Looking for Answers in the Skull of a Zebrafish

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  • เผยแพร่เมื่อ 6 ส.ค. 2024
  • If you want to learn more about the imaging technology that helps to create amazing microscopy like you saw in this video, head to www.microscope.healthcare.nik....
    If you’d like to see more imagery and video that blends science and art, check out the microscopy galleries at www.nikonsmallworld.com
    Follow Journey to the Microcosmos:
    Twitter: / journeytomicro
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    Support the Microcosmos:
    / journeytomicro
    More from Jam’s Germs:
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    Hosted by Hank Green:
    Twitter: / hankgreen
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    Music by Andrew Huang:
    / andrewhuang
    Journey to the Microcosmos is a Complexly production.
    Find out more at www.complexly.com
    SOURCES:
    www.microscope.healthcare.nik...
    www.hopkinsmedicine.org/resea...
    www.yourgenome.org/facts/why-...
    www.genome.gov/genetics-gloss...
    www.ncbi.nlm.nih.gov/pmc/arti...
    www.ahajournals.org/doi/10.11...
  • วิทยาศาสตร์และเทคโนโลยี

ความคิดเห็น • 296

  • @jessebob325
    @jessebob325 2 ปีที่แล้ว +269

    I like Hank's quiet voice. It's such a change from his normal excited voice it makes me smile.

    • @adisfajic9074
      @adisfajic9074 2 ปีที่แล้ว +3

      First of all amazing as always and ty Hank, but Jessebob i came here to actually say the oposite i like more the excited Hanks voice :)

    • @leogama3422
      @leogama3422 2 ปีที่แล้ว +12

      I know it's Hank, but sometimes I still think it's another person. I have to repeatedly convince myself

    • @Le_Mouton_Noir
      @Le_Mouton_Noir 2 ปีที่แล้ว +4

      The video itself is amazing but I can't stand anymore the endless flow of speech in all the videos these days.
      The 9:43 minutes of footage was covered by 9:40 minutes of uninterrupted speech, that's tiresome

    • @blasiuspolo3836
      @blasiuspolo3836 2 ปีที่แล้ว +4

      THAT'S HANK?!

    • @jessebob325
      @jessebob325 2 ปีที่แล้ว +2

      @@blasiuspolo3836 I know, right? I had listened for months when it suddenly came to me. 😳🤭🍻🥓

  • @cutlerphillippe
    @cutlerphillippe 2 ปีที่แล้ว +163

    As a researcher working with micro-scale imaging, I find these kinds of both beautiful and medically relevant results inspiring.

  • @annajoules3033
    @annajoules3033 2 ปีที่แล้ว +289

    I can’t believe this is the humble zebra Danio that’s so common in aquariums! I’d love to have a print of those photos, they’re truly beautiful 😍

    • @patldennis
      @patldennis 2 ปีที่แล้ว +11

      it's also heavily relied upon in evo devo research (evolutionary developmental bio) as is the Aftican clawed frog which is also common to the aquarium hobby

    • @leogama3422
      @leogama3422 2 ปีที่แล้ว +6

      I think scientists were initially interested in its zebra stripes pattern forming. It eventually became so widespread in labs that was turned into a "model species" for research (the simplest vertebrate of them)

    • @Ghryst
      @Ghryst 2 ปีที่แล้ว

      CTRL + Print Screen, newb

    • @sugatasen1997
      @sugatasen1997 2 ปีที่แล้ว +3

      We find these zebra danios swimming in even the most transient watery rice or paddy fields here in Bengal. They're extremely resilient and active little fish, both in the wild and in aquaria.

  • @KH-mx7bg
    @KH-mx7bg 2 ปีที่แล้ว +41

    Love this video, it's a nice break from microbiology. I use transgenic fluorescent zebrafish for investigating human craniofacial birth defects, so I appreciate a video like this showcasing what we do. When you tell people you're doing genetics work with fish to learn about human disease, it sounds really boring. I'll use this video as a visual aide now.

  • @ariochiv
    @ariochiv 2 ปีที่แล้ว +29

    The choice of colors and contrast reveals some solid artistic sensibility. Congratulations on the recognition to the photographer.
    It's interesting how the lymphatic vessels follow the pattern of the scales down the sides of the body. Makes sense, just not something I would have thought of.

  • @ren3171
    @ren3171 2 ปีที่แล้ว +3

    Im very happy that the researchers anesthetized that fish and got the cross sections via optical means rather than killing the fish to do their research.

  • @animalpeeps
    @animalpeeps 2 ปีที่แล้ว +28

    The 3D model of these images are literally how I (try to) imagine life and the physical world as. Never knew there were these detailed 3D models - I'm seriously so mind-blown!

    • @leogama3422
      @leogama3422 2 ปีที่แล้ว

      For a couple years we have "real time" (time lapses) 3D models of live cells/animals

    • @jamesdriscoll_tmp1515
      @jamesdriscoll_tmp1515 2 ปีที่แล้ว

      The semiconductor industry uses the image stacking technology to examine the test fixtures used to test microchips. The process is actually easy, with a little practice.

  • @ProjectPhysX
    @ProjectPhysX 2 ปีที่แล้ว +65

    I have seen the cut spinal cord of a Zebrafish regrow after 3 days. I have no idea how they do it, but unlike humans they can fully recover their neurons.

    • @LANCEtheBOIL
      @LANCEtheBOIL 2 ปีที่แล้ว +10

      It's not just zebra danios, I do a lot of fishing and have caught multiple species that at one point were literally broken yet survive and are fully functional ( kinda)

  • @driverjayne
    @driverjayne 2 ปีที่แล้ว +83

    Every other creator on the planet should take note that THIS is how you do a sponsor video! Beautifully crafted, relevant to the channel theme AND seamlessly integrated. VERY well done.

    • @LANCEtheBOIL
      @LANCEtheBOIL 2 ปีที่แล้ว +3

      What no " raid shadow legends"

    • @Le_Mouton_Noir
      @Le_Mouton_Noir 2 ปีที่แล้ว +1

      Yeah maybe but matter of fact the 9:43 minutes of uninterrupted speech is tiresome.
      Everybody can make a very nice good quality video but speaking non stop is ruining it, especially when you don't have the voice of Sir David Attenborough's

    • @Stettafire
      @Stettafire 2 ปีที่แล้ว +1

      And no VPN BS

    • @Stettafire
      @Stettafire 2 ปีที่แล้ว +3

      @@Le_Mouton_Noir Dude, you're talking like 9min is a long time.

  • @vlogbrothers
    @vlogbrothers 2 ปีที่แล้ว +24

    This is my kind of party. -John

  • @project.eutopia
    @project.eutopia 2 ปีที่แล้ว +14

    Seeing immune cells moving through lymphatic vessels in real time (7:26) in vivo is absolutely incredible!

  • @scotttod6954
    @scotttod6954 2 ปีที่แล้ว +34

    This is amazing! These people who come up with new ways to see the world are on a whole other level. I am in awe of it.

  • @jessicaclakley3691
    @jessicaclakley3691 2 ปีที่แล้ว +41

    Omg, absolutely stunning!! I couldn’t take my eyes off the gorgeous images

    • @jakobraahauge7299
      @jakobraahauge7299 2 ปีที่แล้ว +3

      Absolutely!
      Had to watch it on the tellie after having a look on my phone 👀
      And Hank has a wonderful voice! So good on some nice loud speakers!
      If you haven't watched the first episodes yet it is absolutely brilliant work, despite the fact that the latest updates on the equipment are wonderful!
      Loads of love from Denmark 🤗

    • @jessicaclakley3691
      @jessicaclakley3691 2 ปีที่แล้ว +1

      @@jakobraahauge7299 I need to watch them on a honest to goodness television! I can only imagine how entrancing they would be considering they cast such a magnificent spell even in small format

    • @jakobraahauge7299
      @jakobraahauge7299 2 ปีที่แล้ว +1

      @@jessicaclakley3691 It's amazing like that! As good as David Attenborough!! 😍

  • @rageraptor7127
    @rageraptor7127 2 ปีที่แล้ว +3

    Something about having so much life on our planet. Knowing it’s in the very soil and air we interact with. I find beautiful.

  • @marisanya
    @marisanya 2 ปีที่แล้ว +12

    I was part of a developmental biology lab recently that used a close relative of Zebrafish, Cichlids, as a way to try and understand monogamous behavior in-situ. By staining certain pathways in Cichlids and then comparing those pathways to Zebrafish's ones and scouting for differences, we're in the early stages of understanding why monogamy might arise physiologically. Zebrafish and their kin have a lot of use in science!

    • @emb7854
      @emb7854 2 ปีที่แล้ว +1

      Hasn't this already been explored with pair bonding vs tournament species?

  • @desmontube
    @desmontube 2 ปีที่แล้ว +3

    This video is a whole experience, I can’t believe how much time my jaw was dropped. Just amazing

  • @Ninth_Penumbra
    @Ninth_Penumbra 2 ปีที่แล้ว +5

    Extraordinary. The aesthetic detail is stunningly gorgeous, but the implications of this imaging technique & all the scientific discoveries captured within this single (composite) microscopic photograph, are wondrous indeed...

  • @hipopickle2216
    @hipopickle2216 2 ปีที่แล้ว +52

    This has to be my favorite video by you, I can't wait to see how your channel will progress overtime, keep up the amazing work

  • @nautilusproducciones1040
    @nautilusproducciones1040 2 ปีที่แล้ว +23

    GREETINGS FROM CHILE - I LOVE YOUR WORK, YOU SAVED MY QUARANTINE. Weed + Journey to the Microcosmos RECOMENDED.

  • @Her_Viscera
    @Her_Viscera 2 ปีที่แล้ว +4

    I have a school of Zebra Danios and I breed them from time to time, they indeed lay eggs when I turn on the lights every morning 😅

  • @runs2288
    @runs2288 2 ปีที่แล้ว +3

    Thank you, Hanks, for the beautiful clip, the sound is tidy, everything But it makes you feel like you are in another world

  • @Cillana
    @Cillana 2 ปีที่แล้ว +1

    0:40 Little kid: "What are those two fishies doing?" Adult: "Uhh... they're dancing... yeah, that's it... 😅"

  • @gamedirection_us
    @gamedirection_us 2 ปีที่แล้ว +4

    I've been watching these videos for weeks now and just now learned this was Hank Green!? WTF, how does this man keep showing up in my TH-cam feed. The true master of science and learning videos of the 2010's!

    • @isakholmgren4973
      @isakholmgren4973 2 ปีที่แล้ว +1

      Same! Felt like a glitch in the matrix

  • @milchesarreal6964
    @milchesarreal6964 2 ปีที่แล้ว +1

    What a marvelous image!
    I honestly never knew that about the humble zebra fish, something so small packed something so extraordinary.
    Science is amazing!

  • @texxstalker
    @texxstalker 2 ปีที่แล้ว +1

    Simply just beautiful. Thank you for the trip Hank!

  • @EmilyJelassi
    @EmilyJelassi 2 ปีที่แล้ว +2

    This picture of the zebra fish is definitely art and is absolutely beautiful!!

  • @areside
    @areside 2 ปีที่แล้ว +1

    I study zebrafish and have worked on similar fluorescent imaging projects...SO awesome to see this research presented so beautifully!

  • @Leeuwver
    @Leeuwver 2 ปีที่แล้ว +2

    As a chef I’d like to see yeast and lacto fermenting bacteria. This channels amazing I love it

  • @ArtemisAndromeda
    @ArtemisAndromeda 2 ปีที่แล้ว

    Not just something new or beautiful, but NEAUTIFUL

  • @mickcarson8504
    @mickcarson8504 2 ปีที่แล้ว

    I love the Zebra Danios. My favourite little darlings in my aquarium. I love also the Cardinal Neon. Beautiful fish that help me healthy.

  • @jakobraahauge7299
    @jakobraahauge7299 2 ปีที่แล้ว +15

    Thank you Hank!
    Lovely voice work - I really do appreciate that! The best thing of Journey to the Microcosmos used to be the beautiful speak, despite the amazing footage, exquisite editing, and intriguing topics! I am glad to hear you give a little ech of those magical first speaks!
    🤗
    And the rest of you - fantastic work! Thank you guys! 😙✨

    • @mrslinkydragon9910
      @mrslinkydragon9910 2 ปีที่แล้ว +3

      I dont like him on scishow, use to but not anymore. way too over the top and obnoxious. Here however 👌

    • @jakobraahauge7299
      @jakobraahauge7299 2 ปีที่แล้ว +1

      @@mrslinkydragon9910 early Journey was just beautiful! Hank branched out to Tik Tok - to bring in a new crew perhaps, or just because life happens and we find new paths
      can't disagree with you tho

  • @glennberry4829
    @glennberry4829 2 ปีที่แล้ว +3

    I'd hoped the competition would get some of the images into public domain so we could legally copy and use them (as, for example a desktop image). It doesn't, so all the competition images are copyright protected unless out of copyright for other reasons. Most photo competitions don't do that, but a few do. Anyone know if a microphotography competition that does?

  • @MaryAnnNytowl
    @MaryAnnNytowl 2 ปีที่แล้ว

    Such beauty just from a small change in the light put on it! Thank you!

  • @Hallands.
    @Hallands. 2 ปีที่แล้ว

    Blown away completely! Did you notice a pair casually mating and spawning at the start of the sequence?

  • @mryellow4633
    @mryellow4633 2 ปีที่แล้ว +1

    Most amazing they didn't add 20 seconds of buffer to make the video 10+ minutes :O I've learned so much from Hank and John Green, it truly shows they are in this to spread knowledge-profit is a side concern.

  • @genexxer1
    @genexxer1 2 ปีที่แล้ว

    Beautiful and beguiling. On the one hand, majesty of creation, on the other, the nefarious possibilities.

    • @BeckBeckGo
      @BeckBeckGo 2 ปีที่แล้ว

      Somebody read Square!

  • @daniell1483
    @daniell1483 ปีที่แล้ว

    The images in this video are simply stunning. From the Nikon photography competition, to the 3d model composed of 2d images, it just reminds me that the future is here today. Seeing a 3d reconstruction of a living organism without invasive imaging just blows my mind, as it is something I'd expect to see in Star Trek or something. Our age has its problems to be sure, but there is no other time in human history I'd rather live in. Scientists from just a century ago would say we've discovered magic; what will we have to say of the people in another century or so?

  • @rgibson7305
    @rgibson7305 2 ปีที่แล้ว +1

    "...for obvious...stripe related reasons." I

  • @CatsAndPokemon
    @CatsAndPokemon 2 ปีที่แล้ว +2

    i am so excited I'm alive right now and able to witness these amazing discoveries..

  • @seaham3d695
    @seaham3d695 2 ปีที่แล้ว +2

    The diatoms!!! Oh my god!!! We need a new video every day! Much love

  • @KessuPutte
    @KessuPutte 2 ปีที่แล้ว

    One of the most gorgeous photos I've ever seen. Absolutely beautiful!

  • @Cosmiccoffeecup
    @Cosmiccoffeecup 2 ปีที่แล้ว +3

    Simply breathtaking.

  • @jefferywise1906
    @jefferywise1906 ปีที่แล้ว

    Excellent presentation, thanks Hank.

  • @lourias
    @lourias 2 ปีที่แล้ว

    SPECTACULAR!!!! The florescence of the Zebra fish was truly moving!

  • @thelaughinghyenas8465
    @thelaughinghyenas8465 2 ปีที่แล้ว

    Such a cool video. Great and relaxing video with such incredible images. I am so glad you got a sponsor like Nikon.

  • @dannileigh6426
    @dannileigh6426 2 ปีที่แล้ว

    Woah! That was so beautiful and awesome in the fullest meaning of the word!

  • @alexandrefurtado3469
    @alexandrefurtado3469 2 ปีที่แล้ว

    Always exceptional. A contribution to humanity - images and content (an aesthetic scientific scholarship - very rare)

  • @mcstabba
    @mcstabba 2 ปีที่แล้ว +2

    I though this was gonna be about the third eye of zebrafishes and the relation to our pineal gland, another time perhaps. This was intresting too! Beutiful images as well.

  • @GGGG_3333
    @GGGG_3333 2 ปีที่แล้ว

    I have been a subscriber for several years now to scishow and (more recently to this channel), but I never could hear Hank's voice in this channel and only realised that it is him after he said it in this video. I am mindblown right now.

  • @FayeFahrenheit
    @FayeFahrenheit 2 ปีที่แล้ว

    These are some of my favorite fish to keep. They are friendly and goofy and fun.

  • @Alien590
    @Alien590 2 ปีที่แล้ว

    It is really awesome to see as I currently work with zebrafish Danio for my master thesis! :)

  • @AndriyAndriyAndriy
    @AndriyAndriyAndriy 2 ปีที่แล้ว

    This is something wonderful, thanks for sharing it with us

  • @WhiffenC
    @WhiffenC 2 ปีที่แล้ว

    Gorgeous work

  • @Darkchylde50
    @Darkchylde50 2 ปีที่แล้ว +1

    I had no idea this was a Hank Green voice over much less video! This version of you compared to TikTok & SciShow is massive! Mind blown! Me gusta 💯😎🔥

  • @beansabina3281
    @beansabina3281 2 ปีที่แล้ว +1

    Nice to hear your calm 'Grown up' voice again: I've missed it!

  • @planetmario
    @planetmario 2 ปีที่แล้ว

    STUNNING

  • @crylune
    @crylune 2 ปีที่แล้ว +1

    I'm so glad I found this channel.

  • @joyglocker8318
    @joyglocker8318 2 ปีที่แล้ว

    I like your style: poetic and beautiful and interesting. Thanks.

  • @1.4142
    @1.4142 2 ปีที่แล้ว

    Art and science go hand in hand.

  • @deathsnitemaresinfullust2269
    @deathsnitemaresinfullust2269 2 ปีที่แล้ว

    😯 That's an Absolutely Brilliant image of a Zebra Fish, no wonder why it won.
    It's just So Amazing.😄👍

  • @bigbrady2244
    @bigbrady2244 2 ปีที่แล้ว

    Perhaps your best video yet

  • @earthborn8385
    @earthborn8385 2 ปีที่แล้ว

    Beautiful and fascinating!

  • @AV1461
    @AV1461 2 ปีที่แล้ว +1

    Can you believe I've been watching this channel for over a year and didn't know this was Hank Green, until he said his name now?! Only then I associated the voice xD. I watched SciShow and CrashCourse for such a long time.

  • @olegh21
    @olegh21 2 ปีที่แล้ว

    Stunning !!!

  • @jenniferbailey2214
    @jenniferbailey2214 2 ปีที่แล้ว

    Excellent!!! 👏

  • @instaperil
    @instaperil 2 ปีที่แล้ว

    Truly breathtaking

  • @RDLondon2023
    @RDLondon2023 2 ปีที่แล้ว

    So cool after Antonie van Leeuwenhoek these microscope videos are still from a lot of Dutch people.

  • @nicholasgarrett8594
    @nicholasgarrett8594 2 ปีที่แล้ว

    I watched the video, and then immediately shared a link with three fellow nerds! Great video!

  • @NORIaquaCh
    @NORIaquaCh 2 ปีที่แล้ว

    This is amazing, thank you ☝️

  • @Troy-ol5fk
    @Troy-ol5fk 2 ปีที่แล้ว

    these scales look so cool

  • @mondraymondo
    @mondraymondo 2 ปีที่แล้ว

    I love these fish, i used to keep them and they happily breed in my tank :) very active and lively too

  • @wagonhopper4155
    @wagonhopper4155 2 ปีที่แล้ว

    This is very cool and I like it, thank you

  • @kmcsciguy
    @kmcsciguy 2 ปีที่แล้ว

    This is incredible

  • @fishhubbd
    @fishhubbd 2 ปีที่แล้ว

    Really Amazing

  • @vithalbhaipatel1013
    @vithalbhaipatel1013 2 ปีที่แล้ว

    Well show. Good information.

  • @gebeleysis
    @gebeleysis 2 ปีที่แล้ว

    This channe is an island of calm in a turbulent internet. Thank you.

  • @GryphonGamerBR
    @GryphonGamerBR 2 ปีที่แล้ว

    That's the most beautiful thing I saw today.

  • @markwoll
    @markwoll 2 ปีที่แล้ว

    Wow, just wow!

  • @PACstove
    @PACstove 2 ปีที่แล้ว +1

    I always wondered if a transparent fish got big enough to fillet, would you grill it up and it would be a clear fish you eat for dinner?

  • @Rambl3On
    @Rambl3On 2 ปีที่แล้ว

    Very interesting video!

  • @japalekhin
    @japalekhin 2 ปีที่แล้ว +1

    0:40 casual "we're just gonna have sex here while you film us" moment.

  • @brendakrieger7000
    @brendakrieger7000 2 ปีที่แล้ว

    Awesome🔬

  • @feepluk0
    @feepluk0 2 ปีที่แล้ว

    Amazing stuff

  • @s.n.8128
    @s.n.8128 2 ปีที่แล้ว

    I honestly had no idea it was Hank Green behind the voice. No wonder i find these videos awesome!

  • @joooooooooooooooo9020
    @joooooooooooooooo9020 2 ปีที่แล้ว

    Amazing !!!

  • @mlgiggleman9786
    @mlgiggleman9786 2 ปีที่แล้ว +1

    Absolutely fascinating. The art appreciation wasn't that important to me, anyway. But the information was incredible. All the different structures revealed were just amazing.

    • @stillnobuddy
      @stillnobuddy 2 ปีที่แล้ว

      Perhaps the beauty of life is what makes it art.

    • @mlgiggleman9786
      @mlgiggleman9786 2 ปีที่แล้ว +1

      @@stillnobuddy Good point!

  • @valerieouellet7725
    @valerieouellet7725 ปีที่แล้ว

    Passionnant !!

  • @technoraptor7778
    @technoraptor7778 2 ปีที่แล้ว

    There you go getting me inspired for art again

  • @gibberishname
    @gibberishname 2 ปีที่แล้ว +1

    so flippin cool

  • @badkarm4
    @badkarm4 2 ปีที่แล้ว

    Thank you sir, they choose a good judge. 👍

  • @vndrevlves
    @vndrevlves 2 ปีที่แล้ว

    So amazing...

  • @_Solaris
    @_Solaris 2 ปีที่แล้ว

    Hank Green narrates this? It's a pleasant change from the usual commercial mania of Scishow.

  • @tamarrajames3590
    @tamarrajames3590 2 ปีที่แล้ว

    Stunningly beautiful.🖤🇨🇦

  • @ansonsmith2930
    @ansonsmith2930 2 ปีที่แล้ว

    Very beautiful.

  • @xzevious69
    @xzevious69 2 ปีที่แล้ว

    Beautiful

  • @benjamintice6400
    @benjamintice6400 ปีที่แล้ว

    Watching in 2022 when we found genes that could regenerate hearing in Zebrafish. Truly in awe of nature.

  • @tatoverde9312
    @tatoverde9312 ปีที่แล้ว +1

    Would you address in one of your shows, the artifacts in fixed microscopy and electron microscopy? Artifacts resulting from physisical/chemical changes as a result of the slide preparation and use of dyes?
    What is the impact of those artifacts on the development of thesis and theories? How to validate them?
    Thank you.

  • @km6832
    @km6832 2 ปีที่แล้ว

    Just found this channel and this is the coolest craziest shit ever

  • @volmyk6196
    @volmyk6196 2 ปีที่แล้ว +2

    you should also check out work of Ertürk Lab from Helmholtz Zentrum München. they developed DISCO clearing techniques to make transparent mice for imaging

    • @limiv5272
      @limiv5272 2 ปีที่แล้ว

      Are the mice bald? I'd imagine the hair gets in the way

    • @volmyk6196
      @volmyk6196 2 ปีที่แล้ว

      @@limiv5272 As I understand, fur must be gone after a mouse is treated with all those solvents. Or they just use furless mice, Im not sure.

  • @yddishmcsquidish3904
    @yddishmcsquidish3904 2 ปีที่แล้ว

    I'm genuinely surprised this channel hasn't hit 1mil yet