Restrictive Lung Diseases - Interstitial Pulmonary Fibrosis. Pathology, Clinical, Tests, Treatment
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- เผยแพร่เมื่อ 2 ธ.ค. 2017
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This video presents the introduction to restrictive lung diseases. We will discuss:
Definition
Types
Extrapulmonary restrictive lung diseases
* Obesity
* Scoliosis
Pulmonary parenchymal restrictive lung diseases
* Idiopathic
* Autoimmune
* Granulomatous (Wagner's granulomatosis, Sarcoidosis)
* Occupational (pneumoconiosis, silicosis, asbestosis, coal, etc.)
* Other irritants
* Chronic infections (Tuberculosis)
Neuromuscular restrictive lung diseases
* Myasthenia gravis
* Diaphragm issues
* Polio
Cellular events/pathogenesis
* Damaged Type I Pneumocytes
* Hypertrophy of Type II Pneumocytes
* Irritated epithelium
* Irritated macrophages
* Apoptosis of epithelium
* Tissue damage leading to local inflammation and lung destruction/scaring.
* Neutrophils releasing cytokines, proteases, tumor growth factors (TGF)
* Macrophages releasing transforming growth factor beta, tumor necrosis factor (TNF), platelet activation factor.
* Fibroblasts overactivity resulting in more extracellular matrix and hardening.
* Epithelial-mesenchymal transformation.
* Smooth muscle proliferation.
* Respiratory interface thickening. Disrupted gaseous exchange.
Clinical:
Dry hacking cough
* Dyspnea
* Hypoxia
* Respiratory alkalosis
* Late inspiratory crackles
Abnormal chest X-Ray
* Reduced volume in chest X-Ray
* Lower lobes show more involvement and the reason why.
* Right heart failure/cor pulmonale
Lung Function Changes
* FEV1/FVC ratio increases above 80% (normal or above normal)
Treatment
* Anti-inflammatory (may not be very effective)
* TGF Beta-blockers
* Oxygen
* Lung transplant ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Wow....you are the only one....who can make restrictive lung diseases understandable...thanks a lot for the lecture.
Well done! It's so much fun to listen to you! Thank you!
I have never saw the teacher like you .. You are so great..if these type of teachers teach in my college I will definitely become a doctor one day..thank you so much mobeen sir..
I am glad that lectures are valuable. Check out tons of more lectures on drbeen.com.
This was an amazing lecture! Thank you sir 😊
Such an amazing lecture......very conceptual ......thank you so much❤️❤️
Great lecture.Very educational and clear.Thank you.
Finally i can understand..bravo.good explaining
This is so great ,thank you so much
Thank you for your work 💓
Thanks a lot sir... Keep it up... Your videos are very helpful
This was helpful. Thanks.
Good lecture God bless you
great lectr,thanku sir.
Thank you for this 🙏
you're a god ! appreciate this so much :)
very good presentation, reminds me of respiratory school.
excellent.you are a great teacher. keep it up. thanks fromGreece
My pleasure. We got tons of content on drbeen.com. Check it out.
Nice job sir , specially fev1 ,about restrictive lung disease have more elastic
Thank you very much.
Nice ..thanks
Sir, I think decrease CO2 from blood to cause build up CO2 in blood and hence Respiratory acidosis will develop not alkalosis. Plz correct me if I'm wrong
A comprehensive explanation.
Thank you!
Thank you so much sir 🙏
Excellent
Nice Lecture, Thank You Sir.!
My pleasure.
Sir .. as co2 cant go outside during exchange , how it cause alkalosis ?
There must be acidosis
Thank you sir
Thank you sir😊
You are awesome sir
THANK YOU SO MUCH !
You are very welcome.
Sir... Would u take respiratory failure lectures???
Sir , you said the irritant will cause apoptosis of epithelium then you said that pneumocyte type ii will be hypertrophied and thus making more pneumocytes type i so where the apotopsis exactly occurs?
Amazing teacher. Masterhood at display. Great teachers are are always Purposeful.
Thank you dear!
thnx a lot sir😊😊😊😊
thanks sir we want more lecturere s from you plzzzzzzzzzzzzzz
Thank.you.so.much.sir.
Increase CO2 pressure suppose to cause Respiratory Acidosis rather than Alkalosis BTW nice explanation Sir
Great ❤️
Tq so much
Sir I need your all lecture where to get those ?
wouldn't the increasing of co2 pressure in the blood cause acidosis not alkalosis ? . thank you for the lecture
yes it would cause respiratory acidosis! the lecture is great though.
Top class
Sir whyy respiratory alkalosis occurs if co2 cant go out there should be respiratory acidosis????
Sir please upload complete lecture on COPD 🙏🙏🙏🙏
Thank you so much sir
Very welcome!
great lecture sir !
thank you so much
Your are very welcome.
grt lecture sir....
sir plz make vedio on general pharmacology which is highly tested in usmle..
Amazing
At 15:58 you said elevated co2 in blood cause respiratory alkalosis... I think its cause respiratory acidosis..
Sir Is this resp alkalosis Or resp acidosis?
Thank you sir ....i wish if only i would get a lecturer like you
Awesome ur
Sir please make a video on wbc disorders.....🥺🥺
Sir, why do we usually have tremors of rib casge for patients with Idiopathy interstitial fibrosis or lung disease.
1st you said transforming growth facter then after some time tumour growth factor.....
@15:52 it should be respiratory acidosis not alkalosis
Bestttt
Can you tell what to do in ild last stage
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Hi pls give some advice they told me I've got ristrictive lung I dont smoke am so stressted as dont know what's happening to me pls help any advice
Grupo de HP no facebook facebook.com/groups/683424751844146/
If sarcoidosis is a restrictive lung disease then why does it show a different kind of pathology
why cracles
Good lecturer , but I thought increase in carbon dioxide pressure would cause metabolic acidosis, ..
Respiratory acidosis
Exactly
around 16 minutes mark I guess that should be respiratory acidosis.
I agree with DrAbhisek Nanda - the increased interstitium thickness initially results in a localized acidosis due to the inability for CO2 to diffuse and leave the blood vessel. It isn't until there is a response from the patient (in which they would be breathing more deeply or more rapidly) that there is the potential for hyperventilation... However, hypercapnia is the primary driver for breathing - once that is resolved, the hypoxemia may not be sufficient enough to justify breathing as deeply/rapidly. Instead, the patient will feel tired, but generally more comfortable than symptoms associated with hypercarbia, so I posit to you that there will continue to be a compensated respiratory acidosis until late-stage processes in the disease occur.
yes
even great teachers make mistakes
it would b acidosis!!
i think it's correct alkalosis because co2+h20=h2co3 which is a normal compensatory mechanism of the body. So if co2 increases, also h2co3 increases so it gives alkalosis
this happens over time. initially the body develops acidosis, but as time goes by, the kidneys start to produce more bicarbonate to compensate the acidosis, so finally we have alkalosis.
I'm not a teacher or student but I do have Restrictive Airway Disease at 32% and Chronic Obstructive Pulmonary Disease at 52% pluse Asthma which were caused by a Ventilator I was on while in my long Coma. I NEVER smoked one day in my Life. I am 62 years old and very ANGRY cause I was healthy all my LIFE until 3 years ago! How does this happen?
Sir, my father is suffering from "cronic I L D", and he is near about 70.
Doctor has told that 60% of the lungs has been ruptured.
I want to ask that, is it curable or not ?
This very disease caused due to infection.
Jesus bless you
Thank you
Excellent
Thank you sir