Oh my god, I am so happy to find someone researching ME … AND relating it back to the people who are actually experiencing it- In a way thats easier to understand than reading through massive studies!! Thank you 🙏 ❤ From a ME sufferer
I have a list of things that calm microglia cells because I struggle with this. But it would amazing to have you recap some of the known existing most powerful and direct targets in some ranked order of efficacy since I'm mostly grasping at straws. As well as your all your new and promising therapies. Thanks for all you do!
I postulated that the microglia were involved after i achieved temporary remission with ketamine therapy. my swollen lymph nodes havent returned since, but theres more to it though in ME. stellate ganglion block worked well for some time, and has reduced the pressurised swollen feeling i used to get preceding crashes, which i can only explain feels like overheating and foreign substances entering the brain. the PEM threshold and the lactic acidosis tremor are the most stubborn of my symptoms.
That all makes sense. Some people respond to dextromethorphan (ketamine's little sibling). The problem is dextromethorphan is the short half-life, which requires frequent dosing, or the addition of quinidine. To the other point, we and other groups are seeing lots of lactate in the ME brain. I think it is the most repeated brain finding in that condition. - Jarred Younger
Please keep doing your videos, I can’t begin to express my gratitude for what you do. If you have more recommended reading material please personally let me know if there is a way I could request that personally. I have very very badly behaved microglia and PSA in it’s most severe form. I had been dx’d with fibromyalgia and chronic fatigue in 1994 after having what a doctor described as saying the absolute worst case of mononucleosis in his 40 years of practice. I still went through college, had a family and had my mind but was in pain until when my son was 1 and I became completely symptomatic with Lyme’s and had been symptomatic for PSA since I was 17 but it was undiagnosed and actually I dx’d myself with the aha moment of severe uveitis and I am losing my vision and have had 2 heart attacks. I worked as a nurse but studied at a higher level and taught, precepted , tutored even doctors to pass there boards, physics, chem, A&P as well as helping with differential diagnosing to pay the bills but I loved my work and helping others and also wanted to know why I was so so sick. I used to keep up with the different studies and papers published but have now been too sick. So I really appreciate what you are doing and I am able to understand the science and if you have more recommendations on papers and valuable papers please please let me know how I could request them from you. I almost chose to go into your field of work but I had to just get into the workforce to take care of my family. I wish more medical doctors would pay more attention to these things as well because the first on the line to understand even when medications go bad that there has to be a check and balance and that is why I always have appreciated the blood sweat and tears of lab work. I used to pull meds and leave notes for the pharmacy on such things like when Darvocet was removed from the market and noticing the effects first hand on pts always had me on pins and needles so to speak. It always has fascinated me that the more we learn the more we realize that we don’t know and are touching the fringes not even of the universe but just our human bodies with the same amount of connections in our brains as the quantity of galaxies. It is so true the quote from the Bible that says “God put eternity in the hearts of mankind.” If we have a measure of meaningful health then we don’t think about anything else but to continue to enjoy it every day like eating a delicious meal. Those of us that don’t have a measure of health,well it is understandable completely why one wouldn’t want to continue to suffer. I certainly am at that point anyways. So thank you, I am keenly interested in your work and would love to have the ability to have more access if possible. 😊
Thank you for saying that! Yes, I will certainly keep doing it. Most of my videos will have one or two key articles for further reading. And after some foundational videos covering the physiological targets, I will do more treatment videos. I hope there is something that you find helpful! - Jarred Younger
I was a nurse too, driven and passionate. I like you am searching for answers to end this nightmare of a half life. Some days I just feel like I can’t physically go on..
Once again, Jarred, thank you so much for taking your precious time to make these clearly explained videos for us. I've been bedbound and forgotten by the world for 7 years because of M.E and these videos are a light in the darkness.
Dr. Younger, thank you for all of your clear, easily digestible updates and explanations. I look forward to them each week. I recently started LDN for my severe ME/CFS, and your discussions of it helped me make the decision with greater confidence in its safety. Side note: Before becoming too disabled to work, I was an art director. Your videos look professional, however I would suggest positioning the camera so your head is higher in the frame rather than in the middle. Also, anytime you include slides or graphics, it's good to leave a wider margin on all sides. They are often cut off. I hope you don't mind the unsolicited design tips! 🙃 And … best of luck with your grant!! 🤘🏻
LDN calming microglia has helped my fibromyalgia, but allithiamine, also known to calm microglia has helped much more. If I go off it my bad health returns rapidly.
I looked up allithiamine, it describes it as the lipid soluble form of vitamin B1. Could you tell me the mg dosage you take daily if that's possible? Thankyou
@@caroline356 The capsules are 50mg and one day is recommended. I take one a day for a week then move up to two. Dr Berg used to sell it as allithiamine, but now it's called Natural B1+ allithiamine Other companies list allithiamine but send you TTFD instead. I'm sure TTFD works for some folks, but it didn't for me.
I did a video a while ago urging people to check all their B-vitamin levels. I actually think a comprehensive vitamin/mineral screening is one of the first things to do with fibromyalgia or ME/CFS symptoms. If the levels are not correct, it is impossible to feel well. I'm glad you found something that helps! - Jarred Younger
@@youngerlab Good advice but this is not about deficiency. Lipid soluble thiamine,, acts as a drug in larger amounts, down regulating several inflammatory pathways that excite microglia.
@@jeffhutjensimportant point! 1. Nutritional deficiency 2. Functional dependency Two different things. This is made very clear e.g. by Italian neurologist Costantini and the related high-dose Thiamine protocol for Parkinsons sufferers as described and promoted by Daphne Bryan. I look at the effect of high-dose thiamine protocols as a drug-like effect that has nothing to do with a deficiency.
assuming that PEM or a crash in someone with ME is caused by the microglia in the prime or M1 state. What is it about repeated crashes and PEM that causes further disability and lowering of baseline (i.e. from mild to severe), which is often talked in the ME community. Is continued microglia activation just damaging in some way or they just burn out?
I'd like to know this too! It's not only that smaller PEM repeatedly lowers your trigger point AND makes you sicker over time, but also even a single large PEM event can massively reduce your trigger point for PEM and make you really much sicker, very quickly, I went from mild almost recovered to severe from one event, and a year or so ago lost half of my remaining functioning after a distasterous trip to A and E. Overnight. Why is this happening? What happens?
I haven't seen it studied specifically in PEM, but the general idea is that each successive severe immune hit (or immune hit too close in time to another) converts more of the microglia to the M1 or primed state. I'm just making up these ratios, but say that 5% of the microglia were in the inflammatory state. Then there is a big Epstein-Barr infection and now 7% of the microglia have been pushed into a chronic inflammatory state. And then there is a SARS-CoV-2 infection and now 9% of the microglia are inflammatory. With each higher M1 ratio, there is a lowering of the tolerance baseline, energy, and motivation. Right now we don't have a method to accurately measure the ratios in a living human brain. With PEM, we know less, but we know that microglia can sometimes adopt a reactive microgliosis state, where activated microglia prompt other microglia to become inflammatory and start to damage other cells. So, again, not tested directly to my knowledge, but a severe PEM experience might be associated with a microglia activation flare which converts more microglia to the chronic primed state. That would be my hypothesis if I did a study on that specific phenomenon. - Jarred Younger
@@youngerlab super interesting. So would it be possible, potentially, to turn them back into their other states, by removing all physiological stressors including repeated PEM? Might this in some people be able to allow them to switch back on their own without drugs to help? (assuming if they course that removing those stressors is actually possible to begin with, which I think guess in some cases it might not be - disrupted gut for eg, or pathogen persistence or reactivation or variously other possible stressors). Could this be why some people are able to increase their functioning again after a time?
Thank you so much for doing these weekly talks, your work and explanations have brought me newfound hope that there is active research attempting to tackle this tough problem. I am a microbiologist in research but have no background in the human body/immunology so I really appreciate these talks that deliver non-superficial information that is still clear! Also as a general comment, seeing your videos made me realize that I wish more medical researcher did this type of outreach so patients could learn first-hand about the cutting edge work being done. I am wondering whether a pathway connecting exercise to glial activation is known. Is there a hypothesis in how physical exertion can reinforce this inflammatory pathway in the brain? It would be amazing to learn about how known symptoms of microglial overactivation (independent of mecfs) overlap with mecfs symptoms if that makes sense! Good luck with your grant writing - fingers crossed for your important application!
Thanks for sharing. I am looking forward to watch your next video! If you have time and interest, I would be very grateful if you could make a video with your thoughts/ideas on PEM in ME/CFS. TIA!
Thank you so much Jared! You give me hope. I’ve had ME for a few years now, doctors did not recognize initial symptoms back in 2018. It slowly progressed especially after covid, now I have no life. We can’t thank you enough.
Hi Dr. Younger! That hypothesis sounds very likely to me. I've been diagnosed with both ME and fibromyalgia - and in 2015 an MR-scan revealed gliosis in my brain, which to me either means overgrowth of microglia or that they are found in one of the pathological stages you just drew. Thank you so much for all that you do ❤🙏❤ Our hope is green - and we are so excited to following along and learn about your new findings in your videos to come. Many greetings from Anna, Copenhagen, Denmark.
I’m pretty sure this is what is going on with me. I think that after a very stressful period the microglia in my body changed. I have ME/CFS, fibromyalgia and (facial) neuralgia(s) symptoms. Very excited for future videos and future possibilities. Thank you for all that you do!
Dr Younger, is this micoglia disorder a hypothesis or proven in me/cfs? Also, is it compatible with your Leukocytes entering the brain hypothesis? And are both compatible with Rob Phair's intaconate shunt hypothesis? Thank you
Good questions. The microglia hypothesis is being tested with PET radioligands called translocator protein (TSPO) agonists. They dock exclusively on activated (M1) microglia. My lab, and two others are running those studies right now. The preliminary data from all the labs are all showing that the ME/CFS microglia are abnormally activated. Here is a paper using this technique in fibromyalgia - the majority of whom meet ME/CFS criteria as well: pubmed.ncbi.nlm.nih.gov/37326674/ - Jarred Younger
How is this mechanism connected to the autonomic nerve system and the sympatic action and parasympatic action of the vagus nerve? And does cortisol levels in blood affect the states of microglia? Do you know any research teams looking into all these connections? Thank you for your great videos and great efforts in this area!!
Great questions. Yes, parasympathetic balance is important to managing the inflammatory state of the brain - and vagus nerve stimulation is a top candidate to modulate that inflammation. You will definitely hear more about VNS and brain inflammation in the future. - Jarred Younger
This sounds like it would alleviate some of the acute symptoms of me/cfs but would it address the fatigue, sleep disturbances, brain fog, inability to be fully awake at times and difficulty maintaining a consistent sleep wake schedule. Also all the digestive and food reactivity issues? I often try to think what causes my symptoms and find reasons to believe certain things might be responsible but than those things seem to clash with other hypothesis of which my three main hypothesis are toxic exposures, virus of some type, immune disorder. I wonder if it couldn't be some combination of all three. That would explain why it's so totally disabling.
To the first question, pushing microglia from M1 to M0 should address pain sensitivity, fatigue, sleep disturbance, energy and motivation problems, brain fog, malaise, and cognitive issues. The reason is that all of those symptoms are called the "cytokine-induced sickness response" which are well known to be caused by microglia. So returning microglia to their normal state could help all those symptoms. But, to your second point - I do not think microglia modulation is the way to help GI issues. So that problem will likely need to be addressed in a separate way. But your three hypotheses match up well with some of my immune work that shows 1/3 of ME/CFS patients seem to have a chronic inflammatory/viral issue, 1/3 appear to have an autoimmune disorder, and 1/3 are unknown (but exposures, diet, gut microbiome, leaky gut, etc. are all possibilities). - Jarred Younger
@@joyceknox1341 I do intermittent fasting so I tend to load up on my 2 meals but I eat small portions of a wide variety of food. No gluten although I do drink milk I try to keep it down to 1 gallon over 2 weeks. Try to eat lots of plant food, beans lentils, rice, potato carrots, cabbage, broccoli, corn, peas etc. I keep the broth from meats I cook for my dog and stew carrots, cabbage, broccoli, onions, ginger, spices whatever I think will make it taste good. I was never able to nail down any particular culprit with my food allergies so my thinking is just small doses of a lot of different items. Although labor intensive eems to work well for me. I did go back on gluten for more than a year maybe 18 months. The idea was to get an antibody test. Ashole dr told me if you had celiac you would have a lot of diarrhea which of course I have. Had to switch dr's to get the damned test. Came back negative. That same ahole wanted to do a colonoscopy even though I had one 5 years prior and wanted me to get flu vax even though I had that 7 months earlier. and x rayed me unnecessarily for a shoulder injury I sustained from falling off a ladder. Any decent dr would have had a wait and see attitude. I live in a metal building I insulated with styrofoam panels. I cannot tolerate moldy buildings. I suspect the styrene from the foam might be giving me issues but it's too cold in the winter and hot during the summer not to have insulation.
an actual scientist with a channel about chronic diseases here on youtube? from someone who is chronically ill and science-oriented, you're a godsent. could you maybe make a video about the research funding of autoimmune/ chronic / rare illnesses as compared to other diseases?
Thank you! Oh yeah, funding topics will come up. :-) For anyone who follows the videos regularly, I think they will see a lot about these diseases, but also quite a bit about what it is like to be an active scientist in this area -- because I am not planning on hiding any aspect of the work. :-D - Jarred Younger
Thank you so much. I am in year 4 of long covid with severe autonomic symptoms. I have finally found a doctor who has an integrative approach. One of the things that she has added to the list is sensitivity to electrical current. She is going to start me on LDN but not before looking at all the environmental challenges, both inside and outside the body.
Hi great Video So I am very interested in the how do you get them into state M2 especially with natural substance’s that you can buy over the counter or food What do you think about proprionic acid is it on of the substances? What are the best natural options you can get your hands on without being a doctor. All the best wishes from Germany Oliver
There are supplements like rutin that have some scientific evidence showing an M1-->M2 effect. I will be introducing some of these in future videos. I don't like to just list them though because there are caveats that need to be explained. So, I will likely prioritize them and do one at a time, with all the needed information contained in the video. But yes there are some supplements with promise. - Jarred Younger
What causes the glia to malfunction? Seems like glandular fever is one trigger. Since it is an endemic, recurring infection, perhaps curing the underlying disease will become necessary.
I think of viral infections in at least my reasoning because those that I have had as patients in the past usually have mentioned a viral attack or maybe a strong viral attack and a bacterial or parasite infection. So many have keen memories of these things including myself but there is an immune trigger response that obviously the microglia control. Obviously can’t obliterate the microglia. Wonder what Einstein would have thought, his brain had more than the average glial cells. 😊
Yep. The video I will do this coming Monday will identify the factors that cause microglia to adopt these unhelpful states in the first place. A chronic or particularly severe viral infection (especially one that infiltrates the brain - like some EBV infections) is one clear trigger. - Jarred Younger
I've had good luck using palmitoylethanolamide (Normast, in particular) likely because of its effect on the microglia. Reduced pain and other symptoms.
amazing, Jarred. Thank you so much. Now could you talk about the influence or interaction these four states have with neurotransmitters? Best of luck with writing 👍 Rob from Holland
Yes, several studies (going back quite a ways) show minocycline pushes microglia out of the M1 inflammatory state. There are several animal models of fibromyalgia and ME/CFS showing effectiveness and a small number of human patient studies. I don't think there is a doubt it has the microglia response we want. The issue is that the drug can have other, adverse effects when used at too high of a dosage or for too long a time. It would need to be carefully monitored by a clinician, and I'm not surprised if most physicians would be uncomfortable managing that particular drug. But it is one option to consider. - Jarred Younger
Thank you so much for this! I met an enteric neurologist who told me there are lots of glial cells in the gut. I wonder if these would cause the digestive system symptoms we get? Thanks again!
It's interesting to note, that the digestive tract, has such a complex nervous system that it is nearly independent from your brain. I can't remember the exact number but something like 70 percent of "traffic" goes from that to the brain, not the other way around, like alot of the rest of the body. It's why it is also dubbed "the second brain". It's not too far a stretch to think that if a food sensitivity effects your glial cells in the digestive tract, this could "prime" those in the brain for fibro & vice versa.
This is a terrific explanation, thanks much. I feel my glia must be highly primed causing daily headaches. Ive tried LDN but can't get beyond .5mg without exacerbating my headaches to intolerable levels, even after 6 weeks. Must be doing something in that realm? I look forward to your future presentations.
Thank you for these weekly talks- they bring us such hope. Have you talked about tremors/shaking and physical weakness with me/cfs? I assume those are brain related and I’m curious how common they are.
Really enjoying your new video series. Good luck with the grant application 😊 Would like to know about the anti-inflammatory substances that microglia should pump out. What are they, and how would (e.g.) dextro-naltrexone help encourage their production in enough numbers to return the CNS to homeostasis? Cheers from Melbourne Australia, where LaTrobe University & Walter and Eliza Hall Institute are recruiting for a new ME/CFS study 😊
How much is related to toxins that we are all swimming in . By learning to make everything that goes in or on my body. I avoid plastics, chemicals, drugs, perfumes, cleaners, and most things with a bar code. I found avoiding all nitrogen fixing plants including all legumes which are in everything. That I have had dramatic improvement. I have lost 140 pounds, and gone from being able to be on feet 90 minutes total in a day to being up and about for 14-16 hours. I do many therapies throughout the day to manually run lymph and parasympathetic system. And I do have to 100% avoid triggers. Or go down! Many events trigger hemolytic events that take me weeks to recover from. I was unaware I was becoming anemic after the events until I started to wear cheap watch tracks several things including oxygen. Even dropping into the low 90’s causes serous brain issues for me, once brain fails so does body. Could lower oxygen be a piece of the puzzle and the thing tweaking the microglia? I am currently waiting for testing for porphyria even if it is nothing much will change. Avoidance of my many,many triggers seems to be my only option. Masking being made common by covid has actually made my life a little easier. I wear carbon filter mask anytime I go out. As other perfumes, clothing and body care products are huge triggers. If neighbor starts drier I have to instantly get on mask. Mask is not enough with pesticides, herbicides, and fungicides which are just horrible triggers.
ME struck along with the flu on 12/24/09! This information is so reassuring and seems so logical! If only we could get those microglia whipped back into place because they have made my life a living hell!! It seems outrageous that it has taken this long for the CDC or NIH two even look at the problem, let alone to say hey- here’s what could be causing all of your pain & this pain that is very real!!!!
What do you think of Dr Katz research suggesting fibromyalgia patients have intramuscular pressure three times higher than controls? And the theory that a straight neck could be a diagnostic indicator of fibromyalgia? So its more of a relationship between muscular tension and the CNS?
None of these diseases are infections, doesn’t that answer your question. Also WHY DID YOU MAKE 7 DIFFERENT COMMENTS INSTEAD OF ONE? And all of your questions can be answered with simple common sense!!!
I often wonder about the same thing. One would hope, however, that our bodies could finally clear the infection after so many months or years. They never do. Therefore, a malfunctioning pattern (hyperactive state) must at least be considered. I don’t think that any calming treatment option would disable the microglia. At least I hope not. I’m assuming this is an attempt at a reset.
I hope to see those tips for working with microglia 🙏 if you could possibly start with behavioral interventions rather than medical, that could be great. Not all of us have doctors to work with.
You may have seen anti-virals (e.g. famciclovir) used for chronic conditions like ME/CFS. But there isn't much evidence leading us to use anti-virals as microglia modulators. It is more likely that the anti-virals are reducing microglia activation indirectly by suppressing the virus that is prompting the microglia response. So, in the absence of a stubborn/hidden virus, I don't think use of anti-virals is recommended. - Jarred Younger
It is! While not proven, many scientists in the field (including me) are working under the hypothesis that all these conditions have the same or very similar core pathophysiology. - Jarred Younger
I've had chronic pain for 40 yrs from a L 4-6 injury in my teens. Red wine has been an excellent sciatic nerve pain reducer. Does anyone know why? Only deep red wine works. Others w/ back injury have noticed it too.
Hi I don’t know about the wine but I had a lot of back pain myself and what I Think is the Only Solutions ist to Get You Back Strong . Which means weight training. firstly you have to give the muscles what they need At least 100gram of Protein better ist 130 gram Depending your Body Weight. Get some Zinc 10mg and Copper 2 mg a day for myelation 200 mg magnesium and 3000IE Vitamin D Take some extra glycine 8 gram And try (if it’s not upsetting your stomach) frankincense All the best wishes from Germany Oliver
I have low and upper back pain. I would be totally disabled if I didn't learn how to apply traction to my back. That and some simple exercises. Low back I use a nylon weight belt for scuba divers. Strap it to my waste loosely and put my hands on my hips inside the belt and push down on my pelvis in different types of positions. I do it draping my upper body over something like a counter hanging my legs off o the ground. Also wad a bunch of blankets up on my bed and drape my body over them. This makes it easier to focus on the vertebrae in my low back. I usually get a few pops and it relieves 70% of the pain the other 30% is gone the next day. The vertebrae between my shoulder blades can cause intense pain to the point of nausea. Feels like what I imagine it feels like having a heart attack. I hang from rafters with my hands like a child on a set of monkey bars. 2 or 3 reps of 20 seconds is about all I can handle but he does the trick. Again 50 to 70% relief instantly and another 30% the next day. I also occasionally have issues with my neck and I loop two dress belts from a rafter put the front one on the back of my scull and the back one under my chin and slowly shift my body weight from my feet to the straps around my head. Same thing. This works for me I am not a dr talk to your dr before following any medical advise from a random guy on the internet.
This sounds quite different from the microglia-mediated chronic pain and fatigue disorders. My first thought is to explore resveratrol supplementation if you haven't already (in consult with your primary care physician, of course). It is *possible* that the red wine benefit is because of the resveratrol concentration, and that compound has some good studies showing its benefit in nerve pain like sciatica. The fact that other forms of alcohol or even other forms of wine don't help in particular makes me think of resveratrol. - Jarred Younger
Have you published this study? If so, where is the article located? Thank you for all your research. In one video, you explained that microglia were very active when we have the flu. That really hit home for me. I have told people for years that I feel like I have had a bad case of the flu 24/7.
Do you use SPECT, PET, qEEG or NIRS to diagnose ME and distinguish it from CFS? Are you looking at hypoperfusion or just temperature? What would microglial treatment do to increase perfusion, if anything?
Are you looking at this in the context of SFPN (ie the periphery too??) and regardless of that, are you looking at the use of IVIG which might be best indicated for pwme who have autoimmune markers?
I haven't been monitoring the peripheral nerves directly, but I'm keeping an eye on the small SFPN literature to see when I might be able to contribute. The recent observation that small fibers innervate more systems than just the skin, and seem to be very important to the autonomic system. There are some clear targets to explore for treatments - Jarred Younger
@@youngerlab Thank you very much for taking the time to reply. I'm absolutely sure you're aware of Anne Oaklander's work wrt aaSFPN and with Jill Schofield's excellent work describing 'autoimmune dysautonomia (my test results fit that dx as well as the ICC ME set of criteria). And of course the way Carmen Scheibenbogen has linked anti GPCR AABs to ME, and then together all 3 of those individuals create a compelling argument for IVIG. I know it's expensive, but if you do look at this more closely and perhaps consider a trial of IVIG (especially amongst those patients who might have specific positive AABs and a positive punch for SFPN...there's probably far more of us than one might first think) then that could make an argument for truly meaningful therapy for people who are suffering indescribably. If memory serves I think it's Jill S who has observed that it doesn't matter how long someone has been ill, if they fit these markers then IVIG (if tolerated) can have a potentially massive impact even on long timers (I'm over 50 years down the road with this disease). I have tried LDN but was unable to use it.. even in micro dose it spiked my SFPN very badly.. (10/10 pain, and I live with an extraordinary amount of pain as it is). I do realise you have lots of input from very many desperate patients and you can only follow your course, and that's dependent on funding, but there might be ways to make a subset of the ME cohort (and there is evidence to suggest the LC cohort might be helped too) considerably better. But a weight of good research is required before medics will help. In the UK the situation is far more dire than in the US. But thank you so much for doing what you are doing. I feel I'm being a right old 'nag' ('nagging' is my 'superpower' 🙃 ) but I don't underestimate your value to this community either! 🙌
I'm curious about this too. Hubby is on a lutein and PEA supplement, and it does help with some things, but it's not a major change, so I'm wondering if a higher dose would be more helpful.
Even during a week of a PEM crash, upon waking for about 5 minutes, I usually feel significantly better than I will that day. Does the state of the glia change with sleep and wake cycles?
The glia can change state over the day, but they usually do so in response to something else that is changing. For example, cortisol is highest first thing in the morning, and a normal burst of cortisol can temporarily suppress microglia inflammatory activation. But cortisol lasts longer than 5 minutes in the plasma, so it doesn't explain what you experienced. There are relevant neurotransmitters like epinephrine that last about 5 minutes. Both of these chemicals can spike significantly right when waking in some people. - Jarred Younger
He said avoiding certain triggers, replay that part again. He isn’t referring to cognitive behavioral therapy if that’s what you were thinking… it’s been proven MANY times to be ineffective and HARMFUL.
@@GodsChild145 brain training is not CBT. It is things like Gupta and Lightning process. Chill, it was just a joke, because it sounded like he meant something similar.
Thanks for another in depth video. Was hoping you could one day talk about functional neurological issues(FND, FMD, NEAD, PPPD) if you have any interest in that area.
What did protect many was that for medical reasons were taking HIV meds which essentially were blocking those same receptor sites as HIV, bubonic plague. When I saw the release off the info on the main Covid structure that was an Aha moment. It was sad that doctors didn’t see that as fast and resort to using them to get people of the ventilators until all that testing.
I have hereditory haemochromatosis and ME/CFS and since a failed cardiac ablation 3 mths ago (heart normal) diagnosed with dysautonomia I have been on a mission to find the route of my fatigue and mitochondrial dysfunction. Depression migraine and fatigue are huge. I do have a monthly inj of CRGP and would be interested to know your thoughts on these meds. I’ve tried LDN, I’m now trialing hrt ( slight improvement) I follow Dr Sarah Myhill program for CFS and find diet has huge implications..supplements inc Acetyl L Cartinine, Magnesium, Lipoic acid CoQ10 Multi vits & minerals B complex. Also Tumeric with Ashwaganda concentrate…all helped. I have notified my consultant neurologist of your studies Dr Younger, he was very interested. Thank you for what you’re doing. Newcastle UK
so very grateful for all your work & for the ways you endeavor to help us understand it -- & thus our conditions, too.
😀 - Jarred Younger
Gratitude spilling over. Thank you Dr. Younger
Thank you for all your work. I’m looking forward to your Monday uploads every week.
Thanks! - Jarred Younger
@@youngerlabme too! Exciting!
Oh my god, I am so happy to find someone researching ME … AND relating it back to the people who are actually experiencing it- In a way thats easier to understand than reading through massive studies!! Thank you 🙏 ❤ From a ME sufferer
Thank you so much for your efforts! It means the world to people like me with ME/CFS & Fibro 🙌
I have a list of things that calm microglia cells because I struggle with this. But it would amazing to have you recap some of the known existing most powerful and direct targets in some ranked order of efficacy since I'm mostly grasping at straws. As well as your all your new and promising therapies. Thanks for all you do!
Can you write that list I need help
I will do that soon! - Jarred Younger
I think there is also a connective tissue disorder at play.
I postulated that the microglia were involved after i achieved temporary remission with ketamine therapy. my swollen lymph nodes havent returned since, but theres more to it though in ME. stellate ganglion block worked well for some time, and has reduced the pressurised swollen feeling i used to get preceding crashes, which i can only explain feels like overheating and foreign substances entering the brain. the PEM threshold and the lactic acidosis tremor are the most stubborn of my symptoms.
That all makes sense. Some people respond to dextromethorphan (ketamine's little sibling). The problem is dextromethorphan is the short half-life, which requires frequent dosing, or the addition of quinidine. To the other point, we and other groups are seeing lots of lactate in the ME brain. I think it is the most repeated brain finding in that condition. - Jarred Younger
@@youngerlab I found less frequent but higher doses of ketamine had a greater effect than frequent lower dosing in switching off the microglia.
Please keep doing your videos, I can’t begin to express my gratitude for what you do. If you have more recommended reading material please personally let me know if there is a way I could request that personally. I have very very badly behaved microglia and PSA in it’s most severe form. I had been dx’d with fibromyalgia and chronic fatigue in 1994 after having what a doctor described as saying the absolute worst case of mononucleosis in his 40 years of practice. I still went through college, had a family and had my mind but was in pain until when my son was 1 and I became completely symptomatic with Lyme’s and had been symptomatic for PSA since I was 17 but it was undiagnosed and actually I dx’d myself with the aha moment of severe uveitis and I am losing my vision and have had 2 heart attacks. I worked as a nurse but studied at a higher level and taught, precepted , tutored even doctors to pass there boards, physics, chem, A&P as well as helping with differential diagnosing to pay the bills but I loved my work and helping others and also wanted to know why I was so so sick. I used to keep up with the different studies and papers published but have now been too sick. So I really appreciate what you are doing and I am able to understand the science and if you have more recommendations on papers and valuable papers please please let me know how I could request them from you. I almost chose to go into your field of work but I had to just get into the workforce to take care of my family. I wish more medical doctors would pay more attention to these things as well because the first on the line to understand even when medications go bad that there has to be a check and balance and that is why I always have appreciated the blood sweat and tears of lab work. I used to pull meds and leave notes for the pharmacy on such things like when Darvocet was removed from the market and noticing the effects first hand on pts always had me on pins and needles so to speak. It always has fascinated me that the more we learn the more we realize that we don’t know and are touching the fringes not even of the universe but just our human bodies with the same amount of connections in our brains as the quantity of galaxies. It is so true the quote from the Bible that says “God put eternity in the hearts of mankind.” If we have a measure of meaningful health then we don’t think about anything else but to continue to enjoy it every day like eating a delicious meal. Those of us that don’t have a measure of health,well it is understandable completely why one wouldn’t want to continue to suffer. I certainly am at that point anyways. So thank you, I am keenly interested in your work and would love to have the ability to have more access if possible. 😊
Wow! Keep going please. What a brain you have, and a huge heart.
Thank you for saying that! Yes, I will certainly keep doing it. Most of my videos will have one or two key articles for further reading. And after some foundational videos covering the physiological targets, I will do more treatment videos. I hope there is something that you find helpful! - Jarred Younger
@@youngerlab Thank you Jarred!
I was a nurse too, driven and passionate. I like you am searching for answers to end this nightmare of a half life. Some days I just feel like I can’t physically go on..
Once again, Jarred, thank you so much for taking your precious time to make these clearly explained videos for us. I've been bedbound and forgotten by the world for 7 years because of M.E and these videos are a light in the darkness.
Dr. Younger, thank you for all of your clear, easily digestible updates and explanations. I look forward to them each week. I recently started LDN for my severe ME/CFS, and your discussions of it helped me make the decision with greater confidence in its safety.
Side note: Before becoming too disabled to work, I was an art director. Your videos look professional, however I would suggest positioning the camera so your head is higher in the frame rather than in the middle. Also, anytime you include slides or graphics, it's good to leave a wider margin on all sides. They are often cut off. I hope you don't mind the unsolicited design tips! 🙃
And … best of luck with your grant!! 🤘🏻
LDN calming microglia has helped my fibromyalgia, but allithiamine, also known to calm microglia has helped much more.
If I go off it my bad health returns rapidly.
I looked up allithiamine, it describes it as the lipid soluble form of vitamin B1. Could you tell me the mg dosage you take daily if that's possible? Thankyou
@@caroline356 The capsules are 50mg and one day is recommended. I take one a day for a week then move up to two.
Dr Berg used to sell it as allithiamine, but now it's called Natural B1+ allithiamine
Other companies list allithiamine but send you TTFD instead. I'm sure TTFD works for some folks, but it didn't for me.
I did a video a while ago urging people to check all their B-vitamin levels. I actually think a comprehensive vitamin/mineral screening is one of the first things to do with fibromyalgia or ME/CFS symptoms. If the levels are not correct, it is impossible to feel well. I'm glad you found something that helps! - Jarred Younger
@@youngerlab Good advice but this is not about deficiency. Lipid soluble thiamine,, acts as a drug in larger amounts, down regulating several inflammatory pathways that excite microglia.
@@jeffhutjensimportant point!
1. Nutritional deficiency
2. Functional dependency
Two different things.
This is made very clear e.g. by Italian neurologist Costantini and the related high-dose Thiamine protocol for Parkinsons sufferers as described and promoted by Daphne Bryan.
I look at the effect of high-dose thiamine protocols as a drug-like effect that has nothing to do with a deficiency.
assuming that PEM or a crash in someone with ME is caused by the microglia in the prime or M1 state. What is it about repeated crashes and PEM that causes further disability and lowering of baseline (i.e. from mild to severe), which is often talked in the ME community. Is continued microglia activation just damaging in some way or they just burn out?
I'd like to know this too! It's not only that smaller PEM repeatedly lowers your trigger point AND makes you sicker over time, but also even a single large PEM event can massively reduce your trigger point for PEM and make you really much sicker, very quickly, I went from mild almost recovered to severe from one event, and a year or so ago lost half of my remaining functioning after a distasterous trip to A and E. Overnight. Why is this happening? What happens?
I haven't seen it studied specifically in PEM, but the general idea is that each successive severe immune hit (or immune hit too close in time to another) converts more of the microglia to the M1 or primed state. I'm just making up these ratios, but say that 5% of the microglia were in the inflammatory state. Then there is a big Epstein-Barr infection and now 7% of the microglia have been pushed into a chronic inflammatory state. And then there is a SARS-CoV-2 infection and now 9% of the microglia are inflammatory. With each higher M1 ratio, there is a lowering of the tolerance baseline, energy, and motivation. Right now we don't have a method to accurately measure the ratios in a living human brain. With PEM, we know less, but we know that microglia can sometimes adopt a reactive microgliosis state, where activated microglia prompt other microglia to become inflammatory and start to damage other cells. So, again, not tested directly to my knowledge, but a severe PEM experience might be associated with a microglia activation flare which converts more microglia to the chronic primed state. That would be my hypothesis if I did a study on that specific phenomenon. - Jarred Younger
@@youngerlab super interesting. So would it be possible, potentially, to turn them back into their other states, by removing all physiological stressors including repeated PEM? Might this in some people be able to allow them to switch back on their own without drugs to help? (assuming if they course that removing those stressors is actually possible to begin with, which I think guess in some cases it might not be - disrupted gut for eg, or pathogen persistence or reactivation or variously other possible stressors). Could this be why some people are able to increase their functioning again after a time?
@@youngerlabplease look into micro-dose (
Love the clear explanation too 💙🙏🏼💙
Thanks! - Jarred Younger
Thank you so much for doing these weekly talks, your work and explanations have brought me newfound hope that there is active research attempting to tackle this tough problem. I am a microbiologist in research but have no background in the human body/immunology so I really appreciate these talks that deliver non-superficial information that is still clear! Also as a general comment, seeing your videos made me realize that I wish more medical researcher did this type of outreach so patients could learn first-hand about the cutting edge work being done.
I am wondering whether a pathway connecting exercise to glial activation is known. Is there a hypothesis in how physical exertion can reinforce this inflammatory pathway in the brain? It would be amazing to learn about how known symptoms of microglial overactivation (independent of mecfs) overlap with mecfs symptoms if that makes sense! Good luck with your grant writing - fingers crossed for your important application!
Same with the hope 🤞
Thanks for sharing. I am looking forward to watch your next video! If you have time and interest, I would be very grateful if you could make a video with your thoughts/ideas on PEM in ME/CFS. TIA!
Thank you so much Jared! You give me hope. I’ve had ME for a few years now, doctors did not recognize initial symptoms back in 2018. It slowly progressed especially after covid, now I have no life. We can’t thank you enough.
Hi Dr. Younger! That hypothesis sounds very likely to me. I've been diagnosed with both ME and fibromyalgia - and in 2015 an MR-scan revealed gliosis in my brain, which to me either means overgrowth of microglia or that they are found in one of the pathological stages you just drew. Thank you so much for all that you do ❤🙏❤ Our hope is green - and we are so excited to following along and learn about your new findings in your videos to come. Many greetings from Anna, Copenhagen, Denmark.
I’m pretty sure this is what is going on with me. I think that after a very stressful period the microglia in my body changed. I have ME/CFS, fibromyalgia and (facial) neuralgia(s) symptoms. Very excited for future videos and future possibilities. Thank you for all that you do!
Dr Younger, is this micoglia disorder a hypothesis or proven in me/cfs? Also, is it compatible with your Leukocytes entering the brain hypothesis? And are both compatible with Rob Phair's intaconate shunt hypothesis? Thank you
I second this question. Thank you!
Good questions. The microglia hypothesis is being tested with PET radioligands called translocator protein (TSPO) agonists. They dock exclusively on activated (M1) microglia. My lab, and two others are running those studies right now. The preliminary data from all the labs are all showing that the ME/CFS microglia are abnormally activated. Here is a paper using this technique in fibromyalgia - the majority of whom meet ME/CFS criteria as well: pubmed.ncbi.nlm.nih.gov/37326674/ - Jarred Younger
How is this mechanism connected to the autonomic nerve system and the sympatic action and parasympatic action of the vagus nerve? And does cortisol levels in blood affect the states of microglia?
Do you know any research teams looking into all these connections?
Thank you for your great videos and great efforts in this area!!
Great questions. Yes, parasympathetic balance is important to managing the inflammatory state of the brain - and vagus nerve stimulation is a top candidate to modulate that inflammation. You will definitely hear more about VNS and brain inflammation in the future. - Jarred Younger
This sounds like it would alleviate some of the acute symptoms of me/cfs but would it address the fatigue, sleep disturbances, brain fog, inability to be fully awake at times and difficulty maintaining a consistent sleep wake schedule. Also all the digestive and food reactivity issues? I often try to think what causes my symptoms and find reasons to believe certain things might be responsible but than those things seem to clash with other hypothesis of which my three main hypothesis are toxic exposures, virus of some type, immune disorder. I wonder if it couldn't be some combination of all three. That would explain why it's so totally disabling.
Agree 💯.. guf micrbiome must be addressed .. gut /brain connection
To the first question, pushing microglia from M1 to M0 should address pain sensitivity, fatigue, sleep disturbance, energy and motivation problems, brain fog, malaise, and cognitive issues. The reason is that all of those symptoms are called the "cytokine-induced sickness response" which are well known to be caused by microglia. So returning microglia to their normal state could help all those symptoms. But, to your second point - I do not think microglia modulation is the way to help GI issues. So that problem will likely need to be addressed in a separate way. But your three hypotheses match up well with some of my immune work that shows 1/3 of ME/CFS patients seem to have a chronic inflammatory/viral issue, 1/3 appear to have an autoimmune disorder, and 1/3 are unknown (but exposures, diet, gut microbiome, leaky gut, etc. are all possibilities). - Jarred Younger
I found that treating my fermented gut has helped a lot. I eat a clean low carb diet, gluten and dairy free, no processed food and small portions.
@@joyceknox1341 I do intermittent fasting so I tend to load up on my 2 meals but I eat small portions of a wide variety of food. No gluten although I do drink milk I try to keep it down to 1 gallon over 2 weeks. Try to eat lots of plant food, beans lentils, rice, potato carrots, cabbage, broccoli, corn, peas etc. I keep the broth from meats I cook for my dog and stew carrots, cabbage, broccoli, onions, ginger, spices whatever I think will make it taste good. I was never able to nail down any particular culprit with my food allergies so my thinking is just small doses of a lot of different items. Although labor intensive eems to work well for me. I did go back on gluten for more than a year maybe 18 months. The idea was to get an antibody test. Ashole dr told me if you had celiac you would have a lot of diarrhea which of course I have. Had to switch dr's to get the damned test. Came back negative. That same ahole wanted to do a colonoscopy even though I had one 5 years prior and wanted me to get flu vax even though I had that 7 months earlier. and x rayed me unnecessarily for a shoulder injury I sustained from falling off a ladder. Any decent dr would have had a wait and see attitude. I live in a metal building I insulated with styrofoam panels. I cannot tolerate moldy buildings. I suspect the styrene from the foam might be giving me issues but it's too cold in the winter and hot during the summer not to have insulation.
an actual scientist with a channel about chronic diseases here on youtube? from someone who is chronically ill and science-oriented, you're a godsent. could you maybe make a video about the research funding of autoimmune/ chronic / rare illnesses as compared to other diseases?
He talks about funding issues and processes in some of his other videos. I agree - very interesting topic!
Thank you! Oh yeah, funding topics will come up. :-) For anyone who follows the videos regularly, I think they will see a lot about these diseases, but also quite a bit about what it is like to be an active scientist in this area -- because I am not planning on hiding any aspect of the work. :-D - Jarred Younger
thank you for your research and your work and contributions
You're welcome! - Jarred Younger
Thank you and good luck with the grants.
I appreciate it! - Jarred Younger
Thank you! Looking forward to the next video.
Thank you so much. I am in year 4 of long covid with severe autonomic symptoms. I have finally found a doctor who has an integrative approach. One of the things that she has added to the list is sensitivity to electrical current. She is going to start me on LDN but not before looking at all the environmental challenges, both inside and outside the body.
Any thoughts on upstream of the microglia? Why are they getting activated? Maybe it's necessary for a persistent infection.
Coming up next week! - Jarred Younger
Hi great Video
So I am very interested in the how do you get them into state M2
especially with natural substance’s that you can buy over the counter or food
What do you think about proprionic acid is it on of the substances?
What are the best natural options you can get your hands on without being a doctor.
All the best wishes from Germany
Oliver
There are supplements like rutin that have some scientific evidence showing an M1-->M2 effect. I will be introducing some of these in future videos. I don't like to just list them though because there are caveats that need to be explained. So, I will likely prioritize them and do one at a time, with all the needed information contained in the video. But yes there are some supplements with promise. - Jarred Younger
What causes the glia to malfunction? Seems like glandular fever is one trigger. Since it is an endemic, recurring infection, perhaps curing the underlying disease will become necessary.
I think of viral infections in at least my reasoning because those that I have had as patients in the past usually have mentioned a viral attack or maybe a strong viral attack and a bacterial or parasite infection. So many have keen memories of these things including myself but there is an immune trigger response that obviously the microglia control. Obviously can’t obliterate the microglia. Wonder what Einstein would have thought, his brain had more than the average glial cells. 😊
Yep. The video I will do this coming Monday will identify the factors that cause microglia to adopt these unhelpful states in the first place. A chronic or particularly severe viral infection (especially one that infiltrates the brain - like some EBV infections) is one clear trigger. - Jarred Younger
I've had good luck using palmitoylethanolamide (Normast, in particular) likely because of its effect on the microglia. Reduced pain and other symptoms.
amazing, Jarred. Thank you so much. Now could you talk about the influence or interaction these four states have with neurotransmitters?
Best of luck with writing 👍
Rob from Holland
I also remember reading about using the antibiotic menocycline to treat arthritis. I've occasionally begged my doctor to give me a 30 day trial.
Yes, several studies (going back quite a ways) show minocycline pushes microglia out of the M1 inflammatory state. There are several animal models of fibromyalgia and ME/CFS showing effectiveness and a small number of human patient studies. I don't think there is a doubt it has the microglia response we want. The issue is that the drug can have other, adverse effects when used at too high of a dosage or for too long a time. It would need to be carefully monitored by a clinician, and I'm not surprised if most physicians would be uncomfortable managing that particular drug. But it is one option to consider. - Jarred Younger
Thank you so much for this! I met an enteric neurologist who told me there are lots of glial cells in the gut. I wonder if these would cause the digestive system symptoms we get? Thanks again!
It's interesting to note, that the digestive tract, has such a complex nervous system that it is nearly independent from your brain. I can't remember the exact number but something like 70 percent of "traffic" goes from that to the brain, not the other way around, like alot of the rest of the body. It's why it is also dubbed "the second brain". It's not too far a stretch to think that if a food sensitivity effects your glial cells in the digestive tract, this could "prime" those in the brain for fibro & vice versa.
Does rintatolimod (Ampligen) have an effect on the state of the microglia?
This is a terrific explanation, thanks much. I feel my glia must be highly primed causing daily headaches. Ive tried LDN but can't get beyond .5mg without exacerbating my headaches to intolerable levels, even after 6 weeks. Must be doing something in that realm? I look forward to your future presentations.
Thank you for these weekly talks- they bring us such hope. Have you talked about tremors/shaking and physical weakness with me/cfs? I assume those are brain related and I’m curious how common they are.
Pretty common I think. They are one of the main reasons I can't walk. I have 2 other friends with Fibromyalgia & they report the same.
Really enjoying your new video series. Good luck with the grant application 😊 Would like to know about the anti-inflammatory substances that microglia should pump out. What are they, and how would (e.g.) dextro-naltrexone help encourage their production in enough numbers to return the CNS to homeostasis? Cheers from Melbourne Australia, where LaTrobe University & Walter and Eliza Hall Institute are recruiting for a new ME/CFS study 😊
How much is related to toxins that we are all swimming in . By learning to make everything that goes in or on my body. I avoid plastics, chemicals, drugs, perfumes, cleaners, and most things with a bar code. I found avoiding all nitrogen fixing plants including all legumes which are in everything. That I have had dramatic improvement. I have lost 140 pounds, and gone from being able to be on feet 90 minutes total in a day to being up and about for 14-16 hours. I do many therapies throughout the day to manually run lymph and parasympathetic system. And I do have to 100% avoid triggers. Or go down!
Many events trigger hemolytic events that take me weeks to recover from. I was unaware I was becoming anemic after the events until I started to wear cheap watch tracks several things including oxygen. Even dropping into the low 90’s causes serous brain issues for me, once brain fails so does body. Could lower oxygen be a piece of the puzzle and the thing tweaking the microglia? I am currently waiting for testing for porphyria even if it is nothing much will change. Avoidance of my many,many triggers seems to be my only option. Masking being made common by covid has actually made my life a little easier. I wear carbon filter mask anytime I go out. As other perfumes, clothing and body care products are huge triggers. If neighbor starts drier I have to instantly get on mask. Mask is not enough with pesticides, herbicides, and fungicides which are just horrible triggers.
Toxins are taboooo 😳
You are apostate
(me too)
ME struck along with the flu on 12/24/09! This information is so reassuring and seems so logical! If only we could get those microglia whipped back into place because they have made my life a living hell!! It seems outrageous that it has taken this long for the CDC or NIH two even look at the problem, let alone to say hey- here’s what could be causing all of your pain & this pain that is very real!!!!
What do you think of Dr Katz research suggesting fibromyalgia patients have intramuscular pressure three times higher than controls? And the theory that a straight neck could be a diagnostic indicator of fibromyalgia? So its more of a relationship between muscular tension and the CNS?
What if the inflammation is actually necessary to deal with an ongoing infection? Wouldn't inducing a resting state be risky?
None of these diseases are infections, doesn’t that answer your question. Also WHY DID YOU MAKE 7 DIFFERENT COMMENTS INSTEAD OF ONE? And all of your questions can be answered with simple common sense!!!
@@GodsChild145 I don't know, you failed with this one.
I often wonder about the same thing. One would hope, however, that our bodies could finally clear the infection after so many months or years. They never do. Therefore, a malfunctioning pattern (hyperactive state) must at least be considered. I don’t think that any calming treatment option would disable the microglia. At least I hope not. I’m assuming this is an attempt at a reset.
I hope to see those tips for working with microglia 🙏 if you could possibly start with behavioral interventions rather than medical, that could be great. Not all of us have doctors to work with.
Would RNAse-L fragmentation, as in ME, affect the performance of the microglia?
Thank you very much for your important work!
May I ask you why you call ME, GWS, FM and LC "disorders"?
Dr. Younger, is it true that anti-viral medications calm the microglia?
what antivirals do you have in mind?
You may have seen anti-virals (e.g. famciclovir) used for chronic conditions like ME/CFS. But there isn't much evidence leading us to use anti-virals as microglia modulators. It is more likely that the anti-virals are reducing microglia activation indirectly by suppressing the virus that is prompting the microglia response. So, in the absence of a stubborn/hidden virus, I don't think use of anti-virals is recommended. - Jarred Younger
Great video. I’ve read/heard that LDN changes microglia in patients with long COVID and fibromyalgia etc. Is this the same thing?
It is! While not proven, many scientists in the field (including me) are working under the hypothesis that all these conditions have the same or very similar core pathophysiology. - Jarred Younger
I've had chronic pain for 40 yrs from a L 4-6 injury in my teens. Red wine has been an excellent sciatic nerve pain reducer. Does anyone know why?
Only deep red wine works. Others w/ back injury have noticed it too.
Hi I don’t know about the wine but I had a lot of back pain myself and what I Think is the Only Solutions ist to Get You Back Strong .
Which means weight training.
firstly you have to give the muscles what they need
At least 100gram of Protein better ist 130 gram Depending your Body Weight.
Get some Zinc 10mg and Copper 2 mg a day for myelation
200 mg magnesium and 3000IE Vitamin D
Take some extra glycine 8 gram
And try (if it’s not upsetting your stomach) frankincense
All the best wishes from Germany
Oliver
I have low and upper back pain. I would be totally disabled if I didn't learn how to apply traction to my back. That and some simple exercises. Low back I use a nylon weight belt for scuba divers. Strap it to my waste loosely and put my hands on my hips inside the belt and push down on my pelvis in different types of positions. I do it draping my upper body over something like a counter hanging my legs off o the ground. Also wad a bunch of blankets up on my bed and drape my body over them. This makes it easier to focus on the vertebrae in my low back. I usually get a few pops and it relieves 70% of the pain the other 30% is gone the next day. The vertebrae between my shoulder blades can cause intense pain to the point of nausea. Feels like what I imagine it feels like having a heart attack. I hang from rafters with my hands like a child on a set of monkey bars. 2 or 3 reps of 20 seconds is about all I can handle but he does the trick. Again 50 to 70% relief instantly and another 30% the next day. I also occasionally have issues with my neck and I loop two dress belts from a rafter put the front one on the back of my scull and the back one under my chin and slowly shift my body weight from my feet to the straps around my head. Same thing. This works for me I am not a dr talk to your dr before following any medical advise from a random guy on the internet.
This sounds quite different from the microglia-mediated chronic pain and fatigue disorders. My first thought is to explore resveratrol supplementation if you haven't already (in consult with your primary care physician, of course). It is *possible* that the red wine benefit is because of the resveratrol concentration, and that compound has some good studies showing its benefit in nerve pain like sciatica. The fact that other forms of alcohol or even other forms of wine don't help in particular makes me think of resveratrol. - Jarred Younger
Have you published this study? If so, where is the article located?
Thank you for all your research. In one video, you explained that microglia were very active when we have the flu. That really hit home for me. I have told people for years that I feel like I have had a bad case of the flu 24/7.
Do you use SPECT, PET, qEEG or NIRS to diagnose ME and distinguish it from CFS? Are you looking at hypoperfusion or just temperature? What would microglial treatment do to increase perfusion, if anything?
What about meth blue?
Oral supplement or IV?
Danke ❤
😁 - Jarred Younger
Are you looking at this in the context of SFPN (ie the periphery too??) and regardless of that, are you looking at the use of IVIG which might be best indicated for pwme who have autoimmune markers?
I haven't been monitoring the peripheral nerves directly, but I'm keeping an eye on the small SFPN literature to see when I might be able to contribute. The recent observation that small fibers innervate more systems than just the skin, and seem to be very important to the autonomic system. There are some clear targets to explore for treatments - Jarred Younger
@@youngerlab Thank you very much for taking the time to reply. I'm absolutely sure you're aware of Anne Oaklander's work wrt aaSFPN and with Jill Schofield's excellent work describing 'autoimmune dysautonomia (my test results fit that dx as well as the ICC ME set of criteria). And of course the way Carmen Scheibenbogen has linked anti GPCR AABs to ME, and then together all 3 of those individuals create a compelling argument for IVIG.
I know it's expensive, but if you do look at this more closely and perhaps consider a trial of IVIG (especially amongst those patients who might have specific positive AABs and a positive punch for SFPN...there's probably far more of us than one might first think) then that could make an argument for truly meaningful therapy for people who are suffering indescribably. If memory serves I think it's Jill S who has observed that it doesn't matter how long someone has been ill, if they fit these markers then IVIG (if tolerated) can have a potentially massive impact even on long timers (I'm over 50 years down the road with this disease). I have tried LDN but was unable to use it.. even in micro dose it spiked my SFPN very badly.. (10/10 pain, and I live with an extraordinary amount of pain as it is).
I do realise you have lots of input from very many desperate patients and you can only follow your course, and that's dependent on funding, but there might be ways to make a subset of the ME cohort (and there is evidence to suggest the LC cohort might be helped too) considerably better.
But a weight of good research is required before medics will help. In the UK the situation is far more dire than in the US.
But thank you so much for doing what you are doing. I feel I'm being a right old 'nag' ('nagging' is my 'superpower' 🙃 ) but I don't underestimate your value to this community either! 🙌
What do you think about palmitoylethanolamide?Is it indicated or not for micro-glia activation?
I'm curious about this too. Hubby is on a lutein and PEA supplement, and it does help with some things, but it's not a major change, so I'm wondering if a higher dose would be more helpful.
Even during a week of a PEM crash, upon waking for about 5 minutes, I usually feel significantly better than I will that day. Does the state of the glia change with sleep and wake cycles?
The glia can change state over the day, but they usually do so in response to something else that is changing. For example, cortisol is highest first thing in the morning, and a normal burst of cortisol can temporarily suppress microglia inflammatory activation. But cortisol lasts longer than 5 minutes in the plasma, so it doesn't explain what you experienced. There are relevant neurotransmitters like epinephrine that last about 5 minutes. Both of these chemicals can spike significantly right when waking in some people. - Jarred Younger
@@youngerlab thanks, Jarred! Really appreciate being able to ask questions and learn about your progress!
Can fibromyalgia be caused by a viral infection of the pancreas, affecting elastase levels?
What do you mean by behavioural treatments?
Maybe he'll recommend brain training programs. LOL
I think he says in the video. Just avoiding certain triggers.
He said avoiding certain triggers, replay that part again. He isn’t referring to cognitive behavioral therapy if that’s what you were thinking… it’s been proven MANY times to be ineffective and HARMFUL.
@@GodsChild145 brain training is not CBT. It is things like Gupta and Lightning process. Chill, it was just a joke, because it sounded like he meant something similar.
Thanks for another in depth video. Was hoping you could one day talk about functional neurological issues(FND, FMD, NEAD, PPPD) if you have any interest in that area.
Is MCAS, Connected to all this?
Yes
Tetrahydroxystilbene?
Have you tried hyperbaric oxygen therapy to treat patients? How would that affect the microglia?
I have been diagnosed with fibromyalgia, do you recommend any medication
Ldn?
Does the secretion of IFN-gamma in ME provide protection against an infection with a coronavirus?
No… why would it? Haven’t you heard of many people getting covid? That should answer your question
@@GodsChild145 Sorry dear troll, but it does not. Goodbye.
What did protect many was that for medical reasons were taking HIV meds which essentially were blocking those same receptor sites as HIV, bubonic plague. When I saw the release off the info on the main Covid structure that was an Aha moment. It was sad that doctors didn’t see that as fast and resort to using them to get people of the ventilators until all that testing.
The Red Book may help us ! The answer exists. Now we must find a path to reach the answer.
I have hereditory haemochromatosis and ME/CFS and since a failed cardiac ablation 3 mths ago (heart normal) diagnosed with dysautonomia I have been on a mission to find the route of my fatigue and mitochondrial dysfunction. Depression migraine and fatigue are huge. I do have a monthly inj of CRGP and would be interested to know your thoughts on these meds. I’ve tried LDN, I’m now trialing hrt ( slight improvement) I follow Dr Sarah Myhill program for CFS and find diet has huge implications..supplements inc Acetyl L Cartinine, Magnesium, Lipoic acid CoQ10 Multi vits & minerals B complex. Also Tumeric with Ashwaganda concentrate…all helped. I have notified my consultant neurologist of your studies Dr Younger, he was very interested. Thank you for what you’re doing. Newcastle UK
Have you looked into low-dose Lithium? We need more research!
CBD calms them down.
Long covid🤥🤥🤥🤣🤣🤣
It's a propaganda term for a real-symptom cluster that many are suffering from.