We discuss: 0:01:32 - Feng’s background, experience in developing optogenetics, and his shift toward improving gene-editing technologies 0:10:05 - The discovery of CRISPR in bacterial DNA and the realization that these sequences could be harnessed for gene editing 0:21:48 - How the CRISPR system fights off viral infections and the role of the Cas9 enzyme and PAM sequence 0:29:48 - The limitations of earlier gene-editing technologies prior to CRISPR 0:39:08 - How CRISPR revolutionized the field of gene editing, potential applications, and ongoing challenges 0:51:59 - CRISPR’s potential in treating genetic diseases and the challenges of effective delivery 0:57:55 - How CRISPR is used to treat sickle cell anemia 1:05:51 - Gene editing with base editing, the role of AI in protein engineering, and challenges of delivery to the right cells 1:13:10 - How CRISPR is advancing scientific research by fast-tracking the development of transgenic mice 1:17:43 - Advantages of Cas13’s ability to direct CRISPR to cleave RNA and the advances and remaining challenges of delivery 1:27:55 - CRISPR-Cas9: therapeutic applications in the liver and the eye 1:40:15 - The ethical implications of gene editing, the debate around germline modification, regulation, and more 1:52:45 - Genetic engineering to enhance human traits: challenges, trade-offs, and ethical concerns 1:58:25 - Feng’s early life, the influence of the American education system, and the critical role teachers played in shaping his desire to explore gene-editing technology 2:13:15 - Feng’s optimism about the trajectory of science
I don’t think the average joe realizes how much of a big shot Zhang is. He’s essentially the Elon Musk of gene therapy. With his leadership, the Broad Institute essentially has the best claim to the patent of CRISPR tech
I'm not sure Zheng is the Elon musk of gene therapy. Maybe he is. I thought about this before seeing your comment. The question that Attia asked about scaling these therapies currently in trial, don't have a clear path. It's also not clear that Zheng is driving the scaling of this technology. He's much more on the scientist discovery side. Whereas Elon is much more on the industrial Mogul side, driving up manufacturing scale and driving down cost. I think we have yet to see an Elon musk like person run with this tech and disrupt big pharma... (Disclosure: I've worked for one of Elon's companies as an engineer for many years and have seen it on the inside)
@@joshydillens148 not so easy for certain disease causing alleles like ApoE4 in adults. If you listen from 1:40:00 to 2:00:00 or so you'll gain some understanding as to why.
I read that this palindrome sequence has a function of repairing DNA, it's bidirectional symmetry? Charge imbalance on one side allows it to bend in the middle?
The Freak Show you continue instead of organic learning, brain health and spiritual, mental, physical health. HUMAN Engineering….🧟♀️ It’s starts out great to help diseases-Blah Blah Blah-- and turns into “The Blob” freak show in the movie “The Substance.”
We discuss:
0:01:32 - Feng’s background, experience in developing optogenetics, and his shift toward improving gene-editing technologies
0:10:05 - The discovery of CRISPR in bacterial DNA and the realization that these sequences could be harnessed for gene editing
0:21:48 - How the CRISPR system fights off viral infections and the role of the Cas9 enzyme and PAM sequence
0:29:48 - The limitations of earlier gene-editing technologies prior to CRISPR
0:39:08 - How CRISPR revolutionized the field of gene editing, potential applications, and ongoing challenges
0:51:59 - CRISPR’s potential in treating genetic diseases and the challenges of effective delivery
0:57:55 - How CRISPR is used to treat sickle cell anemia
1:05:51 - Gene editing with base editing, the role of AI in protein engineering, and challenges of delivery to the right cells
1:13:10 - How CRISPR is advancing scientific research by fast-tracking the development of transgenic mice
1:17:43 - Advantages of Cas13’s ability to direct CRISPR to cleave RNA and the advances and remaining challenges of delivery
1:27:55 - CRISPR-Cas9: therapeutic applications in the liver and the eye
1:40:15 - The ethical implications of gene editing, the debate around germline modification, regulation, and more
1:52:45 - Genetic engineering to enhance human traits: challenges, trade-offs, and ethical concerns
1:58:25 - Feng’s early life, the influence of the American education system, and the critical role teachers played in shaping his desire to explore gene-editing technology
2:13:15 - Feng’s optimism about the trajectory of science
Feng is an EXCELLENT science communicator, in addition to being a world-class researcher. Rare combo. Kudos to you both!
This type of content should have 8 billion views within the 1st 24 hours and 32 billion views after 96 hours ...Thanks to you both and youtube
I would encourage you to think big.
Peter, this is the best discussion you’ve had so far. Thank you! Feng is a genius and I have so much respect for him.
I’m so thankful that there are humans like these 2 out there trying to find cures for chronic diseases. 🙏
Hoping you’re doing well Peter. Thanks for the podcast
Thank you for this video, much respect for both of you. Also for mentioning the attack on meritocracy 💚
Awesome guest!
Mother Nature is so amazing! Awe inspiring.
Best ever. Thank you
Brilliant stuff!
Jennifer Doudna, Nobel prize, anyone?
talking about palindromes and the number of episodes is 323...
Great episode
I don’t think the average joe realizes how much of a big shot Zhang is. He’s essentially the Elon Musk of gene therapy. With his leadership, the Broad Institute essentially has the best claim to the patent of CRISPR tech
But... where the key difference is that Elon Musk takes credit for other's technological developments.
I'm not sure Zheng is the Elon musk of gene therapy. Maybe he is. I thought about this before seeing your comment. The question that Attia asked about scaling these therapies currently in trial, don't have a clear path. It's also not clear that Zheng is driving the scaling of this technology. He's much more on the scientist discovery side. Whereas Elon is much more on the industrial Mogul side, driving up manufacturing scale and driving down cost. I think we have yet to see an Elon musk like person run with this tech and disrupt big pharma... (Disclosure: I've worked for one of Elon's companies as an engineer for many years and have seen it on the inside)
Ahh man this gonna be a good one thanks doc🙌
Fascinating.
where Doudna or Charpentier?
Do you know anything about lichen sclerosis? I’ve been diagnosed and don’t know what to do. There are no doctors that can help.
Darwin? You’re describing what a God put together!
Very interested in changing ApoE4 staus
@@joshydillens148 not so easy for certain disease causing alleles like ApoE4 in adults. If you listen from 1:40:00 to 2:00:00 or so you'll gain some understanding as to why.
2:07:00 The first time I heard Peter asking a totally inadequate questio.
I read that this palindrome sequence has a function of repairing DNA, it's bidirectional symmetry? Charge imbalance on one side allows it to bend in the middle?
what’s the hold up? This will not happen for at least 25 years? Other therapies will happen before this.
Intelligence is paramount to health
Thoughts on Dr Jack Kruse?
Imagine your resume says Stanford, Harvard, and MIT. Wow 😮
OMG, they are using gene editing for my potato chips, it says CRISPER right on the bag.
wow
As most try to find meaning in their daily survival
Good lord awareness is a fn curse
This makes the anti-vax and anti-immigration crowd's ears bleed
Immigration?😂 take your meds
@@Abbale💀🫡🇺🇸
Please reply to me
Please consider Peter's comments about meritocracy and the left's discrimination of Dr. Zhang's ethnicity in your vote next week.
The Freak Show you continue instead of organic learning, brain health and spiritual, mental, physical health.
HUMAN Engineering….🧟♀️
It’s starts out great to help diseases-Blah Blah Blah-- and turns into “The Blob” freak show in the movie “The Substance.”