When we start using drugs it seems like there is always some sort of side effect. I will just continue using organic food, grassed animal products, food grade organic supplements, and walking every morning. I just turned 70 and it is working for me so far.
Are there studies on what clears out the apopt'ed cells and how successfully the junk is removed? - What or which combo of senolytic and boosted macrophages/phagocytes assures a better mechanism of junk removal or minimizing inflammation. I've heard some 'digestive' enzymes in the circulatory system helps, in some cases, improve circulation/cardiovascular but maybe supplemental senolytics and boosted macrophages can help de-stress diabetes and those induced conditions. Always wondering if subsequent angiogenics, etc could support rerouting/repair of circulation and improved rate of regeneration, resilience ... and who's investigating this?
What is the name of the hypothesis (by Gordon Lithgow) mentioned at the 22m41s mark? Regarding senolytic drugs to kill senescent cells, and the Mayo protocol (20 mg/kg body weight of oral fisetin / Quercetin on two consecutive days and repeating the same dose, one month later), there was a great Munk debate (S02E24) between David Sinclair and Joanna Masel. Joanna suggests aging is impossible to stop and is therefore impossible to reverse...because there are only 2 sides of the same coin.. 1) Increasing number of senescent cells and 2) Increasing tendency for cells to become competitive and therefore cancerous (natural selection leads Rebel Cells to use all the evolutionary tricks to survive and proliferate). David Eagleman suggests that when part of the brain loses function, surrounding areas quickly take up the real-estate. Interestingly, he says the reason we dream is due to all this neuroplasticity.. it keeps the visual processing part of the brain active, so that it doesn't let other parts take over! BTW, it's often said that every species has a 2 million-year run... I wonder if humans will have the same longevity!
2 million-year run for species? Depending how you define species (there is no clarity there): humans can be from 30,000 yrs to 2-3 million years old species.. There is nothing in evolution that would dictate 2 million yrs run, it maybe just some sort of average, which is clearly no applicable to intelligent life, since all other species are now under our control to substantial degree. Your point on Sinclair-Masel debate is interesting, yet - 2-sides of same coin argument (J. Campisi likes it so much) is most likely false. Non-elderly subjects are very well capable of managing the balance or harmonize 2 sides, so- the answer is likely not there.
luteolin also excellent for disrupting the degradation pathway of amp to uric acid in the polyol pathway of fructose metabolism and hence reducing the obesogenic effects. two birds...
Kirkland refuses to answer any of those questions, since he slavishly follows FDA 'guidance', which prohibits him to recommend ANYTHING, until some 15-20 years (or forever) later when 'safety and efficacy' are proven. In this case all his trials will hit dead end (sadly), since they are not vaccines and will never be allowed for approval, since that will interfere with vaccine mafia. Plus - Kirkland himself does not understand any of that (mainstream typical inability to see real world as it is). The answer to your question: most likely post-50 yrs of age. Plus remember: the other lifestyle factors (Kirkland failed to acknowledge them- keto diet, intermittent fasting, fitness etc) are way more impactful than senolytics.
When we start using drugs it seems like there is always some sort of side effect. I will just continue using organic food, grassed animal products, food grade organic supplements, and walking every morning. I just turned 70 and it is working for me so far.
Are there studies on what clears out the apopt'ed cells and how successfully the junk is removed? - What or which combo of senolytic and boosted macrophages/phagocytes assures a better mechanism of junk removal or minimizing inflammation. I've heard some 'digestive' enzymes in the circulatory system helps, in some cases, improve circulation/cardiovascular but maybe supplemental senolytics and boosted macrophages can help de-stress diabetes and those induced conditions.
Always wondering if subsequent angiogenics, etc could support rerouting/repair of circulation and improved rate of regeneration, resilience ... and who's investigating this?
Why didn't you ask him if he himself has tried a therapeutic round of any fisetin.
What is the name of the hypothesis (by Gordon Lithgow) mentioned at the 22m41s mark?
Regarding senolytic drugs to kill senescent cells, and the Mayo protocol (20 mg/kg body weight of oral fisetin / Quercetin on two consecutive days and repeating the same dose, one month later), there was a great Munk debate (S02E24) between David Sinclair and Joanna Masel.
Joanna suggests aging is impossible to stop and is therefore impossible to reverse...because there are only 2 sides of the same coin.. 1) Increasing number of senescent cells and 2) Increasing tendency for cells to become competitive and therefore cancerous (natural selection leads Rebel Cells to use all the evolutionary tricks to survive and proliferate).
David Eagleman suggests that when part of the brain loses function, surrounding areas quickly take up the real-estate. Interestingly, he says the reason we dream is due to all this neuroplasticity.. it keeps the visual processing part of the brain active, so that it doesn't let other parts take over!
BTW, it's often said that every species has a 2 million-year run... I wonder if humans will have the same longevity!
2 million-year run for species? Depending how you define species (there is no clarity there): humans can be from 30,000 yrs to 2-3 million years old species.. There is nothing in evolution that would dictate 2 million yrs run, it maybe just some sort of average, which is clearly no applicable to intelligent life, since all other species are now under our control to substantial degree.
Your point on Sinclair-Masel debate is interesting, yet - 2-sides of same coin argument (J. Campisi likes it so much) is most likely false. Non-elderly subjects are very well capable of managing the balance or harmonize 2 sides, so- the answer is likely not there.
luteolin also excellent for disrupting the degradation pathway of amp to uric acid in the polyol pathway of fructose metabolism and hence reducing the obesogenic effects. two birds...
What about fasting away the senescence.
What age should u use senolytics
Kirkland refuses to answer any of those questions, since he slavishly follows FDA 'guidance', which prohibits him to recommend ANYTHING, until some 15-20 years (or forever) later when 'safety and efficacy' are proven. In this case all his trials will hit dead end (sadly), since they are not vaccines and will never be allowed for approval, since that will interfere with vaccine mafia. Plus - Kirkland himself does not understand any of that (mainstream typical inability to see real world as it is). The answer to your question: most likely post-50 yrs of age. Plus remember: the other lifestyle factors (Kirkland failed to acknowledge them- keto diet, intermittent fasting, fitness etc) are way more impactful than senolytics.
I would listen to Dr. Kirkland’s caution as the senescence is a VERY fundamental component of all biological phenomena…caution is warranted
Do you need senolytics in your 30s?
short answer is no.. unless you got some horrible chemo in the past, which caused you to be deeply damaged..