PALOMA-3: subcutaneous vs intravenous amivantamab + lazertinib in refractory EGFR-mutated NSCLC

Natasha Leighl, MD, FASCO, Princess Margaret Cancer Centre, Toronto, Canada, discusses the findings of the Phase III PALOMA-3 (NCT05388669) trial, which evaluated subcutaneous (SC) versus intravenous (IV) administration of amivantamab plus lazertinib in patients with EGFR-mutated advanced non-small cell lung cancer (NSCLC). The study met its co-primary endpoints, demonstrating noninferior pharmacokinetics (PK) and objective response rate (ORR) for SC administration. SC amivantamab showed a median progression-free survival (PFS) of 6.1 months versus 4.3 months for IV, and an overall survival (OS) advantage with a hazard ratio of 0.62. The SC form also resulted in significantly lower infusion-related reactions (IRRs) and venous thromboembolism (VTE) rates. These results suggest a favorable profile for SC administration in terms of efficacy and safety. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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