Ivor Cummins - 'Inside-Out or Outside-In? The Pathogenesis of Atherosclerosis'
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- เผยแพร่เมื่อ 15 ก.ค. 2024
- Ivor Cummins BE(Chem) CEng MIEI PMP® completed a Chemical Engineering degree at UCD in 1990. He has since spent over 25 years in corporate technical leadership and management positions, and was shortlisted in 2015 as one of the top 6 of 500 applicants for “Irish Chartered Engineer of the Year”. Ivor’s focus and specialty is leading teams in complex problem-solving scenarios. He has often led worldwide teams with over 60-70 engineers working on major technical issues; the largest of these involved product issues where hundreds of millions of dollars were in the balance.
Several years ago, Ivor encountered a complex technical challenge in his personal life. Receiving poor blood test results, he was unable to get solutions via the doctors consulted. He thus embarked on an intense period of biochemical research into the science of human metabolism. Within eight weeks he had resolved and optimised all of his blood test metrics. Also, he had shed over 15Kg of body fat with relative ease.
In the following years he continued his research on the many “root causes” of modern disease, from “cholesterol” through to insulin resistance. He has become a professional speaker of note, giving many public lectures and chairing interviews with worldwide health experts. Most notably he was invited by the President of the British Association for Cardiovascular Prevention and Rehabilitation (BACPR) to give a keynote talk on heart disease root causes, at their annual conference in London last October.
All of Ivor’s public lectures and interviews are available on his TH-cam channel, where over seven million views have been recorded to date: / @ivorcumminsscience .
His book on chronic disease root causes and resolution strategies (co-authored with Denver doctor Jeffry Gerber MD, FAAFP) was released by a major US publisher on February 27th 2018:
www.amazon.com/Eat-Rich-Live-...
His blog and other content is available at www.thefatemperor.com
Ivor lives in Dublin, Ireland, with his wife and five children. - วิทยาศาสตร์และเทคโนโลยี
Having watched Ivor Cummins' presentations for years, I am always impressed by his insight. Despite not being formally credentialed in medicine, he has done a masterful job at demystifying health quandaries for the layperson and debunking long held myths about health. He does this better than most health care professionals. Outside of Mr. Cummins being naturally astute, I attribute part of his ability to get to the root of complex problems as the result of his engineering mindset. Its this type of super analytical and empirical mindset that I not only envy, but that world needs more of. The world would be a better place if we glorified the incisive thinking that is pervasive in a field like engineering more so than we revere celebrities. I am thankful for having such an intellectual juggernaut on our side.
Just discovered him. 😎 🍃
He's okay but when my car needs fixed I take it to a mechanic even though a car salesmen can talk about cars all day.
@@carvedwood1953 by that logic, salesman is the useless cardiologist, selling you fake cure- statin drugs. Ivor is real mechanic, saving lives from big pharma criminals.
Maybe it is time that more engineers and engineering approaches get involved in medicine.
Yep. Long overdue. Group think is fine, as long as you have multiple groups. ;)
Well the difference is that he wants to help where as pharma wants to make money.
I'd be concerned for their safety. Modern medicine and big Pharma makes way too much money keeping us ignorant.
I worked as a software tester for a decade ... The programmers, engineers, most managers, and above, are the smartest people I have ever been around in my life ...
He is a biochemist. They work for pharma too. He would be maybe dangerous if he had an electrical engineering degree...
I was an 5 & 10k runner into my 40s. I have been the proud owner of a hiatal hernia since my mid-20s. When proton pump inhibitors came out I got on them immediately. My quality of life improved dramatically. Turns out I was damned if I didn't take them for fear of Barrett's esophagus disease or cancer as opposed to what the PPI did in the long term. I am 70 years old weigh 180 and I'm 6'1" and my blood pressure is normal and I only have one kidney. I had an EKG done that raised the eyebrow of the doctor. She then suggested a Nuclear Stress Test which came back normal. So she suggested a CT scan of the heart which according to her came back functioning normally. I then asked for a CT CAC test. It came back at 2192. I have no shortness of breath, no chest pain and I do not get tired very easily. I am currently waiting to hear from the cardiologist . Here is what I learned about PPIs:
I learned that PPIs reduce the enzymatic activity of dimethylarginine dimethylaminohydrolase (DDAH). In this way, PPIs increase plasma levels of asymmetric dimethylarginine (ADMA) 4. Because it inhibits the generation of vascular nitric oxide, ADMA would be expected to increase platelet interaction with the vessel wall.
In summary, it means that because of the PPIs I was taking it inhibited the production of nitrous oxide in my blood vessels that protect the endothelial lining of the arteries.
If you know anyone on a PPI try and get them off of it.
Ivor, I love what you have been doing and I am working hard on Keto for 6 months now to bring about all the good things that should be happening in my body, thanks to you. Years of sugar and carb abuse were wearing down my systems, but the human body is amazing and all systems came back onlinie quickly in my case. When I think of all the health problems I have had, I can attribute them all to my sugar addiction. I was not fat (skinny fat, fat inside with a little tummy) and so I thought my body could just metabolize whatever I gave it, and blood tests seem to indicate good health. My body systems did a fine job to try and cope, but for years I knew I had to stop the abuse. I finally did after seeing some of your videos, I got on the Keto diet. If anyone is reading this, I can only hope you give Keto a serious try. Do not wait another minute to reverse all the crap you have eaten.
Which is better: vegetarian keto or carnivore keto?
I reversed fatty liver with the fat deposits going from golf-ball to shrinking to nothing. Saturated fat makes the body like a well-oiled machine or "butter makes ya pants fall off!" (Great song)
Paul Schneider, ketovore, hands down. Keto vegan is impossible to get low enough carbs, high enough protein. If you add concerns about plant toxins (Lectins, oxalates etc) it makes it hard to find enough plant to eat, and hard to work out which are safe. Animal based eating has none of those probs. It is nutrient dense in the right proportions without any effort. No hunger, no calculating and counting and shuffling around to get adequate protein.
@@PaulSchneider-bp2ic Carnivore keto is very nutrient dense. The plant path needs multiple supplements.
I’m around medical providers all the time. I’d be very surprised if many of them understood physiology at this level off the top of their mind. They are just following algorithms that are largely structured by the FDA and pharmaceutical companies.
What algorithms are you referring to?
@@250txc He has no idea what an algorithm even is LMAO
Algorithm was a metaphor for the word directions.
Ivor is simply awesome!! One of THE BEST speakers out there. His comprehension of the material he‘s presenting goes very deep. And his „matter of fact“ humour cracks me up every time. He‘s convinced me for sure! Outside in my friends, outside in. Keep up the great work Ivor, we‘re all counting on you 🤓
I watched your discussion with Subbotin a while back and was very interested in his theory. It made a Lot of sense to me. Great that you have put it all together in a nutshell with very useful graphics. It is very much appreciated, thanks Ivor! This theory makes simple sense to me, whereas the conventional one does not and never has, they ignore too many inconvenient truths.
Out of interest, when did you make this presentation? Looking forward to watching all this unfold, I think Subbotin has hit the nail on the head.
Thumbs up, yet again.
Ivor may have saved my life with his lectures, podcasts and talks. Thank you @FatEmperor
Ivor, I recall from the original talk, some time back, that Vladamir Subbotin gave, that there was mention that cells of the lining of the arterial wall changed their morphology and composition due directly to lack of exercise, or at least a very active lifestyle. To me, that was a real give-away as to the associated knock-on effect with the Subotin outside-in hypothesis. Anyway, keep kicking the door in. You and your muckers are doing a brilliant job. The more I follow these developments the more I feel you need some help from a good psychologist to help you get through the denial of the established orthodoxies, and the plethora of non-medical experts piling into such matters. Your conversation with Dr. John Lee brilliantly exposed this conundrum. I'm thinking someone along the lines of Harry G. Frankfurt ('On Bullshit'). No matter, someone is holistically needed to call out the multiplicity of errors in all that you and yours are broadly focused upon, and so for what it is worth, you buddy are it! No question. Take care.
So of a person is sick can they reverse this disease with exercise and low calorie
@@Chris-kr7gg Low carb, not low calorie, and healthy fats, which means, no vegetable oils!!
This was an awesome presentation of a very complex issue. I can now better visualize what I was very confused about for such a long time and finally understand the major differences of these two competing cholesterol theories.
Thanks Ivor, for so eloquently and simply turning on the lights!
Much appreciated
1. Some vasa vasorum originate on the lumenal surface and penetrate into the intima. With pulse pressure they will close, so flow in them is during diastole, when lumenal flow actually has a slight reversal before the next pulse.
2. One quarter of the body's LDL is in the INTERSTITIAL FLUID. It gets there through fenestrations in the endothelial cells or through gaps between them in the capillary beds. There are about 45,000 to 107,000 LDL particles for every Red Blood Cell (share of blood volume is 45% RBC to 55% serum).
3. Apo-B were found in veins WHEN HARVESTED to used for coronary artery bypass grafts, indicating LDL was present IN THE VEIN. Veins DO NOT DEVELOP ATHEROSCLEROSIS, however, AFTER being used as grafts, when retrieved at autopsy, the veins had MORE Apo-B and had become ATHEROSCLEROTIC.
4. ONLY ATERIES with VASA VASORUM develop ATHEROSLCEROSIS. Smaller ateries and arterioles DO NOT. The largest thickest veins may have some vasa vasorum, but do NOT develop atherosclerosis.
5. Atheroslcerosis seems to have prefered locations, like bifurcations.
6. Blood passes the aortic valve at 60 cm/s, so is at the umbilicus in 1 second, and at the toes in about 5 seconds. The return trip takes about 5 seconds also. The body's entire blood volume is pumped about once a minute. A Red Blood Cell's "round trip" takes 10 seconds, while 50 seconds is spent slowly passing through the capillary beds with pores large enough for SMALL, old, rancid (oxidized), glycosylated LDL to pass through. The Artery walls have capillary beds too.
THE STANDARD EXPLANATION funded by the makers of statins IS NOT PLAUSIBLE, that tiny LDL racing headlong down the artery would be pushed PERPENDICULARLY through the endothelium and into the intims to the intima-medial junction, when those same LDL ALREADY HAVE ACCESS TO THE INTERSTITIAL FLUID of the ARTERY WALL through the vasa vasorum and capillaries of the media and intima.
Wow! Who are you masked man?
Thank you
You should be up there co-presenting up there with Ivor!
Another scientifically sound presentation. The entire nutritional conversation is so polluted with misinformation and toxic to people's well being. Thank you for being the voice of reason with these insightful science backed presentation.
I will need to listen again, but as ever Ivor ... you are a breath of fresh air. Thanks. x
Thank you Ivor!!!
Now I know so much
Indeed interesting!!!
Love Ivor’s step by step presentation.
That was an awesome presentation, I really hope you do a followup to this very soon.
Outstanding presentation!!!!
Thank you Ivor...your work on CAC also has been very helpful to me personally. A 3 year foray now into a very low carb very animal product (so high in saturated fat) way of eating has seen my blood pressure go from medium high(145/90) to normal (125/80) , my HDL go up nicely, my triglycerides drop 60% to the low side of the normal range, my Hb1ac drop from 6 to 4.4 and a CAC score of 0. My calipered body fat is 18%. All this at age 68. My weight dropped from 98 kg to 83. And I can eat to satiety which means that I am never starving. For the first time in 30 years maintaining an optimal weight is not a fight I was always losing because of the sugar and carb cravings. I realize now that these interventions are at the heart of the Root Causes Ivor speaks of. With my Swiss doctor's agreement we don't even include LDL in a blood panel. It is a simple approach while not necessarily always easy. But definitely easier than the alternative risks.
As always, wonderful info!
If a high carb, vegetable oils and junk food diet were the cause of heart disease, why would my 60 something wife who has consumed the SAD her whole life have a zero calcium score while I also consuming the same diet end up with a 363 calcium score. I think are still miles away from getting to the bottom of this puzzle.
Puzzled over Dr. Subbotin's first presentation/interview. I did enjoy his simplistic logic. I will keep following this outside-in theory.
Wow, exciting stuff! Well done as always, Ivor!
Thanks for sharing this!!
Ivor, you have a unique ability to present information as a neutral observer who just discovered something for the first time. It's endearing and very necessary in an emotionally charged world were you're supposed to defend your team at all cost.
Sounds convincing! More reasonably as the old hypothesis. Congratulations.
Awesome!
A wonderful mind in a ground breaking team🙏
The best as usual!
Does this mean that we don't have to worry about the LDL levels anymore? We have to worry about insulin resistance and high blood pressure?
More than LDL levels, you would do better to examine the LDL particle sizes and inflammation markers like ferritin and crp (c reactive proteins). A calcium artery score would help too
Also see Dave Feldman's website cholesterolcode.com
Peter, I took it to mean that if one successfully resolves root causes - high blood pressure, oxidative stress, glycation, hyperinsulinemia, etc. - then LDL level in blood is less a worry, but if one does not resolve root causes, then LDL even though not a root cause (in Subbotin's hypothesis) remains a worry and is best lowered such as via statins.
yes
@@TH-camr-ep5xx I don't know about statins. And why would one need to lower LDL if it's not the root cause?
Thanks Ivor. Keep up the good work.
Amazing analysis
Often the industry denies changing of paradigms, hence it often comes down to outsiders to bring the message to the people that might eventually demand change.
Extremely interesting
Excellent.
I have been on he health roller coaster for the past 16 months. Irradiated for prostate cancer last April, DVT in May, operated on for kidney stones blocking my ureter in July resulting in a loss of hemoglobin to 8g/dl (now 12g/dl). I went on a strict low-carb, high-fat regimen exactly one month ago combined with intermittent fasting, vitamin supplementation and rigorous daily exercise. I summarily dropped 20 lbs, visibly erasing visceral abdominal fat though I can't seem to shake some stubborn subcutaneous adipose fat.
Three days ago I had a physical with my doctor. BP is 120/80, O2 level 98%. My blood work showed an LDL number of 179mg/dl, HDL 65mg/dl, triglycerides 73 mg/dl, VLDL 15mg/dl. Urinalysis showed negative on protein, glucose and blood but 20 in KETONES!
Am I in trouble with Ketones and LDL? My doctor doesn't know anything about fluffy vs oxidated LDL and I am hesitant to rely on his recommendation.
What a pleasure to see involvment of rational scientists and resulting questioning of the gatekeepers of conventional biological wisdom!
I was about to comment on Malcolm Kendrick supporting this, but then saw his photo among the "team" at the end of the video :-)
An excepțional, very well documented and easy to follow presentation! Thanks for the wealth of information regarding the real causes of CVD! As a LCHF practicant, I see a big relief that slowly, but steady, the truth is revealed.
Fascinating hypothesis.
👌
Great lecture ;)
2 absolutely historic presentations from Lo Cal Denver 2020, this and Chris Knobbe’s Diseases of Civilization!
You always seem to convince me, and once again you've done it.
In this discussion of whether sdLDL enters arterial wall from the blood in the lumen (suggesting high LDL may be dominant root cause) or from outside via the vasa vasorum (suggesting various forms of intimal insult may be dominant root cause), very interesting tidbit at 24 minutes in - the identification of PVAT - perivascular adipose tissue, fat cells surrounding arteries.
From a study: "PVAT plays key tissue-specific roles during the development of atherosclerosis. Under physiological conditions, PVAT is able to store and combust lipids, generate heat and take up fatty acids from the blood. PVAT also releases multiple vasoactive molecules such as NO, H2S and adiponectin, which protect against atherosclerosis development. Under pathophysiological conditions (e.g. obesity, hyperlipidemia and diabetes), PVAT becomes dysfunctional. Together with reduced thermogenic capacity due to whitening of BAT (brown adipose tissue)-like PVAT, dysfunctional PVAT releases pro-inflammatory adipokines that promote endothelial dysfunction, infiltration of inflammatory cells and migration of VSMC, subsequently promoting atherosclerosis development. Thus, targeting PVAT function is emerging as a novel therapeutic approach for the treatment of atherosclerosis that warrants validation in future research"
Well Done very nice lecture Ivor. This hypothesis is very interesting. I was never a big fan of The single hypothesis of atherosclerosis. Specially when you see the new studies on the effects of pharmacology to treat hyperlipidemia. The literature coming out about LDL now has left me skeptical of the old theory which is good. Science has become very interesting in the sense that if you can’t prove your hypothesis somehow you’re a loser. When in fact that’s great science. You have a hypothesis, you don’t prove it. So you scratch that off and move onto a new hypothesis. That science! That’s how we get better. Very very good lecture
Wonderful to see new and exciting developments in the area of cardio health..... unfortunately, your team will have it's work cut out to break the level of cognitive dissonance surrounding this issue. All of us with a heart wish you well🥰
I like this and greatly appreciate this presentation. I'm glad people are questioning the orthodoxy.
However, the slides shown of cholesterol or lipids (dyed) slowly accumulating deep in the media do not seem to indicate that the intima is (visibly) inflamed. If hypoxia is driving the infiltration of vasa vasorum because of "swelling" - some intima cells are now too far from blood flow to get oxygen/nutrients - why don't see this swelling in the early phase slides? Or am I missing it? Thx. I don't mean to sound harsh - I am a fan, but I would love an answer to this pls. Thx.
I’m a New Zealander and based in Nelson, I was wondering how I can get help with some issues my husband and I are having please? Is there a Doctor who supports low carb in NZ or how can I find a doctor to support us
Great presentation! This to me seems much like what you see in diabetic retinopathy care to comment on that?
It comes in from one side or the other. But, how do we stop it is the main question isn't it? Lower LDL versus (?) increased HDL too? We'll see. Seems like LDL is indeed the main initiator, either one side or the other.
How is the research on this going? is there anything up-to-date ?
Also following this. Please advise if anyone has seen new information about this. The silence is very loud.
What is the (anticipated) publication date for this paper please?
Thank you. Good presentation. Personally, I think you are calling some associations and symptoms as causes. Probably just comes across that way as I know how you think ;-) I think the root cause is actually poor diet which is the only sensible lever to pull to prevent and mitigate the problem.
What is the best diet for the prevention of heart disease?
This affirms the importance of the lymphatic
system in cardiac health.
ie moving the body
If LDH goes out to in , how did LDH get out of the intravascular location in the first place. Unless it’s in to out followed by out to in
I have a few questions; why is the atherosclerosis, which causes events, normally at junctions in the artery ie high flow areas? Why don't we see this in all arteries and not only the coronary arteries?
Because high flow is high friction and insult to the endothelial and glycocalyx. This with high blood sugar and high insulin causes the initial wound- Malcom Kendrick book answers this well
Would like to see the explanation of differences in physiology for blood vessels & veins vs coronary arteries regarding atherosclerosis.
It's mainly about pressure. The coronary arteries are under massive pressure. That's why they are prone to damage. When people get a bypass and they harvest of vein from another part of the body like a leg, as soon as they patch it into the heart it immediately starts developing the same damage and it too will develop plaque.
@@claybutler pressure and structural properties. Veins have a different function, and transport already "used up" deoxygenated blood. But you're 100%, because of the high pressure role in heart and coronary arteries damage occurs much more easily to the endothelium before nutrients and oxygen are removed, therefore higher concentration of damaging properties. I also wonder if damaging the VV with high sugar also causes them to grow to seek out other sources to complete their job?
Is it true a teaspoon extra virgin olive oil along with a mediterranean diet can greatly improved this condition?
The best! 30:37
I’m trying to reconcile this with Malcom Kendrick’s presentation of thrombosis and insults to the endothelial and glycocalyx. These insults are the underlying pathology. Cholesterol was never more than a sales con to swap meat for seeds and meds
I love Sevilla.
Why is it OK for researchers to use an illustration of another , smaller artery when talking about the structure of the coronary arteries? Well, to support their ( probably) incorrect hypothesis. It’s not logical that the lining of vital arteries which are always under pressure would be porous or “leaky”.
please, anyone knows the intro song name?
I'm sorry but I cant hear your criteria for helping a situation whichI have
Big if true
Can the vascularization of the intima be reversed with say a low carb, anti inflammatory, ketogenic lifestyle?
Well low helps decrease the sugars and oxidizing fats from seed oils that damage the lining, which is the catalyst of injury starting the process! Reduce injury to lining, less atherosclerosis, from the latter theory point of view.
Yes it can and does heal. It is never too late to try.
I would suggest everyone avoid chemically extracted seed oils YUCK! and go into carnivor/keto to kill their carb addiction. When you eat real food with plenty of healthy saturated fats (grassfed beef mince 500g ) you will lose your insulin resistance and reset your body. Carnivore and intermittent fasting for fat loss. Butter does make your pants fall off.
And when you eat healthy grassfed beef, you dont want too much carb/fibre pushing it through your body too fast. The saturated fatty meat passes easily, but when its food value has finished being absorbed which feels nice and relaxing.
Just imagine our society is just built on a pile of lies stacked up over the decades, and you will start to see clearly. This experience has helped me as a woman to stabilize my moods as i dont get hungry/angry like i used to. I feel so chill. I respect real food now.
A vascularized intima is a physiologic reaction to a pathologic state. You don't want to reverse it.
On what date did Ivor Cummins give this presentation?
Early March '20 if I'm not mistaken
Jippiekayee!!!!
The "silo" approach within the medical community, and regarding medicine is a detriment to a better understanding of these problems.
Instead of building these silos taller, remove them.
Or bridge them.
Calcium in dairy or calcium supplements? I eat lchf and my CAC score increased by 50 points in 18 months.
lactose is 10 times more glycating than glucose and whey protein spikes insulin more than even carbohydrates do. calcium can also be an issue if there is a lack of vitamin K to remove it from the blood circulation. so if you eat dairy, dairy might be a significant contributor to your problem. especially if you went low carb because you were already suffering from metabolic disease, your body was already struggling with hyperinsulinemia and oxidative stress, and dairy intake feeds these metabolic abnormalities
I'm learning way to much about microbiology
Is that from other videos? As that is a study of other organisms like virii..bacteria..
Science by consensus and the use of models gets it completely wrong. Why does this sound familiar?
You're doing God's work!
💚
“Ivor little story”
I cant just count calories?....dangit. Human Physiology for the win.
Will removing fat from around coronary arteries reduce atherosclerosis?
By removing excessive sugar intake, less fat will be stored. By being in ketosis with very low sugar i take, you can burn body fat and lower the root cause list. Making statements of reversals you wont find as thats a lawsuit waiting to happen. These are both theories and one makes more sense. If reducing root causes stops progression or reduces atherosclerosis and heart attacks, that's a win. Either way staying where your at that caused the storm within yourself will only get worse if you dont change.
Is he saying Keto could be problematic for someone that already has atherosclerosis?
He clearly says high LDL is an issue once you’ve been compromised. Well this is going into plant based diet territory than, or regular fasting.
too many hours reading/watching (not enough?) keto, malcolm kendrick, dave feldman, sarah hallberg (rip), paul mason, the usual suspects brought me here ... and this connects many pieces of the jigsaw. it makes more sense. however
i have a question for Subbotin and/or those better able to distill the mechanics of the vascular system. I'm scratching around the implications of this genesis description: before any insult and injury is done to cause the thickening of the intima, what is happening with lipids being deposited into the tunica media where there is already blood supply? is there build up? does the vasa vasorum (??) not bring the bad stuff there first ? is it not delivered there, or handled differently than by the intima later. ??
Ivor, what percentage of people with a zero calcium score have afib or arrhythmia problems? Could calcium be the cause? Do you know of any studies? Is this too simple of a question? After all calcium is conductive.
So should I take a statin or not?
Great sarcasm😂✌
if you do ingest statins you need more meat for CoQ10
I was a welder all my life and yes I did a lot of dumb things to my body as a young man such as smoke and eat too many carbs and probably drank too many beers. That all ended at age 55 with a 4 way bi-pass in 1998!
For the pas 21 yrs I've been on pills. I've had a stroke and a few heart attacks resulting in stents! Well as a welder I worked close with engineers. So a blood clot is a rusted pipe. You cut it away and replace it. When a pipe is clogged it takes more pressure to pass water to the sink!
Maybe eating healthy would have kept my pipes clean. I was athletic. The day before the heart attack I walked 18 holes of regulation golf.
Get off the Sugar folks it'll kill U
Does anyone suspect linoleic acid is at the heart of this issue?
👏👏👏👏👏👏👏👏👏👏👏
Very good presentation. Perhaps I am naive, but it seems that root cause list applies in either case; the prevailing inside out or the Subbotin hypothesis. In your earlier presentations on inside out the LDL moves in to put a band-aid on a compromised arterial lining and when a piece of this LDL plaque breaks loose, it potentially takes you out of the game. It seems that what you call root cause in the Outside in theory are simply risk factors to mitigate, on the inside out hypothesis and LDL still has a role to play.
Nailing the mechanism down is clearly an interesting intellectual exercise, but I am not sure how it changes the way we treat this very dangerous problem; diet, exercise, vitamins, no smoking.
How do people like the Japanese stay slim and incredibly healthy when just about everything they eat are carbs? I can’t understand…
Randle effect
As Dr. Kendrick a practising GP, Ivor an engineer, here is a Cardiologist's take on "thrombogenic hypothesis", Dr. Nadir Ali:
th-cam.com/video/iOwfhFWUwhE/w-d-xo.html
Tocotrienols reduces angiogenesis (which reduces cancer growth). I wonder if it also would reduce the growth of vasa vasorum, and if that would affect arterosclerosis.
If tocotrienols accumulated there (as it does in the skin) it would certainly have a strong antioxidative effect. Perhaps preventing LDL oxidation, if those particles stays to long there.
This is just a thought, but I would like to know if there's any sign of any such effect.
But why add more when we can reduce oxidants from the diet to reduce the need of antioxidants? Maybe as secondary after a heart attack but prevention is always best, otherwise.
Could you help me, I'm just passing through? Trying to find help for an older friend who is suffering from repeated cardiac problems necessitating hospitalization.
He says, "I gave up beef over 15 years ago. My meat consumption is exclusively fish and poultry. I do eat a lot of vegetables (many drawn from my own garden where I know (as much as possible) the environment.
I have been told about the benefits of being a vegetarian if you have CHD. My surgeon made a big point of it. I am moving that direction."
Is his surgeon correct to advise my friend to adopt a vegetarian diet? What diet would be best to minimize or eliminate CHD?
Recall that David Diamond referenced Subotin and all this back in 2018 as part of his statin rant. Saw it at Low Carb Houston. His conclusion was that the vaso vasorum repeated blockage leads to the boo boo in the intima. Result of unfavorable clotting factors from high BG etc. Still want to hear how and when calcification develops and progresses in light of all this.
Or maybe it's both Inside Out and Outside In?
It has never made any sense that cholesterol was what initiated the damage.
Seems pointless. ldl still the initial driver for AS in both mechanisms. Which means lowering ldlc / ldlp is still the way to avoid AS. In this new mechanism ldlc delivered by the VV ... so - lowering ldlc STILL the only therapy to (a) avoid and (b) reduce existing intema cholesterol burden. Agree with comment below - if my car breaks I'm taking it to a mechanic not the guy who sold it to me.
LDL is necessary but insufficient to explain atherosclerosis
I have a feeling both inside out and outside in are correct and both play a role.
Well the inside has the damaging components of the initial injury to the lining that causes the snowballing effect.
Lol, I actually think the Orthodox priest has a pretty good likeness to Richard Wagner, the opera composer. I think it's quite striking. Interestingly, Wagner was sort of famous for being an anti-semite.
Well I understand the issue. Seems academic. How will it save a life to know this?
May change the focus of research - on solutions - if you identify that it's not 'bad' LDL as the major cause of the disease - but LDL just a factor. So I consider - as one of a billion statin users.
Well, with the knowledge that LDL is not (in Subbotin's outside/in hypothesis) a causative factor in atherosclerosis, but that poor metabolic health drives atherosclerosis, one might improve metabolic health such as via proper nutrition to save one's life. Subbotin's hypothesis, if borne out, could in this manner save millions of lives. People could stop eating statins and loads of sugars/carbs and thereby lessen their chances of being struck down by atherosclerosis.
It puts root causes front and center instead
of meaningless numbers such as LDL count.
It's almost funny to watch a man going in to unbelievable length to justify his craving for meat.
our health care in US mine is KAISER are decades behind in science. It is a sad state that they do not understand heart disease,diabetes,hypertension and like to treat illness instead of prevent or reverse it. They will only parrot the AHA eat low fat, whole (heart healthy carbs) even though it is obvious that since dietary guideline people have gotten fatter and more diseased. AHA is in bed with big pharma and a simple google search will show it from who funds them which is the companies that profit from people being diabetic , hypertensive etc and want AHA to keep giving bad dietary advice. Thank you Ivor for trying to get true science to make people healthy.
For goodness sake, there is no malice or conspiracy to ruin people's health for profit.
Well said. The cheapest ingredients are used in processed foods. It is clear to me; buyer beware. I dont trust pharma, agriculture, government, society nor mega companies to care about my long-term health. I am meerly a "consumer."
And a fool and his money are soon parted. Question everything.
A true scientist is not afraid to defend his position. A charlatan avoids discussion and invents a consensus.
At last back to your grounds.
Ivor - great vid, this is where you excel. Forget the virus BS and fake data, stick to real anatomy, physiology and molecular biochemistry - stuff that will really help people going forward !