What Are the New Discoveries in Human Biology? - with Dan Davis
ฝัง
- เผยแพร่เมื่อ 27 พ.ค. 2024
- Recent and dramatic breakthroughs in our understanding of the body will profoundly change the experience of being human in the coming century.
Dan's book "The Secret Body" is available now: geni.us/I185Yg
Watch the Q&A: • Q&A: What Are the New ...
We may soon be eating bespoke diets for our microbiome, taking drugs to improve our brains and genetically modifying our unborn children to prevent disease. Join immunologist Dan Davis as he explores how radical and disconcerting possibilities have been made real thanks to the ingenious technologies and decades-long collaborations of scientists worldwide.
Daniel M. Davis is Professor of Immunology at the University of Manchester and author of two previous books: The Beautiful Cure, shortlisted for the 2018 Royal Society Science Book Prize and a book of the year in The Times, Telegraph and New Scientist, and The Compatibility Gene, longlisted for the 2014 Royal Society Science Book Prize and shortlisted for the Society of Biology Book Prize. His research, using super-resolution microscopy to study the immune system, was listed in Discover magazine as one of the top 100 breakthroughs of the year. He is also the author of over 140 academic papers, collectively cited over 13,000 times, including articles in Nature, Science and Scientific American.
This talk was livestreamed on 6 July 2021.
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Worth every minute I listened. I am not either a scientist or a researcher. I am just the average Joanne who is so grateful that there are enquiring minds always striving to know more
Average Joanne. I've never heard that one 😄 we're forever learners! You don't need an excuse to seek wisdom
To visually see, the smallest machines working in a living cell is a wonderment. The smallest machines in the cell exhibit intelligence and decision making. To actually see them in action in real time is astonishing.
almost like they were intelligently designed
@@MyMy-tv7fdYes, even the individual proteins, especially the enzymes, are a marvel of design. It's so conspicuous, one must actively ignore the obvious to deny it.
"New directions in science are launched by new tools much more often than by new concepts. The effect of a concept-driven revolution is to explain old things in new ways. The effect of a tool-driven revolution is to discover new things that have to be explained." Freeman J. Dyson, Imagined Worlds.
This is a really great quote, thank you!
Nothing like a new tool be ita hammer or a new rail gun
Ewe muôns realize that ewe huemans are cliche clone drone parroting pssiticorum 🦜
That alien analogy works well in every branch of science....what a wonderful way to establish a context for such an engaging lecture...thank you
Right? I thought it was brilliant too!
This though experiment is lifted directly from Carl Sagan's "Cosmos" TV series.
In my dissertation work, I used the non-fluorescent halves of different fluorescent proteins and engineered expression vectors for genes that encoded these appended to target proteins (wt and oncogenic mutant c-Fes kinases) such that the targets would be competent/functional with the attached FP halves, but then when they bind/dimerize/oligomerize to perform phosphorylation-dependent enzymatic activity, then the FP halves would bind as well to become a whole fluorescent protein tagging the target protein dimers! This approach allowed us to observe the action of our targets, localization, quantify dimerization (as a proxy for kinase function in this case as well), etc. Molecular biology is built upon so many tools/techniques that are in and of themselves amazing!
It is too complicated, I cannot understand this paragraphs. It is more for scientists and not laymen like me. I usually do not even try to understand complicated things like this. It sounds impressive though.
Can you translate this into “idiot” for me?
@@jesselucier7251 Probably nobody but professors and their students can understand what he is saying. Presumably the rest of us do not need to read what he says. Or he wants to impress us. Such a paragraph really belongs in a scientific journal, perhaps as an abstract of some research the author did.
Sounds like you made a lighting system to watch what your target protiens do as well: kind of like putting color on a certain component being assembled, and whatever it interacts with in assembly would also light up, highlighting what the target protien did in the process of it's activity within a working part.
Great way to pass an hour.....LEARNING.
This lecture just flew by - always a good sign (for me) and kept me interested throughout - thanks. Love how seemingly unrelated events/discoveries lead to more investigation, experimentation and discovery. Reminds me of that great BBC series Connections.
Uuji
The start was excellent. A good metaphor! Maybe it's the way we understand the world around us. And the way we learn any subject! Thanks for sharing!
How I end of here??? All I know I watched the whole thing!!! Wow great work great video.
Amazing so exciting! Just in time for A BIG REVOLUTION in medicine needed technology is on work! Thank you all good people of our planet!
The best analogy of science ever? I think so.
I really wish I was born 200 years later than I was. I am going to miss all these medical miracles that are coming down the line. The only comfort I do have is knowing that all the kids today, including my 20 yr old triplets and one day grandchild will benefit from healthier and much longer lives. Thank you to all the people who have dedicated their lives to improving the world.
شكرا للجمعية الملكية لتقاسم هذا العرض الممتع، والشكر موصول للباحث وقد أمتع وأحسن اختيار المقدمة كما أجاد في انتقاء الخاتمة.
"The Secret Body" book arrived yesterday, and it was difficult to put down. (Just a warning for anyone thinking of getting it.)
this was fascinating and the personal stories of the scientists was enough fodder for several films
You can hear directly from many of the scientists themselves and their stories, lives, influences, hobbies etc on The Microscopists podcasts (Eric Betzig, Jennifer Lippincott-Schwartz, Marty Chalfie (coming soon) and Dan Davis himself!)
🥰 That end quote!!!!!! Thank you for sharing
Really enjoyed every minute of that, thanks for posting.
Incredibly illuminating!
A truly great talk for the general public. Inspiring. Great many thanks!!
Incredible presentation. These guys are geniuses.
Such admirable people. I am stunned.
Beautiful! Thank You for BEING YOU!
This was absolutely fascinating! One of the best lectures on TH-cam ever; well presented, very enthusiastic, knowledgeable and informative. I look forward to making my choices in the future. (I think!) The quote at the end was superb.
Amazing so exciting! Revolution, A BIG REVOLUTION is finding its technology!
Loved every minute of this talk. Thank you!
Stochastic discoveries and chance contingencies combined with courageous and brilliant thinkers and hard work. Captivating presentation!
Just Awesome! It's inspired me even more to try and get involved in this area
The football analogy is very similar to Feynman's analogy of someone watching two people playing chess without knowing the rules.
Thanks! Love from Sweden
Thank you, sir! Wonderfull video!
thank you Dan keep it coming
Thank you for this lecture. I'm still amazed about origin of those tools.
One of the best Ri talks I've ever seen, thank you!
This is a great talk. Thanks.
Very well done. I liked your analogy with football (soccer) and the microscope to start. As you went on I got more interested and I had to buy the book to learn more. Although I am not a scientist of cells, I am a scientist of knowledge, so your book will add to my knowledge base and maybe a breakthrough for me in certain aspects of my domain.
You mean foosball,,,,
👍
The introduction is a masterclass in how to present, and from then on it’s completely enthralling. So many great science discovery stories seem to be about the people involved, their quirks and coincidences. Really interesting: thank you!
Expected something else, got a surprise, which turned into a delight. I‘ll buy this book tonight.
Amazing and awe-inspiring! Thank you!
Excellent. I am buying the book for more
Brilliant presentation!
Great lecture! we need to promote that football analog as its the best description of science that I've heard since Feynman. and the closing wasn't bad either ;)
You lost the point. It's about acquiring more and more powerful tools for observation and processing of data. In original Carl Sagan's thought experiment it was just aliens and telescope.
@@yanikkunitsin1466 I don't think I did, but if I did, I wouldn't think so. but its just my opinion so feel free to skip.
Sagan's aliens thinking cars are dominant metaphor was a warning about assumptions leading to falsely positive assertions. yes based on the resolution of data. he wasn't expressly describing the method of how we refine our modeling.
The soccer metaphor is more precise. I think better for affirming the scientific method in light of new evidence.
you could have your better tools and higher resolution data, but if you don't see a ball, or ignore it because it doesn't fit the current model, you lose the opportunity to correct course.
as Sagan said the method has a ""built-in error-correcting machine"
How fascinating, a Human Cell Atlas! What an amazing work.
Great talk
Thanks for sharing your experience and thoughts with all of us 👍😀
Nice quote to end on!
Thank You, Good Sir.
GFP is sooooooo important. Huge breakthrough tool.
Excellent lecture!
That was amazing. Thank you so much
Oh, as an animator I really enjoyed your alien-footbal metaphore. It deserves the animation I saw in my head :)
Wonderful 🔥♥️
Great presentation-thanks.
Astonishing!!
Amazing, fascinating lecture
That football stadium describes a relation between two kinds of movement, the linear adding of points, each with a value which can be added to increase that value: the other is a lens like swelling and contracting of the crowd. The stadium is contained in that single object which is the jump up, same object quality amplified, perhaps the will to power gone wrong as a quasi religious endeavour, but balanced by the lens like action of the crowd. This balance is the dissemination of energy into the individual units which also contain those two kinds of movement.
if ya can ever see really deep into the brain, you will eventually find you are in space,inner space witch is just as infinate as outer space, evrything in between which we can see normally is our event horizon.this is what we should nurture and make sure continues so that we can, the inner and outer space will always be there, people wont if we dont ensure the planets well being first or you will run out of time.
Brilliant! Great presentation!
The future is going to be exciting and scary at the same time.
Great technology seems to get weaponized asap in our world.
Thank you!
Governments and militaries try to weaponize everything,,, even drugs ,,,
A wonderful report! Thank you so much! My study is actually on Consciousness, and I know theses things you've shared feed into what I am fascinated with!
Please write down summary of this video if anyone who watched this video completely?
Incredible analogy...
Fascinating!
Thank you that you do this great effort for US who did not know:)))
This is awesome. I am hoping to get a Nobel prize soon myself. Because I know things. 🤔
how very humble of you...
@@NegativSpace-pd6cz thanks, yes 🙌 🥰
I will pray for you!😇
Have you tried using this technology on Type 1 diabetes and why the white cells attacks the cells in the pancreas that produces insulin?
Amazing !!!
very lovely talk, thanks. miss my visits to the Ri
Great talk! Thank you so much!
great talk, thanks
6:00 How good a light microscope could _ever_ be:
In the radiative regime anyway. *near field* microscopes using so-called "superlenses" (which are flat and not actually lens shaped, as it turns out) have in fact been constructed.
The resolution limit shown holds when you are more than a couple wavelengths away from the object.
Theres laser topography. Better than any microscope or MRI.
Thankyou so much
Very interesting, many thanks.
Wonderful!
So...a cell doesn't need the chemistry of the protein or hormone... just the quantum recognition that the hormone/protein hit the net? And the body reacts. The affect of simple recognition.
Is this the tech that brought us all the vaccines that play out a mysterious end run in our bodies, similar to the first move of a chess masters game?
No one knows what that 'end run' looks like, unless they played that very game.
just amzing info
While I can not relate to the football analogy at the beginning of this video, I find the rest of it very interesting.. i am glad that I pushed through the ill placed analogy to try to understand the heart of what you were trying to say.
Football is by far the single most popular sport in the world and is understood by the vast majority of the global population. In this respect it’s a pretty good analogy to use. I’m guessing you’re from the US.
@@alanhenderson9092 That was a good guess, but to be honest, even American football wouldn't be a good analogy for me either. I played one year of it in high school, and had one video game of it years later for the playstation 2 , and only played that to enjoy spending time with the kids I was raising at the time. Just a personal point of view, I found it to be a good video though and am glad to have watched it.
Actually, I just paused it because of the drawn out analogy. After what you say, I'll go on. ;-)
Good ideas!
very fun opener
Green glowing worms would be the ultimate bait for bass fishing! How can I get some?
awesome!!!
awesome! normal smart dude doing incredible micro science. I hope his work gets some decent collaboration. you do realize that's the future of for todays science to advance is cooperation from different fields. good lecture.
Incredibly well presented.
I can see the ball, but why are they treating it so roughly?
Marvelous
This is very interesting. I've since applied this concept to the working of Western governments to see if any of my observations begin to make sense. So far no luck! Maybe I'll get a grant to further my research!
Make our decisions, our choices for our health. Enter mandated procedures.
Right off the bat ,I was thinking of the wrong football. I must be alien here.
I could not find his Nobel Prize end quote on the internet. It would be nice to write it down and post it in images.
Eric Betzig, Nobel Prize speech ending ...
“The last thing I would like to say is about taking risks. People are always exhorted to take risks, and that’s fine, but you’re hearing that from guys whose risks paid off. It’s not a risk unless you fail most of the time, and so what I’d really like to do is I’d like to dedicate my talk to all of the unknown people out there in any walk of life who have gambled their fortunes, their careers and their reputations to try to take a risk but in the end failed. I’d just like to say that they should remember that it’s the struggle itself that is its own reward, and the satisfaction that you knew that you gave everything you had to make the world a better place. “
three issues. cloth merchants used lenses for thread counting before the development of the microscope. Mr Carry Mullis never called his invention a test, it is used for assays. HCoV (I guess high resolution microscopy in the 60's, not the electron microscope?) isn't the same as CoV discovered in battery chicks in the 1930's. As far is i can recall RNA doesn't have proteins? Still no route of infection established.
Could you wrap dry clay or mica dust in the masks, then tap over slide?
Other wise that was an awesome adventure. Didn't notice any editing? If that was one take you can add incredible to awesome.
Excellent
Now that's what I call gain of function; I can't see covid development scientists winning a Nobel prize!
Just read Erwin Chargaff's book "Heraclithian Fire" ...
what are the 'overarching codes'? I get everything else, but that one is a mystery to be revealed
I strongly suspect this is the direct interaction between a healthy mind communicating at cellular level.
If your microscope is only able to register electrical impulses, is it surprising that this is all you will ever see with it? Does this mean that is all there is?
We don't know..as we are limited to what we can see
@@kellytidwell8319 But we know very many things having never seen them. Reason is the source of most all of what we understand even by the things we see, and certainly of the things we know with certainty but either have never seen or which of themselves cannot be seen. The fact that the human person is composed of so many properties which are invisible yet which confer his power to act with purpose should make us reluctant to charge into any rearrangement of the cruder (visible) properties which these invisible properties order in a mysterious and fragile way. I am sure it would be possible to alter the conformation of a human foot into some form easier to shoe, but I certainly doubt that any man can construct a foot which walks better than the one with which we were created.
The plot of cell sorting (about 50:00) is undercompensated for the "label B" flurochrome ;-)
From what I know Robert Hooke competed in this field with Isaac Newton they opposed each other Newton had to publish a book
Aliens could condense this 1 hr into a sentence. " That everything is exactly similar to our visual understanding of a Mandelbrot set".
Aliens are demons and the Father is the only one who saves.
@@missionlightsgrp9187 Father who? Christmas 🎅 that is 🤣 also 👽=👹 that's also 🤣 being the 20th anniversary of the twin towers removed I was concerned about a mushroom explosion from brainwashed ideologists. Keep up the funnies people need more laughter 😉🤣
@@missionlightsgrp9187 gotta be satire
@@teenee4 Maybe one day you'll know the truth whatever it is... Good luck with your self-denial.
Thalidomide wasn't used as a sedative in pregnant women? wasn't it used for morning sickness?
Yes. I taught some of these children more than 50 years ago. The mothers had been in Switzerland when they became preganant. :-(
You didn't mention Van Leeuwenhoek?
Wouldn't attaching GFP to other proteins alter their shape in some way? Would that not result in some change in the behaviour of the protein?
Maybe the GFP protein is very small WRT the other protein.
Like a whiteboard and a pinhead
@@Ragusubedi May be, but in that case when you see the glowing things in microscope you would be seeing only very small part of the whole thing, cause out of the whole whiteboard only the part where the pinhead is, would glow.
Yes, this does happen sometimes. You have to be clever how you attach it to your protein of interest, and some proteins just don't work for one reason or another.
They attach the gfp with a thin linker section like glycine amino acids to put distance between it and the gfp so they can fold independently or something similar.
To be more real, the football inference could have been handled with generations of research into the ‘dark football pitch effect’ .
@ 34:30 the amine on the benzene ring of lenalidomide has a single, not a double, bond.
Dan - totally fascinated. Great lecture. We are an R & D co. applying nanotechnology to water [purification. With molecular identification we could apply same to rogue cells. Want to work with you?