Heightened stimulus likely triggers the complex reflexive system where the RAS is capable of driving simple behaviors for which the control systems are primarily subcortical! In those STN damaged individuals, you are driving actions likely through the direct pathway. It is likely that the Direct and the Indirect pathways are simultaneously activated to some extent rather than one or the other. So that they act like opposing muscles to control output. Thus, the damage to the STN makes some essential balance less possible, but it can be overridden with high stimulation driving just the Direct. DBS driving the STN provides an essential smoothing of movement restoring this essential balance. Recall that too much DA can drive impulsivity, making some medicated parkinsonian patients compulsive gamblers. But perhaps in these patient the heightened stimulus is capable of driving a small amount of DA to reach the cortex and drive synchronization/activation. The ACC is also part of the network that registers mismatch negativity and is part of the controls for subsequently triggering more DLPFC DA to increase the executive's ability to switch perspectives, etc... So, no surprise that the circuit is far more complex with more components than spoken of in the video. Note that the D1 (direct) to D2 (indirect) relationship is likely reversed in the DLPFC. Also the right brain which tends to be more about doing is countered by the left brain which tends to be more about expanding the contribution of additional aspects of the context; such as prosody when understanding speech. It would make sense that, for various reasons, the CNS would have ways to slow processing while engaging the environment adaptively.
Really great talk! Pity about the comments re hijab in this feed. However, an a n e doctor woudl know that a gcs of 9 would warrant intubation! So abit wrong to say “I would say get an airway in” you are not the only doctor here.
amazing presentation with great delivery, would like to see more research in neurotheology
Awesome presentation 🙏
Heightened stimulus likely triggers the complex reflexive system where the RAS is capable of driving simple behaviors for which the control systems are primarily subcortical! In those STN damaged individuals, you are driving actions likely through the direct pathway. It is likely that the Direct and the Indirect pathways are simultaneously activated to some extent rather than one or the other. So that they act like opposing muscles to control output. Thus, the damage to the STN makes some essential balance less possible, but it can be overridden with high stimulation driving just the Direct. DBS driving the STN provides an essential smoothing of movement restoring this essential balance. Recall that too much DA can drive impulsivity, making some medicated parkinsonian patients compulsive gamblers. But perhaps in these patient the heightened stimulus is capable of driving a small amount of DA to reach the cortex and drive synchronization/activation. The ACC is also part of the network that registers mismatch negativity and is part of the controls for subsequently triggering more DLPFC DA to increase the executive's ability to switch perspectives, etc... So, no surprise that the circuit is far more complex with more components than spoken of in the video. Note that the D1 (direct) to D2 (indirect) relationship is likely reversed in the DLPFC. Also the right brain which tends to be more about doing is countered by the left brain which tends to be more about expanding the contribution of additional aspects of the context; such as prosody when understanding speech. It would make sense that, for various reasons, the CNS would have ways to slow processing while engaging the environment adaptively.
Great presentation.
Really great talk! Pity about the comments re hijab in this feed. However, an a n e doctor woudl know that a gcs of 9 would warrant intubation! So abit wrong to say “I would say get an airway in” you are not the only doctor here.