Finally caught this live. I, too, refuse to claim to be an expert in matters that I'm NOT. I told my patients all the time, "I don't know". I have no ego about not knowing the answer especially when it comes to your life. I hear people on YT ameveryday who are handing out "facts" that are wrong but want people to believe their every word. You never do that and I have huge respect for that.
Hi Dr. Bikman, I have been following your lectures for a few weeks. 32 days ago I decided to change my life. I started out walking a mile a day. This week I'm up to 10 miles a day. 2 miles at a time. I have lost 24 lbs. no carbs except salad greens etc, under 20 total per day. eating once a day about1200 cals, then the next day 2 meals about 1600 cals. done by 2pm. I'm not hungry and feel like I could go omad easy. I walk about 4 hrs a day now, and take sundays off. I think I will fast sundays as well. I was 332 lbs, now 307. I was completely sedentary and ate trash food everyday. I am also bipolar 1. diagnosed at 19. Have dealt with many serious up episodes but only a few really downs. I can attest to the weight gain from antipsychotics. The last one I tried was an injection of abilify that caused a 100 lb weight gain and pretty much shut my brain off. They all make you feel like garbage and gain weight and I avoided them most of my life. I am taking a low dose of lithium now, and not hungry feeling much better actually. My question is what does lithium do to insulin levels? Im doing everything I can to lower them . I read some studies that suggest lithium can help diabetics with blood glucose, but they were to technical for me to understand if they were raising insulin levels or not. I know you must be very busy and if you dont know off the top of your head, dont bother answering. Incidentally my cousin is faculty at the Y and my neice is a student. My cousin is Taylor Nadauld. Any thanks for your lectures and consideration
Getting off the greens and nuts might help mental health stabilize. Sure helped me - got off the meds and back to living. Carnivore or as close as you can get. Stay away from spinach, peanuts and almonds. People think they’re healthy. At least try life without them. Maybe no difference- fine add them back after 30 -60 days without them.
Follow Dr Anthony Chaffee. He is carnivore doctor and has many success stories. Good on you for taking charge of your health... Good Luck, you are going to inspire so many people...
Dr Georgia Eads a Harvard trans psychiatrist talks about the importance of meat in mental health. She's a low carb person. And Dr Chris Palmer is also a psychiatrist using a metabolic approach to mental illness. I would suggest them to check out over just a pure low carb Dr in your case.
respect for starting your journey! while the ketogenic perspective is certainy helpful, it is not the complete story. if you miss out choline, omega3 and iodine, even at the RDA level, the brain has little chance to heal. in simple terms: eggs and sardines every day, and 2 drops of Lugols Iodine. Very likely you have quite damaged mitochondria, and cell membranes everywhere in yuor body, whch would require additional actions
@@monnoo8221 consuming 4 or 5 good eggs per 24 hrs. 2 cans sardines per 48' real wild salmon as well. i will check blood work regarding iodine. gracias.
May I ask you to please make a video on ashwogandha and similar natural components that lower cortisol and their effects on metabolic health? Also could you please share more stories on your sleep problem and why ketogenic diet can’t help with it?
Thank You Dr. Bikman. It is also depressing watching someone you love deeply, so addicted to sugar that you cannot get them into a ketogenic state to try to stop tthe viscious cycle. They suffer depression and early stages of dementia. So sometimes the depression is not just metabolic kind. Although maybe I am confusing depression with sadness.
Nice video. Would be interested in knowing more about metabolic effects of stimulants . They increase fat metabolism ... but how does that relate to insulin resistance and adrenal fatigue? Always learning thanks !
Many thanks for sharing your insights. I find you to be a well-informed, knowledgeable teacher and hope you will continue your discussion of neurotransmitters.
I have been following you for a while now. I’m a psychiatrist and was very excited to see the topic of this mini lecture. I’m aware of the limitations of time etc on this talk. But… 1) why didn’t you mention Bupropion? It’s one of the primary antidepressants and completely different from the others. 2. Would you consider covering this topic in more depth. As you say, you’re not a psychiatrist but you ARE an expert on metabolism. More specifically, could you do a talk on antipsychotic medications and their metabolic effects? I am not an expert in metabolism but I’ve been practicing psychiatry for 35 years. I struggle with how our psychiatric medications are wreaking havoc on people’s metabolism to the point that I often feel I’m am doing more harm than good when I prescribe them. My primary work is with extremely ill psychotic patients and I prescribe mainly antipsychotic medications and mood stabilizers. We need more in-depth knowledge about what these medications are doing to our patients outside the brain. Any help or suggestions would be greatly appreciated.
kudos to you as a psychiatrist for caring about and looking into the metabolic consequences of these drugs. So much silo mentality going on, where we aim to improve one issue a little bit but cause a worse one.
im on buproprion. losing lbs. bipolar1. low dose of lihium. over thirty years, been hospitalized with psychosis and delusions quite a few times. not many lows. I've been on zyprexa, risperidol, depakote, and a handful of others. Always gained alot of weight. Tried abilify injection and gained a ton of weight and becaqme really non functional depressed. I think the most shocking side effect I've experienced was on risperidol. Feeling no pleasure at all during intimacy. I wasnt on that very long.. I dont have much experience with anti depressants, never needed them much and most docs felt it was a risk. The doc I have now told me buproprion usually causes weight loss. Is there anything I should look out for? I am feeling alot better eating a clean keto diet and exercising. I have zyprexa perscribed as a prn if I start to spin up, It is very effective and a few days on it usually knocks me right down. If you know anything about buproprion and it doesnt violate any rules, let me know what to watch for, thanks for your consideration
HI, I wouldnt feel like you are doing more harm than good prescribing antipsychotics. AS you well know, mania and psychosis destroys familys, careers and reputations. From my perspective, in an ideal world, the hospitalized patient would be stabilized and would receive a ton of help stabilizing and learning to manage their life and symptoms. I think that with the right supports, medication could be used sparingly and people could avoid alot of unnecessary side effects. Sadly, that is not the way things work in the real world. All that said, I thank you and your profession for creating the drugs that have returned me to reality and given me a much better life than existed for people with my condition in the fairly recent past.
Hello. I am a cardiologist. My sugestion. Read this 2 books: energy brain from cris Palmer and the other change your diet change your mind from georgia edema (both MD). Dr. Bikman lectures are very helpful .
I almost died!!! On 10/11/24 at about 4am I went via ambulance to Intermountain Health Medical Emergency Services in Salt Lake City (actually in Murray UT), was immediately admitted to ICU. I am a type 2 diabetic who had diabetic keto acidosis! (And this is important because we are NOT SUPPOSED to get that!!) But it was atypical, my sugars had been relatively low (I had finally woken up with a 108 BS according to my CGM! Yay! No dawn phenomenon!!!). I was ON the keto/ketovour diet and was doing pretty good, but I was ALSO ON JARDIANCE (SGLT2)!!! That combination almost killed me!! I was feeling sick for a few days, and had thrown up a few nights ago. I thought I just had the “keto flu” you hear about, and so I just tried to push through it and ugh, boy did I feel yucky! Things finally came to a head when at about 3:30am in the morning as I was “trying” to sleep I started hyperventilating! It was as if I had tried to run a marathon at a sprinting speed, my lungs wanted to explode. My whole body was hurting and spasming. I was dizzy, too wobbly to walk or get out of bed. I also threw up then and it was BLACK... I remember thinking “Hmmm.. I don't recall eating anything BLACK! What the heck is THAT!?” I finally admitted I needed to go to the hospital because I needed PAIN KILLERS to help me with excruciating pain, I also figured that black vomit was not good, so ya, please take me to the hospital! I ended up on life support. I can have my husband (a doctor) help me decipher the medical records, but my “health” markers were WAYYYYYYYY OFF! One important “buffer” needed for life was unreadable, meaning I had NO more “buffer”. My blood acidity level was also up off the charts. So anyway first thing they did was try to ask me questions, kinda hard as I was going in and out of consciousness. I remember vaguely the ride to the hospital, being rolled out of the ambulance into a metal room (or maybe just metal doors, I don't know?”) being lifted/transferred to the hospital stretcher, then rolled into another room, then a team of about 8-10 ER staff all surrounding me. The questions were “what was that from” (from me groaning in pain) “where does it hurt” (everywhere) “can you be more specific” (ok I'll try... my back, my stomach, my legs, my feet...) I guess they were trying to figure out if I was having a heart attack before they did anything else. After a few more groans in pain they said “Lets get her some morphine” and I immediately got some relief. But I was still breathing REALLY HARD, that didn't slow down until much later on, I'll have to go view my medical records to figure out when that was. The rest of my time that next 24 hrs is kinda a blur. I was trying to sleep, but they were waking me up trying to prick my finger to see what my blood sugars were doing every hour, and they were drawing blood for labs often, and they were waking me up to see if I could do any physical therapy, and I was asking them to please UNTIE ME from the IV's from both elbow pits & from the compression leg thingies tying both legs down to help me get to the toilet so I could pee. I wasn't allowed to eat or drink for 24 hrs. They didn't even want me sipping on water (only allowed to chew/swallow ice chips), because THEY were giving me water via IV and they needed to know exactly how much water went into me, and then as I was peeing into this container they were measuring how much fluid was coming out of me as well. Ugh. I'm just tired again just writing/reading this all. Ok, next phase. Next day I am transferred to the regular hospital floor. They are now giving me insulin shots. But I am dismayed, because I did not WANT insulin shots! I was trying every which way but loose to AVOID insulin shots! The diabetic educator was trying to convince me I needed insulin shot prescription. I was being a pain-in-the-butt because I kept insisting I did NOT want insulin shots! We were at an impasse. They were looking at me like I'm crazy. And I was just having SUCH a hard time. I do over react to stress and that can make my BS go UP. Shots/pokes/jabs drive me crazy! I have a complete meltdown internally, meanwhile outside I'm trying to hide that. My poor sons inherited this from me. When they get labs drawn or get a shot they faint! They are fully grown men and they are fainting! One time I was trying to show my younger son how my glucose monitor worked so I pricked one of his fingers.... AND HE FAINTS! So ya, they inherited that from somewhere, and that somewhere was ME! Now I'm getting “poked” more than a hundred times a day it seems! And they have me on insulin, for the first time in my 15 years with diabetes I'm on insulin. But to tell the truth the insulin DID SAVE MY LIFE!!! AND THE GLUCOSE ALSO SAVED MY LIFE!!! How confusing is that?!? It's confusing! Anyway, I'm having a hard time because what I WANTED TO DO (do Keto, no insulin!) was not what THEY wanted me to do. I am battling the medical establishment.... AND MY HUSBAND THE DOCTOR TOO. Ok, so 24 hours in ICU. Then the next day I am transferred to the regular hospital floor (oh ya! REALLY FUNNY STORY associated with that!!! I didn't sleep a wink after that “visitation”!!). And now it's the next day and I will be discharged from the hospital. We have a meeting with my ER doc. And he has consulted with some hospitalists & endocrinologists. They very clearly decided that my problem was NOT the keto diet! My problem was the JARDIANCE ON the Keto diet! They released me saying “No insulin, NO JARDIANCE, you can do Keto” End of story!! YAY!! So now instead of spending more than $800 a month on diabetes prescriptions (no more Jardiance, Invocana, no more Metformin, no more ANYTHING!!) I'll instead be spending that money on LOBSTER and eating that with BUTTER & LEMON, and I'll have a side of RIB EYE to go with that!!! Cartman of South Park was correct!!! “Tell the President to have a little steak with his butter!” I hope I survive this new diet! We will see!! Wish me luck! So anyway I'm writing all of this with the hopes to GET THE WORD OUT!! I was looking out the window of my hospital room as we were talking with my doc, we were sharing that the ER staff was saying “we see this all the time” and I'm thinking “Well, that is WAY TOO MUCH then”. And the ER doc was saying “well, its not all the time, maybe once a month” and I'm still thinking “THIS IS STILL WAY TOO MUCH!!” People with type 2 diabetes are out there, and they are getting SICK AND TIRED of this disease PROGRESSION!!! Do we keep going with this PROGRESSION? Do we lose our sight and go blind? Do we lose our Feet? (I've got horrible nephropathy in my feet! I'm scared!) Our Legs? My thumb? (because that is constantly hurting me and is numb, is my thumb dying and am I going to lose my thumb?) How far and how long are we going to let this disease PROGRESS?!? Can we get off the merry-go-round of gain more weight->become insulin resistant->have higher blood sugars->take insulin shots->gain more weight-> etc and on and on. No people! NO!!! We are TRYING TO GET HEALTHY! We go to the store, we buy the GOOD stuff, we learn to cook it the right way and say “oh DANG, that is YUMMY!!!” We might even (if you are like me) lick the plate clean leaving our poor puppy nothing. So ya, back to my point, how many type 2 diabetics out there ON JARDIANCE who want to give this Keto thing a try? Because I tried it 3 times, 2 times I failed.... because I was likely about to go into DKA back then too, and I stopped it by giving up & eating CARBS (and thereby continuing on with my disease progression)... not by GETTING OFF JARDIANCE!!!!! I have a HUGE question..... HOW MANY PEOPLE WHO HAVE SUFFERED WITH KETO FLU WERE ON JARDIANCE or other SGLT2's? I would seriously LOVE to see a survey done to ask that question! I'm writing here because this IS THE TARGET AUDIENCE!! Please help me get the word out!!! GET OFF JARDIANCE or other SGLT2's if you want to STAY ON KETO!! Thank you for reading this! Stay safe! God Bless!
@kjsreedsport absolutely 💯 talk to your doctor! And then have them look up how often Jardiance (or the other SGLT2 inhibitors) will cause PROBLEMS for low carb dieters, and THEN have him come learn from Dr Ben Bikman here about insulinemia and insulin resistance, and how to reverse it! Dr Jason Fung will also tell ya! But, yes, my advice is get OFF Jardiance 1st, if you don't you are going to feel AWEFUL CRUMMY! Trust me! I know! Thanks for your reply! Stay well!
Thank you. While not medications for anxiety, psychostimulants for ADHD are said to increase dopamine and noradrenaline levels. They are consistently associated with weight loss. As a paediatrician, I have generally thought this was due to appetite suppression, but improved insulin sensitivity might be a factor too.
Thank you Ben for this video. My 78 year mother has been dealing with chronic depression for most of her life. It’s interesting knowing how the medication she is taking may increase insulin resistance. She’s not type 2 diabetic, however, I’m hoping to have her doctor check her a1c & insulin with the next set of blood tests.
When I was first diagnosed with type 2 Diabetes they put me on metformin and wanted to put me on antidepressant. I’m a nurse and said “ I’m not depressed “, I’m not going on those meds. WT heck is wrong w you ppl?. That was 20 yrs ago, I’m still not depressed. But I stay away from more meds and stay away from drs as best I can.
This wonderful man and a few other Doctors who post information on TH-cam are gifts. Dr. Bikman's book, 'Why We Get Sick", really has a lot of good information. I recommend it, and Dr. Jason Fung also has some informative books.
The link between metabolic health and mental health is obvious from my own personal experiences. In 2019, I was severely depressed. I was laying in bed for 12-16 hours a day, spending the remaining hours behind my computer playing video games. I went to bed at 5am and woke up late afternoons. I rarely if ever went outside. I was also overweight by roughly 30 kgs. While the root cause of my depression was likely due to trauma, the symptoms were extremely severe because (in hindsight) I had a horrible diet. 80-90% of my food was junk food, instant meals and candy and soda. Once I fixed my diet and learned how to fast, first periodically and then later extended fasts (mid 2020s), my health improved RAPIDLY in just a few months. And most notably, my depression symptoms became significantly less severe. While it was still present, I had much more energy, I didn't feel doom and anxiety all day, I actually started to care about life itself a bit more. The link between metabolic health (reflected primarily through diet and fasting imo) and mental health is still fleeting but imho very clear-cut and important.
Dr Bikman - Great and helpful info! Bought your WWGS book years ago and often re-reading *** PLEASE NOTE: Amazon Australia is showing your surname as Kikman instead of Bikman on the entry for aforesaid book!!
@@shamilton6870too much protein, my wife tried to increase her keto diet towards carnivore and it made ketones drop and glucose rise. The easiest way to increase fat and lower protein is with double cream, clotted cream or mayonnaise in our experience. Almost every other meat source has too higher protein you end up way over everyday. We still have protein just small quantities while still achieving high fat to get high ketones
My first experience with antidepressant medication was Zoloft and was prescribed by my PCP at the time. I had recently been diagnosed with type 2 diabetes. That doctor committed suicide about 4 years after I saw him for the first time in 1998. I was getting hired into the postal service and they sent me for a physical exam which included screening for diabetes by checking for glucose/sugar in the urine. I was not even 200 pounds but ended up learning that it does run in my family. Aunts, uncles, cousins had/have it and none of them were/r obese. The genetic predisposition is a big factor. The news leaves people with the impression that it's a disease of the obese which really is a half-truth.
Wellbutrin, aka Bupropion. Very effective against depression for many and also sometimes prescribed for weight loss because it reduces appetite somewhat. Good stuff.
Yeah and easy to get off of which is equally important. Just do carnivore and you won’t need that. Stay away from greens and nuts/seeds and seed oils especially soybean oil (in everything by design). Sends me to the pits mentally. Beef, eggs cheese and cream stevia coffee chicken pork and plenty of salt and butter and animal fat. Yes it’s healthy. You’ve been lied to.
Worked great for 3-6 months. Then just stable. No nuts, no spinach Keto and carnivore fixed it without meds. Keto didn’t work all the way til I got off nuts and greens. Then I could drop the meds very slowly over months.
Saw equally good improvement getting off nuts and greens. Weird withdrawal. Almonds and spinach shouldn’t be eaten. Now carnivore with 80%+ meat. Beef and eggs.
@@BeefNEggs057 I'm lucky. Can eat greens. Nuts I have to just peck at...moreish...tend to eat too many. Carbs go up, undoes all the good work. Same with dairy, suits me fine but too much milk in my coffee I start gaining weight. So I have to go back to black coffee and cleaner food, you know what I mean. Steak with just a few veg.
@@Happymomto9 I have been Keto for the past 5 and a half years. Keto is probably the best thing that has ever happened to me, but it has done nothing for my sleep. I have been struggling with sleep since menopause 11 years ago, and it keeps getting worse...
@@aurapopescu1875 that an incredible accomplishment ! Way to go!! Have you looked into carnivore? That’s how I found Ben. It’s totally improved my sleep, possibly because of the increase in animal fats? Another thing I learned from Ben.
I too struggle with sleep. Tried Ambien and finally settled on a low dose of trazadone. T settles my mind and let's me fall asleep fast and if I get up to use the bathroom, I can fall back asleep. Dr. B discusses at about 20:00. I plan to wean off of it though.
I have a question about tirzepatide and other GLP’s. Google says they work by stimulating the pancreas to make more insulin. Does this mean the meds are working by burning glucose? Other symptoms aside, Is this the number one reason not to take them bc they produce more insulin while we need less?
Serotonin has been found to not be connected to depression. I’m hopeful one day, this makes it through mainstream. Depression has been found to not be a chemical imbalance. Dr. Albert Ellis has this pinpointed decades ago. I’ll leave his findings to be seen by those who look..
Yes, hopefully the word will get out that it is not a fact. It was only a theory and was debunked several decades ago. I was told by a counsellor in 2010 that I needed an AD for life like a diabetic needs insulin. After 25+ years of SSRI and then SNRI after a 6 year taper I've been AD free for 3 years now. The cause of my depressed moods were due to many major life stressors over a long period of time, which also caused poor sleep which contributed.
@@BeefNEggs057 it’s never a dietary thing. In fact, research has already highlighted its the opposite.. how you think affects your gut. Anxiety and depression are thinking problems. That’s why the likes of Dr Albert Ellis had profound results in both with REBT.
everyone who has depression or anxiety, start from blood test for thyroid, vit D, iron, ferritin, magnesium, cortisol, glucose, cholesterol and sex hormones
Dr Bikman (or others) you mention quite late on in you video that psychiatric patients have a glucose energy deficiency in the brain and Ketones can provide energy instead. My question is, for what reasons does this deficiency occur and the mechanisms. I think insulin resistance/metabolic/mitochondrial dysfunction from diet/lifestyle is one but that surely doesn't explain the 'majority' of schizophrenia and bipolar patients who develop their conditions in early adulthood. Is there a genetic component or vulnerability and are those switchable through lifestyle factors or almost guaranteed. I.e if a child knew there was a family history of schizophrenia i.e a glucose deficiency in the brain could they prevent it through metabolic therapies or would for example if they stopped keto in their 30's would that gene expression show up because of the family history?
I have a thiamine deficiency…thinking it is beriberi. Before finding this out I was sent to a neurologist for my symptoms-one being a burning feeling of my tongue. He claimed they were age & anxiety related. He wanted to prescribe an antidepressant. I declined.
there is a saying/joke about medcal discinplines: "surgeons don't know anything, and do everything, doctors of internal medicine know everything, and do nothing, and psychiatrists know nothing and do nothing". We have a vivid example in the comments here, quote "I am not an expert in metabolism but I’ve been practicing psychiatry for 35y" I find that amazing. The problem with medicine is a syndrome that cross-breeds specialization with pharmacological corruption. If you track your diet you easily see a deficient area. I had a minor issue, and just for joke - i thought - lets track the diet. it was an eye opener. the cronometer app has a free version, and is easy to use.
Probably one of the most critical bodily functions is that of the thyroid. Can you please do some research on Iodine and it’s absolute necessity in our body.
I've been on ADs and val for 10+ years for the simple reason that getting off them is near impossible. I'm hoping that my carnivore diet mitigates any harmful metabolic effects. *I gained an enormous amount of weight on mirtazepine until I started keto...lost all the weight even though I have continued on the mirtazepine*
I got off my AD (SSRI then SNRI) after 25+ years by tapering roughly 10% of current dose with 4 week hold (I had to tailor my taper to the compounded capsules I could get made). The website Surviving Antidepressants has information on how to get tailored doses of various drugs. It took me 6 years to taper off 100mg Pristiq and I've been off for 3 years now and feeling better off them than I did on them.
@jobrown8146 I started taking ssri 23 years ago. I was on 50 mg Pristiq for the last 10 years. After retiring, I dropped down to 25 mg. That was a year ago. With my doctor's approval 2 days ago, I have stopped. I'm off of pristiq. I have some dizziness, but it will go away with time. Pristiq has overall been beneficial for me to tolerate very stressful environments. The main thing is that I'm free of meds.
@@dougmedbery2566 That's good. But please be aware that if the drug had reached tolerance, then sometimes what happens is that you can feel okay for a while and then you feel worse; delayed withdrawal. That's what happened to me when I stopped citalopram. It was after I started to feel worse that I was told that I needed an AD like diabetics insulin (which is a load of rubbish to put it bluntly). If you have any issues I suggest that you visit the website Surviving Antidepressants where you can get information and support about reinstating a *very* small dose. I had Pristiq compounded and put in capsules and used the powder to make a liquid but it has to be dosed at least twice a day because it becomes immediate release. I was a moderator on SA for about 5 years so I am very familiar with what people may experience. Wishing you all the best!
You didn't mention NDRI's like wellbutrin. these seem to make some people lose weight. I take a low dose during winter, and it didn't mess with me like ssri's did. Along with being active and eating low carb, it hasn't cause weight gain, and maybe has helped me a little with weight loss.
So the mechanism of carb craving in depressed people is associated with brain’s insulin resistance and inability to get enough fuel from sugars? Is there an actual resultant deficiency of the neuro transmitters or it’s the psychiatry’s way to address the symptoms? It seems like elevating levels of the neurotransmitters leads to a vicious cycle perpetuating the the disorder.
Love your metabolic classroom! I have one important question: Many leading nutrition Doctors are claiming we shoudn't have excess Protein as our Bodies store it as fat since the body is primarily using Fat and Carbs for fuel. Is that true? They claim Gorilla's and Oxen are growing muscle by only eating plants and that is the best way for health since the "blue-zone" cities with the oldest living people are primarily eating vegetables. They do agree that pesticides and ultra processed food are bad, but there seems to be an Vegan agenda here and I don't know the science well enough to say one way or another.
My understandings of the digestion in gorillas and oxen is that the bacteria in their intestines digests the fiber and then produce fatty acids that then get used by the animals for energy and growth. That’s what I have understood from dr. Google
How much is known about the propensity of ketone bodies to form protein adducts similar to the AGEs formed by sugars. Obviously, blood levels would matter, but is it a consideration?
no. Some basic biochemistry helps: Ketones are ketones and not sugars. They do not build AGEs which are advanced glycation end products. Ketone bodies do not participate in the non-enzymatic=direct Maillard reaction, which creates those AGEs, linking glucose and fructose to proteins and fats. Ketones are burning "clean", producng much less free radicals (ROS). Ketones are produced in the liver from Acetyl-CoA, and when used as fuel, readily converted back to it. Meaning ketones can be quite directly used by the RCA cycle to produce ATP.
Was hoping to hear if SSRI can cause wt loss. My 25 yr old has been on Zoloft about 6 months and losing substantial amount of wt. 😌. Guess i have yet one more thong to worry about. Dr cannot find reason for this wt loss.
Not knowing anything about your particular conditions of your son, it would be important to know about diet and lifestyle, and which type of body mass he is losing... fat or muscle? There are also many factors regarding energy meabolism, which all would be requierd to be considered... track your diet first, then you can find deficiencies in micronutrients. If h inded loss muscle mass, it should be considered kind of sarcopenia. I just would like you to know this, as a functoinal biologist. As Dr.Bikman mentioned, SSRI can lead to insulin resistance. This can impair muscle protein synthesis, and can definitely lead to muscle loss. It has been shown that Leucine-enriched protein and exercise leads to muscle buildup, independent of insulin. It can be supported with AKG. That would be cheap to try, with no side effects.
Honest questiom - if cells max out fat content and become insulin resistant and reject fat, how do you gain weight? Does all the excess fat go into the blood stream or fatty liver?
The evidence for a link between low serotonin levels and mental illness is weak at best. People with low levels of serotonin metabolites in their CSF aren't unusually likely to be depressed, or to respond well to SSRIs. SSRIs reliably raise serotonin within hours, but take weeks to affect mood if they work at all. I think SSRIs are in a similar position to statins. They clearly don't work because of their alleged mechanism, but there's some evidence that they might work anyway, and one of the best candidate mechanisms is an antiinflammatory side effect of the medication.
Gee Dr. could my depression be a normal reaction to our increasingly dystopic society. No, no, no it is definitly an imballance of neurotransmitters that we really dont understand.
No it’s a side effect of your diet. Try beef butter and eggs for 30 days. You can find what foods trigger the depths. Mine is soybean oil for sure. It’s in almost everything packaged. Feel so good.
I wish that psychiatrists would have the same respect towads nutritional physiology as you have for the field of medical psychiatrics. They don't. Instead, they make their patients jump to an isolated island of manipulated brain function wthout almost any chance to ever return to a normal life. I lost 3 friends to them.
Finally caught this live. I, too, refuse to claim to be an expert in matters that I'm NOT. I told my patients all the time, "I don't know". I have no ego about not knowing the answer especially when it comes to your life. I hear people on YT ameveryday who are handing out "facts" that are wrong but want people to believe their every word. You never do that and I have huge respect for that.
Hi Dr. Bikman, I have been following your lectures for a few weeks. 32 days ago I decided to change my life. I started out walking a mile a day. This week I'm up to 10 miles a day. 2 miles at a time. I have lost 24 lbs. no carbs except salad greens etc, under 20 total per day. eating once a day about1200 cals, then the next day 2 meals about 1600 cals. done by 2pm. I'm not hungry and feel like I could go omad easy. I walk about 4 hrs a day now, and take sundays off. I think I will fast sundays as well. I was 332 lbs, now 307. I was completely sedentary and ate trash food everyday. I am also bipolar 1. diagnosed at 19. Have dealt with many serious up episodes but only a few really downs. I can attest to the weight gain from antipsychotics. The last one I tried was an injection of abilify that caused a 100 lb weight gain and pretty much shut my brain off. They all make you feel like garbage and gain weight and I avoided them most of my life. I am taking a low dose of lithium now, and not hungry feeling much better actually. My question is what does lithium do to insulin levels? Im doing everything I can to lower them . I read some studies that suggest lithium can help diabetics with blood glucose, but they were to technical for me to understand if they were raising insulin levels or not. I know you must be very busy and if you dont know off the top of your head, dont bother answering. Incidentally my cousin is faculty at the Y and my neice is a student. My cousin is Taylor Nadauld. Any thanks for your lectures and consideration
Getting off the greens and nuts might help mental health stabilize. Sure helped me - got off the meds and back to living. Carnivore or as close as you can get. Stay away from spinach, peanuts and almonds. People think they’re healthy. At least try life without them. Maybe no difference- fine add them back after 30 -60 days without them.
Follow Dr Anthony Chaffee. He is carnivore doctor and has many success stories. Good on you for taking charge of your health... Good Luck, you are going to inspire so many people...
Dr Georgia Eads a Harvard trans psychiatrist talks about the importance of meat in mental health. She's a low carb person. And Dr Chris Palmer is also a psychiatrist using a metabolic approach to mental illness. I would suggest them to check out over just a pure low carb Dr in your case.
respect for starting your journey! while the ketogenic perspective is certainy helpful, it is not the complete story. if you miss out choline, omega3 and iodine, even at the RDA level, the brain has little chance to heal. in simple terms: eggs and sardines every day, and 2 drops of Lugols Iodine. Very likely you have quite damaged mitochondria, and cell membranes everywhere in yuor body, whch would require additional actions
@@monnoo8221 consuming 4 or 5 good eggs per 24 hrs. 2 cans sardines per 48' real wild salmon as well. i will check blood work regarding iodine. gracias.
Your lectures are more helpful than you may ever know. I find this information extremely useful!
This information you’ve presented is extremely valuable!
You are a brilliant speaker as well as very knowledgeable in your field!
Great stuff!! Please make a lesson on Sleep Apnea > Growth Hormone > metabolic consequences!
Incredibly helpful and important information.
May I ask you to please make a video on ashwogandha and similar natural components that lower cortisol and their effects on metabolic health? Also could you please share more stories on your sleep problem and why ketogenic diet can’t help with it?
Thank You Dr. Bikman. It is also depressing watching someone you love deeply, so addicted to sugar that you cannot get them into a ketogenic state to try to stop tthe viscious cycle. They suffer depression and early stages of dementia. So sometimes the depression is not just metabolic kind. Although maybe I am confusing depression with sadness.
Nice video. Would be interested in knowing more about metabolic effects of stimulants . They increase fat metabolism ... but how does that relate to insulin resistance and adrenal fatigue? Always learning thanks !
Very valuble information.
Many thanks for sharing your insights. I find you to be a well-informed, knowledgeable teacher and hope you will continue your discussion of neurotransmitters.
Thanks for this video - I appreciate you sharing your knowledge!
God bless you Dr. Ben.
Another great lecture thanks Dr Bikman love your lectures
I have been following you for a while now. I’m a psychiatrist and was very excited to see the topic of this mini lecture. I’m aware of the limitations of time etc on this talk. But… 1) why didn’t you mention Bupropion?
It’s one of the primary antidepressants and completely different from the others.
2. Would you consider covering this topic in more depth.
As you say, you’re not a psychiatrist but you ARE an expert on metabolism.
More specifically, could you do a talk on antipsychotic medications and their metabolic effects?
I am not an expert in metabolism but I’ve been practicing psychiatry for 35 years. I struggle with how our psychiatric medications are wreaking havoc on people’s metabolism to the point that I often feel I’m am doing more harm than good when I prescribe them.
My primary work is with extremely ill psychotic patients and I prescribe mainly antipsychotic medications and mood stabilizers. We need more in-depth knowledge about what these medications are doing to our patients outside the brain. Any help or suggestions would be greatly appreciated.
All those prescriptions are extremely dangerous, including benzodiazepines
kudos to you as a psychiatrist for caring about and looking into the metabolic consequences of these drugs. So much silo mentality going on, where we aim to improve one issue a little bit but cause a worse one.
im on buproprion. losing lbs. bipolar1. low dose of lihium. over thirty years, been hospitalized with psychosis and delusions quite a few times. not many lows. I've been on zyprexa, risperidol, depakote, and a handful of others. Always gained alot of weight. Tried abilify injection and gained a ton of weight and becaqme really non functional depressed. I think the most shocking side effect I've experienced was on risperidol. Feeling no pleasure at all during intimacy. I wasnt on that very long.. I dont have much experience with anti depressants, never needed them much and most docs felt it was a risk. The doc I have now told me buproprion usually causes weight loss. Is there anything I should look out for? I am feeling alot better eating a clean keto diet and exercising. I have zyprexa perscribed as a prn if I start to spin up, It is very effective and a few days on it usually knocks me right down. If you know anything about buproprion and it doesnt violate any rules, let me know what to watch for, thanks for your consideration
HI, I wouldnt feel like you are doing more harm than good prescribing antipsychotics. AS you well know, mania and psychosis destroys familys, careers and reputations. From my perspective, in an ideal world, the hospitalized patient would be stabilized and would receive a ton of help stabilizing and learning to manage their life and symptoms. I think that with the right supports, medication could be used sparingly and people could avoid alot of unnecessary side effects. Sadly, that is not the way things work in the real world. All that said, I thank you and your profession for creating the drugs that have returned me to reality and given me a much better life than existed for people with my condition in the fairly recent past.
Hello. I am a cardiologist. My sugestion. Read this 2 books: energy brain from cris Palmer and the other change your diet change your mind from georgia edema (both MD). Dr. Bikman lectures are very helpful .
I almost died!!! On 10/11/24 at about 4am I went via ambulance to Intermountain Health Medical Emergency Services in Salt Lake City (actually in Murray UT), was immediately admitted to ICU. I am a type 2 diabetic who had diabetic keto acidosis! (And this is important because we are NOT SUPPOSED to get that!!) But it was atypical, my sugars had been relatively low (I had finally woken up with a 108 BS according to my CGM! Yay! No dawn phenomenon!!!). I was ON the keto/ketovour diet and was doing pretty good, but I was ALSO ON JARDIANCE (SGLT2)!!! That combination almost killed me!! I was feeling sick for a few days, and had thrown up a few nights ago. I thought I just had the “keto flu” you hear about, and so I just tried to push through it and ugh, boy did I feel yucky! Things finally came to a head when at about 3:30am in the morning as I was “trying” to sleep I started hyperventilating! It was as if I had tried to run a marathon at a sprinting speed, my lungs wanted to explode. My whole body was hurting and spasming. I was dizzy, too wobbly to walk or get out of bed. I also threw up then and it was BLACK... I remember thinking “Hmmm.. I don't recall eating anything BLACK! What the heck is THAT!?” I finally admitted I needed to go to the hospital because I needed PAIN KILLERS to help me with excruciating pain, I also figured that black vomit was not good, so ya, please take me to the hospital! I ended up on life support. I can have my husband (a doctor) help me decipher the medical records, but my “health” markers were WAYYYYYYYY OFF! One important “buffer” needed for life was unreadable, meaning I had NO more “buffer”. My blood acidity level was also up off the charts. So anyway first thing they did was try to ask me questions, kinda hard as I was going in and out of consciousness. I remember vaguely the ride to the hospital, being rolled out of the ambulance into a metal room (or maybe just metal doors, I don't know?”) being lifted/transferred to the hospital stretcher, then rolled into another room, then a team of about 8-10 ER staff all surrounding me. The questions were “what was that from” (from me groaning in pain) “where does it hurt” (everywhere) “can you be more specific” (ok I'll try... my back, my stomach, my legs, my feet...) I guess they were trying to figure out if I was having a heart attack before they did anything else. After a few more groans in pain they said “Lets get her some morphine” and I immediately got some relief. But I was still breathing REALLY HARD, that didn't slow down until much later on, I'll have to go view my medical records to figure out when that was. The rest of my time that next 24 hrs is kinda a blur. I was trying to sleep, but they were waking me up trying to prick my finger to see what my blood sugars were doing every hour, and they were drawing blood for labs often, and they were waking me up to see if I could do any physical therapy, and I was asking them to please UNTIE ME from the IV's from both elbow pits & from the compression leg thingies tying both legs down to help me get to the toilet so I could pee. I wasn't allowed to eat or drink for 24 hrs. They didn't even want me sipping on water (only allowed to chew/swallow ice chips), because THEY were giving me water via IV and they needed to know exactly how much water went into me, and then as I was peeing into this container they were measuring how much fluid was coming out of me as well. Ugh. I'm just tired again just writing/reading this all.
Ok, next phase. Next day I am transferred to the regular hospital floor. They are now giving me insulin shots. But I am dismayed, because I did not WANT insulin shots! I was trying every which way but loose to AVOID insulin shots! The diabetic educator was trying to convince me I needed insulin shot prescription. I was being a pain-in-the-butt because I kept insisting I did NOT want insulin shots! We were at an impasse. They were looking at me like I'm crazy. And I was just having SUCH a hard time. I do over react to stress and that can make my BS go UP. Shots/pokes/jabs drive me crazy! I have a complete meltdown internally, meanwhile outside I'm trying to hide that. My poor sons inherited this from me. When they get labs drawn or get a shot they faint! They are fully grown men and they are fainting! One time I was trying to show my younger son how my glucose monitor worked so I pricked one of his fingers.... AND HE FAINTS! So ya, they inherited that from somewhere, and that somewhere was ME! Now I'm getting “poked” more than a hundred times a day it seems! And they have me on insulin, for the first time in my 15 years with diabetes I'm on insulin. But to tell the truth the insulin DID SAVE MY LIFE!!! AND THE GLUCOSE ALSO SAVED MY LIFE!!! How confusing is that?!? It's confusing!
Anyway, I'm having a hard time because what I WANTED TO DO (do Keto, no insulin!) was not what THEY wanted me to do. I am battling the medical establishment.... AND MY HUSBAND THE DOCTOR TOO.
Ok, so 24 hours in ICU. Then the next day I am transferred to the regular hospital floor (oh ya! REALLY FUNNY STORY associated with that!!! I didn't sleep a wink after that “visitation”!!). And now it's the next day and I will be discharged from the hospital. We have a meeting with my ER doc. And he has consulted with some hospitalists & endocrinologists. They very clearly decided that my problem was NOT the keto diet! My problem was the JARDIANCE ON the Keto diet! They released me saying “No insulin, NO JARDIANCE, you can do Keto” End of story!! YAY!! So now instead of spending more than $800 a month on diabetes prescriptions (no more Jardiance, Invocana, no more Metformin, no more ANYTHING!!) I'll instead be spending that money on LOBSTER and eating that with BUTTER & LEMON, and I'll have a side of RIB EYE to go with that!!! Cartman of South Park was correct!!! “Tell the President to have a little steak with his butter!” I hope I survive this new diet! We will see!! Wish me luck!
So anyway I'm writing all of this with the hopes to GET THE WORD OUT!! I was looking out the window of my hospital room as we were talking with my doc, we were sharing that the ER staff was saying “we see this all the time” and I'm thinking “Well, that is WAY TOO MUCH then”. And the ER doc was saying “well, its not all the time, maybe once a month” and I'm still thinking “THIS IS STILL WAY TOO MUCH!!”
People with type 2 diabetes are out there, and they are getting SICK AND TIRED of this disease PROGRESSION!!! Do we keep going with this PROGRESSION? Do we lose our sight and go blind? Do we lose our Feet? (I've got horrible nephropathy in my feet! I'm scared!) Our Legs? My thumb? (because that is constantly hurting me and is numb, is my thumb dying and am I going to lose my thumb?) How far and how long are we going to let this disease PROGRESS?!? Can we get off the merry-go-round of gain more weight->become insulin resistant->have higher blood sugars->take insulin shots->gain more weight-> etc and on and on. No people! NO!!! We are TRYING TO GET HEALTHY! We go to the store, we buy the GOOD stuff, we learn to cook it the right way and say “oh DANG, that is YUMMY!!!” We might even (if you are like me) lick the plate clean leaving our poor puppy nothing. So ya, back to my point, how many type 2 diabetics out there ON JARDIANCE who want to give this Keto thing a try? Because I tried it 3 times, 2 times I failed.... because I was likely about to go into DKA back then too, and I stopped it by giving up & eating CARBS (and thereby continuing on with my disease progression)... not by GETTING OFF JARDIANCE!!!!!
I have a HUGE question..... HOW MANY PEOPLE WHO HAVE SUFFERED WITH KETO FLU WERE ON JARDIANCE or other SGLT2's? I would seriously LOVE to see a survey done to ask that question!
I'm writing here because this IS THE TARGET AUDIENCE!! Please help me get the word out!!! GET OFF JARDIANCE or other SGLT2's if you want to STAY ON KETO!! Thank you for reading this! Stay safe! God Bless!
I’m on Jardiance so I appreciate the warning. I want to go Keto, but won’t until I can stop the Jardiance.
@kjsreedsport absolutely 💯 talk to your doctor! And then have them look up how often Jardiance (or the other SGLT2 inhibitors) will cause PROBLEMS for low carb dieters, and THEN have him come learn from Dr Ben Bikman here about insulinemia and insulin resistance, and how to reverse it! Dr Jason Fung will also tell ya! But, yes, my advice is get OFF Jardiance 1st, if you don't you are going to feel AWEFUL CRUMMY! Trust me! I know! Thanks for your reply! Stay well!
sh** happens if physiology gets manipulated without understanding it.
Note that there is no management without measuerment
I’m very interested to
know more about this subject!
Very interesting lecture
Thank you. While not medications for anxiety, psychostimulants for ADHD are said to increase dopamine and noradrenaline levels. They are consistently associated with weight loss. As a paediatrician, I have generally thought this was due to appetite suppression, but improved insulin sensitivity might be a factor too.
Excellent information, as always! Thank-you!
Thank you for this great podcast
This information was relevant to one of my grown children. Thank you for helping me understand.
Thank you Ben for this video. My 78 year mother has been dealing with chronic depression for most of her life. It’s interesting knowing how the medication she is taking may increase insulin resistance. She’s not type 2 diabetic, however, I’m hoping to have her doctor check her a1c & insulin with the next set of blood tests.
Ketones are sure helping my brain function better. If you know depressed people, urge them to give keto a try.
"Ultracrepidarian." Brilliant 👌
Ultra Derpy derp
When I was first diagnosed with type 2 Diabetes they put me on metformin and wanted to put me on antidepressant. I’m a nurse and said “ I’m not depressed “, I’m not going on those meds. WT heck is wrong w you ppl?. That was 20 yrs ago, I’m still not depressed. But I stay away from more meds and stay away from drs as best I can.
This wonderful man and a few other Doctors who post information on TH-cam are gifts. Dr. Bikman's book, 'Why We Get Sick", really has a lot of good information. I recommend it, and Dr. Jason Fung also has some informative books.
This was worth watching just to add a new word to my vocabulary… ULTRACREPIDARIAN!
🎉❤🎉❤🎉
The link between metabolic health and mental health is obvious from my own personal experiences.
In 2019, I was severely depressed. I was laying in bed for 12-16 hours a day, spending the remaining hours behind my computer playing video games. I went to bed at 5am and woke up late afternoons. I rarely if ever went outside. I was also overweight by roughly 30 kgs.
While the root cause of my depression was likely due to trauma, the symptoms were extremely severe because (in hindsight) I had a horrible diet. 80-90% of my food was junk food, instant meals and candy and soda.
Once I fixed my diet and learned how to fast, first periodically and then later extended fasts (mid 2020s), my health improved RAPIDLY in just a few months. And most notably, my depression symptoms became significantly less severe. While it was still present, I had much more energy, I didn't feel doom and anxiety all day, I actually started to care about life itself a bit more.
The link between metabolic health (reflected primarily through diet and fasting imo) and mental health is still fleeting but imho very clear-cut and important.
Thank you
Thank you sir!
Dr Bikman - Great and helpful info! Bought your WWGS book years ago and often re-reading *** PLEASE NOTE: Amazon Australia is showing your surname as Kikman instead of Bikman on the entry for aforesaid book!!
What about Wellbutrin or bupropion? I wonder how this impacts insulin resistance.
Wish SRNI had gotten a mention as I’m on duloxetine for chronic pain. It has really helped.
The perfect storm. It’s been swirling around me for 50 years.
Have you tried carnivore ?
@@antonbelsky been on carnivore for 2 months. Ketones still at 0 according to urine test strips.
@@shamilton6870 interesting.. that’s a question to Ben, though 🤔
@@shamilton6870too much protein, my wife tried to increase her keto diet towards carnivore and it made ketones drop and glucose rise. The easiest way to increase fat and lower protein is with double cream, clotted cream or mayonnaise in our experience. Almost every other meat source has too higher protein you end up way over everyday. We still have protein just small quantities while still achieving high fat to get high ketones
@@shamilton6870
You need to test your Ketons with a blood test. Much more acurate.
Great word: ultracrepidarianism
👊🙂👍
My first experience with antidepressant medication was Zoloft and was prescribed by my PCP at the time. I had recently been diagnosed with type 2 diabetes. That doctor committed suicide about 4 years after I saw him for the first time in 1998. I was getting hired into the postal service and they sent me for a physical exam which included screening for diabetes by checking for glucose/sugar in the urine. I was not even 200 pounds but ended up learning that it does run in my family. Aunts, uncles, cousins had/have it and none of them were/r obese. The genetic predisposition is a big factor. The news leaves people with the impression that it's a disease of the obese which really is a half-truth.
Amazing video. Whoever did the timestamps is clearly having brain glucose hypo metabolism issues 😂
Thanks ❤
Wellbutrin, aka Bupropion. Very effective against depression for many and also sometimes prescribed for weight loss because it reduces appetite somewhat. Good stuff.
Yeah and easy to get off of which is equally important. Just do carnivore and you won’t need that. Stay away from greens and nuts/seeds and seed oils especially soybean oil (in everything by design). Sends me to the pits mentally. Beef, eggs cheese and cream stevia coffee chicken pork and plenty of salt and butter and animal fat. Yes it’s healthy. You’ve been lied to.
It is easy to get off of too. Important.
Worked great for 3-6 months. Then just stable. No nuts, no spinach Keto and carnivore fixed it without meds. Keto didn’t work all the way til I got off nuts and greens. Then I could drop the meds very slowly over months.
I've heen on a high for 2 solid years. Since going keto. Wild!
Saw equally good improvement getting off nuts and greens. Weird withdrawal. Almonds and spinach shouldn’t be eaten. Now carnivore with 80%+ meat. Beef and eggs.
@@BeefNEggs057 I'm lucky. Can eat greens. Nuts I have to just peck at...moreish...tend to eat too many. Carbs go up, undoes all the good work. Same with dairy, suits me fine but too much milk in my coffee I start gaining weight. So I have to go back to black coffee and cleaner food, you know what I mean. Steak with just a few veg.
Dr Bikman, a rhetorical question: have you ever seen a person’s mental health improve as a result of taking SSRIs? 🤔
What do you take for sleep, Professor Bikman?...
I am also a terrible sleeper 😭
That’s so hard to not get good sleep. Do you eat in the way he suggests?
@@Happymomto9 I have been Keto for the past 5 and a half years. Keto is probably the best thing that has ever happened to me, but it has done nothing for my sleep. I have been struggling with sleep since menopause 11 years ago, and it keeps getting worse...
@@aurapopescu1875 that an incredible accomplishment ! Way to go!! Have you looked into carnivore? That’s how I found Ben. It’s totally improved my sleep, possibly because of the increase in animal fats? Another thing I learned from Ben.
@@aurapopescu1875Just in case this helps, I recommend Sleep Coach School on YT. Many of their coaches offer pure compassion and comfort.
I too struggle with sleep. Tried Ambien and finally settled on a low dose of trazadone. T settles my mind and let's me fall asleep fast and if I get up to use the bathroom, I can fall back asleep. Dr. B discusses at about 20:00. I plan to wean off of it though.
I have a question about tirzepatide and other GLP’s. Google says they work by stimulating the pancreas to make more insulin. Does this mean the meds are working by burning glucose? Other symptoms aside, Is this the number one reason not to take them bc they produce more insulin while we need less?
I remember a biologist talking expertly about meteorology. I didnt know the weather and biology were so closely related😂.
Serotonin has been found to not be connected to depression. I’m hopeful one day, this makes it through mainstream. Depression has been found to not be a chemical imbalance. Dr. Albert Ellis has this pinpointed decades ago. I’ll leave his findings to be seen by those who look..
Yes, the 'chemical imbalance' paradigm is bogus...no evidence for it.
Yes, hopefully the word will get out that it is not a fact. It was only a theory and was debunked several decades ago. I was told by a counsellor in 2010 that I needed an AD for life like a diabetic needs insulin. After 25+ years of SSRI and then SNRI after a 6 year taper I've been AD free for 3 years now. The cause of my depressed moods were due to many major life stressors over a long period of time, which also caused poor sleep which contributed.
It’s a dietary problem usually. No nuts/greens keto/Carnivore fixed mine.
@@BeefNEggs057 it’s never a dietary thing. In fact, research has already highlighted its the opposite.. how you think affects your gut. Anxiety and depression are thinking problems. That’s why the likes of Dr Albert Ellis had profound results in both with REBT.
@@BeefNEggs057 I'm starting to notice that my mood seems better when I'm eating clean (for me). I haven't yet linked what foods might worsen my mood.
everyone who has depression or anxiety, start from blood test for thyroid, vit D, iron, ferritin, magnesium, cortisol, glucose, cholesterol and sex hormones
what about when using these meds for neuropathic pain?
Dr Bikman (or others) you mention quite late on in you video that psychiatric patients have a glucose energy deficiency in the brain and Ketones can provide energy instead. My question is, for what reasons does this deficiency occur and the mechanisms. I think insulin resistance/metabolic/mitochondrial dysfunction from diet/lifestyle is one but that surely doesn't explain the 'majority' of schizophrenia and bipolar patients who develop their conditions in early adulthood. Is there a genetic component or vulnerability and are those switchable through lifestyle factors or almost guaranteed. I.e if a child knew there was a family history of schizophrenia i.e a glucose deficiency in the brain could they prevent it through metabolic therapies or would for example if they stopped keto in their 30's would that gene expression show up because of the family history?
I would love to find out if Niacin ( niacinamide) can help fight depression and anxiety. Please and thank you
I have a thiamine deficiency…thinking it is beriberi. Before finding this out I was sent to a neurologist for my symptoms-one being a burning feeling of my tongue. He claimed they were age & anxiety related. He wanted to prescribe an antidepressant. I declined.
there is a saying/joke about medcal discinplines: "surgeons don't know anything, and do everything, doctors of internal medicine know everything, and do nothing, and psychiatrists know nothing and do nothing".
We have a vivid example in the comments here, quote "I am not an expert in metabolism but I’ve been practicing psychiatry for 35y" I find that amazing.
The problem with medicine is a syndrome that cross-breeds specialization with pharmacological corruption.
If you track your diet you easily see a deficient area. I had a minor issue, and just for joke - i thought - lets track the diet. it was an eye opener. the cronometer app has a free version, and is easy to use.
Some popular psychedelics have molecules similar to serotonin. Would flooding the brain with these have an impact on weight gain or loss?
Probably one of the most critical bodily functions is that of the thyroid. Can you please do some research on Iodine and it’s absolute necessity in our body.
I've been on ADs and val for 10+ years for the simple reason that getting off them is near impossible. I'm hoping that my carnivore diet mitigates any harmful metabolic effects.
*I gained an enormous amount of weight on mirtazepine until I started keto...lost all the weight even though I have continued on the mirtazepine*
I got off my AD (SSRI then SNRI) after 25+ years by tapering roughly 10% of current dose with 4 week hold (I had to tailor my taper to the compounded capsules I could get made). The website Surviving Antidepressants has information on how to get tailored doses of various drugs. It took me 6 years to taper off 100mg Pristiq and I've been off for 3 years now and feeling better off them than I did on them.
@jobrown8146 I started taking ssri 23 years ago. I was on 50 mg Pristiq for the last 10 years. After retiring, I dropped down to 25 mg. That was a year ago. With my doctor's approval 2 days ago, I have stopped. I'm off of pristiq. I have some dizziness, but it will go away with time. Pristiq has overall been beneficial for me to tolerate very stressful environments.
The main thing is that I'm free of meds.
@@dougmedbery2566 That's good. But please be aware that if the drug had reached tolerance, then sometimes what happens is that you can feel okay for a while and then you feel worse; delayed withdrawal. That's what happened to me when I stopped citalopram. It was after I started to feel worse that I was told that I needed an AD like diabetics insulin (which is a load of rubbish to put it bluntly).
If you have any issues I suggest that you visit the website Surviving Antidepressants where you can get information and support about reinstating a *very* small dose. I had Pristiq compounded and put in capsules and used the powder to make a liquid but it has to be dosed at least twice a day because it becomes immediate release. I was a moderator on SA for about 5 years so I am very familiar with what people may experience.
Wishing you all the best!
Nice video Dr Ben. Can you do a video on Adderall? A lot of people I know have been prescribed this, and for a wide range of symptoms, thank you.
You didn't mention NDRI's like wellbutrin.
these seem to make some people lose weight. I take a low dose during winter, and it didn't mess with me like ssri's did. Along with being active and eating low carb, it hasn't cause weight gain, and maybe has helped me a little with weight loss.
So the mechanism of carb craving in depressed people is associated with brain’s insulin resistance and inability to get enough fuel from sugars? Is there an actual resultant deficiency of the neuro transmitters or it’s the psychiatry’s way to address the symptoms? It seems like elevating levels of the neurotransmitters leads to a vicious cycle perpetuating the the disorder.
Love your metabolic classroom! I have one important question: Many leading nutrition Doctors are claiming we shoudn't have excess Protein as our Bodies store it as fat since the body is primarily using Fat and Carbs for fuel. Is that true? They claim Gorilla's and Oxen are growing muscle by only eating plants and that is the best way for health since the "blue-zone" cities with the oldest living people are primarily eating vegetables. They do agree that pesticides and ultra processed food are bad, but there seems to be an Vegan agenda here and I don't know the science well enough to say one way or another.
My understandings of the digestion in gorillas and oxen is that the bacteria in their intestines digests the fiber and then produce fatty acids that then get used by the animals for energy and growth. That’s what I have understood from dr. Google
Agreed, probably why comparisons with other animals doesn’t make sense. Great reply!
We don’t have 4 stomachs or a giant colon
And gorillas eat their own poop to get missing nutrients. I don’t see vegans doing this
How much is known about the propensity of ketone bodies to form protein adducts similar to the AGEs formed by sugars. Obviously, blood levels would matter, but is it a consideration?
no. Some basic biochemistry helps: Ketones are ketones and not sugars. They do not build AGEs which are advanced glycation end products. Ketone bodies do not participate in the non-enzymatic=direct Maillard reaction, which creates those AGEs, linking glucose and fructose to proteins and fats.
Ketones are burning "clean", producng much less free radicals (ROS). Ketones are produced in the liver from Acetyl-CoA, and when used as fuel, readily converted back to it. Meaning ketones can be quite directly used by the RCA cycle to produce ATP.
I crave broccoli 🥦🥦🥦🥦 sometimes 🤣
Your playlist is in reverse order. When you Play All on TV or PC, you can't watch them in order.
Was hoping to hear if SSRI can cause wt loss. My 25 yr old has been on Zoloft about 6 months and losing substantial amount of wt. 😌. Guess i have yet one more thong to worry about. Dr cannot find reason for this wt loss.
Not knowing anything about your particular conditions of your son, it would be important to know about diet and lifestyle, and which type of body mass he is losing... fat or muscle? There are also many factors regarding energy meabolism, which all would be requierd to be considered... track your diet first, then you can find deficiencies in micronutrients.
If h inded loss muscle mass, it should be considered kind of sarcopenia. I just would like you to know this, as a functoinal biologist. As Dr.Bikman mentioned, SSRI can lead to insulin resistance. This can impair muscle protein synthesis, and can definitely lead to muscle loss. It has been shown that Leucine-enriched protein and exercise leads to muscle buildup, independent of insulin. It can be supported with AKG. That would be cheap to try, with no side effects.
@@monnoo8221 ty very much for your response! Doing some research!!
Honest questiom - if cells max out fat content and become insulin resistant and reject fat, how do you gain weight? Does all the excess fat go into the blood stream or fatty liver?
Starts putting fat on your organs and places it doesn’t belong. Body makes new fat cells perhaps?
kind of. Dr. Bikman talks a lot about that in other episodes.highly recommended
The evidence for a link between low serotonin levels and mental illness is weak at best. People with low levels of serotonin metabolites in their CSF aren't unusually likely to be depressed, or to respond well to SSRIs. SSRIs reliably raise serotonin within hours, but take weeks to affect mood if they work at all.
I think SSRIs are in a similar position to statins. They clearly don't work because of their alleged mechanism, but there's some evidence that they might work anyway, and one of the best candidate mechanisms is an antiinflammatory side effect of the medication.
Hope you are feeding into RFK - somebody listened
Can these side effects be reversed once anti depressant is stopped? My experience is: no.
LOL love ya work bud.
Thw world is full of smart ass wankers who know shite.
Keep ir up.
👍👍👌
Gee Dr. could my depression be a normal reaction to our increasingly dystopic society.
No, no, no it is definitly an imballance of neurotransmitters that we really dont understand.
YES you are correct.
Dystopia in society and media is the elephant in the room.
No it’s a side effect of your diet. Try beef butter and eggs for 30 days. You can find what foods trigger the depths. Mine is soybean oil for sure. It’s in almost everything packaged. Feel so good.
@@BeefNEggs057 It was written toung and cheek. I ve been keto since 2019.
@@seanlevoy9446I got that right away 😉
I wish that psychiatrists would have the same respect towads nutritional physiology as you have for the field of medical psychiatrics.
They don't. Instead, they make their patients jump to an isolated island of manipulated brain function wthout almost any chance to ever return to a normal life. I lost 3 friends to them.
Prozak (fluoxitine) is really a life saver for anxiety