ARNI: sacubitril/valsartan. Mechanism of action, dosage, indications, side effects

ARNI (Angiotensin II Receptor Blockers Neprilysin Inhibitors) is new drug class that is used for treatment of the heart failure with reduced ejection fraction. Nowadays, this drug class includes combination of sacubitril and valsartan.
Mechanism of action, side effects, dosage, drugs interactions and more see in this video.