Focal Segmental Glomerulosclerosis (FSGS)

It is histologic pattern of glomerulosclerosis.
This lesion is characterized by sclerosis of some, but not all, glomeruli thus, it is focal); and in the affected glomeruli, only a portion of the capillary tuft is involved (thus, it is segmental).
Focal segmental glomerulosclerosis is frequently manifest clinically by the nephrotic syndrome