Immunotherapy in 2022: Provenge, Keytruda, Car-T, and Leukine for Prostate Cancer | Mark Scholz, MD
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- เผยแพร่เมื่อ 29 มิ.ย. 2024
- Medical oncologist, Mark Scholz, MD, answers questions all about immune therapies for prostate cancer. Topics include Provenge (Sipuleucel-T), Keytruda (Pembrolizumab), CAR T-cell therapy, and Leukine (Sargramostim).
0:08 What is immunotherapy in prostate cancer and how does it work?
1:23 Does Provenge have any side effects?
1:44 You've had ten years of experience treating patients with Provenge; how effective has it been in your patients?
3:02 Do you believe in giving Provenge to active surveillance patients? Is it approved for that use?
3:58 Can you explain how Keytruda works in prostate cancer?
5:41 How many patients have you treated with Keytruda and what success have you had with it?
6:15 When do you think Keytruda will get approved for prostate cancer?
6:40 If someone is interested in Keytruda, can any oncologist get them the medication?
7:02 What is CAR T-cell therapy and how will it affect future treatment?
7:59 What is Leukine, how does it work, and what is the side effect profile?
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The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians, for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better individualized care. Feel free to explore our website or call our free helpline at 1 (800) 641-7274 with any questions that you have. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.
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Helpful set of data. Clean, fast paced presentation. Good interaction between the two presenters. Thank you!
Thank you both. I can’t tell you how help supportive these vids are. Thank you. I wish you were in England. X. Hugs to hunter
Very informative. Thank you.
Great information as usual. Ty
Thanks for sharing!
Amazing...
Hello, thanks for great information.
My father, 70y, is diagnosed for prostate cancer 1.5 years ago. Currently on lupron+becalutamide therapy. But his PSA is rose from 1 to 10 this time. Can we go for immunotherapy?
Dr. Scholz,Thank you for your videos, they are a great benefit to understanding prostste health and available options. I'm 76 year old, diagnosed Adenocarcinoma (gleson score 3+4 = 7 involving 18% of specimen, 4 of 6 cores containing cancer. Gleason pattern 4 comprises 5% of the cancer . Cancer length 0,79 cm Grade group 2. Was treated with Lupron 6 month injection September 2021 to reduce prostate size. Current labs. Testosterone 2.3, PSA from 75 to 9.3 Prostate size 130. Was prescribed Orgovyx to further ruduce the prostate and PSA, to be followed by radiation theraphy. Side efects from both treatments were not tolerated well, fatigue factor lingering from lupron, combined with heart palpatations. Orgovyx, was too much. I was switched recently casodex 150 mg. The cancer is confined to the prostate Right Anterior Mid gland. 2nd opinion from JH finds that the cancer pattern ..lacks cribiform morphology. I fell Im being over treated, my body is becoming weaker. Has mild heart valve issues, and on BP medication. Are they any of the newer generation prostate treatments you would recomend if any? Or would I be a candidate for active surveillance? Thank you.
Hello,
Your case is definitely in the grey zone and whether you should do active surveillance or treatment is not obvious. Your doctor should be open and explicit about the risks and benefits of each pathway and integrate your own desires and goals to help you come to a decision. If you have any questions, contact our free helpline at pcri.org/helpline.
@@ThePCRI Thank you for your response. Will follow up with my doctor as suggested. Continue to do well. I hope that you realize how much you and your team is appreciated.
7:48 7:48 😅
@@ThePCRI7:48 7:48 7:48
@@ThePCRI7:48 n i0iyuui
So why can’t someone get immunotherapy at the beginning rather than hormone therapy & chemo? Because of money & insurance companies? What does it cost with & without insurance typically?
Generally, studies with these kinds of agents begin by looking at patients who have run out of proven options, and so Provenge's FDA-approval, and thus insurance coverage, were based on Phase III studies that looked at patients with advanced hormone-refractory disease. In the future, approval and insurance coverage could expand to patients with earlier-stage disease and/or hormone-sensitive disease.
At least initially, in 2010, Provenge was around $90,000, but that could be different now in 2022; you may be able to find out by contacting the company here: www.dendreon.com/Contact-Us. The price with insurance probably depends on the type of insurance the person has, but if a patient has met a deductible, for example, it could be completely covered.
does finasteride lower hemoglobin?
So you talk a lot about treating advanced prostate cancer. But i would like to know how to prevent recurrence after initial treatment of organ confined cancer and as importantly how to prevent the cancer from becoming metastatic? If cancer recurs is it more likely to become metastatic? We have chosen to do focal IRE because it leaves more treatment options if it comes back as IRE can be repeated or radiation can be used. The recurrence is a big risk but not as big a problem as metastasis. How do you prevent the cancer from becoming metastatic?
I got diagnosed last year and was put onto bicludamide then onto zolapex with the intention of following up with radiography. However after 9 months of zopapex I was prescribed 6 sessions of docetaxel. My consultant said I will now have an mri which will determine ( due to tumour size ) if I do indeed need radiography. Is this typical. Can chemo cure me ? Thanks Eddie
Hello,
Feel free to contact our free helpline. We have a patient advocate who will call you and may be able to provide you with some information: pcri.org/helpline
My son mouth tongue cancer 4th stage three kimo now opdyu targeted kimo in Delhi India on 07/4/23 now faces constipation pl let me know why so how can we cure
having 3 or 4 drops of bloob after urnation have had 43 radation treatments for prostate cancer 2018 should I be concered no systems just started 2 days ago 1/31/22
Hello,
Feel free to contact our free helpline. We have a patient advocate who will call you and may be able to provide you with some information: pcri.org/helpline
I'm not clear here. I thought among the mechanisms by which cancer survived was being "invisible" to the immune system.
Side effects are not reported for Provenge. I think pulmonary embolism may be a side effect, but there is no way that I know of to report it.
Provenge