We've known how to make Quaaludes for ages. There's a bunch of reasons no clandestine chemists produce it outside of South Africa. 1. The dose size is pretty big so you need large volumes of heavily watched precursors to make it. 2. The market is surprisingly limited, sure if you've seen the wolf of wall street you might try it but even then they'd probably say its fake considering how rare it is. 3. There's plenty of far more profitable and popular chemicals to make, why make Quaaludes when you can make MDMA? The only reason its even produced in South Africa is because the Triad smuggles some weird fish from there that's a delicacy in China and in return they smuggle back the precursors for making bathtub Quaaludes.
We had this kid at my drug rehab who knew how to make these and he called them "lemon drops." A lot of drug tests were simple 6 panels. So they never showed up. He ended up overdosing on benzos and pain killers. But he was a smart dude
@@Ben-xf7uy I figured. Heroin addicts, especially IV users, are often times VERY smart and intelligent people. its kinda why they turn to heroin in the first place. to escape their overactive brain and whatnot. I was just curious, based off everything you said i could tell lol. I used to use too so i get it.....RIP to him and all the others, this planet has lost a TON of potential to substance abuse. I have met some amazing people who were caught in the web during my time of using and getting clean. met this one dude in rehab named ryan who was legit like 145iq and we became great friends but dont know what happened to him. heard he didnt make it smh...thanks anyways
@@SetTheCurve as he said anthranillic acid can be made and that goes for acetic anhydride too. If one is capable of this synthesis they are capable of producing these anyways.
@@SetTheCurve Are there PPQ chemists out there on the streets I haven't heard about? Hard to buy quaaludes unless someone's selling an ancient stash or if you live in South Africa.
@@derenjoy3rThe anthranillic acid synthesis sucks. Sensitive to temperature and almost impossible to purify to more than brown powder without multiple columns
@@trymatic7151 well for a skilled chemist there will be a way around it, its not that complex of a molecule. I bet rhodium or smth along the lines has a decent procedure
@@JoeRogansForehead No? Lol? There are tons of lysergamide precursors commercially available like: Lysergic acid, lysergamimide, ergoline, lysergic acid methyl ester, lysergol etc.
@@QuinazolinkingUsername checks out for this video. Also, would be interesting to see a conversion from the LSA found in HBW/Morning Glory into the diethylamide. LSA was horrible, caused muscle cramping, but LSD was both more potent, and more clean feeling. Hypothetically, of course.
@@pistilpete9649 i know thats the case in the US for at the very least amphetamines and i think some others but iirc this youtuber is from the netherlands
@@creature2479 I am 100% correct. I met people in prison that were there for various versions of “spice” (because it’s ingredients mimic a banned substance)…
@@creature2479 It is. The US has an analog law, too. I think there's a catch in it, though, if I'm not mistaken. Like it has to be produced with the intention of marketing or distributing as an illicit substance.
Have you seen any literature on the reaction straight to the benzoxazinone with anthranilic acid, benzoyl chloride, and pyridine? I have tried this reaction but was not able to get a product with the correct melting point. Eliminates the need for DCM and triethylamine based on multiple papers I’ve seen, but I haven’t gotten it to work after a couple goes. Great work on this stuff man!
Could theoretically work if you added at least 2 eq of benzoyl chloride, which would acylate both the amine and create the mixed anhydride with anthranillic acid. The mixed anhydride should be activated enough such that the amide carbonyl can attack and form the benzoxazinone. I'm not exactly sure the stoichiometry Chemiolis used in the first step to get the single acylation product but the excess acetic anhydride in the second step essentially activates the acid and dehydrates the rxn driving to completion. Again on paper this looks like it would work, would have to try in lab.
Have a go using isatoic anhydride. I had the same issue as you, but had success with that. The route is toluene to nitro toluene, to o-toluidine (separation is less painful than anticipated), then you can go to N-Acetyl-anthranillic acid or isotoic anhydride. It’s weird seeing Americans give each other advice on avoiding hard-to-get stuff. You guys can get concentrated HCl OTC, but can’t get pyridine or piperidine or cyclohexanone. In the UK I can get everything except strong acids OTC, and to get strong acids all I need to do is create a company (that has a legitimate need for the chemicals - research ticks all the boxes). I could get a canister of HBr gas as a 17 year old with an amateur lab, and when the police raided me they were only allowed to confiscate the 25% H2SO4 lol. They had to give it back, don’t worry. I was able to get several litres of oxalyl chloride and PCl5. I remember going on sciencemadmess and asking for input on a paper claiming “metal acid anhydrides” (eg Fe2O3 - I know, weird) could be converted to the Lewis acid trichloride with Oxalyl chloride. And they were furious - they were trying to make oxalyl chloride with thionyl chloride or AlCl3 and here I was with litres of the stuff lol.
We can't get cyclohexanone, pyridine, or piperidine since they're such common base structures of recreational drugs. Piperidine alone gets you within a couple of steps of making phenethylamines, and we can't have that! 😮💨
My Dad had many a story from the 70s that began with “so we each took a handful of Quaaludes out of this bag my older cousin gave me” I felt an instinctive need to click this video.
*Withdrawal from "LUDS" was totally brutal!!! My Mom had to be institutionalized for 6 months to get over it and ended up on a low dose of valium which she has taken for over 50 years now.*
@@homelessman3483 *My mom lives in an old-folks home now at age 97. You would not believe the amount of Valium they dispense at this place! Almost every old women their has been on Valium since the early 1970's and all are extremely healthy and mentally vibrant!!! They are all sharp and sassy and do not have any cognitive problems. I have seen studies that say benzo's protect the brain from old age and have been called a "Fountain-Of-Youth" for the brain as they have powerful neuroprotective effects against stroke damage and old age which happen when Glutamate levels spike in the brain. Live longer - Take Valium*
If the estimate of an active dose of this is 0.5mg, this synthesis at 13.5g is 27,000 doses! More importantly, it's not hard to absorb such small quantities through the skin or mucous membranes, so PPE would be absolutely essential in replicating this.
I think skin absorption is generally overstated. The skin acts as a pretty good barrier especially to larger compounds. You would have to apply something like dmso to increase permeability to actually be worried about accidental ingestion. Still PPE is always a good safety precaution.
@@aethelred9781sadly this analogue is thought to work on different subsets of receptors and lacks the dopamine affinity associated with qualuudes fun effects. Making it purely sedative. With likely similar levels of recreational use to less euphoric benzos or even possibly antihistamine sedatives
For me it’s more like AMSR, I don’t understand it but it sure sounds neat and I like watching it develop I’m Comp Sci so this is far from my area of expertise haha
Analogs are always cool but I think watching someone synthesize anything is fun! Could you do some videos related to maybe cooking or home improvement or something in everyday life? Keep up these videos tho >:D
8:19 - It wouldn't surprise me if the acetic anhydride acetylates the carboxylic acid first to form the mixed anhydride, which is then more susceptible to the intramolecular cyclisation. Acetic anhydride seems like an odd choice of solvent otherwise. I wonder if it's possible to use excess benzoyl chloride to acetylate the nitrogen, form the mixed anhydride and then cyclise all in one step...
Neat! Yes you can do that, I have done that same cyclisation before for a 3H quinazoline, you do need a drying agent since it generates water - the best out of 6 tested was PCl3 (since it dissolves better in MePh than PCl5)
Please make ethchlorvynol next ! That was elvis’ favorite sedative, known as placidyl pharmaceutically. Should be a simple synth too as it’s a tertiary alcohol
So the step where you ad acetic anhydride and then the next step where you add aniline don't need a separation work up. You can just add the aniline to the mixture with some extra amount of acetic acid, since acetic acid is the solvent and separation and purification seems like it just reduces your yield. Also, the final purification steps should just be toluene. you don't need the dcm stuff.
If only for pure research purposes would I be able to acquire an amount, please? Yes. Only for research . . Ahem lol. Fantastic chemistry skills. Keep the magic alive. Thankyou! Pete 🏴 Stockport England.
Chemolios is one of the best chem TH-camrs by far. One thing I always wonder when I see his videos is how the hell does he aquire some of the chems? I know for sure some of the things he has used isn't commercially available to the home hobbyist. I'd like to have a combo with dude. I have some ideas I'd like to see one of the chemtubers tackle. Hell Ive though about shooting a vid myself but I think someone like chemolios would do it much more justice.
Yeah I was around during the late seventies and eighties when the quaalude was going strong and believe me as much as I like them and enjoyed them they do not need to make a comeback way to dangerous and I remember the roarer 714s and the lemons but then they started counterfeiting them once they banned them and it all went bad
Very strong showings in these most recent videos. Have you perhaps considered the synthesis of an analog of something like clozapine, or maybe that molecule itself? Great work.
I had a really bad chemistry teacher in college i decided to not take anymore classes but it think i would have liked it with the right teacher because I love watching these videos
Was always curious what Quualudes felt like. I’ve done Benzos *all main stream types* and Ambien as well. Haven’t done em in years and don’t ever plan on taking them again but Valium and Librium were the best imo.
@@_Y.J yeah I’ve done em all and xans made me black out the most but still fully functional and running only on my subconscious lol not cool at all I don’t recommend to anyone reading this. I liked Valium because it had a unique feeling to it that was like a warm blanket filled with pure love and also gave me the munchies worse than weed does. But Librium is king of them all and only given to severe alcoholics because it lasts pretty much 24 hours damn near and comes on slow but has a strong peak that lasts without making you black out like xans but just as strong only mellow come up so you get used to it without it hitting you all at once. Temazepam aka Restoril is a combo effect and very euphoric as well. Feels a lot like Ambien but with a Valium like feeling and also lasts longer than Xans do and also stronger imo. I never tried “Research” Benzos but I heard they were legal to buy for years online until people started yappin their mouths just like with the pain meds and they made it illegal to get online from that gray area loophole. I also tried pure phenibut from “Nootropics depot.com” before they banned it and that shit is a hell of a lot more dangerous and worse withdrawals than any benzo or alcohol I ever done lol phenibut loses it’s magic quickly and the withdrawals are far beyond anything I could put in words. Vivid hallucinations and extreme auditory hallucinations as well hearing voices and people not there while fearful of closing your eyes because as soon as you do it’s full on cartoon like *scary* hallucinations so vivid you can’t tell it from this reality. The extreme sweating and convulsions, restless arms and legs with mild seizures just aren’t worth taking pure phenibut for more than 3 days straight. Scary shit and the panic and fear are on a level you don’t wanna reach lol who ever reads this “don’t take phenibut” most is fake now days anyways or cut with shit that will mess you up.
People don't know the easiest hypnotic to procure is kbr. Potassium bromide was used for centuries as a soporific. Nabr, sodium bromide is seldom used as the na+ raises the bp in older individuals.
Other analogues like cloroqualone, etaqualone and diproqualone were developed in france from 1950 to 1966. Used as antitussives, muscle relaxants for neuralgia, mild anxiolytics and moderate potency hypnotics. But was pulled off market by 1970 due to reports of abuse and toxicity. Other analogues were manufactured in clandestine labs jn Germany and Poland for use as street drugs. Some analogues are still prevalent in Underground Rave clubs in Russia as cheap dissociative drugs, cheaper than ketamine or etomidate or xylazine. The downside of all these analogues is the eventual renal disorders and the occasional cerebral inflammation and death, if you od'd.
"Or i have created mass out of nothing" bro either placing himself in The 3 Body Problem plot or simply godlike technique that he actually took stray photons to create more matter
How unique could quaaludes have been, if they acted on GABA modulation, just like benzos and modern barbs? Is the way they're so fondly remembered exaggerated?
According to Wikipedia, "Unlike most benzodiazepines, methaqualone acts as a negative allosteric modulator at a few GABA-A receptor subtypes, which tends to cause an excitatory response in neurons expressing those receptors. Because methaqualone can be either excitatory or inhibitory depending on the subunit composition of the GABA-A receptor, it can be characterized as a mixed GABA-A receptor modulator. The methaqualone binding site is distinct from the benzodiazepine, barbiturate, and neurosteroid binding sites on the GABA-A receptor complex, and it may partially overlap with the etomidate binding site."
Definitely nostalgia plays a huge part in how they remember qualudes.. I’m 34 so I definitely wasn’t around but I’ve been a Xanax (and kpin) connoisseur since o was 18 very experienced with benzos and I actually got my hands on a legit qualude I know someone who knew someone who had some back in the day and stashed them before he went to prison got out and they were still were he had them gave some to my boy who I got it from ,, literally it felt very similar to alprazolam same thing pretty much
@@TimCastro-se7gd Legit ones were last manufactured in 1984, i.e. 40 years ago, and it sounds like yours might have been later than that (depending on the length of the prison sentence you mentioned).
@@amritlohia8240 that could be about right the dude was older probably if he’s not dead 60s so if he got them towards the end let’s say 1980 stashed them and got locked up right after did let’s say 20-25 I do t remember but I know he was in for awhile it wasn’t some 3 4 5 6 7 years I know it was double digit n I wanna say in the 20s mark somewhere ,, n got out early 200s let’s say 2002 went to his stash spot got em and I know he had a lot because he was a dealer back then my friend said , then sat on them for roughly 10 15 more years using them special occasions and only giving limited amounts to close friends and then my boy got em he had only got like 4 or 5 of them and gave me the one somewhere round 2010 ,,,, that’s probably what happened ,,,, or it all could be completely made up story some tweaker told my friend actually gave him some pressed Xanax or some designer benzo in form of a lude
Honest questions about the synthesis. 1) why wasn't the acid chloride added dropwise to the mixture of anthranilic acid and triethylamine? Surely the mono acylated substrate is sterically hindered but I'm expecting double acylation on the amine 2) Was water removal using acetic anhydride described? Also here again I expect acylation of the amine and potentially forming mixed anhydride with the free carboxylic acid which can cause your substrate to form inter molecular acylation reactions. Edit: your over 100% yield is coming from that. 3) why do you never show TLC? It's so fast and easy Not trying to bash, just curiousity.
This is an awesome video, but people in my area don't like the opening imagery. They also don't realize that every chemical that starts with those first four letters m-e-t-h is not necessarily amphetamine related.
You should do an an anthranilic acid synthesis video from methyl anthranilate which would be a simple demethylation, idk the exact chemistry involved but you probably do and the precursor is widely available as artificial grape flavoring
The reaction is base hydrolysis, simply stir and reflux 151 grams of methyl anthranillate in a NaOH aq solution made from 40 g of sodium hydroxide and ~ 300 mL of water. This makes sodium anthranillate which dissolves in the water along with methanol. Then adding 120 grams of 32% Muriatic acid precipitates the anthranillic acid which is insoluble in water.
I think the mechanism can be another: anthranilic acid is a zwitterion, TEA deprotonates that which amino group can then attack benzoyl chloride. I also think about TEA attacking benzoyl chloride making a quaternary ammonium which is a great leaving group displaced by amino of anthranilic acid. I still wonder where do you get all these restricted chemicals. Can you tell me something about fluorescence of PPQ ?
Why not just stay with the original Quaalude? Hugh Hefner called them "thigh openers". Take of {acetyl-anthranilic acid}, add {ortho-toluidine}, mix well with polyphosphoric acid and heat to about 250. Quench into water, basify, extract with organic solvent, wash a few times. Add an equivalent of HCL and crystallize.
Is it weird that I have dreams where we discover a bunch of new analogs & psychoactive substances that have beneficial properties to them. Such as pain management without physical addiction being a uncontrollable aspect of it all...
Ziconotide is a pain medication that doesn’t cause physical dependency, but it has terrible side effects and can only be administered via an intrathecal pump. It’s a selective N-type voltage gated sodium channel blocker. Personally, I’m just fine with opioids being the mainstay of chronic pain treatment, humans have been using opiates for thousands of years. I think the reason why we’re seeing such an increase in opioid deaths is because doctors stopped prescribing them and kicked so many people off of their prescriptions.
That, and the increasing prominence of fentanyl, and its ~50 analogs. Nitrazenes are also becoming more common because they are harder to detect, cheap, and very simple to synthesize (basically the same reasons fentanyl analogs became very common). These nitrazenes are benzimidazole derivatives that have even greater affinity for the δ-opioid and μ-opioid receptors than fentanyl (they were discovered in the 1950’s, but the researchers decided they were far to potent to be safely used in medicine. Thus, they were never approved for use). The consumers of these types of chemicals expect diacetylmorphine, oxycodone, etc., but they instead unknowingly end up with chemicals that are hundreds to thousands of times more potent. The more potent these chemicals are the less effective naloxone is at reversing the opioid toxidrome as well requiring larger quantities, and more frequent repeat administrations of naloxone. Currently there isn’t a test kit for nitrazenes. Fatal ODs have about doubled in the last decade because of these factors. With all of these factors combined it’s really not surprising that we’ve been having this serious problem. This will continue to be an endless cycle until serious policy changes are made, and new strategies/protocols are adopted. Helping patients ween off these medications when it’s no longer needed, and making naloxone readily available everywhere would definitely be a great start though.
@@Sniperboy5551 yeah I think that's a huge issue. It Never made sense to me how they said they wanted to treat the opiod problem yet they completely stopped giving pain treatment and didn't think that would back fire and cause a ton of people to seek other illegal options through out the black market.. I do think it is possible to have therapeutic pain management treatment but apparently our society doesn't believe that exists..
The problem with that is any pain killer stronger then asprin is gonna be addictive, the only real solution is to make pain meds that make you sick at higher doses to avoid misuse
@nothingnothing1799 We could also make medical treatment to treat the underlying pain, free and more available. We could make workplaces safer to prevent more injuries that cause chronic pain conditions. We could provide better psychological and medical treatment for dependency and create a culture more receptive to those who are dependent and wish to end their dependency without labeling legitimate pain patients addicts or using accusatory language such as "drug seeker" based on limited interactions with patients during single encounters. We can make methadone treatment more widely and easily available to those seeking treatment. There is a lot we could do that doesn't involve deactivating the therapeutic effect of the drugs entirely if abuse attempts are made (CR and ER tabs have a crush sensitive component that destroys the drug) or intentionally poisoning folks as you suggest.
![[ ออกกอง ] วัยหนุ่ม 2544 โลกหลังลูกกรง..ทัวร์กองถ่ายหนังใน "คุกของจริง" | JUSTดูIT.](http://i.ytimg.com/vi/vB--aOkZCpw/mqdefault.jpg)
One of you young chemists out there instead of making fentanyl and meth bring some joy back to the world with Quaaludes for us old timers!
Yea I second that I loved Quaaludes
💯
Fentanyl is imported from China, no one is producing fentanyl in the states.
Ice is incredible, just sleep and it's all good. Gotta take care of yourself but you will be awake for 3 days 😂
😊😊😊🎉🎉@@donaldfeger91
My man out here reviving ludes, so our generation can finally start accurately cosplaying wolf of wall street.
WHERE ARE THE LUDES!?!?!
Donnie! Get the ludes!
We've known how to make Quaaludes for ages.
There's a bunch of reasons no clandestine chemists produce it outside of South Africa.
1. The dose size is pretty big so you need large volumes of heavily watched precursors to make it.
2. The market is surprisingly limited, sure if you've seen the wolf of wall street you might try it but even then they'd probably say its fake considering how rare it is.
3. There's plenty of far more profitable and popular chemicals to make, why make Quaaludes when you can make MDMA?
The only reason its even produced in South Africa is because the Triad smuggles some weird fish from there that's a delicacy in China and in return they smuggle back the precursors for making bathtub Quaaludes.
You can still get Quaaludes my guy 😎👌🏻
@@kmoxmedia5717lol i have someone who has some
We had this kid at my drug rehab who knew how to make these and he called them "lemon drops." A lot of drug tests were simple 6 panels. So they never showed up. He ended up overdosing on benzos and pain killers. But he was a smart dude
Was he an opiate/heroin addict by chance?
@SgtNateHigers-BPD yeah, he was IV using and mixing substances by the end. Opiates were his primary
@@Ben-xf7uy I figured. Heroin addicts, especially IV users, are often times VERY smart and intelligent people. its kinda why they turn to heroin in the first place. to escape their overactive brain and whatnot. I was just curious, based off everything you said i could tell lol. I used to use too so i get it.....RIP to him and all the others, this planet has lost a TON of potential to substance abuse. I have met some amazing people who were caught in the web during my time of using and getting clean. met this one dude in rehab named ryan who was legit like 145iq and we became great friends but dont know what happened to him. heard he didnt make it smh...thanks anyways
Very sad wasted potential
Obviously not that smart.
NileRed is like the first boss you encounter in a game. Chemiolis is like the end-game boss.
HAHAHAHA FACTS😂😂😂😂
NileRed is great to sleep to. And very interesting channel
Unhinged lmao
No.
@@spankyjeffro5320 yes. End of debate.
This workup really revived my faith in purification methods
AcOH, DCM, toluene easy-peazy hehe Now we know what Bill Cosby had in his "pudding". lol
Bill Cosby in the thumbnail is diabolical lmfao🤣🤣🤣
🤝
sick actually. what he did isnt funny
@@dylandoss8854 lol no shit loser, I can laugh at memes about Cosby with out dismissing the terrible shit he did. Go touch grass
Yeah
I loved going to his parties, man he made some STRONG drinks...
- Mentions that anthranilic acid is a restricted chemical
- Casually uses 400 ml acetic anhydride as a solvent
A request for next one is 5-minute craft antipsychotic medication that'll get me out of manic behavior into the real world somehow
😂
Imagine if LSD was the cure to psychosis.
Yeah...its not unfortunately @@officermeowmeowfuzzyface4408
You’d have to slow down your brain so much you’d basically be asleep 24/7
@@officermeowmeowfuzzyface4408 It is
/s
My MAN. A Methaqualone analogue? After PCMo, you're the guy.
Yeah, and he only uses a jug of acetic anhydride and other chemicals harder to buy than the drugs themselves
@@SetTheCurve as he said anthranillic acid can be made and that goes for acetic anhydride too. If one is capable of this synthesis they are capable of producing these anyways.
@@SetTheCurve Are there PPQ chemists out there on the streets I haven't heard about? Hard to buy quaaludes unless someone's selling an ancient stash or if you live in South Africa.
@@derenjoy3rThe anthranillic acid synthesis sucks. Sensitive to temperature and almost impossible to purify to more than brown powder without multiple columns
@@trymatic7151 well for a skilled chemist there will be a way around it, its not that complex of a molecule. I bet rhodium or smth along the lines has a decent procedure
And we never heard from him ever again.
Need a trip report on this one
Can’t wait to see one of the many, many LSD analogues.
Mhm, interesting idea. We can maybe do one - like cabergoline or something
@@Quinazolinkingyeah right . He’d need ergot , not easy to find
@@JoeRogansForehead No? Lol?
There are tons of lysergamide precursors commercially available like:
Lysergic acid, lysergamimide, ergoline, lysergic acid methyl ester, lysergol etc.
@@QuinazolinkingUsername checks out for this video. Also, would be interesting to see a conversion from the LSA found in HBW/Morning Glory into the diethylamide. LSA was horrible, caused muscle cramping, but LSD was both more potent, and more clean feeling. Hypothetically, of course.
@@Guffy1990 Bro 💀 why would you consume that crap, its super toxic
this time on how to make technically legal drugs
Anything that could be considered and analog/isomer etc etc is actually a felony lol.
@@pistilpete9649 i know thats the case in the US for at the very least amphetamines and i think some others but iirc this youtuber is from the netherlands
@@pistilpete9649I don't believe it is in the states, over here in the UK it is though since 2017, thank you Theresa may
@@creature2479 I am 100% correct. I met people in prison that were there for various versions of “spice” (because it’s ingredients mimic a banned substance)…
@@creature2479 It is. The US has an analog law, too. I think there's a catch in it, though, if I'm not mistaken. Like it has to be produced with the intention of marketing or distributing as an illicit substance.
I can BARELY recall ludes .
It was a long time ago .
Yeah , that's it ...
Yep do them and wake up not remembering anything lol.
My ex was a pro doctor shopper. We loved the 400 mg blue grey caps!
Maybe parest 400
Have you seen any literature on the reaction straight to the benzoxazinone with anthranilic acid, benzoyl chloride, and pyridine? I have tried this reaction but was not able to get a product with the correct melting point. Eliminates the need for DCM and triethylamine based on multiple papers I’ve seen, but I haven’t gotten it to work after a couple goes. Great work on this stuff man!
Could theoretically work if you added at least 2 eq of benzoyl chloride, which would acylate both the amine and create the mixed anhydride with anthranillic acid. The mixed anhydride should be activated enough such that the amide carbonyl can attack and form the benzoxazinone. I'm not exactly sure the stoichiometry Chemiolis used in the first step to get the single acylation product but the excess acetic anhydride in the second step essentially activates the acid and dehydrates the rxn driving to completion. Again on paper this looks like it would work, would have to try in lab.
Have a go using isatoic anhydride.
I had the same issue as you, but had success with that.
The route is toluene to nitro toluene, to o-toluidine (separation is less painful than anticipated), then you can go to N-Acetyl-anthranillic acid or isotoic anhydride.
It’s weird seeing Americans give each other advice on avoiding hard-to-get stuff.
You guys can get concentrated HCl OTC, but can’t get pyridine or piperidine or cyclohexanone.
In the UK I can get everything except strong acids OTC, and to get strong acids all I need to do is create a company (that has a legitimate need for the chemicals - research ticks all the boxes).
I could get a canister of HBr gas as a 17 year old with an amateur lab, and when the police raided me they were only allowed to confiscate the 25% H2SO4 lol. They had to give it back, don’t worry.
I was able to get several litres of oxalyl chloride and PCl5.
I remember going on sciencemadmess and asking for input on a paper claiming “metal acid anhydrides” (eg Fe2O3 - I know, weird) could be converted to the Lewis acid trichloride with Oxalyl chloride.
And they were furious - they were trying to make oxalyl chloride with thionyl chloride or AlCl3 and here I was with litres of the stuff lol.
We can't get cyclohexanone, pyridine, or piperidine since they're such common base structures of recreational drugs. Piperidine alone gets you within a couple of steps of making phenethylamines, and we can't have that! 😮💨
I love watching synthesis videos, it's amazing.. makes me want to try the easier legal compounds . ,thanks for sharing this with us.
The things I'd do to get my hands on Methaqualone or one of the many analogues, most euphoric substance ever made
You tried it? Is it more euphoric than opiates?
@@NathanBraswell-gq5vyno they made you feel drunk and mildly euphoric. Now Doriden that taken with codeine was unreal😅
Overratd
My Dad had many a story from the 70s that began with “so we each took a handful of Quaaludes out of this bag my older cousin gave me” I felt an instinctive need to click this video.
"cant speak a word when you're full of ludessss" thanks Skynyrd
Well you technically can try, but nobody will understand.
“You will be alright tomorrow, but tomorrow might not be here for youuuuuuu (yeah, yeah)”
It’s so interesting and beautiful to watch chemistry happen. Makes me wish I’d have paid attention in school.
real
Hey thats me
Awesome video! I as an undergraduate who loves organic just get way enthusiastic watching your videos
Absolute madlad with your genius thumbnails. How does he keep getting away with it???
febrifugine at quick glance means fever chaser - not a shit name at all for an antimalarial.
i guess you could say it was discovered by…quincidents.
*Withdrawal from "LUDS" was totally brutal!!! My Mom had to be institutionalized for 6 months to get over it and ended up on a low dose of valium which she has taken for over 50 years now.*
She would a been better off staying in the ludes. 50 years of benzos is fucking wild brother
@@homelessman3483 *My mom lives in an old-folks home now at age 97. You would not believe the amount of Valium they dispense at this place! Almost every old women their has been on Valium since the early 1970's and all are extremely healthy and mentally vibrant!!! They are all sharp and sassy and do not have any cognitive problems. I have seen studies that say benzo's protect the brain from old age and have been called a "Fountain-Of-Youth" for the brain as they have powerful neuroprotective effects against stroke damage and old age which happen when Glutamate levels spike in the brain. Live longer - Take Valium*
god damn to both
@@homelessman3483 I'm not sure that one is better than the other, frankly.
Yo my name is Quandale Dingle, and this is my cousin Quinaziline Methaqualone!
Daniel could use some ludes tbh
Daniel Larson
My name is Garfiel L'Zanya, this is my brother Turdis L'Szechuan.
Quaalude Dingle
If the estimate of an active dose of this is 0.5mg, this synthesis at 13.5g is 27,000 doses! More importantly, it's not hard to absorb such small quantities through the skin or mucous membranes, so PPE would be absolutely essential in replicating this.
I think skin absorption is generally overstated. The skin acts as a pretty good barrier especially to larger compounds. You would have to apply something like dmso to increase permeability to actually be worried about accidental ingestion. Still PPE is always a good safety precaution.
I think you've mixed things up. He synthed PPQ, that 0.5mg figure was for 2Chloro-PPQ
@@alexrogers777Correct, this one lays more in between 10-20 milligrams
PPE is important. Proceeds to pour DCM without gloves into the roundbottom flask at the end and makes sure shake it vigoursly. 12:05
3:46 PPQ is 30-40x more potent. Standard dose 7,5-10mg so that's it 1550 doses not some 27000 xD
I’m excited to watch this, I saw the paper on this compound about a year ago and I’ve been curious
WE INVITED TO THE PPQ WITH THIS ONE BOYS🔥🔥🔥🥩🍗🍖
is the molecule excited to see me
Really enjoyed the video keep it up cant wait for the next one
Hope you’ll be feeling better soon.
It is somewhat haunting that my favourite yt publishers get sick just days before I feel bad myself 👀
Well he'll be feeling pretty darn good now lol.
@@aethelred9781sadly this analogue is thought to work on different subsets of receptors and lacks the dopamine affinity associated with qualuudes fun effects. Making it purely sedative. With likely similar levels of recreational use to less euphoric benzos or even possibly antihistamine sedatives
i realy like how for the end you just speedrun the proces, stil explaing thu
also i would like to see more crystalization processing from you❤
As someone who has chosen to do adv chem this year (6th year chemistry) i can proudly say i am starting to understand some terms used in this vid
For me it’s more like AMSR, I don’t understand it but it sure sounds neat and I like watching it develop
I’m Comp Sci so this is far from my area of expertise haha
Analogs are always cool but I think watching someone synthesize anything is fun! Could you do some videos related to maybe cooking or home improvement or something in everyday life? Keep up these videos tho >:D
I was born in 79. Just a little too late to enjoy Ludes. Damn.
I did this same process 3 weeks ago after watching this video. Woke up today (3weeks later) to comment this.
THE BIG MAN WOULD WALK A MILE FOR A QUAAAAAAAAALUUUUUUUUUUDEEEEEE
8:19 - It wouldn't surprise me if the acetic anhydride acetylates the carboxylic acid first to form the mixed anhydride, which is then more susceptible to the intramolecular cyclisation. Acetic anhydride seems like an odd choice of solvent otherwise.
I wonder if it's possible to use excess benzoyl chloride to acetylate the nitrogen, form the mixed anhydride and then cyclise all in one step...
Neat! Yes you can do that, I have done that same cyclisation before for a 3H quinazoline, you do need a drying agent since it generates water - the best out of 6 tested was PCl3 (since it dissolves better in MePh than PCl5)
If you could get your hands on that i would not be using it on this. I would be processing some sap from pretty flowers
@@stephenfrancis303 You naughty boy 🤣
@@stephenfrancis303 Poppies per chance?
shit, I would love to have this guy as my homie. Chemiolis would be a awesome friend to have.
Please make ethchlorvynol next ! That was elvis’ favorite sedative, known as placidyl pharmaceutically. Should be a simple synth too as it’s a tertiary alcohol
Fun!
“Time to dissociate.” We all know that code for “come on over ladies.”
BEEN WAITING FOR THIS ONE LOLLLL
So the step where you ad acetic anhydride and then the next step where you add aniline don't need a separation work up. You can just add the aniline to the mixture with some extra amount of acetic acid, since acetic acid is the solvent and separation and purification seems like it just reduces your yield.
Also, the final purification steps should just be toluene. you don't need the dcm stuff.
If only for pure research purposes would I be able to acquire an amount, please? Yes. Only for research . . Ahem lol.
Fantastic chemistry skills. Keep the magic alive. Thankyou!
Pete 🏴 Stockport England.
Chemolios is one of the best chem TH-camrs by far. One thing I always wonder when I see his videos is how the hell does he aquire some of the chems? I know for sure some of the things he has used isn't commercially available to the home hobbyist. I'd like to have a combo with dude. I have some ideas I'd like to see one of the chemtubers tackle. Hell Ive though about shooting a vid myself but I think someone like chemolios would do it much more justice.
You can tell me some of the ideas you have and we’ll evaluate them
He probably synthsises the intermediates himself.
@buildaboiworkshop why the clown? Behave yourself
Yeah I was around during the late seventies and eighties when the quaalude was going strong and believe me as much as I like them and enjoyed them they do not need to make a comeback way to dangerous and I remember the roarer 714s and the lemons but then they started counterfeiting them once they banned them and it all went bad
We need a follow-up on how it went
Very strong showings in these most recent videos. Have you perhaps considered the synthesis of an analog of something like clozapine, or maybe that molecule itself? Great work.
I had a really bad chemistry teacher in college i decided to not take anymore classes but it think i would have liked it with the right teacher because I love watching these videos
Was always curious what Quualudes felt like. I’ve done Benzos *all main stream types* and Ambien as well. Haven’t done em in years and don’t ever plan on taking them again but Valium and Librium were the best imo.
Xans were my favorite icl addictive AF so I keep away from them
@@_Y.J yeah I’ve done em all and xans made me black out the most but still fully functional and running only on my subconscious lol not cool at all I don’t recommend to anyone reading this. I liked Valium because it had a unique feeling to it that was like a warm blanket filled with pure love and also gave me the munchies worse than weed does. But Librium is king of them all and only given to severe alcoholics because it lasts pretty much 24 hours damn near and comes on slow but has a strong peak that lasts without making you black out like xans but just as strong only mellow come up so you get used to it without it hitting you all at once. Temazepam aka Restoril is a combo effect and very euphoric as well. Feels a lot like Ambien but with a Valium like feeling and also lasts longer than Xans do and also stronger imo. I never tried “Research” Benzos but I heard they were legal to buy for years online until people started yappin their mouths just like with the pain meds and they made it illegal to get online from that gray area loophole. I also tried pure phenibut from “Nootropics depot.com” before they banned it and that shit is a hell of a lot more dangerous and worse withdrawals than any benzo or alcohol I ever done lol phenibut loses it’s magic quickly and the withdrawals are far beyond anything I could put in words. Vivid hallucinations and extreme auditory hallucinations as well hearing voices and people not there while fearful of closing your eyes because as soon as you do it’s full on cartoon like *scary* hallucinations so vivid you can’t tell it from this reality. The extreme sweating and convulsions, restless arms and legs with mild seizures just aren’t worth taking pure phenibut for more than 3 days straight. Scary shit and the panic and fear are on a level you don’t wanna reach lol who ever reads this “don’t take phenibut” most is fake now days anyways or cut with shit that will mess you up.
@@_Y.Jclonazolam
People don't know the easiest hypnotic to procure is kbr. Potassium bromide was used for centuries as a soporific. Nabr, sodium bromide is seldom used as the na+ raises the bp in older individuals.
Other analogues like cloroqualone, etaqualone and diproqualone were developed in france from 1950 to 1966. Used as antitussives, muscle relaxants for neuralgia, mild anxiolytics and moderate potency hypnotics. But was pulled off market by 1970 due to reports of abuse and toxicity. Other analogues were manufactured in clandestine labs jn Germany and Poland for use as street drugs. Some analogues are still prevalent in Underground Rave clubs in Russia as cheap dissociative drugs, cheaper than ketamine or etomidate or xylazine. The downside of all these analogues is the eventual renal disorders and the occasional cerebral inflammation and death, if you od'd.
Good additional info 🙏
i love how we never find out how effective it is
Just imagine if the big man was here to this.
"Or i have created mass out of nothing" bro either placing himself in The 3 Body Problem plot or simply godlike technique that he actually took stray photons to create more matter
Did You checked by TLC ring closing stage? How many hours did You refluxed it?
Man casually makes 20k doses of a strong sedative, this is the kinda chaotic chemist energy I want to see.
🙏
How unique could quaaludes have been, if they acted on GABA modulation, just like benzos and modern barbs? Is the way they're so fondly remembered exaggerated?
The same people who talk about qualudes being great are also the ones who claim yhe 70-80s where a safer time to be alive .
Nostalgia does a lot
According to Wikipedia, "Unlike most benzodiazepines, methaqualone acts as a negative allosteric modulator at a few GABA-A receptor subtypes, which tends to cause an excitatory response in neurons expressing those receptors. Because methaqualone can be either excitatory or inhibitory depending on the subunit composition of the GABA-A receptor, it can be characterized as a mixed GABA-A receptor modulator. The methaqualone binding site is distinct from the benzodiazepine, barbiturate, and neurosteroid binding sites on the GABA-A receptor complex, and it may partially overlap with the etomidate binding site."
Definitely nostalgia plays a huge part in how they remember qualudes.. I’m 34 so I definitely wasn’t around but I’ve been a Xanax (and kpin) connoisseur since o was 18 very experienced with benzos and I actually got my hands on a legit qualude I know someone who knew someone who had some back in the day and stashed them before he went to prison got out and they were still were he had them gave some to my boy who I got it from ,, literally it felt very similar to alprazolam same thing pretty much
@@TimCastro-se7gd Legit ones were last manufactured in 1984, i.e. 40 years ago, and it sounds like yours might have been later than that (depending on the length of the prison sentence you mentioned).
@@amritlohia8240 that could be about right the dude was older probably if he’s not dead 60s so if he got them towards the end let’s say 1980 stashed them and got locked up right after did let’s say 20-25 I do t remember but I know he was in for awhile it wasn’t some 3 4 5 6 7 years I know it was double digit n I wanna say in the 20s mark somewhere ,, n got out early 200s let’s say 2002 went to his stash spot got em and I know he had a lot because he was a dealer back then my friend said , then sat on them for roughly 10 15 more years using them special occasions and only giving limited amounts to close friends and then my boy got em he had only got like 4 or 5 of them and gave me the one somewhere round 2010 ,,,, that’s probably what happened ,,,, or it all could be completely made up story some tweaker told my friend actually gave him some pressed Xanax or some designer benzo in form of a lude
What are we looking at today Algo
*begins reading chat*
The stronger qualone analogs work really well vaporized.
Great video. 👍Tell me, please, can you show the synthesis of Valeryl chloride?
That one line from nights by frank ocean kept playing in my head thru the entirety of the synthesis 😭😭. UUUNANINANI…THIS FEELS LIKE A QUUALUUUUDE
Hey man can you point us out on the study showing nitromethaqualone too be not carcinogenic
Honest questions about the synthesis.
1) why wasn't the acid chloride added dropwise to the mixture of anthranilic acid and triethylamine? Surely the mono acylated substrate is sterically hindered but I'm expecting double acylation on the amine
2) Was water removal using acetic anhydride described? Also here again I expect acylation of the amine and potentially forming mixed anhydride with the free carboxylic acid which can cause your substrate to form inter molecular acylation reactions. Edit: your over 100% yield is coming from that.
3) why do you never show TLC? It's so fast and easy
Not trying to bash, just curiousity.
6:59 Aah, so that's what Jupiter is made out of
Im having difficulty even finding articles about PPQ and its analogs. Good informational video!
This is an awesome video, but people in my area don't like the opening imagery. They also don't realize that every chemical that starts with those first four letters m-e-t-h is not necessarily amphetamine related.
Ah, those South African bottleneck clips remind me of my youth
Wish there were samples
Funny how none of the darknet markets seem to sell Methaqualone, but here a TH-camr is making analogues
Back on the original Silk Road in 2012-2013 you could get them
It's almost like a chemist who is advanced enough to make methaqualone AND be willing to break bad and sell it on the dark web is pretty rare
You should do an an anthranilic acid synthesis video from methyl anthranilate which would be a simple demethylation, idk the exact chemistry involved but you probably do and the precursor is widely available as artificial grape flavoring
The reaction is base hydrolysis, simply stir and reflux 151 grams of methyl anthranillate in a NaOH aq solution made from 40 g of sodium hydroxide and ~ 300 mL of water. This makes sodium anthranillate which dissolves in the water along with methanol. Then adding 120 grams of 32% Muriatic acid precipitates the anthranillic acid which is insoluble in water.
@@kobold7763 That is crazy simple, thank you for the explanation
YOOOO THE PPQ SYNTHESIS FINALLY DROPPED
Imagine grilling up some delicious ppq sammichs
Hold the mayo
The big man will walk infinite miles.
Great work!
I think the mechanism can be another: anthranilic acid is a zwitterion, TEA deprotonates that which amino group can then attack benzoyl chloride. I also think about TEA attacking benzoyl chloride making a quaternary ammonium which is a great leaving group displaced by amino of anthranilic acid. I still wonder where do you get all these restricted chemicals.
Can you tell me something about fluorescence of PPQ ?
No fluorescence was notes, however N acetyl anthranilic acid is lightly stroboscopic
Imma tell my kids this was NeilBlack
Sir if you ever want to hang out please let me know.
I haven't heard the term Disco Biscuits used in a long time.
Doin gods work out here!
Organic chemistry is wild
Am I on a list now?
How do you make AA ?
They still give me barbiturates for my migraines. Cluster migraines, you have to break the chain to get relief
butalbital, lucky fker
Pheno?
Why not just stay with the original Quaalude? Hugh Hefner called them "thigh openers".
Take of {acetyl-anthranilic acid}, add {ortho-toluidine}, mix well with polyphosphoric acid and heat to about 250.
Quench into water, basify, extract with organic solvent, wash a few times.
Add an equivalent of HCL and crystallize.
How about Glutethimide(Doriden)?
This channel is crazy 😂 (thumbnail)
Your like the plug's best and worst nightmare yo
Do Purdues original formulation of oxy....
Do imidazenil next! Non drowsy memory enhancing anti anxiety drug
Now can you show us how to prepare Triethylamine?
and also Benzoyl Chloride
no.
Hey could you teach me chemistry friend ?
i always wanted to try some
As a curious person I would love to try a lemmon 714 just to see what all the fuss is about 😅
Years ago i tried one of these weird methaqualone analogues. Didnt do anything, probably needed a much higher dose.
Is it weird that I have dreams where we discover a bunch of new analogs & psychoactive substances that have beneficial properties to them. Such as pain management without physical addiction being a uncontrollable aspect of it all...
Ziconotide is a pain medication that doesn’t cause physical dependency, but it has terrible side effects and can only be administered via an intrathecal pump. It’s a selective N-type voltage gated sodium channel blocker. Personally, I’m just fine with opioids being the mainstay of chronic pain treatment, humans have been using opiates for thousands of years. I think the reason why we’re seeing such an increase in opioid deaths is because doctors stopped prescribing them and kicked so many people off of their prescriptions.
That, and the increasing prominence of fentanyl, and its ~50 analogs. Nitrazenes are also becoming more common because they are harder to detect, cheap, and very simple to synthesize (basically the same reasons fentanyl analogs became very common). These nitrazenes are benzimidazole derivatives that have even greater affinity for the δ-opioid and μ-opioid receptors than fentanyl (they were discovered in the 1950’s, but the researchers decided they were far to potent to be safely used in medicine. Thus, they were never approved for use). The consumers of these types of chemicals expect diacetylmorphine, oxycodone, etc., but they instead unknowingly end up with chemicals that are hundreds to thousands of times more potent. The more potent these chemicals are the less effective naloxone is at reversing the opioid toxidrome as well requiring larger quantities, and more frequent repeat administrations of naloxone. Currently there isn’t a test kit for nitrazenes. Fatal ODs have about doubled in the last decade because of these factors.
With all of these factors combined it’s really not surprising that we’ve been having this serious problem. This will continue to be an endless cycle until serious policy changes are made, and new strategies/protocols are adopted. Helping patients ween off these medications when it’s no longer needed, and making naloxone readily available everywhere would definitely be a great start though.
@@Sniperboy5551 yeah I think that's a huge issue. It Never made sense to me how they said they wanted to treat the opiod problem yet they completely stopped giving pain treatment and didn't think that would back fire and cause a ton of people to seek other illegal options through out the black market.. I do think it is possible to have therapeutic pain management treatment but apparently our society doesn't believe that exists..
The problem with that is any pain killer stronger then asprin is gonna be addictive, the only real solution is to make pain meds that make you sick at higher doses to avoid misuse
@nothingnothing1799 We could also make medical treatment to treat the underlying pain, free and more available. We could make workplaces safer to prevent more injuries that cause chronic pain conditions. We could provide better psychological and medical treatment for dependency and create a culture more receptive to those who are dependent and wish to end their dependency without labeling legitimate pain patients addicts or using accusatory language such as "drug seeker" based on limited interactions with patients during single encounters. We can make methadone treatment more widely and easily available to those seeking treatment.
There is a lot we could do that doesn't involve deactivating the therapeutic effect of the drugs entirely if abuse attempts are made (CR and ER tabs have a crush sensitive component that destroys the drug) or intentionally poisoning folks as you suggest.
Can I buy this? No reason, just curious.
Not possible for this one x)
Just wait until the big man hears about this