The Drug Trial That Went Horribly Wrong
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- เผยแพร่เมื่อ 29 ก.ย. 2024
- On Monday 13 March 2006, eight healthy young men took part in a clinical trial of an experimental drug known as TGN1412. The drug was intended to treat leukaemia and had already been successfully tested on monkeys but never on humans.
It should have been a routine clinical trial but it soon spiralled into one of the most infamous medical emergencies in recent British history.
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I'm being treated for ovarian cancer. I cannot express my gratitude to the people who have risked their life to try to save mine
@@india1422 me too and I’m so thankful to the people and animals that helped keep me going. My very best wishes to you.
@@india1422 my thoughts and prayers🙏🏼🩷
Be careful those drugs have severe side effects effects that allow doctors,to get away killing off whistleblowers later in off that k ow they were forced into fling along or being blamed for o get away with committing atrocities against ,minorities to suffer the same cover up by I forced treatment t and th. Blaming them and for them to to get away with to b blamed and killing them by and forcing me to do Nyerere I to palletive care to cover it up
Please help me thy are blaming me for to cover up their crimes and allow the government to,ent to blame these please people to comply and now I know they are killing off these to people and blame them for instead of rich people,to get away to comply and are know and forcing me into end of life care
My best wishes to you both, and to all cancer patients. Please don't give up.
I can’t imagine being the person who received the fake medicine, and having to sit there, listening to all this wondering if you are next.
Wait I don't get this where do they say that they were given the fake drug?
two people recieve something completely else while the others recieve the drugs. But no one knows who got what but the doctor/nurse. i believe its explained in the beginning of the video.
neither the docs nor the nurses knew, only the one who packaged them.
at 8:03
ah thats right, thanks.
me: oh man my knees hurt again
*watches documentary *
never mind i’m good
Joji Jo I love it 😂
Same
legit me
@@becky2322DM me, you look stunning :)
LMAO
Part 1: company brings patients to trial. Part 2: patients bring company to trial.
If only it was that easy
And loose!
AppleYou Brilliant comment!
I'm sure the patients signed away any probability of liability
Uno reverse card
ME, thinking I'm going to only watch 5 minutes of this and end up watching the whole thing!
Sammmme girl
This really does intrigue me .
God Is So Merciful .. Amen .
No amount of $$$$$ ... Is worth playing the , maybe , or , maybe not day !!! Which is a memory of , I'm alive !
Same! 😬
The saddest patient death I've ever dealt with was a man who had an unexpected allergic reaction to a psoriasis medication we were testing. He was a healthy guy in his early 50s. No one had any reason to believe he wouldn't be going home to his family the next day with some Christmas shopping money in his pocket. It was really a huge shock to everyone, especially his wife and kids.
I wish I wouldn't have read this.. Now I'm sad....I could only imagine how the wife and kids felt..
That is something you should understand taking any drug, isn't it? Let alone the one that was never tested on humans, no one knows whether it is safe and that's exactly the risk they are paid for.. If it was safe (and none of the drugs are just cause of the personal reactions anyway) there wouldn't be a need in testing it..
The people are lured by money like the 50 years old man that sadly lost his life. When you are 50 YO with family of your own, it’s not advised to take a trial test. Unfortunately he probably needed the money.
This is the devils medicine now learn natural medicine.
Just him? its a lot worse than you think be hind closed doors .
They all must have some form of PTSD from going through that
With a phobia of medication, needles and that i suppose
Well they nearly died that's pretty traumatic in itself
Yea thats for sure
Well then, they now should be advocates for banning all animal testing since they know the horrors.. but they had it WAAAY better than the animals that are still being tortured
Taunja Brockway but if animal testing had happend it would be different
Imagine being one of the ones that got the medicine and being right behind the guy showing the first symptoms. That would be terrifying. He starts screaming and you have to wait until it happens to you. Talk about a horror movie.
😩
I'd rip the IV out b4 it was my turn. Not worth 2k.
@@ryanblack3285 apart of the 2k, you would get in a lot of legal trouble, you signed a contract. also by the time the first severe symtphoms showed up, the drug was already administered on everybody.
I was in labor with my first baby and the pain was absolutely horrible. My husband said that I tried to get out of bed and leave. I truly believed that if I could just leave the room that I would be pain free.
Wording is a bit off
I tried this too. 😂 Funny now but at the time I was in so much pain and I was so scared. I told my husband I just needed to get out of the room and out of the hospital then I'd be ok. He was compassionate but also amused and said something like "but what about the baby? If you leave you still have to give birth." 😂 I don't know, man.
Should of stood up to deliver baby.
If this would have happened in America, they would have been stuck with the medical bill as well.
@@Tyler-zw4kq just because a law suit is won doesn't mean they ever see the money
big facts. good ole american health“care.”
Lol accurate
@AL Cats They absolutely would have. It's the American way. Oh and when you write a sentence calling people stupid, make sure it isn't two sentences crammed into one.
@AL Cats I don't know . you tell us. How do you.
As someone with auto immune disease its heros like this that risk their lives that give me the medicine I need to survive.
@@ItzBrittKneeBish ❤️
This is why I'm open to being involved in clinical trials! I have these conditions, and am interested in improving the care that other people with them can obtain. Like Subject #1, I understand that it's important to report anything even slightly out of the ordinary because information is vital! I wish these men hadn't suffered like this, and thank them for their sacrifice.
Calling People fighting for their lifes and suffering trough a lot of pain "Elefant Man" shows just how disguting humanity can get.
To those who are interested, the reason was finally found.
Fair warning: I'm neither a chemist nor a physician, so I cannot guarantee I summed it up correctly. Also, before you jump to any conclusion or think "It sounds obvious that it was bound to go wrong", I suggest looking into the reports on your own, to understand the complexity of in vivo chemistry.
TGN1412 was designed to bind to the CD28 antigen of T lymphocyte cells.
Those T lymphocyte come in two sub-types: "Regulatory T cells", and "Memory T cells".
TGN1412 was designed/intended to stimulate the Regulatory T cells, which are the same in humans as in the monkeys.
However, the Memory T cells have that CD28 antigen as well for humans, but not in the monkeys.
And those cells started to emit a high amount of cytokines when activated by TGN1412.
This widespread sudden and overpaced emission of cytokines is what is called cytokine storm, and the cytokines attack and kill cells. This is what is called and happens in an inflammation. In a normal functioning immune system, this should happen in direct proximity of an infected cell to kill that cell (and only a few others as collateral damage, which are easily replaced in a healthy person). But here it happened in the whole body at once, basically attacking all cells everywhere at the same time.
THANK YOU SO MUCH, it makes perfect sense to me now. Your comment is the only one in here that had the science behind what happened.
Wow a overlook that had devestating result,altho making a new drug is never easy so small things are bound to be missed from time to time
And isn't it ironic that the covid virus that's going around now does the same exact thing in some people, causes a cytokine storm? The monocolona antibodies since then has been perfected and is currently being used in people with covid-19 successfully. The drug is known as regeneron.
Now they use 0.1% less of the drug at 40 times slower rate of infusion then they did in that trial. So basically it was a bad calculation on their part.
Can we call it a Drug induced sepsis
I was one of the early people treated with skin grafts. I had 3rd and 2nd degree burns when i was little. Now I have no scars. I appreciate the human test subjects for what they have helped achieve.
@@nathanh2917 I met a group of children who had received grafts in the 60s. The grafts were done with full thickness host skin so they were very bulky compared to today's grafts. Huge thanks to all the pioneers!
I found this a very interesting article. My granddaughter had a rare cancer at the age of 2 and ALL of her treatment was through international clinical trials. Part of her treatment was immunotherapy, where one of the risks was a cytokine storm because of the use of monoclonal antibodies. After nearly four years of treatment she is now five years in remission. The harsh treatments she had have left her with a variety of health problems, but she is a happy 10 year old now and very precious to our family. Whilst she has contributed to many clinical trials through her treatments, we are indebted to the children who have gone before her and may have since died of the illness or the treatment. Anyone who contributes to the advance of medicine through participating in clinical trials (of whatever stage) is making a massive contribution to the rest of humanity.
Amen. I agree. And with any trials, all precautions should be taken, and there should ALWAYS be an ESTABLISHED anecdotal plan in case of known, and especially unknown, side affects.
The posh doctor interviews between creepypasta-like reenactment scenes is such a mood
@@pamsam8933 I I IC think ⁹I 99
@@pamsam8933 the problem is that you can't know the side effects to 100% certainty in advance. You can inject them into mice and monkeys and test on human cells and determine it "might" be safe. When you are the one taking a drug that no human has taken before, nobody can predict with certainty what is going to happen, it's a big risk and they should (and almost always do) tell you that it is a risk.
The reason things like this are big stories is because of how rare events like this are. The vast, vast majority of first for human clinical trials have the worst problem of people withdrawing due to side effects. This occurs in both the cohort getting the drug and the cohort getting placebo. Multiple fatalities in a single trial is so unusual as to lead to videos like this. The risk is higher in rare illness, where there just fundamentally isn't as much data in. Even then, like in this case, actual death is exceptionally rare.
the 2 people who got injected with the placebo where so lucky
How hard is it to know the word “were” exists?
Maddie Trafford that was 2 months ago and people make mistakes
@@maddietrafford1225 oh get a life
DaisyV. Wolf хаха какво се случва
eh not exactly they probably have survivors guilt
The 2 receivers of the placebo are in my opinion entitled to damages as well, as are the staff who all were undoubtedly traumatized by witnessing this dreadful horror.
You do know they willing signed up for this, knowing that there could potentially be a risk of death right?
Nope
Agreed.
@@SaraWOanH Where does it say in the contract "risk of death"? Do you work in this field?. They would never get people by stating that fact. They Will Say it may cause side effects (like organ failure) but not death. I do see what you are saying but they picked strong healthy young men. Emphasizing death is not a priority.
Also... I would never do it. My friend fell fast after being talked into a trial cancer drug by her doctor friend....sad scary and I'm not built for it. My nerves and worry are too bad...😆
Sounds like an inside job done by a lone crazy scientist.
This is absolutely horrifying. I find it almost predatory, that researchers post advertisements about these trials on college campuses. Yes, most college students are legally adults, but I don't think your average broke 18yo is really going to think through the possible long-term consequences to their health. (Or short-term, for that matter- if a drug is dangerous enough, it can kill the research subject outright.)
after watching this it’s safe to say I’m never gonna sign up for a drug trial
this came up in my recommendations on youtube after saving some links to sign up for a few lol!
2000 pounds mate come one what could go wrong?
ME, thinking I'm going to only watch 5 minutes of this and end up watching the whole thing!
Well once your vaccinated with the rna covid vaccine your included
I recommend don't. Against my advice my sister okayed my father recieving experimental meds when he was on life support years ago for multiple lung clots. What he was given caused major problems that are now permanent. His lungs aren't like soft sponge now but leathery and he has constant breathlessness. It did help the experiment in that it gave them information on who couldn't receive it, but IMO was not worth it.
I am a New Zealander, struck me, as in saying that someone from my small country got affected by this. Also, this is absolutely horrific, stomach turning.
documentary: shows up in my recommended
me: aight ok guess i’m staying up another hour
claudia There is no sleep when there is TH-cam 😆
It is nice when the algorithm works.
Me rn
claudia same!!
claudia 4:42 here
these guys are really great human beings to look back on the trial so positively.
They don't have a choice but to look on it positively. They know how brutal life is, it's in their eyes.
It’s like labour, you never really remember how painful it is.
Sara Burke Really stupid human beings if you ask me who in their minds would allow themselves to be injected with something that they don't even really know what it is or that could potentially have deadly consequences..
@@ariellucas7755 it's like they said, every drug has to go in a first in human trial. You have a family member who's life was saved?
I think it's a human coping mechanism to look back at a thing like this and see it for it's purpose. I have seen similar cases where people are for example enslaved but they are glad they pushed through so that they cant do it to anyone ever again. Again focusing on the purpose.
I wish we could have had Ryan in the interview. I completely understand that he wouldn’t want to since he went through so much. I just wish we could understand what his life was afterwards.
He probably can't due to settling litigation out of court.
I wouldn't want my life broadcasted online either... but I wish him the best
ryan died actually
@@tshs1663 according to who?? Simple google search says absolutely nothing about him dying. He nearly died during his 4 months in hospital but he is very much alive after this horrific experience
@@tshs1663 source? I googled it, but couldn't find anything regarding him dying.
17:20
Testimony: “Shivering with cold, but I wasn’t cold.”
Actor: “I’m cold.”
Riptide27 he felt cold but his temperature was fine
Riptide27 I get this all the time.
he was cold on the inside but didn't feel it on the outside
More like: His body had a fiver, its like having a shiver when your sick. Your body muscles start moving, to warm you up, when it thinks your "to cold" or to "fight" of an intruder like a Virus or else. He felt Cold inside, but they all had a fever and the shivering, like their Body was fooled by the drug to think "your cold". I go so far to think that their bodys were Burning. In an article i read on the German Wikipedia it said that one felt like he is burning from the inside out. :3
I think a few of you guys are taking this comment too seriously. It was just something I found funny when I watched it.
I know the guys in this trial regret doing it, but I just want to tell them thank you. Because as much as that sucked they saved so many lives. Think of the consequences if this had gone for trials at st judes.
Which lives are you talking about? There's no cure for leukemia.
ThyGreek they mean the lives of other test subjects I think
@@hevbushnell4013 Yeah that makes more sense.
ThyGreek yes there is? People are being cured from it every day.
@@thygreek8076 um yeah there are cures for many forms of leukemia. What used to be a certain death sentence is now curable in up to 95% of cases, depending on the type...
This is how zombie apocalypse starts
That’s what I thought lol
Buahahaha
I literally said this then saw yr comment
Racist!!
So true my worst fear
I must've watched this at least five years ago. I'm back.
same! I forgot how fascinating the story was. the re-watch was just as interesting.
I love these documentaries that get straight to the point unlike American ones... this coming from an American. Very well done.
@Rally And remember. No matter what it is, we have to get it already worn out by the so-called 'media' and I use the term VERY loosely. Lots of people are finally waking up to the bare fact that EVERYTHING they say is a LIE. But, sadly, some will never see it. And we're ALL lab rats to some extent. Some more than others.
@Rally You're right.I despise business.
I agree! I couldn't keep watching a documentary earlier because they kept going in circles, and taking forever with their pretty cinematography! I'm American too, but seriously! Just get to the point! lol
Wee Brits do everything better
@@divcrfc My jury is still out on that because I haven't seen 'everything'!!
Once I took some medicine to treat heavy allergy, the name is Xyzall. I never felt so horrible, I became deaf for 1 week, had nose bleeding and I was paralyzed for 8 hours. I can’t imagine some people went though the medical trial with that crap, and why it is not discontinued. That was a very scary experience.
Did you check the articles they most likely published? Were all the side effects you had mentioned? Or are you aware of any other trials they did after yours? Having a trial doesn't automatically mean that the drug is put in a short term on the market. There might be a need for the drug or the method of administration to be changed... One needs a trial to find out how exactly a drug works on people and if and what is wrong...
@@potocatepetlno no no don't you see? It took some allergy medicine so he's an expert in pharmacology and clinical trials.
Now you know
Gosh, that was... unexpectedly harrowing. I'm so relieved that everyone made it out alive. I hope they go on to live full, happy lives.
No not really
School nurse: Here have this lovely *ICE BAG.*
Our school matron gave us milk of Magnesia. "Matron, my arm has been severed and I'm bleeding out" "take 2 of these milk of magnesia and pop down in the cot for a sleep"
Have a wet paper towel
‘Just get some _fresh air_ ‘
Wet paper towel*
Nah just walk it off
Everyone: Literally dieing.
The two guys who got the placebo: O_O O_O "Am I fine?"
😂
@Some1The4Got10 no one cares
@@ryanhoward211 I do
@@ryanhoward211 i care
@@ryanhoward211 I care third
I feel so bad for all the patients involved. It had to be terrifying not knowing what is happening to you or possibly going to happen due to the placebo. I hope they all received mental care for their well being. You all are courageous. We salute you for your efforts to help people get healthier. Thank you.
David: *rolling around in agony*
Doctor: How we doing David?
Edit: It's at 16:08
David ' yeah a bit unsettled. Yourself?'
It’s to see if they can talk or respond
Probably could have asked a different question
Plot Twist...Dr HabibiStein knew all along what was going to Happen!
Thanks guys for all of the likes, greatly appreciated
The waves of headaches are his brain and tissue swelling. You’d think they would stop administering at that point of immediate bad reaction
the more, the merrier!
Stopping a trial too early unsuccessfully would lead to a crash in the stock market. Any trial is known and timely monitored by investors. There are even databases with such data from ongoing trials ... very costly. But you can get alerted if something happens.
@@bob-qf4hl it's the more, the merrier this Christmas at Aldi.
Your brain doesn't have any nerves. That's not how headaches work
@@MadGaming10 the brain does have nerves.....im not sure what your saying about headaches but swelling of the brain would certainly cause a massive headache.
The youngest guy in the trial that had his foot, fingers and toes amputated. Did he still live beyond that? They didn't mention. Feeling most concerned for him.
He ended up getting 2 mil. Still not worth what he went through tho.
@@mimimummy5672 exactly
@@brandonytfreefire8898 That guy was legendary too LOL
@@mimimummy5672 Yeah, He lost his wee wee too, I read it in earlier comments. every finger and toe should've been a million. His wee wee alone should of been 35 mill.
th-cam.com/users/redirect?event=comments&stzid=UgzW-FcV4xZ__kRiSQV4AaABAg.8xiVg_XH3PB90mhzvMn0aI&q=https%3A%2F%2Fwww.dailymail.co.uk%2Fnews%2Farticle-559760%2FElephant-Man-drug-trial-victim-set-win-2million-payout-losing-toes-fingers.html&redir_token=yN15v5LxpyOVQm3onrBBFPCTftZ8MTU4NzU0NjkwMUAxNTg3NDYwNTAx
As a Thalidomide victim this is shocking
Damn!!
It makes me wonder if my Mom took it. She lost a baby. I'm 67 years old.
So I’m guessing it doesn’t cure luekemia
Dark Vader it does...it saved my 17 year old granddaughter' life...she participated in a worldwide clinic trial nearly 3 years ago in the United States. As a result of this trial study, this procedure was approved for use in the Stares. More than blessed that the treatment worked. She has since graduated from college and is getting married soon! I am so grateful for those that participate in these trials. Grateful for the scientists and doctors that do the research to make this treatment possible.
@@joanncasey5655 cool story bro
How would they know. None of them have it.
r/whoosh
Big B Kenobi Lowing the population one by one.
That one guy who got the placebo looking at everyone else…
👁️👄👁️
It’s wild that the company said it was “unpredictable human immune response” but earlier on the doctor was reading the risks to figure out what was wrong with them and she said it was written in there that “cytokine storm was possible”.
This
This very much.. !
(I am stunned they gave 500 times the monkey dose. 500!?!?! Not 50 but 500?
Wtf.)
I think they said 1/500th of the dose
@@ricewithaspoon9607 they received a 500th of the highest safe dose in monkeys. It was the safe amount divided by 500, not 500 times the safe amount. For example, if the safe amount was 100 ml, then they would have received 0.02 ml. I'm not saying those quantities are reflective of the doses used, only representative.
Protecting themselves from self incrimination
Thanks to the testing of this medication people like myself are recieving new therapy options. Regulations have changed so this was not in vain. I do believe there should be compensation for the many losses from the volunteers. I wish that I could say thank you to each one of these volunteers.
YES! I have thanked them several times in the comments already, though your idea would be so much better!
Soooo we all know why youtube is recommending this now....
Yep a doctor who got vaccine trial of covid died in south Africa
Cuz of covid trails 😂😂😂
Definitely not a coincidence
Well, cytokine storm is also a known complication of Covid-19.
Wowow😨
Hadn’t thought of that
This is bad, but we still need clinical trials. New medicines has to be developed and tested for the betterment.
Titaniam_w0lfie123 AJ gaming ok no one is stopping you! Go sign up! You’ll find all the ads on Craigslist. Good luck
@@GroundedSolidarity I'm thinking about doing one (am 15) bc my family REALLY needs this money rn, but now I'm getting all scared bc mine would be for a better treatment for excessive acid reflux (or GERD)
Kalina B the people that panic over drug trials really overblown the entire situation. Hundreds of thousands of drug trials happen every year with no negative impacts, less than 200 every year show patient discomfort, and a situation like in this video is less than one in a million. Idk if under 18’s are even allowed to participate in drug trials tho
Kalina B your kid they will reject your application
Kalina B You’re too young for a trial but the chances of what happened in the video are extremely low.
A lot of people are mentioning the selflessness of clinical trial participants. Maybe it sounds negative, but I don't think people would sign up for this if they didn't need the money. They do care about advancing medical treatments, but capitalism is what pushed them to this point. That doesn't make their contribution any less meaningful, though.
You’re probably right, but for every person who signs up for a paid trial, there could be many more who wouldn’t do it for any amount of money! I don’t know if these men are selfless or foolish, but I’m glad they exist.
@Sashazur i don't think they're selfish or foolish. I think they're hungry
People who wouldn't do it for any amount don't need money that badly.
To be honest, few minutes watching this, I’m sick to my stomach.. I’m so scared.
I will have to remember this next time I get annoyed at the FDA for Americans having to wait 5 years, or 10 years for a promising new treatment to hit the market.
They should test these drugs on sadistic serial killers
RyanORourkelol are you dumb? You realize sadistic serial killers administered cruel abuse on other people, right? God, do you have even one single brain cell?
Maddie Trafford it’s illegal thats what he means. government isnt allowed to use “cruel and unusual punishment”. you clearly are the dumbass if you don’t know something so simple.
These people signed it they wernt forced
@@maddietrafford1225 and why do you want to do what serial killers do?
In the last few years I’ve discovered just how much doctors don’t know what they’re doing.
💯
Makes sense considering that they did not build humans and have to learn what humans are made of and how each organ plays a role in order to know how to treat each organ
@@lebohangm7252 well, I wish they didn’t use my body to experiment with. I’m done with western medicine with several exceptions.
Medical science is like an Ocean. It's impossible to learn everything
Yes
I'm having trouble coming to grips with the fact they gave a cancer medication to a group of healthy men. I know they were just trying to test the medicine but that just feels like a recipe for disaster and was doomed from the beginning. That feels really absurd to me, I know morally they couldn't do it on actual leukemia patients but I wonder if they had, would they have had a successful trial???
People with cancer should have had the opportunity. If I was terminal, I'd go for it. Last ditch effort.
Isn't that the point of medical trials? To test new drugs on patients with said disease or illness? To see if it actually works? This was a recipe for disaster since the drugs they were testing had no bad cells to target.
Funny how there was no mention of it in the report. How exactly were they going to find out if it did work? Seeing as no one had leukemia.
The first trial is to see at a lowered dose if there are adverse effects and how the body reacts to the medication.
They were given I think 1/500th of the effective dose they said at the start right?
I am too!!!!! I CAN NOT wrap my head around it! The drug is targeted at triggering a part of the immune system to attack. Which isn’t that what an autoimmune disease does? It completely mind boggles me
This is precisely why typically we wait several hours if not an entire day between dosing subjects during First In Man trials. I'm shocked they dosed multiple subjects so close together for a monoclonal antibody.
And then they had the audacity to claim they did everything correct. Wtf
Isn't that the point of this documentary? That they changed the laws, so this mistake will not be made again.
They did it multiple people 10 minutes apart & apparently even though it was diluted they pushed the drug in too fast
Well, that's no doubt what caused the problem. They should have waited!
@@Elegant_Sausage initially, the MHRA said the drug company did nothing wrong, and it wasn’t until further studies dug deeper to establish the errors made. They did apologize and paid out millions to the guys. The testing company went bankrupt within a year.
They should have given the first patient a dose then waited longer than 10 minutes, if they saw that the first patient was in pain they wouldn’t of tested the others
Alex Tater Tots Mark R what was this drug trial for ?
what the heck was the drug trial for because all those people were 100% healthy and had nothing to cure ,
So do you think , is it really a cure they were looking for
or is it a way to make people sick to cut down the population , the government plan ?
It was to test side effects, and HOO BOY that failed.
No, they still would have tested the others. Every body reacts differently. Usually, you can't take a chance with outliers. One person could get sick, but another's symptoms could be completely manageable. It's hard to define when to take the chance and give up hope that this drug could save millions of lives.
As for what they were testing. They're testing the side effects. The end result of the drug should it be successful was to fight lukemia. But if you give a sick person a drug and they feel sick it's harder to tell what symptoms are caused by the previous illness and what are caused by the drug. Not to mention if the drug did horrible things like in this case, sick participants probably wouldn't even survive. Sick bodies have no more room to decline. Your body can only handle so much before it taps out.
So once a drug is deemed safe for the general human body, THEN it's tested to make sure it serves the purpose it's supposed to
if the first guy had the placebo, then what
No amount of money nor any amount of money paid in compensation could possibly compensate anyone for the physical, physological and spiritual harm these people have suffered and endured. To me this trial is a sick Frankenstein eclipse of insanity.
I don’t know how a doctor can ethically and morally conduct a drug trial. The Hippocratic oath states “first do no harm.” Injecting a perfectly healthy human with an unknown substance seems the epitome of doing harm.
Do you have a better way to test new drugs?
@@KyleMatt11 Because we wouldn't be where we are right now if it wasn't for these tests.
I got an ad for a clinical trial. No thanks
UsoShigo In spite of all of this I want to do it
Lods of emone!
Damn, talk about inappropriate targeted advertising.
"How are you doing David?"
*NGGGHURNNGHH*
LMAOOO
David:ahhhhhhh
Them: okay, now can you just give us your credit card information
@@duck3819 i don't think the hospitals are scammers duck
@@pau6545 dude, it's America, health care is expensive
@@duck3819 this is in the uk so its free
so we not gonna talk about what happened to Ryan, just his finger and toes fall off and they don't even tell us if he's alive or not???
Well they did talk about six patients get an undisclosed pay out so presume his was just the highest one
Im sure he survived... i think he went on the news in the uk a bit after it happened
@@Bbbabebruni out of the 8 men only 3 did the interview which scares me tbh. I was diagnosed with cancer back in February of this year, before my second procedure began they asked if I wanted to participate in a trial which makes the nerves in the body glow so that surgeons would be able to see them better. I told them I'd think about it and a couple days later they called saying I didn't qualify since I already had a procedure done a month before. At this point I'm glad I didn't qualify, studies are so terrifying.
He got 2 million pounds in compensation and spent it on houses women and partying. Google Ryan Wilson Paraxel.
@@danniis9444 Dont say wasted it. He thought he was going to die. He also couldn't not continue his job. Also he may be suffering from ptsd from the whole experience. So dont be to harsh when you write your judgements of this person you have never met.
But, I mean. . . why are the medical staff so surprised and unprepared for possible adverse reactions? Poor patients.
Because of the fact that it both hypothetically worked and was tested completely fine in animals. Sure, they could have been more prepared, but literally no one predicted it would escalate like it did. Not to mention, it is expensive to have the machines on hand for something like this, especially when someone already having issues could need them. Sure, they did need them in this case, but in most cases they are not necessary, and is wasteful for people who would actually need them.
@@secnytsecnyt2981 Yes, that makes sense; it's just so tragic.
Praying for wisdom and guidance for future trials. Well done documentary.
I almost had an anxiety attack watching this, I can’t imagine how terrifying it must’ve been to be one of the participants. Also, really feeling for the placebo guy, I would’ve been losing it a lot sooner than he did if I were him. 😱
I almost did too.
yea as soon as i would have been asked to leave by the nurse i would have asked them to give them as much help as possible at that point and asked them to help them as i’d obviously be very conserned for the other members for obvious reasons
The brother of a friend of mine just tried a trial drug for cancer and the first round, he spent 32 days in a hospital and a few days later he was back in ICU for a longer period. He has cancer so he wanted to try this. He is not doing well at all at the moment and he is not expected to live much longer.
They tested a drug for leukemia on people that were in perfect health? How would this help, wouldn't it make better sense to test on people with the illness to see how it performs?, did I skip over a part..
No, the healthy volunteers have no leukaemia for the drug to attack, so nothing should happen. There's always a safety check.
Doctor: So David how ya doin
David: **screams into the 9 worlds**
David: ascends into the next world
But if the drug was injected at 10 times the speed, then they weren't replicating the animal trials. I don't understand how that isn't seen as a glaring mistake. If the instructions on Tylenol say I should take 20mL every 4 hours, not to exceed 100mL in 24 hours, and I decide to instead take 100mL all at once, I will likely feel very ill. It's a huge difference to take something all at once than to stretch it out over time, letting your body adjust to the dose.
They shouldn’t have infused the drug so quickly at such a full dose and it should have at least been a few hours apart per patient.
ThankyoooDoogie
I see you know better, great. I assume you'll be working as a physician in clinical trials
that would be sane and responsible . what makes you think big pharma is either ?
The 6 men who received the actual drug all got compensation as they rightly deserved. However, the 2 men who didnt receive the drug in my opinion should also have been compensated (to a lesser extent). They had to sit in the room for hours while the other men deteriorated, they heard every scream, even moan of pain and would have been aware of what the doctors and nurses were saying all while wondering when/if it was going to happen to them. The mental turmoil that put on them will possibly leave them scared for life
I agree. They definitely experienced mental stress and trauma.
They will never do that again
PTSD
I've done drug testing before, they don't tell you if it is placebo or real but they still pay you the same along with travel expenses.
@@Annaie1234 I agree. Watching another human being, let alone watching multiple humans suffering is very tramatic. I think most people are empathetic to others pain. When someone around me hurts, I hurt too.
I've got to stop reading comments while watching documentaries. The amount of times I have to rewind is absurd.
into the mystic comment section is better than the vid
@@ethank5681 there would be no comments without the video
Keep doing the same lmao
thanks for the reminder, i wouldve gone 10 minutes deeper without this comment
I was thinking the same... lol
Everyone else:
*screaming in pain*
That one dude:
*mom come pick me up im scared*
mmm
That guy would be me
@Saint Beelzebub 😭😭😭
「 Cinderblock 」 😂
Hahahahs
They knew about the headache and pain and still injected the last patients. It's hard to comprehend.
@@kris2455 Yeah, you would think they would test one person, and see how they reacted, before continuing.
@@MaryDeanDotCom SAFE AND EFFECTIVE. I mean it's only killed millions....
@@jennifermarlow. this wasnt in 2024
@@nanofivee I think they mean that we have lived through how the world reacted to co.v.id. Nothing will suprise me anylonger when it comes to butched up medical treatment after that.
its very easy to believe, shareholders,pressure, company might go bust if its a failure etc.
Patient “am I going to die?”
Doctor “the real question is am I going to prison?”
@Kimber 10MM wtf are you talking about
@Kimber 10MM don't you understand it's just a joke , if you don't understand, Okey let me tell you it's a human thing & you need to settle up in a zoo
That’s funny
😆
It's an experimental drug, he volunteered.
Shame on drug company. One guys fingers and toes fell off. They infused 8 x faster than on monkeys. These people deserve big compensation and massive apology
Greed usually does it,the hurry to make $$$$$$$$
They got compensation and literally told you that if you had bothered to watch the documentary all the way through
@@bradenharris8718 an undisclosed amount. could've been chump change for all we know.
10x
Big pharma doing big pharma things, and hiding behind obscure legal loopholes and endless legal battles to do whatever tf they want. It's a way too big of a business, in the hands of way too few people.
They're artificially creating a lack of ADHD medication so they can jack up the prices.
They claimed oxycodone is barely addictive and can be prescribed for even minor pain and injuries.
They said Xanax and Lyrica are perfect risk-free options for generalized anxiety disorder.
They constantly make vitally important things like epipens and insulin more expensive.
They also try to invent medicine for the symptoms rather than cures. And isn't it also kinda convenient how often you need to take booster shots for this new kind of vaccine?
I know it's basically a business and they need to profit, but they're building their empire on human suffering and dead bodies. The amount of greed is just overwhelming.
It’s truly strange watching British documentaries as an American. American documentaries are so loud with constant motion and nonstop drama. I appreciate watching something that takes its time to tell the story without the need for embellishment.
I mean this was quite intense too.
August Break Same
It isn't that it's British. They just didn't really need to be flashy because of the content... People fighting for their lives... pretty hardcore as is
L L there’s a balance that a lot of documentaries and reality shows strike. This one hits right on the mark.
August Break omg ikr!
I have been receiving a type of monoclonal antibody infusion every 4 weeks for the last 10 years to treat an autoimmune disease. This medication saved my life and allows me to continue surviving. The people who are willing to submit themselves to clinical trials like this are part of the reason I’m still alive, and I have so much respect for them.
True but 😅😅😅😅
My son has a number of symptoms that are autoimmune in nature rendering him at 35 unable to work and using a cane but some days unable to leave the bed. He has been given possible bur never firm diagnosis for everything from MS to Parkinsons to Meneirs to heavy metal intoxication as he shows signs of all. One of the neurologists who seemed most hopeful finding neuropathy and all the signs of his own immune system attacking his digestive and nervous systoms suggested a drug to him which was described as a chemo drug originally for cancer patients but has shown to aid patients such as he. God i wish we coyld speak to you to somehow find out if you have a similar set of issues. If so much comfort it would be while making this very important and heart wrenching decision
I also have an autoimmune disease. I am taking Telfast and Montelukast daily. If I stop, my throat gets tight and itches all over the body. I live with misery and doctors couldn't help me.
There probably not so happy
Maybe try prolonged water only fast around 10 days? Prolonged fast is the only thing that treats and cure autoimmune diseases. And then carnivore diet.
This reenactment is SO WELL DONE. Holy crap.
Ikr!! I had to go back to the beginning of the video to find where it said it was reenactment I was like damnn
They found actors who look incredibly like the real people involved.
Yes. I totally forgot that it wasn´t real while watching … :D
Susan Foley are all of them actors? I straight up thought one of them (the placebo guy watching everything go down) was the actual person
You believe this? They gave clinical trial medication, as a test...to humans with nothing to actually cure.. it was meant to cure leukemia....which these random people did not have
As a healthcare professional that works in a hospital, this is an absolute nightmare all the way around. Everyone lost in this one
and how do you feel about the covid vaccines? That experiment was forced on the world, this was volunteer
Everybody’s screaming in pain and the other dude’s just sitting there
He’s soooo lucky 🍀!
@@Timeless80 Haha, I was about to say that.
i would’ve hated to be him. imagine everyone around you screaming in pain... terrifying
@@dangerousbuterax6891 i'd rather be him than the ones that actually took the drug
L Frosty me too but would’ve still been scary
It makes me mad to think that the medication was administered 10 mins apart, rather than 90 mins apart. This could have only been one.
'Berto O. A. you never know if another person will react the same way to the medication if only one person got the trial. that’s why there’s usually more than one person getting tested
They just wanted to know who got the placebo.
@@birthdayplant it was never appropriately thought out and therefore that was negligence in a big way.
niyah and yet they all reacted the same way
niyah yeah and If it went that bad on one person then they wouldn’t do it on another however if one person was fine
For those of you making fun of the doctor for asking if they're okay, it's actually a very good practice. First of all, he's making sure they're still responsive. Second of all, he's trying to keep them calm. If you saw someone crack their skull open, you wouldn't start shouting "OMG ARE YOU OKAY!? OH MY GOD HE'S GONNA DIE THAT'S A LOT OF BLOOD" no, you'd say "It's going to be okay, you'll be fine."
Just so you know
lmao some doctor (well, nurse) screamed "OH MY GOD THAT'S A LOT OF BLOOD!!!" when I threw it up once, thought I was gonna die
Index III is OUT my point exactly
Raven Ryder I don’t know why Parexel claimed to have no knowledge of their responses, but the pharma doctor read in the literature supplied by Parexel that their reactions were thought to happen rarely.
*aRe YoU oKaY*
(OMG YOUR DEAD i mean) its fine ur gonna be okay:)
Best re-inactments I've ever seen. Usually SOOO cheezy
Dana Ashlie British do it better
@natalie L Same but that's mostly because I am British.
Dana Ashlie i agree plus the faces are quite identical too. i didnt realized it was just reenactment for the first 10 mins lol
I honestly though it was actual footage
So true !
Doctor: How are we doing, David?
David: *screams into the 5th dimension*
heiress of stupidity more like weirdly cut moans
I was thinking the same thing. The patient is clearly in distress and a great deal of it!!
lmfao best comment
Valincia Pruitt They ask anyways to make sure you can respond. Yeah you aren’t doing good but are you responsive?
That's what I thought.
The worst part was how quickly they dosed everyone. They first guy is in a cold sweat and writhing in pain, and while this is going on they are dosing the guys in the other room.
Julian Bell Mark R what was this drug trial for ?
what the heck was the drug trial for because all those people were 100% healthy and had nothing to cure ,
So do you think , is it really a cure they were looking for
or is it a way to make people sick to cut down the population , the government plan ?
They should have waited way longer for each person getting injected and they should have given a way smaller dose to check how they reacted to it
@@kristie-leecorney7388 lol
@@kristie-leecorney7388 can see that you didn't watch the documentary, so you'll come up with ingenious conspiracy theories. Get out.
Kristie-lee Corney This isn’t a conspiracy video. If the government wanted to cut down on the population they wouldn’t have tested the drug, they would have given it to the patient so they could die.
Everyone: puking, screaming, dying
That one guy: okay think imma head out ✌️
@Jimo National ok boomer
@Jimo National ok snow roach
@Jimo National and this is a problem because...
@@harssamoanlal2947 kip
@Jimo National apespeak isn’t a real word either 💀 what a mong
Placebo guy: reading his book
Guy next to him: in horrible pain
Placebo guy: *chuckles I’m in danger*
Ralph wigam
Doctor: How we doing David?
David: Screams with agony and discomfort
Me when my mom wakes me up for school
flamingwolfgaming 101 disrspectful but true
Ikr
@@old-yd2kp
My bad
Doctor : seams ok to me
everyone: throwing up, screaming
that one dude sitting: alright ima head out
Megan Khadka it’s like... i didn’t know that
He was a control/ placebo
When was that? Just so I can skip a sis is scared of sick
B lasagna
anna commanda what does that mean?
Get this casting director a raise. All these actors look so much like the real people while also being able to actually act
I swear some of them are the actual people. Number 2 was definitely the same guy.
It’s epic bro
Best I’ve seen
Robert Gardea im aware what a re-enactment is... hence why I said props to casting director
StrawberryNinja Nibbles #mansplaining at its worst-🙄🙄
StrawberryNinja Nibbles omg you’re right. Without thinking about it, I unconsciously found myself thinking, how did they have video of these people when it was happening Lolol duh
I still remember how my 6th year biology teacher warned us to never volunteer to be a guinea pig. Thank you sir.
See, I'm thankful I study chemistry, not biology or medicine. I can watch them do trials from another building, thanks.
Honey Bee 😂😂😂 that's a great teacher
I had a science teacher start our origins, universe life etc with: don’t believe everything they tell you, remember many think a supreme being, god, caused creation, others do not... in any case we don’t know how or why the universe came into being let alone having physics perfect for star formation, nuclear reactions, time, matter, all of it. That said... shall we begin.... first there was nothing, then there was a universe... any questions? Right... ok.. and we opened our books to chapter one. The Big Bang. Haha and the lesson commenced. I thought he was clever and wise and he was a great teacher. He also gave us real experiments, not cheesy ones. More dangerous chemicals and dissection, less baking soda and vinegar. Haha... break out the scalpels and Bunson burners baby.. whoops. Bang. Teacher my test tube is no more! You ok? Yeah. Had your eye wear on? Yeah. Ok... do it again but this time don’t skip step three in the directions... sorry Mr. Moss. Haha he was cool.
The FDA also recommends not being the first to take new drugs; I'd suspect only people desperate for money (poor/poverty) would/will volunteer.
@@renees1021 I don't think they normally end this badly due to prior testing on animals but yea this is also a very plausible outcome.
While nobody deserves the outcome of this particular medical trial, it’s an incredibly brave and selfless act to anyone who needs medicine and even to the lives that are forced into trials like animals. It’s scary but to think of all of the lives and families this event has saved. I’m so sorry to everyone involved but the gratitude I have for such people is incredible.
I'm sure they instantly regretted it lol
They risked their lives for a few $$$…. Desperation is more like it - not bravery.
Omg. Kid was 19 and saving up for driving lessons and now he has no fingers
Gavin Haase 47:09
He lost all his toes and parts of fingers. The tips
He can still drive. My mother had crippling arthritis, and could not hold the steering wheel, just guide it with her palms, and turned with her elbows. He only lost the tips. Not the whole fingers. Yes, it is a tragedy he suffered. So did my mother. She still made do. Reiterate, he CAN still drive.
I mean he could still drive? But they didnt specifically say what exactly happen to ryan..
@@nickhiggins1091 doesn't sound safe at all. That's why in your driving test you have two hands on the wheel. Not your elbows
The placebo boys can count their lucky stars
Vehicle/control gang.
Black people can count their lucky stars….not 1 Black person experimented on.👊🏾
@@yamindapage1963 what does that have to do with anything? Further more that isn’t true 😂
@@yamindapage1963 🙄
I knew a guy in our 20s who signed up for clinical drug trials all the time for cash - never did anything else for a living. He also never wore anything but pajamas and flip flops.
I noticed they never talked about the eighth man, I looked him up and he’s wheel chair bound and had his fingertips fall off too.
How unfortunate for all of them.
Wow
Thank you for looking that up for us all!
what did you look up to find it?
Nicole Slaughter ...It mentions what happens to him right there in the video.
any link or name of the man so i could search it pls :) its very scary docu really if i could i would wish for this to never happen :(
Who else watched this, and immediately decided to never participate in a clinical trial? 🤯🧐
I heard about this at the time it happened and then decided the same. Your life and health isn't worth playing Russian roulette with. Even if nothing like this happens to you, you don't know what unknown long term effects might be caused.
Sarah Vela I have participated In one! Nothing happened to me thank goodness lol
Where did you participate in your study at ?
@Poppy Mystique I'm in a study right now in the states at a place called PRA Health Sciences in Lenexa, Kansas City, Kansas
My study right now is 5 days for $3,000 us
I had considered cosmetic trials, but after this there is no amount of money in the world that could make me want to participate. Just to risky for me.
I watched this when it first came out 6 yrs ago and let me tell you that i have never forgotten about it. It's truly haunting to think about what they went through.
Patient: No one is going to die right?
Doctor: Who's your favorite Avenger? Just wondering..
Patient: I prefer DC
Doctor: yeah im just gonna give you another dose
😂😂
I don't feel so good doctor
I like how these reply’s are taking the joke in so many different ways
HA
His fingertips fell off!! They weren't even amputated! Imagine just laying there watching your fingertips FALL OFF!!! I feel so bad for those men...
@jorge rodi Ohhhhh I'm dumbbbb
I got so freaked out!!
Bruh
@jorge rodi please use your inside voice
Necrosis is the term for Dying tissue. This is why I think this was blood poisoning. Necrosis can occur when the blood isn't healthy enough to provide the flesh nutrition, and the cells in the tissue die.
@jorge rodi Capital letters means you're shouting. So low your voice 🤗 and be caring.
This is why I don't do trials. I did one and I had the symptoms of malaria. Never again.
Well, the entire world went trough a massive trial three-four years ago.
Did you get the vax? I hate to tell you but, you did it again 🤦🏼♂️
Lesson learned😢
@@Emsev100👍👍👍👍👍
You took the vaccination for Covid, right? That probably saved your life
This should be a Netflix documentary
It should be that would be amazing
This could be on House MD or the good doctor
It’s better on TH-cam.
Nah, TH-cam's where it's at.
There is a indie style horror movie made based on this, wouldn’t recommend it.
I cant imagine being one of the people with the placebo... just watching and listening to everythung around you, always wondering if youre next and when its going to happen. It sounds so terrifying...
Yeah and he was so young at the time so it really pulls at your heart for the poor boy.
American roulette
@Addicted 2This but also guilty though. Survivors guilt
Nah. after they were the onlyone in the room it didn't happen to, Im guessing they figured out they had the placebo. But the first hour or so would've been rough, yea.
I would feel so very guilty honestly
Those 2 men won a LOTTERY called PLACEBO
precious lol
@@sunandmoon139 That's not actually what it is. It's when a person experiences a decrease in symptom severity, because they believe they are receiving medication. The placebo effect does not cure illnesses, it just helps to relieve symptoms.
@@sunandmoon139 It has to do with believing that you are receiving a treatment that will make you feel better. I reccomend that you look up some examples and/or articles about it on google, as it's actually quite fascinating. There is also the nocebo effect, which is when a person believes a treatment will have negative side effects, so they end up experiencing those side effects simply because they expected to experience them. There have been trials done where one group of people is give sugar pills (though the trial participants were told it was real medication) and were not warned of any potential side effects, while the second group received the same placebo pills, but were told a list of potential side effects they might experience. The people in the second group reported experiencing those side effects at a much higher rate than people in the first group. By believing they might feel unwell, the trial participants actually caused themselves to feel sick. It really goes to show how much your mindset can effect you. This even manifests psychologically as well.
For example, if you believe that you won't ever succeed, chances are you will have a lessened ability to perform tasks, low motivation, and little dedication. One of the biggest effects would be that you stop trying, and that you never actually put 100% into something. I mean, why bother putting your all into something if you are sure you will fail?? Alternatively, if you believe that you could be very successful, you would likely take way more opportunities, work harder and put more effort into things, have high motivation, and be very dedicated. These changes in behaivor have a serious effect on your life, and could actually cause someone to fail at things simply because they are convinced they aren't capable of succeeding.
This is called fortune telling in psychology, if I remember correctly. I'm very guilty of doing this myself, actually. It's harder than it sounds to let go of all the negative beliefs one has about themselves and start believing in themselves all of the sudden. It's really hard, and at this point I actually fortune tell about fortune telling. I know that I do it a lot, so I end up doing it even more simply because I expect myself to. It's maddening 😂😭
@@sunandmoon139 it has nothing to do with religion if that's what you're asking, although those words can be used in a spiritual context. if that's not what you meant ignore me haha
Comment war
"No one's gonna die right?"
"Well, we'll see"
well at least he was honest
That part made me laugh so hard
"We'll see... Well... I'mean I will see. In case you, ... you know."
followed by evil cartoon villain cackle lol
yeah doctors cannot affirm things they don't know or they might be charged with lies
After trial: here’s your two grand. Don’t spend it all at once!
patients: we are dieing here
Actually two thousand pounds converts into $2,562.91
Definitely deserved a lot more. As in 5,000,000,000 for each person effected by the drug physically
James Only r u mad? If a person died there they would have to only pay from 100k - 2-3M €
James Only that’s why they have u sign all ur rights away before the test :)
This is probably why clinical trials span a few months rather than a few days
Even the placebo dosing is done over a month these days.
Most of the medical trials that I've looked into ask for a commitment of 2-3 years, and specify that the patient can withdraw at any point. I've never looked into a First in Man study (now I understand that as a female, I don't generally qualify for that), though I do understand how vital that step is. Now I understand a bit better!
unless you are in a global scamdemic and they are virtually forcing everyone on the planet to partake
@@wendychavez5348actually we can now. I was in a phase 1 trial. Its for a medicine for specific heart disorder. Although I'm healthy now, I've had quite an extensive heart history. Its like being a ticking time bomb with no way of stopping it. This opportunity came about and I was all for it.
Its a double blind study. Couldn't get my blood work for my syndrome until 6 months after I was done with the trial. My number actually was decreased. I know I got the drug and it works.
Cannot wait until phase 2. Hoping it will be at the same hospital so I can take part.