This is a very well organized and descriptive presentation of a seemingly complex process. It can help all levels of education learning Immunology i.e. undegrad, grad, and medical students. Definitely helped me as a grad student! Once again, GREAT JOB!
The MHC I pathway is also essential to antitumor immunity. Just as the immune system views viral proteins as "non-self", peptides derived from mutated genes are also presented on MHC I and will also be viewed as foreign by T cells.
Three clearly defined loci are recognized within the HLA complex for classⅠHLA antigens. The principal role of the CD4 molecule is to promote interaction of T cells with class ⅡHLA molecules on antigen-presenting cells. The MHC genes expressed in the thymus play crucial role in the selection of the T cell receptor repertoire during maturation ?
Great presentation , thank you . Though I wish to ask why would the peptide loading groove have more affinity to the viral peptide than that of a self-peptide ?
I think they don't have a higher affinity per se because self peptides are loaded as well. Therefore we have the negative selection of CD8 cells in the thymus so we don't have self-reactive CTLs...
WOW! THE WONDERS OF GOD!!!! HE SURELY IS EVEN IN THE SMALLEST OF ALL DETAILS! PERFECTION IS NOT A MISTAKE, IT IS THE PRODUCT OF GODS HAND AND INTELLIGENT MIND.
This is a very well organized and descriptive presentation of a seemingly complex process. It can help all levels of education learning Immunology i.e. undegrad, grad, and medical students. Definitely helped me as a grad student!
Once again, GREAT JOB!
Amazing videos like this help us to hav a better notion of how beautiful our Immune System is! Thank you very much for the content!
The MHC I pathway is also essential to antitumor immunity. Just as the immune system views viral proteins as "non-self", peptides derived from mutated genes are also presented on MHC I and will also be viewed as foreign by T cells.
This is incredibly comprehensive. I got goosebumps after watching it!
Nice work. I understand the MHC process much better now. Thanks.
best video about MHC I have ever seen , very helpful
Best Animation+best narrator, good job!
The best medical animation I've ever seen
I wish I could give this video a thousand likes.
Thank you so much for the excellent video!!
Excellent video, thank you so much!
Brilliant explanation...Hats off!
Beautiful animation!
Would have loved a mention of ERAAP, but aside from that still a 10/10.
Absolutely amazing video!
This was amazing. Thank you!
Tq soo much sir.... For this wonderful animation concept
Three clearly defined loci are recognized within the HLA complex for classⅠHLA antigens. The principal role of the CD4 molecule is to promote interaction of T cells with class ⅡHLA molecules on antigen-presenting cells. The MHC genes expressed in the thymus play crucial role in the selection of the T cell receptor repertoire during maturation ?
I LEARNED SO MUCH... YOU TOOK ME VERY VERY DEEP
Into the human cell... 😅
Mind blowing work.
Brilliant. With God, anything is possible. Jesus loves you!
thank you so much for this amazing video.. 👍
Well presented and helped a lot.
Presented it very nicely
Very helpful animation!
Great video... What software did you use in making it?
great video ,presentation of antigen by mhc1 tomorrow begin cell mediated immunity
Great presentation , thank you .
Though I wish to ask why would the peptide loading groove have more affinity to the viral peptide than that of a self-peptide ?
i believe because self peptides do not have the correct conformation and also sometimes the self peptide do not have a chance to be loaded
I think they don't have a higher affinity per se because self peptides are loaded as well. Therefore we have the negative selection of CD8 cells in the thymus so we don't have self-reactive CTLs...
Excelent video! Thank you so much
Excellent animation
I wish there was the same video for MHC class II assembly and presentation.
How are viral peptides different than regular peptides? And also the viral peptide has to have a high affinity?
How was all this discovered? Anyone who can give a link leading to the answer would be of a great help ! :)
That was really good. Thanks
Thanks a lot, nice Video
Wonderful video, thank you!
stunning!
Thanx You saved my ass 👍🏾👍🏾😍😍
very clear explanation, thanks a lot :)
This is excellent.
Great. nice and price explanation
Great video, found the music made it so dramatic (ha made the revision a bit more exciting)
Amazing, thank you!
Loved this !
I need these for every concept in immunology these diagrams are exhausting lol
WOW! THE WONDERS OF GOD!!!! HE SURELY IS EVEN IN THE SMALLEST OF ALL DETAILS! PERFECTION IS NOT A MISTAKE, IT IS THE PRODUCT OF GODS HAND AND INTELLIGENT MIND.
If he's so good then why the f*** are autoimmune diseases and cancer things that exist.
KEEP MAKIN MORE OF THOSE!!! :P
this is so great
no ERAAP or did i miss that?
superb!!
Excellent!
Awesome.
We want more such video's. ....Plzzzzzzzzzzzzzzzzzz
NICE VIDEO, THANKS
Excelente vídeo! :D
Beautiful. Thanks a lot! :D
made so much more sense
thank you!
love it really helpfulllll!!
beautiful :)
thx all
the immune system is some impressive shit!
Perfeito!!!
Thank you
Super
ty. nice;)
Watching the cytotoxic T cell releasing perforin and killing the cell makes me feel sad for the poor cell
❣
تم
I´d like to see this video in portuguese :(
Absolutely fantastic video!
Just perfect . Thanks a lot
❤