Membranoproliferative Glomerulonephritis( MPGN)

MPGN is characterized histologically by alterations in the glomerular basement membrane, proliferation of glomerular cells, and leukocyte infiltration.
MPGN either can be associated with other systemic disorders and known etiologic agents (secondary MPGN) or may be idiopathic (primary MPGN

[@MehmetYılmaz-m1b]

Very simplified and given abundant information

[@raghuram4410]

I was struggling to understand this complex topic before finding your video. Great work.

[@dibyasattwakarmakar]

Thank You , Ma'am

[@kuruvimbbs3667]

Awesome explanation mam..tq mam

[@sarahmansoor6173]

I have Mpgn type 1 since I was 9 years old. Now, when it had reclassification of the types, the one i have is considered now to be C3GN.

[@monaoumsara]

Great thank you

[@KNKN-ts3zi]

Mam, you have explained type 2 MPGN is due to activation of alternative pathway leads to excessive C3 and properdin deposition then how come C3 being unidentified in the dense deposition during immunofluorescence.

[@pathologysimplified]

By immunofluorescence C3 will be present focally in basement membrane but not within the dense deposits. And composition of dense deposits is unknown.

[@KNKN-ts3zi]

Thankyou mam