CAR T-cell Therapy: The Good, The Bad and The Long-Term 2022
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- เผยแพร่เมื่อ 23 มิ.ย. 2024
- Summary: CAR T-cell therapy is a new treatment option for patients with acute lymphoblastic leukemia, some lymphomas, and multiple myeloma that have not responded to prior therapies. This presentation describes how CAR T cell therapy works, its risks and side effects, and how these may be effectively managed.
This presentation was made possible, in part, by Kite, a Gilead Company.
Presenter: Michael Tees MD, MPH, Colorado Blood Cancer Institute, part of the Sarah Cannon Cancer Institute at Presbyterian/St. Luke’s Medical Center
Meet the speaker: faculty.mdanderson.org/profil...
To read the transcript, go to: www.bmtinfonet.org/video/2022...
Highlights:
CAR T cell therapy involves removing some of a patient’s T-cells and engineering them to recognize particular cancer cells. These enhanced T-cells are then returned to the patient’s body where they can attack cancer cells.
CAR T therapy can cause cytokine release syndrome leading to fever, lower blood pressure, and shortness of breath. The likelihood of this side effect is high, but its severity varies a lot. There are several treatments for this problem.
CAR T-cell therapy can also cause neurotoxicity or ICANS. The likelihood, severity and symptoms of neurological problems vary with the underlying disease. Neurotoxicity is almost always reversible.
May 3, 2022 Part of the Virtual Celebrating a Second Chance at Life Symposium 2022
Presentation is 39 minutes long with 20 minutes of Q & A.
Key Points:
(07:50): CAR-T cell therapy is currently approved for B-cell acute lymphoblastic leukemia, some lymphomas and multiple myeloma if other treatments have failed.
(09:46): Acute myeloid leukemia, myelofibrosis and some solid tumors are not yet good candidates for CAR T therapy.
(13:23): The correct T-cells must be selected for conversion to CAR T-cells in order to be effective.
(13:42): Viruses are used to insert genetic material into T-cells and convert them to CAR T-cells.
(15:38): Patients with aggressive disease may require bridging therapy to control their disease while CAR T-cells are being created.
(17:41): The major side effects between Day 0 and 28 are infection, cytokine release syndrome and neurotoxicity.
(27:46): After CAR T-cell therapy, “chemo brain” or “brain fog” can affect concentration and short term memory.
(29:45): Low blood counts and ongoing risk of infection are possible late effects of CAR T-cell therapy.
(32:33): Patients do not respond well to the COVID vaccine after CAR T-cell therapy, so precautions against COVID, like wearing a mask for a year, are important.
(33:39): Anti-viral therapy is recommended after CAR T-cell therapy to reduce the risk of shingles.
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Thank you, gentleman!
Thank you for all that information.
As a 66 year old man who is in my second remission for MCL, I will likely have to at least look at Car-T in the future. I have already had R HyerCVAD MTX/ARA C for a frontline therapy and a combination of Ibrutinib ( a BTK inhibiter) + Loncatuximab teserine ( a monoclonal antibody drug conjugate) in a just completed year long clinical trial .
Hopefully I will have a long remission and Car-T will evolve even farther before I'll need to look at it again.
Again thanks!
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I harvest this week at Emory. I pray for a good, long term response.
Thank you for this information. We listened in the car and I sent it to family.
You can visit our website and join our list for info updates www.bmtinfonet.org/subscribe-bmt-infonets-electronic-newsletter . Also, visit us at bmtinfonet.org
Hope you are OK
Unfortunately, CAR t Carvykti didn't work for me.
Since then, November 2022, I have been on Venclexta and it lowered my blood counts to the point of needing several platelet transfusions and hospitalized for red blood transfusions. So, no more Venetoclax.
Then I did Blenrep and it became toxic to me and I went legally blind in my left eye. No more Blenrep.
I've never had an M protein, and my Myeloma is Kappa Free Light Chain Multiple Myeloma. Then my Kappa kept trending up, and thankfully Talvey became FDA approved just in time.
I was hospitalized for a week to do the step up dosing the middle of September, and since then I've had every side effect associated with Talvey. But I'm trying my best to hang in there, as I've done every treatment available for MM. I'm doing this for my little family that means the world to me. The Talvey adventure has been more challenging on my body than any other treatment I've had in the last 10 years, including the 2 stem cell transplants.
I pray that a new treatment will become approved that is tolerable and is a cure for MM. 🙏
Fantastic presentation. Thank you both.
Thank you Dr. Tees. Robin and Rachel Speas.
did not work for my husband, who had MM.
Thank you for sharing this valuable pre, just one more question, where can I download the PPT?
Any application of this treatment for Behçet's disease?
Is cytokine storm is possible fot CAR T cell therapy?
You can read about CAR T therapy on our website: bmtinfonet.org. Pls join our list for info updates www.bmtinfonet.org/subscribe-bmt-infonets-electronic-newsletter .
How about if a person has T cell lymphoma?
You can read about CAR T therapy on our website: bmtinfonet.org. Pls join our list for info updates www.bmtinfonet.org/subscribe-bmt-infonets-electronic-newsletter .