ฝัง
- เผยแพร่เมื่อ 2 พ.ย. 2016
- UPDATE: In this video, I am showing you guys what the "proper" procedure would be, but it is by no means the fastest. If you want the fastest way, follow chemplayers method. I just prefer to not evaporate solvents, but that takes extra time.
Hey guys, today we are starting on the journey from Aspirin to Tylenol. I would use a gravity filtration though in both cases though. It's just as fast and doesn't have as many problems as a vacuum one. Still do a recrystallization though. Without a recryst/hot filtration, the ASA is still pretty dirty.
Tell me what you guys wanna see by voting here: www.strawpoll.me/11567284
ChemPlayer video: • Video
My old aspirin extraction video: • How to extract Acetyls...
-------------------------------------------------------------------------------
Merch - nilered.tv/store
-------------------------------------------------------------------------------
■ NileRed is now available on Nebula! go.nebula.tv/nilered
(when signing up with this link, a portion of your membership directly supports the channel)
Join the community:
Patreon - / nilered
Discord - / discord
NileRed Newsletter - nile.red/home#newsletter
You can also find me here:
Facebook - / nilered2
Instagram - / nile.red
Twitter - / nilered2
Nile talks about lab safety: • Chemistry is dangerous. - วิทยาศาสตร์และเทคโนโลยี
![เกิดใหม่ทั้งทีก็เป็นสไลม์ไปซะแล้ว ซีซั่น 3 - ตอนที่ 58 [ซับไทย]](http://i.ytimg.com/vi/TgNEbYSTY0Y/mqdefault.jpg)
When you buy aspirin and realize you're allergic, but you also have a PhD. in chemistry... So you just convert it into paracetamol.
crnobijeli13 relatable
I want it to be relatable ._.
just saying, i get headache from Aspirin, like, what the fuck, isnt that supposed to cure that?
Chrischi3LPs Aspirin is also a blood thinner. If you already have low blood pressure that could be the reason for that.
possible, but id rather say i have high blood pressure. anyways, id say ill stick with other alternatives for the time being.
Reminds me of a joke - a man walks into a pharmacy and says "Can I get a jar of monoacetic acetylsalicylic acid?" - The guy behind the counter says ".....do you mean Aspirin?"
and the man says "That's it! I never can remember the name......."
David Alexandrou haha
ME (I'm a pharmacy technician and we almost only learn the active ingredients)
@@DannyTVoriginal what course did you take becasue i pretty much literally had pharmacist course light when i was studying to be a technician. I left knowing as much and the same stuff as a pharmacist; is that not the norm?
@@michealpersicko9531 They know more than doctors when it comes to medications, dosage for age/pregnancy/liver or kidney disease, indication, contraindication, side effects
Theyre just extremely humble
So no, it's not the norm and you certainly dont know anywhere close to what they do
Just your dunning kruger effect
I am this person, in many contexts
The combination of a highly technical explanation with a totally laid back attitude is what makes it!
*if you burn yourself with boiling aspirin water... will it hurt?*
Yes, cause the aspirin won't get into your circulatory system
yes because of the temperature, but aspirin can actually be used topically when crushed into a powder and add little water to make it into a paste and it can relieve pain
IT WAS A JOKE
Callum Anthony Leake yes I'm aware, but there was actually a lesson to be learned from the joke
***** ah yes, that was the first lesson, young grasshopper. The second, was what I stated in my previous comment. **pats head**
It's funny that Bayer uses a dye to brand their Aspirin in Canada. Here in Germany they don't do that.
I dont know why they dont stamp their logo into the pills like everybody else
At least they don't use yellow dye.
I probably won't ever do this, but..
Cool!!
I love that you make little mistakes in these videos. Makes it feel a lot more human.
I wish I could hit that like button a second time! I love this channel! I really enjoy the other channels NileRed gets inspiration and or reaction adaptations from. ^.^
It's funny to see you making what we learn this year only on paper ( nitrosation, reduction... ).
Lot of thx for your work from France !
Dude, 94% with all those steps is golden!
Just out of curiosity (and in case that I missed it), did you do anything to verify the purity of the ASA? For example did you measure the melting point and/or check the purity with tlc? Nice video; and I don't know anyone who hasn't forgotten to add a stir bar!
Awesome concept. Looking forward to the entire series. :)
*beautiful crystallization shot with nice music* *immediately shakes flask violently*
Another lovely video, thanks Nilered :)
No problem!
Watching his videos while in quarantine, because I miss my chem labs in college.
Mesmerizing once again ! I love your videos and I might consider supporting you on Patreon you really deserve it :)
I appreciate the love!
Y
Nile red!, you are the best on youtube!. just a question: can you do a more *detailed* version of extracting litium out of a litium battery? (you can use a button-cell battery too if you want, it wont stink as much and they are small,even if shorted maybe gets a bit warm, but not that dangerous.) have a great day sir!
Maybe you could try adding some activated charcoal, during the recrystallization, to get rid of the pink dye that had the tablets. Although, it would imply a loss in the recrystallization yield due to adsorption of aspirin on the charcoal. But it should work!
Video suggestion, do redux reaction with a mercury salt. I know that murcury is highly toxic, but it would look pretty cool.
beautiful quality! what lenses do you use?
By far this is the first time you have messed up so many times in a vid.
I purposely kept the fails there so people can see what not to do!
NileRed my guess 52%
+NileRed I really like how you include the failures and problems, because that is how science most of the time is like and it is uplifting to see that I'm not the only one having such issues.
Y
Hi Nile Red. Do you think it would be possible to do an extraction of salicin from willow tree bark?
thats actually a pretty good idea
NileRed would you be willing to do it?
gg
If this video has been done already I want a link.
But since it hasn't been done I will simply moan about it in this comment thread
Was wondering the same
Nile Red can I ask for an advice, can I use solvent extraction and crystalization to separate components of an essential oil coming from a plant called dumb cane (Dieffenbachia picta)???????
Hey man, I'm a chem student and I find your videos fascinating. USA curious, what level of education do you have in chemistry?
According to Wikipedia he holds a Bachelor's in it
Got an Aspirin Ad before that video lol
I see that the two aspirin boxes are in two different languages. Do you have to account for there being a mixture of the English and French isomers of ASA?
Dude, this is amazing, thanks man
Thanks!
Hey NileRed, I know that I've asked you if his this before but you never answered me. Where do you get those blue alcohol thermometers? I am a very big fan of yours and have watched all of your videos multiple times over. If you could please answer this question I would greatly appreciate it. Thank you. E.S.
Hey Nile do you think you could make a video about the oxidation from anthranlilic acid to IBX? Would be pretty awesome (especially if you use the IBX you make in a future video)
I dont know if i can even get IBX
You should add activated carbon when you are heating the water for the recristallization. It will adsorbe organic dyes and you eliminate it during the hot filtration
Nice! I would try the nitration first; better regio control and should be easier to decarboxylate the deactivated ring.
This is getting nice. Lovin' it!
:)
Y
Nile red (or anyone), Last night while doing this experiment I got to the recrystallization of the acetylsalicylic acid and heated up the water. I ended up forgetting to turn off the hotplate and the next day (Today) I noticed that the bottom of the beaker was full of burnt compounds, however, snow white crystals were on the top of my beaker. (I didnt use an erlenmeyer flask for the recrystallization.) I was wondering of ASA thermally decomposes into any compound like salicylic acid. Are these crystals ASA? Id like to know because I dont want to waste them attempting to identify if they're ASA. Also if they are why didnt you vaporize the ASA to remove the dye? Thanks in advance.
Can you perform some acid/base extraction? As in, turn the ASA into sodium acetylsalicylate, dissolve it with water, react the water with some acid, get the ASA back.
What about extracting the Ibuprofen from Hydrocodone? lmAo
Nile, please answer this. When you get to paracetamol, why does most ofn it get lost after the first recrystalization? Synthesis is good yield, after recrystalise and wash the yield becomes single digit. Can you ellaborate?
That usually means either you had a lot of contamination or you used too much solvent to recrystallize (or the wrong solvent!)
I was thinking 30% in my head before you said it !:D
We shall see!
oh my god I'm legit so excited about this series lol
I am glad to hear that!
Y
Could the pink colour be due to iron impurities? Iron certainly complexes with salicylic acid to produce a deep pink/purple colour.
It is possible, but where did the iron come from?
New to channel love your content
is that 100% acetone or the diluited version easy to find?
Great beer pour style bro :)
Can you do acetaminophen to phenacetin? My second year orgo lab made us do it, and while they said we were supposed to get high yields, everyone got poor yields. Just curious about what method you'll try, something makes me think they screwed us over intentionally.... that or we just suck lol.
haha so the volume here is s little more *increase of 50%. love you videos!
Would you ever consider making some sort of polymers?
I plan to make nylon
So, how can we get this from willowbark?
Is that pretty much the same process?
Are you going to extract acetylsalicylic acid from willow bark please.
Instead of learning for my organic chemistry mechanisms exam I'm watching your videos :( Still love chemistry tho (and your videos)
Dont fail!
might you get better para selectivity if you nitrate salicylic acid before decarboxylation?
I think you also get some meta, but it might actually help a lot in yield. My purpose in going from phenol though is 2 fold:
It would show the normal synth of paracetmol. Also, I dont know how well the decarboxylation of the nitrated compound works.
I know the salicylic acid one works well, but the nitrated one might give me troubles.
Converting acetylsalicylic acid to acetaminophen?? How very interesting! We didn't even get the chance to do that in our class!!
Because it would take the entire semester probably, haha. 6 distinct steps is at least 6 lab periods
NileRed It would be five considering we wouldn't have to do the extraction step seeing as how we had pure ASA, but that's still a long time considering we only had lab time once every two weeks... :/
Is it bad if i just like listening to you explain all of this while im not paying attention
I only have ethyl alcohol .Will it work as an alternative to acetone ,to dissolve it ?
Pls make a video on how to make citric acid. Thanks
Damn! Your video gave me an idea; I wish you would've put this out 10 days ago. I had just enough acetone (500mL) to dissolve the ASA I had. I didn't want to waste it so I only used about 400mL heating it up and complementing it with some butanone but I could've gotten away with 100mL. Pour a portion (or all) of the ACA in to a beaker, add 100mL of acetone to dissolve, heating it to a boil and getting a saturated solution. Then do a hot filtration just like you did (well, not exactly like you did . . . sorry). Then scrap the undissolved solids back in to the beaker, allow the solution in the flask to cool and the ACA to precipitate out, possibly putting it in to a freezer or ice bath. Then decant off the acetone back in to the beaker, add more crushed ACA tablets, heat, and repeat until all of the ACA is in the flask. This of course only matters if your too broke to spend $6 on a liter of acetone AND your largest boiling flask (a modest 500mL at that) broke and you don't have any money to replace it, nor the patience to do half a dozen distillations to recover the $1 of propanone.
There are definitely many ways to be more efficient with solvents. It just usually requires more time. When you have the budget, it is so much easier to be wasteful unfortunately.
Would this work for extracting codeine from hydromorphs?
I know this is a kind of weird question, but what music (if any) do you listen to?
Oscar Poll please answer this
I listen to most genres and it really varies what I like. Some artists that im listening to recently is "Oh Wonder" "Alan Walker" "Zedd". My phone is dead so I cant see my spotify...but this is just from the top of my head
Here are some links:
Oh Wonder - Dazzle - th-cam.com/video/A1EJOnYvA5Q/w-d-xo.html
Oh Wonder - Lose it (Jerry Remix) - th-cam.com/video/NhK8Ehv6aPI/w-d-xo.html
Oh Wonder - All we do - th-cam.com/video/F30G87zlRPw/w-d-xo.html
Black Coast - TRNDSTTR (Lucian Remix) - th-cam.com/video/r7Ve8ExE8YY/w-d-xo.html
Alan Walker - Sing me to Sleep - th-cam.com/video/2i2khp_npdE/w-d-xo.html
Disclosure - You and Me (Flume remix) - th-cam.com/video/_zPlr-o-YEQ/w-d-xo.html
Zedd - Beautiful Now - th-cam.com/video/n1a7o44WxNo/w-d-xo.html
Chainsmokers - Inside Out - th-cam.com/video/oygNmMISdC0/w-d-xo.html
Chainsmokers - New York City - th-cam.com/video/rSwdh3tITwE/w-d-xo.html
When somebody says "Zed" i think about plump fiction.
Fabienne: Whose motorcycle is this?
Butch: It's a chopper, baby.
Fabienne: Whose chopper is this?
Butch: It's Zed's.
Fabienne: Who's Zed?
Butch: Zed's dead, baby. Zed's dead.
NileRed Great thank you!
NileZedd
You should've done a full time lapse of the ASA crystallizing instead of jump cuts...
You do know that if you turn the grinder off then over with the lid still on you can knock the contents into the built in bowl of the grinder then pour the contents out from there. Much less messy. Yes, the lid is a bowl for the coffee or in your case aspirin. Try it out.
would it matter if i used aspirin with lactose in?
Perhaps this is dumb question, but what is the name of the filter you were using?
The general name is a "fritted glass funnel"
hi, what kind of vacuum pump do you use?
Maybe you should start using erlenmeyer flasks for distillation,like NurdRage. It would be soo much easier to get out solid than from round bottom
That is true. I just like my round bottoms and the heating mantle. Gives me really good temp control
Can we use extracted ASA instead of asprin
AYYY I did this exact experiment in my AP chem class. It was dope as hell, until someone took some and threw up lmao
Could you do a behind the scenes type video?
Nilered why deleted the Picric Acid Video was it copyrighted or was removed by youtube
Picric acid is toxic and an explosive, so youtube striked the video. and it was removed.
I’m probably very wrong but isn’t ASA a 3D printing filament?
could you extract syn-propanethial-S-oxide? I don't think it's ever been done before and recorded publicly, at least that I can find.
it would be really awesome to see if you could.
I imagine you'd need a lot of onions to get any sizeable amount of it, but yeah that'd be cool.
I looked it up at some point and itll be very hard to do a practical extraction
hey can you send me what vacuum pump you are using please
is buying tylenol upright cheaper than all this long tedious extraction . i assume this is the best method to use if not chem players method .
What is the vacuum filter made of?
Why not use ethanol instead of acetone?
have you seen nurdrage's pyrimethamine series?
Nope I havennt been following it. Ill update myself on it
Where do you do all this experimental shit? like in the woods or something?
nice idea
why you take this dirty way with nitration of phenole?
i think iodination of it with NaI in aq. and RT or reflux is better.
Could anyone name the track that starts at 11:48? It sounds like some royalty-free thing from Chris Zabriskie, General Fuzz, etc., but I can't place it.
Could you try to make grapefruit mercaptan from limonene?
What was that yellow stuff?
Probably also want to avoid enteric-coated aspirin. I imagine that's a bit more complex to extract from than plain aspirin tablets.
Can we extract opiorphin from human saliva ? If yes ..what will be our yield ? ..and imp one ...is it legal ?
If you don't mind me asking why do you want to make Tylenol and is it safe for human use?
I just thought it would be cool to synthetically go from one to another. Would it be safe to use? Probably, but I wouldn't. Ive made too many poisonous stuff and mercury salts to trust my glass.
tylenol, dont you mean paracetamol? "Para aceta phenol"
I KNOW! SEND IT TO CODY'S LAB!
Or Acetaminophen. Guess it depends which side of the pond one is on.
@NileRed; Hey, maybe you can use some activated carbon, followed by an ion exchange column chromatography, and finally a C-18 flash chromatography as a viable purification method on the Tylenol?
I realize that it is a lot of work to put into polishing, but I was wondering if it would even work at all?
I think it would be super cool if you could turn safe, drinkable ASA into safe, drinkable Tylenol; however, I suppose that would probably require getting a second, clean set of glassware that can only be used with food-grade reagents, which is not really practical... at all, lol.
this takes me back to my chemistry degree.
where can you buy lab equipment?
Online. ebay is pretty good and so is aliexpress
you can mono nitrate the aspirin right away, and do a reduction in a mixture of acetic acid and acetic anhydride to get the para acetaminophen. that way you would save quite a few steps. You can even use only acetic acid if you let the reaction run for a longer time. The yield should be better that way too.
To be honest, it didnt even occur to me to start with the mononitration
Decarboxylation of aromatic nitrocarboxylic acids proceed way easier than the non nitrated compound. Plus, more often than not it will decarboxylate in situe
legoalex
what are those diagrams at 0:45 called?
why didnt you extracting it form willow trees bark ? ^^
Could u extract ephedrine HCl pls
just buy it pure noob
you can buy tylenol too...
It's a hydrochloride so it's very water soluble. Extract with water, then turn it into its free base form with something like NaOH. This is not very soluble in water. There are more professional ways though.
I don't think that Nile Red will do it because it is a controlled substance. If you have chemistry as a major hobby you already have a hard time even if you aren't doing anything illegal.
6:35 was very satisfying.
Wait....the Aspirin across the Atlantic is dyed?
You sound like that guy from 'think before you sleep' & another channel that would test out cool inventions (cant remember the name). So are you the main voice behind a few different youtube channels ?
that stir bar throw was clutch tho
Why not start with the nitration?
@NileRed, whats the song that you use around 12:10?
It is a random "song" I made: soundcloud.com/user-628235621/cliffhanger-discovery
@@NileRedit's nice! Thanks for making it :)
Would snorting ASA be a faster way to absorb it than through pills?
It wouldnt absorb very well and it would probably hurt a lot
What is wrong with you?
I remember pulling ASA from Aspirin in Organic Chemistry Class in college....no matter what I did, no matter how much I cleaned and dried my equipment, my ASA always came out Yellow. I fail at the O Chemistry haha
why don't you show how to extract it from the plant Salix alba ?
Video suggestion! :) How about extracting Strychnine from Strychnos nux vomica? Then trying it to a frog, like an experiment. Computing for the Lethal Dose 50. That would be a cool way to start a toxicology class. Kudos! :)
What do you use all the chemicals you make for? I don't see the purpose.
It's just for fun mostly.
#AchievementUnlocked
Can you make lsa