Decoding Parkinson’s Subtypes
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- เผยแพร่เมื่อ 15 ก.ย. 2024
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In this video, Dr. Alberto Espay talks with Polly Dawkins about subtypes of Parkinson’s, the significance of each person's individual biology, clinical trials, and what it will take to cure Parkinson's. You may also find value in our blog post about this webinar: davisphinneyfo...
Keep your eyes peeled for part two of this conversation, in which Dr. Espay answers questions about symptom-based subtypes and more! Click the subscribe button below the video to be notified when we publish this important extension of the conversation you can watch in this video.
More about genetic testing for Parkinson's: davisphinneyfo...
More about the Cincinnati Cohort Biomarker Program, Dr. Espay's study that focuses on expanding precision medicine for Parkinson's: ccbpstudy.com/
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Speaker Bio: Alberto J. Espay, MD, is a movement disorder specialist who practices at the University of Cincinnati's Gardner Center for Parkinson's Disease and Movement Disorders. Dr. Espay currently serves as chair of the Pan American Section of the International Parkinson and Movement Disorders Society (MDS-PAS), and he has published over 350 peer-reviewed articles and 40 book chapters. He has also written 10 books, including Concise Neurology (Lippincott Williams & Wilkins/Wolters Kluwer Health, 2011), with Dr. Jose Biller; Common Movement Disorders Pitfalls (Cambridge University Press, 2012), with Dr. Anthony Lang; and Practical Neurology Visual Review (Lippincott Williams & Wilkins/Wolters Kluwer Health, 2013 [in press]), with Dr. Jose Biller. He has also co-authored a book--Brain Fables--with Benjamin Stecher, who lives with Parkinson's.
This is the explanation I’ve been waiting for. From someone who doesn’t seem to have a stake in his own hypothesis. Please bring Dr. Espay back!!
We have already recorded a follow-up to this conversation with Dr. Espay! Keep your eyes peeled (or better yet, subscribe!) to be notified as soon as we publish it, which will likely be a few weeks from now.
Amazing! Dr. Espay is inspiring in his brilliant and ethical approach to PD. This has been the first time since my diagnosis this spring that i have felt inspired and hopeful! Please bring Dr. Alberto Espay back for further discussion!
Thanks for your comment. We have already recorded a follow-up to this conversation with Dr. Espay. In it, he answers some additional questions from the audience of this webinar. Keep your eyes peeled for that video. It's in our video production queue and we'll have it out as soon as we can!
this neurologist knows his stuff, best discussion I’ve ever heard on the subject of Parkinson’s 😊😊😊😊❤❤❤❤
Well, he’s not going to make too many friends with this video, but what do they say “someone has to speak truth to power?” very well explained and I can’t say that anything here was a big surprise. Bravo for being honest!
Thanks for your message! We are very grateful for Dr. Espay's candor and passion for the wellbeing of all people with Parkinson's. This year marks the 20th anniversary of the Davis Phinney Foundation, and we're fortunate to have had Dr. Espay as a friend of the Foundation since the very beginning.
Of course, please bear in mind that, in keeping with Dr. Espay's message, you have your own experience and circumstances, and you should always consult your own personal care team before making decisions about your treatment plans--including decisions about whether to pursue any diagnostic test or participate in any clinical trial.
Brilliant presentation. Making things clear and understandable. I'm a participant in the Fox Foundation PPMI research. I've had non-motor symptoms for years (I'm 79). I'm now in the "you exhibit parkinsonisms" stage. I wanted to participate in the research to help move the process along.
Hi, I joined the study also after I did the smell test. I do not have any noticeable symptoms and am nearing age 70. I fly up to Ct. to have the DSTAT test 10\124.
This is important information. Eye opening.
If I had to guess, I'd think our speaker is leaning on future discoveries of Parkinsonian susceptability being genetic because he is looking to a mitochondrial placement for the strained connection (in sufferers) between the 'will' or desire to perform a task, and the failure to produce a physical response to satisfy the desired action. The broken link then, moves beyond the brain and cns, to the body in sum. Our poor, sleepy little mitochondria just aren't getting the message!
❤❤Very very interesting.
Great insights
Thank you
Does MSA is a parkinsonism ? A Parkinson subtype or a condition in itself ?
Is there any currency to the idea that a-Syn deposits locally as a means of 'insulating' areas of the brain and cns experiencing 'leakage' of the small charges, or to inhibit an area experiencing excessive output from adjoining areas?
Never answered the question…so what are the subtypes? Everyone is different isn’t an answer
Thanks for your comment and observation. You're right that Dr. Espay does not precisely define the subtypes he sees as most important/significant. Instead, much of the webinar conversation focuses on need to improve our understanding of the biology of Parkinson's to improve our ability to subtype effectively.
We will be releasing a follow-up conversation with Dr. Espay wherein he more directly addresses some of the common ideas about subtyping. We are working to release this video within a few weeks.
I was very disappointed, too. The subject title and the content didn't match at all.
@@sunahamanagai9039 thanks for your reply
With all this uncertainty & lack of knowledge of the subject I’m wondering if you would consider the theory propounded by Sackner-Bernstein that the problem is too much rather than too little dopamine. (Just not getting where it’s needed). One reason why in time levodopa causes more problems.
Dr. Sackner-Bernstein's idea is complex and worthy of thought, but at present much more research is needed to know what the consequences of his treatment proposal might be.
As for whether we would consider the theory: yes, members of our staff and board have been in contact with Dr. Sackner-Bernstein to discuss the theory.
@@davisphinneyfdn Your open-minded willingness to explore all avenues is a great encouragement to me. Thank you!
Why hasn't this been solved already??? We have the advantage of and the researchers losing their jobs because this would be done! I'm disgusted with the inability of people like yourself to come up with a solution that is helpful and any manner regarding Parkinson's there I've said it exclamation for the millions of people who have been diagnosed with this disease there's absolutely no reason why I cannot already been solved.
I believe cortisol related
There is NO reason that the government researchers can’t get necessary funding. 😂
Big Pharma controls the people who control govt. funding
Without a-Syn as a causative, is 'Parkinson's' anything more than a collection of symptoms?
nothing new 😢