in prophylaxis of Migraine ????? Waiting to answers ... Plz Guide us
2nd most predominant adrenergic receptor on vessels is beta-2. So blocking of that gives some cerebral vasoconstriction.
🙇👍❤
Excuse me, can anyone help me? How does vasodilatation cause pain?
It’s related to the pro inflammatory effect of the neuropeptides that are released during a migraine. The Inflammation caused by these leads to vasodilation and pain.
@@physiopathopharmaco4190 thank u, i might be dumb, but I’m curious how too much blood flow cause pain?
EXCELLENT
FUTURE IS CGRP
How vasodilation is related to migraine
2nd most predominant adrenergic receptor on vessels is beta-2. So blocking of that gives some cerebral vasoconstriction.
Sumatriptan is a miracle pill.
2:02 explain..
🥹🙏🙏🏻
hello po
Thank you