Morgan Levine, PhD, on PhenoAge and the Epigenetics of Age Acceleration - can we change the pace?
ฝัง
- เผยแพร่เมื่อ 16 พ.ค. 2024
- Morgan Levine, Ph.D., developed the phenotypic aging clock called PhenoAge and is a Founding Principal Investigator at Altos Labs, a biotech company that seeks to understand the mechanisms that drive the aging process and age-related diseases with the hope of identifying possible interventions. Additionally, Dr. Levine is an assistant professor of pathology at the Yale University School of Medicine, where her research focuses on the science of biological aging.
Dr. Levine completed a postdoctoral fellowship with previous guest Dr. Steve Horvath, a pioneer in the field of epigenetic clocks.
EPISODE LINKS:
Show notes and transcript:
www.foundmyfitness.com/episod...
"True Age: Cutting-Edge Research to Help Turn Back the Clock" Book: www.amazon.com/True-Age-Cutti...
Dr. Morgan Levine on Instagram: / dr.morganlevine
Dr. Morgan Levine on Twitter: / drmorganlevine
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Full interview playlist: • Interviews
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CHAPTERS:
00:01:19 - What is aging?
00:03:20 - Why biological aging matters to scientists
00:04:45 - Hallmarks of aging
00:05:24 - What are the drivers of aging?
00:06:58 - What CpG methylation says about aging
00:08:59 - The advantage of epigenetic clocks in research
00:10:12 - New generation epigenetic clocks: GrimAge and PhenoAge
00:11:51 - Clinical biomarkers vs. epigenetic clocks
00:12:50 - Differences in aging between organ systems
00:16:47 - Do some people age faster than others?
00:19:05 - Epigenetic age acceleration
00:20:39 - Is age acceleration a genetic risk inherited from your parents?
00:22:27 - The effects of menopause on aging
00:23:16 - Does the pace of epigenetic aging change throughout life?
00:24:39 - How does obesity and human disease affect epigenetic aging?
00:26:12 - Why genes from development may be key to understanding aging
00:27:13 - Determining epigenetic age in non-human mammals (all of them)
00:27:50 - Is aging an accident of evolution or by design? (See also 00:48:20)
00:30:17 - What happens to the epigenetic age of immortal cells if you grow them forever?
00:31:40 - Effects of cancer treatment on epigenetic age
00:35:43 - Severe COVID-19 and accelerated epigenetic
00:36:40 - Are epigenetic changes in aging a cause or consequence?
00:39:23 - Are the CpG sites used by epigenetic clocks functionally meaningful?
00:42:15 - Reversing epigenetic age with interrupted reprogramming techniques
00:49:27 - Therapeutic plasma exchange in aging and pro-geronic blood factors
00:53:23 - The effects of neutral plasma exchange on the brain
00:56:01 - Lifestyle factors that accelerate epigenetic age
00:57:56 - The aging acceleration effect of smoking
00:59:37 - Omega-3 hypermethylation of inflammatory pathways
01:03:23 - Reliability of consumer epigenetic clock tests
01:06:12 - Construct validity of epigenetic clocks
01:12:06 - Thoughts on most exciting research in aging field
01:13:44 - Dr. Morgan Levine's lifestyle habits
01:15:00 - Intermittent fasting effects on epigenetic age
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#aging #EpigeneticClocks #TrueAge - วิทยาศาสตร์และเทคโนโลยี
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True Age: Cutting-Edge Research to Help Turn Back the Clock." You can pre-order it on Amazon now:
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I have a request for a future video.
Listening to these podcasts always makes me want to go back to college for biomedical engineering.
I appreciate Morgan's no nonsense approach. Everybody wants to hear there is a quick fix but she serves up the truth as she sees it.
I always have to lisren to these discussions from Dr Patrick at least twice to make sure my dumb brain gets a glimpse of the knowledge.😂🤣
Hey Taylor - you're doing better than me! I need x3 listens..... 😝
Glad to see I'm not alone
Hi Taylor, don’t feel bad. My husband is dumb too. He always says that he could have been a Doctor but his mom drank alcohol when she was pregnant.
She is the perfect spokesperson for longevity research, she looks amazing and she's super smart :)
Much looking forward to this discussion!
So thankful Rhonda! Life-changing information - for free! Such a public good. Science educators have no idea how much they impact the population. Truth is the greatest medicine.
What a great format update!
Grateful for this knowledge and these strong and skilled women!
This was really great and informative talk!
Another brilliant upload. Although I amazed that most people don't realise there is difference between chronological age and biological age.
Me too. It is simple to make the distinction.
If there is ANYONE talking about longevity and aging, *this* is the woman to listen to; leading by example. Brilliant podcast!
Thanks, as always, Dr Patrick... a gift.
Amazing info :3 thank you for this
I need like 10 times on repeat with these intellectuals...always educational!!! N fun!!
Thank you so much! So interesting!
Great information as always. 👍
Smart ppl beautiful inspiring women amazing podcast informative talk just love this channel
Hey Dr.Patrick, what do you put on your skin that makes it shine so much?
Discovering and listening to Dr Patrick on Joe Rogan's podcast wasted beginning of me learning about nutrition getting off the standard American diet. And this going down all the rabbit holes I have found hope Physicians physician researchers and researchers about diet nutrition
Great, very informative, interview! Side note: different styles, but both very attractive.
I am glad that the cacti are rearranged. The previous setup had a bit of Freudian flavor.
Bring her baaack!!! 😊
HCG treatments are currently used to reverse inflammation. How does this affect epigenetics in cells?
They said genetics accounts for “only 10-20%” of aging as tho it was an insignificant percentage. That’s approximately 7-20yrs… that’s very significant in my opinion.
Any studies on GrimAge comparing long term diet effects? e.g. on long term low-carbers?
Nice big picture and survey of the issues re measuring age. BUT it would be great if a one or few age tests where mentioned as the best as of today??
Would cell free dna tests like Grail allow us to capture fragments of dna from various tissues with high specificity (~90%), and at the same time allow epigentic aging by tissue type if enough fragments from each tissue are captured?
Discovering and listening to Dr Patrick on Joe Rogan's podcast was the beginning of me learning about nutrition getting off the SAD= standard American diet. And thus going down all the rabbit holes I have found -- many Physicians, physician researchers and researchers about diet nutrition
Same here. She is an invaluable resource 💗
And unfortunately the last time she was on he used it as some weird opportunity to litter the interview with "gotcha" questions. I was really disappointed.
@@alkeegan9915 . That were not "gotcha" questions. Perfectly legit as he's asked everything else on the topic. I was disappointed with her answer but that does not detract from what she does; she is tremendous.
Interesting book. But I must take issue with p195 where you say that lactic acid causes pain etc. Not true, we have known that's not the case for two decades (commencing with Nielsen et al 2001), though sports commentators keep on about lactic acid. It is used as an energy source for skeletal and cardiac muscle after its conversion to lactate. In fact, lactate can also be converted to glucose by the liver. Lactic acid is a relatively strong acid, and thus quickly separates into a hydrogen ion and lactate within the muscle fibres. Elevated levels of hydrogen ions cause the muscle to become more acidic. This in turn can stimulate pain receptors within muscles, causing discomfort and the exercise “burn”.
Two beautiful and very intelligent woman talking about one of my favorite subjects , this one is going to be great !!
ur creepy.
@@ayo9057 if you say soo, i guess i must be
@@ayo9057 why would you call someone you (I assume) don't know creepy? One reason to want to live a long life, that helps us to live long and healthy is good company, something to live for, family and friends etc it makes life worth living in the first place, sadly I've lost hope in the human race with constant conflicts, deception, greed on and on. People need to be good to each other that's the first step in good health from my point of view, love and happiness equals health.
Are the epigenetic changes also causing a structural change in the nucleus and maybe in the cytoskeleton of the cell.
Talking about the lower levels of organization, I've always thought it's all related to changes in polarity.
What do you think of Dr Michael greger's assertion that vegans fare the best for overall health, according to the meta-analysis of all the evidence?
Poor Audio for TH-cam. Please use better mics.
Thanks,
I watch everything double speed, even this, and I understood everything...I think...except...where the floor ends and the wall begins.
The effect has been perfected!
A first set of 71 CpG islands can fit the chronical age.. another completely different set can similarly fit... that basically argue against any shred of causality of the epi aging clock.
I work as a machine learning engineer and now I want to be the engineer looking at all this data. And possibly work in this field. Does anyone know good open source datasets? Dr. Levine mentioned that bio bank is quite expensive and it got me thinking what kind of personal projects i can do to learn more
Why are you not on Spotify as well? I will talk to them about offering you a deal! This is life-changing information.
she is
So what are the actionable steps regarding optimising one's Omega 3 index? I eat Salmon twice a week, flaxseeds daily, but take no Omega 3 supplements - should I be getting blood work and supplementing based on the results in the same way I do with Vit D? - David
Yeah you need way more. I personally consume 4g of OM3 a day (around 2G DHA / day). AM not a doctor, but I have been doing this for about 7 years, and I notice within a few weeks when I stop in my skin, mood, hair, and cognition (and in blood lipids).
You mentioned women epigenetic age being younger than man with same chronological age assuming similar lifestyle is adopted with women and as long as they get their period this stays consistent. Later you talked about the current hot topic which is young and old plasma exchange or even dillution which shows rejuvenation effect. Well, thete is a relationship here- women age is affected by their period since they lose blood which helps with rejuvenation procedures forced by the body. Now, most likely this could be observed just by drawing blood from men once a month for some time to validate the same. That is why prp treatment which is often used as hair growth catalyst or wound healing could also have this side effect on aging in a positive manner. Especially when done repetitively every x time. Some data suggests that there is a negative over accumulation of iron in aging blood and removing some of it enables rejuvenation to take effect
Mitochondrial rejuvenation is the most important part
Hello. Do you suppose the lungs of a smoker be aging faster than other organs? Would a brain of a shift worker be aging faster?
Any studies on epigenetic age reversal?
Yes! Listen to 00:42:15 when we talk about interrupted cellular reprogramming.
@@FoundMyFitness I did see a study where a certain diet and lifestyle change reversed 'epigenetic age' or markers, its interesting but it doesn't necessarily mean that the person will live longer, they may even shorten their lives following such a protocol, the diet for example - participants were allowed to eat I think more than safe levels of Liver (longterm it may damage their livers due to too much vit A) a few servings of red meat, intermittent fasting, exercise etc, now what if a person who has CKD for example decides to follow their example nd starts pounding down red meat, they will progress faster down the rout to end stage kidney disease as the kidneys are already damaged and cant filter as they used to, depending on the exercise this can also tax the kidneys and so following the example of lifestyle and diet changes that showed a reversal of epigenetic age would actually (more than likely) REDUCE their life.
This is why these studies have to be taken with a pinch of salt as they may NOT work on us as individuals and could even harm us. I love your interviews by the way. I wondered what you thought about what I said, thank you.
Ultimately, I don’t need this info.
I need the interview to go like
“You look great!
And you study aging, perfect.
So what do you do, specifically in detail, to slow aging?”
It seems reasonable that the methylation is an indicator and therefore a marker than a cause. It should be pretty easy to prove.
Idk if anyone can answer me this. So. If an epigenetic age test is comparing what your methylation pattern is against....sort of a Standard curve of methylation patterns. And the standard they use is based on the mass population, how do we know the population standard curve is necessary a good standard? So really the test is saying how well do you fair against the rest of society? Is that correct?
I hope we find something that reverses aging without drastically changing lifestyles aside from not smoking and bad habits like that. I don't think fasting all the time is for most people.
*Take Rapamycin, you will extend your life span.*
I've not gotten over the GMO clock, so independence vision is easier-- for me.
Mitochondria is the powerhouse of the cell.
Ageing and getting old 24hrs aday 365 days a year causes no harm no damages no sickness or even death to people.
The hypothesis of the Epigenetic Clocks is that it shows the biological age. If so, slowing it, or reversing it would hopefully reduce the biological age to.
Has this been shown in mice?
Or is it still just a correlation, such that changing the epigenetic clock is ineffective. That is, does reducing the epigenetic clock actually reduce the biological age?
Oris it perhaps like making your clock go slower, which hardly makes you live longer!
Where can we get a GrimAge test??
I don't think GrimAge is available anywhere. However, Elysium's is trained "a bit more like" a second generation test like GrimAge. Probably the best consumer option right now.
I would love to understand why and what it means when illegal research made my epigenetic age 10 to the minus -43
What do longer lifespan animals have that differs from shorter lifespan animals?
3 main things: 1. Higher temperature tends to accelerate aging. This is due to a higher probability of enough heat quanta meeting in proximity to complex molecules where a bond can be broken, made, or arms around a stereo center switched, that is not part of normal function, damaging proteins and other molecules (Said more succinctly, there is higher quantum tunneling damage with higher temperature). 2. Antioxidant activity. Some animals have less effective forms of SOD, fewer forms, and lower concentration, and some other antioxidants that their bodies make. 3. Various species have better or worse DNA repair systems, and different rates of damage.
Temperature is pretty big. This likely explains why bowhead whales, naked mole rats, some fish, lobsters, bivalves, and reptiles like tortoises, live so long. And is certainly a factor in why humans live so long. We also live a long time because we have the best SOD levels around. But some other creatures may have better DNA repair than we have.
We are the temperature we are, because enzymes only operate well at a range of temperatures, and our enzymes are fairly particular, which is why we die easily if our core temp changes much...too many processes are too slow outside that window. So just dialing it down, at least a lot, is not a viable life extension method. However, having very low inflammation does lower temperature. Same thing with lower blood sugar, and fasting. But clearly there is a point of diminishing returns as we move away from optimal temps for our enzymes.
Some super centenarians make a lot more Sirtuin 6, this improves the accuracy of double DNA break repair...which could easily be why they reach an advanced age.
There are other factors, of course, for the variability of animal aging. Immune system is one of these. We have a pretty terrific immune system...probably too good, due to recent selection in cities and long exposure to domesticated animals (over the last several thousand years), which we really were not designed for...likely leading to more autoimmune disorders.
@@ChessMasterNate Thanks Nate! If you have any references on the subject, please let me know!
Just wondering - how old is Morgan Levine?
She is 37. instagram.com/p/CcS5_p3L6SL/
I use Morgan Levine's PhenoAge to track the impact of my diet. Interestgly, I did slightly better on a vegan + sardines + yogurt + cheese diet than I did on a vegan + sardines diet.
Have you tried adding eggs?
@@DonnaLHaney I ate about 2 eggs a week in both cases. Eggs consumption is associated with an increased all-cause mortality, and in randomized trials with increased Tryglecerides and insulin resistence, so I try to limit their intake.
@@ok373737 thx for replying. I was vegan for 7 years, then had my DNA analysis which showed an extremely high need for choline, so I added eggs (and fish, as well as dairy & some cheese). I understand, as you say, eggs are generally "associated with" higher all cause mortality, but I wonder how else someone like myself should balance that with getting enough choline in their diet.
@@DonnaLHaney what in the DNA analysis suggested that more Choline is needed? How many eggs do you eat a week? Eating nuts, fish, some chicken and red meat should provide some Choline but not as much as eggs. But who know if the RDA is actually optimal for you.
@@ok373737 one related SNP is PEMT rs7946, indicating a lower conversion rate in the liver to acetylcholine (per Dr. Rhonda Patrick genetic analyzer 2019). Later analysis with Chris Masterjohn limited to choline recommended 800+mg dietary choline/day. RDI is about 1/2 that. I've been eating two eggs/day plus fish, cruciferous veggies, nuts, etc and supplement with both choline & TMG. I've always had very low triglycerides, but became insulin resistant as a vegan. I now follow the old ZoneDiet macros, but violate Dr. Sears' advice to avoid egg yolks, trying to balance all of this, but can't really afford to get a lot of repeated tests to see how it's going.
Aging is a disease. Thank you for this great interview.
She said "there is no one cause of aging" but different species live very different life spans. Dogs and cats live only 20 years or so and parrots live to 90.
So in my view there must be a genetic clock and we should be able to switch it off. I'll definitely subscribe if you can switch my clock off.
@FoundMyFitness, Thought you might enjoy knowing that I first heard of Joe Rogan as a result of taking in as much as I could find of your content here and on FoundMyFitness. Keep up the good work!
That's a reversal of what I might otherwise expect... Thanks so much for listening, Larry!
This woman is going to be a super super super centinarian
Follow the SENS model.
Damn, Dr. Levine looks like she has already reversed her aging
Using a sunua and being in a fasted state before a Biological age test sounds like a good trick to cheat the results :)
Add Rapamycin ànd you will extend your lifespan.
and this one time, at age acceleration camp
mRNA vaccines and epigenetic aging?
My mom got double pneumonia at 16 they read her the last rites. TB at 17 relapse at 36 cancer at 54 cancer again at 78. She is now 93 and going strong so I am not sure where disease is predictive of other serious illness shortening lifespan?
Kane Tanaka underwent pancreatic cancer surgery at the age of 45. She is 119.
Interestingly, alot of very long lived people have had many serious diseases including cancers. I guess the saying is true: "That which does not kill us, makes us stronger". Body has a remarkable way to bounce back from disease. But there are no guarantees.
Your personal anecdotes don't mean anything in the grand scheme of what the information says.
Everyone always has that typical personal take "well my grandma drank and smoked her entire life and she lived to 90" ok cool but that doesn't mean anything in regards to the literature and statistics.
I am trying to understand that whole process. From what I have gathered it has a lot to do with belief and expectation. Also, emotions are important and being in a state of joy, interest, knowledge most of the time. When feeling in the negative emotions being able to own where you are at and then work your way up the higher emotions by self soothing and looking for positive aspects in all things.
@@alphonso0077 yes, optimism according to some studies also has an impact on wound healing! So a positive mental well-being, along with optimism and reducing stress, are key for health and wellness. This is not merely to be rejected as 'quackery'.
With all due respect Dr Rhonda please try to shed light on the livers ability to heal cells by sending out photochemical compounds attached to amino acids and antioxidants to seek and heal the cell instead of only researching the cell.
We fully get it oxidative stress is bad and antioxidants are good but the liver needs some light shed on it’s more than 2000 chemical compounds
Yes 2000 not 500
Links to learning resources?
Hello Ladies, I am single tan, and rested. 😍
Unless you can can change the epigenic clock all you are doing is looking at the speedometer.
Great conversation. It would be even better if longevity researches like this would stop saying plant based diets are better for longevity. This is an archaic notion regarding mtor stimulation. Dig a little deeper please.
Wasn't she purely stating her findings based on the biomarkers? Ie evidence based observations? No notions being spouted. Only watched it once so happy to be corrected.
So what's your point about MTOR ? Is this not a factor accelerating aging? And animal protein boosts MTOR more than plant protein... More anabolism, but less longevity.
@@ThierryPianoSolo you are correct, but mtor stimulation seems to only be problematic in metabolically unhealthy individuals. Also, I would argue the benefits of animal based protein with regard to muscle gain and prevention of muscle loss as we age outweigh any negative consequences. My argument isn't that plant based diets aren't effective with regard to longevity, just that they aren't optimal.
Of course, the truth is we just don't know enough yet to make definitive claims!
@@ericsevyn5464 Mtor is not bad in itself, but problematic in excess. That's why centenaries people eat not so much animal protein (but are not strictly vegetarians). We have enough data to be certain of that.
May I pay a compliment? Very smart and attractive Ladies indeed. :)
Aging is a metaphysical reality. No amount of human biomedicine can stop aging.
Wrong.
@@ThierryPianoSolo Wright.
I don't think you understand what "metaphysical" actually means....
@@iranjackheelson Who knows, right? I obv think I do, and I have no reason to believe you, a random youtube commenter, more than myself, right? So it's sort of a pointless thing to say. But perhaps you felt the need to say it, and that's okay too. It's the same feeling as caused me to make my comment.
🙏🙌
I'm listening on headphones and all the people talking in the background are a little distracting.
Lesgoooooo
Great podcast but the point ultimately becomes what does all this effort actually accomplish? Through not overeating and exercise alone you are getting the lions share of the benefits. Everything else seems like noise, including intermittent fasting, which is not even reproducible beyond mice data so far. The obsession is just a waste of time
Steve Hirvath has repeatedly refused to answer the question.
評價非常高
把我*** ***嚇親。
把我*** ***嚇親。
POINT 3 POINT 3: DR DOCTOR RHONDA PATRICK
・学歷很高学歷很高
・把我*** ***嚇親把我嚇親
・QUESTION:边一方面那一方面 *** *** 嚇親我嚇親我？回答I GIVE ANSWER I GIVE ANSWER 我
回覆:/ANSWER ANSWER:高学歷高学歷 AND AND 和和 RHONDA PATRICK 非常聰明非常聰明
Save me reach out to me. I understand
(On Janurary 7, 2023 on a Saturday). The subject of Epigenetics and The underlying Genetics, of course, is awfully esoteric and elitist; and because so much of the so-called novelties are based, interestingly and distressing enough, on a Single Cell Type (HeLa Cells, a Pathological Immortalized Cell Type of a Subject who died in 1951 [October 4] of an Aggressive Carcinoma of the Cervix, the Vaginal Tissue and was justified as the most representative of DNA Instability) is somewhat of s Cinderella Story, where the multitud try on an elusive but unbefitting idea, the intelllectual class included. While the Environment, any the Reproductive Function of Biological Specimens, all Govern the central Biological Meaning and Function of Human Biologics (Biology is not Exclusive Eukaryotic [Mammalian] or Prokaryotic Either). In the essential Quest of Age Reversal and the Perennial preoccupation with Life and its development, or better understood as The Faustian Bargaining for Eternal Youth, is certainly to have meaningful discoveries as we know more about Molecular Pathways and Chemical Reactions Therein, but fine tuning, if they are every discovered scientifically speaking, is the true Puzzle, or bounded to become a Secret Formula (you guessed it, for sale). Needless to say, the difficulty and very concerning means to this end (The scientific Challenges to arrive at Complete control of Molecules functioning just right), but the moral apprehension people like me find in this massive Academic Enterprise bordering the boundaries of legality and Moral Rectitude (somewhat an arbitrary and subjective predilection of mine, but I am not the lone ranger here either). This is my take in Age-determining methods or Assessment of DNA Molecule especially with Tax-payed Monies or in the name of Public Domain Benefits etcetera. Ph.D Morgan Levine And MD Rhonda Patrick are better herein described herein as socializing dears....Heil!
You only have to look at the English to realize that some people age in an accelerated fashion.
Oui Oui, Vive la france
L🤣L
Poor diets, alcohol abuse and sun damage just melts years off.
@@RandomNirvanaSXE Sun damage? in the UK? 🤣 , Ethnic brits in Australia then yes maybe..
@@RandomNirvanaSXE more like: a lack of sun, stress, working into the 60s, poor diet, lack of exercise, sugar, alcohol etc. Greetings from England!
These smart women are hot..
Some folks age like milk.
Secretly hoping they’d kiss.
🤣
Eat a carnivore diet, don't drink or smoke, exercise often, do regular sauna and ice baths sessions, get proper sleep, and learn to manage stress properly. Solved.
Balanced diet, not carnivore... Carnivore diet leads to red face, hoarse voice and poor skin quality as all the carnivore TH-camrs prove... It's not a healthy diet in the long run.
Good content, of what I could hear. Stop mumbling please
All of our videos are transcribed and close captioned.
Indeed! The (otherwise incredible) guest’s glottal fry was just too much for my ears. Ugh. God, I hate that trend.
Good to know a transcription is possible for voices such as this one.
The way she talks reminds me of Mark Zuckerberg🤔
I had that immediate thought as well!
She "speaks" versus talks..
Yeah, good luck with your plant based diets. lol
Great topic here but I gave up. I find the interviewer to talk WAY too much. The concentration should be on asking questions such that the interviewee is speaking, not rambling around and repeating the same question 10x.
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