Vitamin K - forms, functions, deficiency, RDA

K1- Phylloquinone- plant source
K2- Menaquinone- intestinal bacteria
K3- Menadione- synthetic
only fat soluble vitamin act as a coenzyme
Biochemical Functions
1. post translational gamma carboxylation of clotting factors II,VII,IX,X
2. Activation of Osteocalcin
3. Activation of protein C and S
Deficiency manifestation
hemorrhagic disease of newborn
RDA- 70-140 microgram

[@pratikpanigrahiofficial7276]

0:19 Introduction
4:22 Principle role of Vitamin K
9:10 Vitamin K cycle
11:40 Required for Activation of Osteocalcin
12:38 RDA
13:05 Sources
13:44 Deficiency
16:31 Toxicity

[@manojkumarp7941]

Thank u man ❤

[@dr.damerayadaiah6699]

Explanation is good,
Vitamin K deficiency causes Hemorrhagic disease of the Newborn ,not Haemolytic disease. Both are different diseases.
Vitamin K deficiency bleeding is Haemorrhagic not Haemolytic,
👍

[@Nani-ng4vq]

It is correctly written in his notes
May be he mistakenly said in this video

[@manukavi5535]

Wow...sir.... Awesome. I did my mbbs in 2003. When i saw your video in 2021, you should have been my biochemistry professor. I would have enjoyed much more. Awesome sir. It's a great service

[@Shy_mh]

I was born in 2003
I'm doing 1st yr MBBS now😂
I'm blessed to have this great teacher 🙏

[@danyalyounas3659]

Same here😂

[@aditista6967]

​@@Shy_mhsame buddy ... gud luck

[@Shy_mh]

@@aditista6967 Wish u same👍

[@doctorfs331]

​@@Shy_mhsame😂

[@cmmr5548]

This is the first video I have found with clear concise information on Vitamin K. Thank you so much!!

[@sahendrapaswan9307]

M up I up I'll up offer tu try to find Tyr let to

[@mrinmayeewarode7943]

Very well explained esp the cycle of vitamin k and functions , also how can vitamin k itself being helping in coagulation act in activation of anti-coagulants activation ?

[@radhakrishnanravichandran534]

Awesome explanation sir....best bchem professor in world ...tq sir 🙏🙏🙏🙏

[@anatomyatitspeak9391]

Lots of respect and thank u so much sir for doing this great work .... spreading knowledge without any money deposit

[@neetasingh2390]

Sir the RDA value of vitamin k in Vasudevan is 50-100mg/day

[@YashikaKapoor-kj3pc]

Sir in satyanaryan it is given that all the three vitamins are napthoquinone derivatives but isoprenoid side chain is present in only K1 and K2 . K3 is also napthoquinone derivative??

[@Kaluvalu129]

Yes k3 is also naphthoquinone derivative

[@stevebh9846]

Plants use K1 for photosynthesis, which is why it always comes with the green parts.
It's not at all clear if the body can use K1 without stripping off the side chain and converting to K2. This goes though K3 in the process (which has no side chain). A lot of K3 is poisonous which is why it is not used in vitamin pills. K1 is used by medicine because it's cheap to make.
The body makes K2 from K1 by stripping off the side chain and putting on another, and the K2 produced always has 4 isoprenes (MK-4). It's done in blood vessel walls, not always bacteria. K2 Mk4 definitely can be used to make gla proteins and clotting and osteocalcin and matrix protein. It's not clear if k1 is a provitamin for K2 or can be used without conversion. In any case you don't need K1.
Bacteria in natto and in the small and large bowel can make at K2 which is MK-4 up to MK-9. MK-7 from natto is often sold. It dissolves in fat and lasts a long time. These vitamin Ks are used by bacteria for the own anaerobic metabolism. I suspect that like K1 they are provitamins and also converted to MK-4 before your body can use it them. All these steps require removal of side chain and sticking on a proper geronyl-geronyl group (4 isoprenes) to get K2 MK4.

[@dro4189]

Your explaining is so good

[@capgains]

You’re beautiful, my lord

[@ghrumbijjar7283]

Sir g very good video all composition became clear

[@jeyabalasingamnitharshan5942]

Thank you sir

[@teamxcolt]

Sir thank u 🙏
Online classes in our college is bad
But ur classes help me understand the topics 🙏 thank u sir

[@MelbourneMaster]

The name Vitamin K from koagulation doesnt stem from german, it stems from the danish word: Koagulering / koagulation. The man who identified vitamin K was the danish chemist Henrik Dam, in 1929.

[@9dushan]

Kamishininoyari you’re wrong

[@MelbourneMaster]

@@9dushan could you elaborate

[@sonalijaiswal7583]

Wrong. It is given in harper and vasudevan. go check.

[@nasimulhoque9443]

Not hemolytic , it shoud be hemorrhagic

[@indragrant7356]

@@nasimulhoque9443very good sir l learn so much thank you do more please

[@elyassarmast]

Thanks for your valuable information and also very good explains regarding vitamin k,

[@ayeshajamali1997]

Sir your videos are very very helpful 😊😊 thank uuu sir for ur efforts

[@deekshashakya4806]

Thank you sir

[@mazharazizramdan6811]

Thank u soo much sir this is the first video that gives me alot of concept about vit k

[@suhanakulsum6900]

Thank you sir. Explained very well👍
With full of clarification.. 😊Thanks again..

[@harshitapandey2924]

Thank you so much sir

[@14th.farana42]

Thank you sir

[@preethi.h9049]

Thank you sir
It's very very helpful
Clearly understand

[@indianspiceswithbhoomika9566]

Thankyou very much sir 🙏 great respect 🙏

[@nitishtrikha5910]

thank you so much Sir !!!! Please keep posting videos

[@sradhakv2359]

Thank you sir
You are a great teacher

[@ANKITKUMAR-ne1ez]

Sir please explain the importance of vit k cycle🙏

[@zainabkhan-yn3qn]

v informative sir . thnks alot

[@AliBhai-gi5kv]

Outstanding ♥ your videos helps a lot

[@nazo437]

Why it leads to hemolytic anemia in newborn, as it does not involved in heme synthesis or RBCs synthesis.

[@070.ravishashwathj.k.9]

I think it is haemorrhagic anaemia

[@shivamchhabra1115]

Nice quesion but it caused due to hypervitamin k when vitamin k amount is more than needed it causes hemolysis of rbc

[@dr.ak4794]

Now date 1/July/2023 views are 184k but likes 4.3k how people can be bad for their teachers.

[@Nani-ng4vq]

Now 21/July/2024 2.4 lakh views and 5.7k likes

[@mazharazizramdan6811]

Sir please make a video on Prostagladins and inflammation
Thanks sir

[@Rajesh_Jambhulkar]

th-cam.com/video/ki74WPJAepg/w-d-xo.html

[@N1986-t2r]

Does anyone know is vit k synthetic aka not real and not safe for babies ? I just want to confirm

[@Gigi-ti8ru]

N 1986 it’s not safe. It’s not a vitamin.

[@afshanyasmeen4182]

Thank youu so much sir for
concise and accurate explanation
On this topic ❤❤❤

[@ghassanauf8103]

I’m suffering with biochemistry ( names, structures , compounds) what should I do , my study is for the dental school not need to be a professor but I need to understand and relay the concepts !!!!

[@lamppostinnarnia]

Thank you, for the information 😊

[@amudhavalli6448]

Super sir 😻😻

[@Shiraz321]

Thanks very informative
best wishes from Canada

[@rampraveshpurbey2099]

Superb lecture sir❤❤❤

[@SalmanAli-zj6ht]

❤️

[@siddheshjadhav7839]

Sir are you from Maharashtra??

[@taaptee]

thank you thank you 🙏🙏

[@drgurpreetsinghsidhu6280]

Well done sir Ji thanks

[@kariatvarit7480]

Thank you so much sir🙏

[@KomalMeena-j3j]

Thank you sir😊😊

[@babymamaz9871]

Is synthetic vit k phytonadione good? I want take megafood vit d k1 k2 supplement but k1 comes as phytonadione

[@nardostadesse827]

10q

[@Zerhun_markos]

great explanation
great respect and love from ETHIOPIA

[@JavanKibet-lv7kw]

[@shivamchhabra1115]

Doing a great job sir 👍👍

[@aayushjain9521]

Very nice Video sir ji

[@lioness5549]

Very well explained! 👏🏻
Easy to Grasp💯

[@UmairKhan...490]

Sir ♥️♥️

[@mahmudulislam4081]

Your lecture is very nice sir.
But please improve your video quality and sound quality.
Thank you so much.

[@22aswathi.g43]

Sooper class

[@tufail7237]

Excellent

[@CarlosOrtiz-ht6rn]

thank you Sir.

[@jayanthkumar967]

Thanks sir🙏

[@zackabdihakim2737]

Thanks Dr

[@durgadevi681]

Thanks ❤️ you

[@ramandetergentpowder9516]

Sir what is a caidrine? means k3?
already used in agriculture.
please sir answer. 🙏

[@drkapilyogi478]

tq sir

[@pediatricmadeeasy7319]

I think its hemorraghic disease of newborn...

[@rushikeshchapaitkar8905]

Sir manadione not used in newborn ...

[@kirankiran2987]

Tq sir

[@aqsashah6238]

Great Job Sir 😊❤

[@shwetasharma3460]

Thanks sir

[@rashtrapaldhupe3547]

Thank u sir

[@gaurabguru5289]

You are not a teacher or Lecturer..........YOU ARE THE GOD 🙏 SIR.....THANK YOU SO MUCH ❤️

[@biswajitkundu2044]

What is Prothombin time??

[@yogeshfarkande7287]

Very nice explanation sir .... Awesome

[@sujarp6099]

Hats off sir🙏

[@oibal60]

K2 = the 'secret' vitamin.

[@ramamohanaraotanuku6077]

You explained just like drinking water from a glass. Great sir.

[@AyeshaKhan-hv4wr]

Can anyone plz plz plz send me the pdf for RAFI MD book... Plzzzzz??!!!

[@missjuly1807]

It's not available

[@AyeshaKhan-hv4wr]

@@missjuly1807 okay mam, thanks!

[@shekhar8385]

Sir plz enumerate Vitamins containing Sulphur?

[@shekhar8385]

@@Enzymes-w8t teri aisi taisi

[@thanujaasalla1414]

Thank you sir

[@sumransinghgurjar2992]

Tq sir

[@asfiyatabassum9411]

Excellent

[@thekrh1375]

Nice sir

[@mirasad717]

👍

[@nidhichoudhary3326]

Good job 👍👍👍

[@40.jagadeeshkancharla97]

Super sir

[@harvendsinghjaggi2451]

👍❤🔥

[@sivasankar372]

Nice explanation. Dr sab, try to use duster

[@RS-pu9ti]

He is using a duster