Cancer-busting vaccines are coming: here's how they work
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- เผยแพร่เมื่อ 26 มี.ค. 2024
- Most vaccines work by teaching the immune system to recognize harmful viruses or bacteria before a person gets infected and becomes unwell. A few cancer vaccines do this, too. For example, a vaccine is given to young people as protection against human papillomaviruses that can cause cervical cancer.
But scientists are also developing cancer vaccines that could be used as treatments, after cancer has been found.
These vaccines work by teaching the body's immune system to distinguish between healthy cells and abnormal cancer cells. To do this, researchers need to identify proteins that are made by cancer cells but not by healthy cells. These proteins can be used like a barcode. The vaccine teaches the body's immune cells to 'read' the barcode, as a way of identifying the cancer. This video explains how these vaccines are made, and the pros and cons of various types of cancer vaccine.
Read more here: nature.com/collections/cancer... - วิทยาศาสตร์และเทคโนโลยี
If they work it will be a miracle for mankind!!! My entire family has died of the dreaded C
you will too
I know 3 people who died from the jab
Cancer has been curable since before it was rampant. They died because you use Rockefeller drugs and not God's drugs.
@@piece4philgrim
Oh my god why would you do that? Why would you tell that to a person? Have some kindness@@piece4phil
This would be one of the greatest breakthroughs in medicine history!
So it will be the game of those they harm and those they help.
Just eat fruits & vegetables & juice them, lol
How's the canteen in GCHQ? God sees what you all do..
It doesn't sound like a breakthrough to me when you listen to the science. It sounds like a profitable remarketing scheme to me.
@@elliotpolanco159 What the heck? Don't write nonsense.
Hurray for science! Hurray for scientists!
Le epic based science AMIRITE
Ah yes, the "religion of Science" that needs to be praised.
I say Hurray to the people who made it possible using scientific methods.
I wish im still alive if this comes. I have cancer stage 3
I hope you are too!! Stay strong and hold on!!
i wish you good luck, you'll make it
Have you tried Dr.Thomas Seyfried's metabolic therapy?
Stay strong 💪!! We are rooting for you.
Thank u guys 🥺 but everyday im stress and depress
This is more complicated than show. Every cancer is different, so we have developed vaccines for some cancer, not for others. But this is exciting and everyday we make progress!
i know something the 99% dont lol
@@Igor65361 Cheers bro
Share it or be quiet ya muppet
Very true! And some cancers are directly related to viruses, such as cervical cancer with HPV.
Look up Thomas Seyfried for more info on how the body defends against cancer.
@Igor65361 you have been Occupied, sibling muppet
Amazing progress at molecular level researches! Commonly shared strategy is to help our own body or immune system to combat. That is, scientists get more, wider & deeper knowledge about organisms including ourselves!
Glad to see comments from both sides of the arguments.
Very well illustrated and informative video. There are already some clinics which propose such personnalised treatment for activating dendritic cells. However, the cost is rather high as mentioned. Hopefully, with automation and diffusion this cost will decrease over time.
Short and precise video. Loved the overview and animations of methods used for soon-to-be treatments. 🙌🏼
Science is so awesome
Oh I live in a time to see this....what an honor❤😊
Couldn't the insitu method also trigger auto-immunity? Because radiotherapy will also rupture normal cells and their proteins, exposing them to the activated dendritic cells.
I believe the key here is that the proteins are foreign, but the immune system is unaware of them. Whereas your own cells are not foreign, and therefore the immune system is aware they are friendly and will not attack them.
@@Vnifit but that's the issue with auto immune disorders. The body over reacts to non- foreign proteins and starts attacking normal cells.
@@DeusVult77763 it's the immune system's reaction that is flawed, not the presence of self-proteins per se.
@@DeusVult77763 The mechanism by which autoimmune diseases do damage is complex and I completely understood. Some T-cells in our body are innately self-reactive - they attack and destroy cells of our own body. But that's a good thing - this is something needed in the normal process of healing a wound, for example. There are some other T-cells in the body, which, through mechanisms not yet understood, inhibit the uncontrolled multiplication of self-reactive T-cells. Under circumstances also not yet understood this regulation mechanism breaks down and the self-reactive T-cells multiply out of control - that's when autoimmune diseases manifest themselves. So in order for the autovaccine to cause autoimmune reactions it's not enough that T-cells are trained by dendrites on proteins that occur in healthy cells, it would need to somehow damage the self-reactive T-cells regulation mechanism too. Also, even if activated, dendritic cells are unlikely to acquire normally occurring proteins and then train T-cells on them, very specifically because those proteins are already naturally occurring in the dendritic cells themselves.
As T-cells mature in the thymus gland, they undergo a selection process to ensure they do not target the body's own cells.
There's one thing about this that makes no sense to me: if cancer antigens and neoantigens are already present in the individual's body, why does the immune system not recognise them in the first place? What good does extracting the proteins and reinjecting them do? I feel like this video is missing something out.
Scientific journals need to improve their reputation. Continuing to be given funding from companies (like Moderna in this video) really exposes the conflict of interest.
The content they're showing isn't advocating for anything, they're showing different methods currently being tested
@@danielszekeres8003 They’re not like smaller TH-camrs or even corporate entities who can just take sponsorship money from whoever. They bear a lot more responsibility, imo.
I don’t know if this will ever be released. Too much money in keeping you sick.
Probably only the top 1-10% will use these
@@creatingBurstbruh. Touch grass
The sound effects were so soothing to my ears.
Yeh really great sloshes and zaps and things!
More research required
This is why developing good artificial intelligence is so important
Look up Prof Richard Scolyer. Australian of the Year doing work on the melanoma stuff. He was diagnosed with glioblastoma in 2023, and has had this therapy done with brain tumour. Ten months on (April 2024) he was still cancer free (usually recurs within 6 months). The technology has been advanced incredibly in 12 months.
@@aussie405a singular anecdote can’t be used to show if something works; that’s why they’re randomized trials with every trial failing for a vaccine that cures a cancer (as opposed to prevent)
But nobody is going to take a vaccine for every cancer type out there as there are thousands; at best, ones they’re highly predisposed to or like HPV (which is a virus that leads to cancer mutations rather than being the cancer itself)
Very cool! Thanks for sharing
This would be a breakthrough!
Great video, and very nicely animated as well!
Every single one has failed a trial. There was one that was approved by fda on bad data
How amazing will that be. Would people who have an auto immune disease and cancer be helpless?
Chemotherapy was developed after the gas attacks in the First World War were noticed to attack only specific cells and some modern chemo drugs are still WW1 gases.
Will take it fast
Excellent
You could also help t cells create antibodies to latch onto cancer proteins so they can't attatch
This is how every zombie movie starts.
Car T cell vaccines have been aroround fo a while though. Excellent video - informative and easy to follow.
Car? Maybe killer T cells...
Something great to look forward to in 2085!
It’s simple. Call it Can’tcer
* shakes my head disappointed n slowly but smirking *
But...
"Hyperprogressive disease in lung cancer and other tumors is an urgent clinical issue affecting 1 of 5 patients treated with immune checkpoint inhibitors (ICI), affecting their prognosis and leading to death in a very short time. As the use of immunotherapy increases in the clinic, it is important to understand the intricacies of this new treatment option to optimize treatment approaches."
I hope they are fast with it…
Where does the cancer come from? Covid mRNA vaccines.
Yes, before covid vaccine no one had cancer
Looking promising 😊
Believe this and you will believe anything at all.
I wonder if Priince Charles and Catherine are gettiing this treatment.
Please touch grass
👏🏻 we need this
No. We need to change our lifestyle in first then think what we can do more. The best thing would change organism from organic to metallic or smth else...
I like nature videos because they are very informative.
Agreed! The knowledge and enjoyment I got was unexpected. This should get more views!
Cancers constantly change the rules, most cancer cells will be destroyed but the survivors will come back different.
Everyone wants to live*
"Nanomachines son!" MGS joke or not, nanomachines that live with us and are updated during our life are the end goal in my mind. Theoretically they could make us literally immortal by correcting in real time our genome for example, avoiding the issues and diseases that come with aging. As for these vaccines ever existing I am not so sure, its like nuclear fusion, they are the holy grail, but those that stand to "lose economically" from this, might not adore the idea...
beware of big harma genocides
Although it sounds promising, as with many immunity-triggering treatments, unpredictable variable response (specifically - autoimmunity) is my biggest concern.
Even if that turns out to be an insurmountable risk depending on the cancer someone has it could still be a risk worth taking. An existing treatment might only offer a few months with drastically reduced quality of life. And, while people tend not to talk about it, many cancer treatments have years long or lifelong side effects. I don't want to dismiss autoimmune conditions, I know I don't have one but I've had close friends and family whose lives have been devastated by them, but they might genuinely not be worse than the existing alternatives.
Also this is the kind of cutting edge immune research that might turn out to have knock on discoveries. No guarantee but if scientists can figure out a new mechanism that triggers a novel autoimmune disorder that might lead to a whole new avenue of research. Even just an increase in the number of sufferers could increase awareness and then funding that could lead to new treatments or even cures.
"She'll probably die of autoimmune complications after we give her the drug or surely die of cancer if we dont" - House M.D. (jk)
Unfortunately things like these always take much longer than we hope. So probably another 20-30 years before this becomes effective and available.
interesting!
More good news 🥰
Surprise! This treatment costs one meeeellion dollars!!!
❤❤
Didnt they say this decade ago. Cancer curing stuff.
Nice progress 👍
I hope that effort of similar scale will be done to defeat aging, which currently kills around 3 of 4 humans 😢
You know how much money they are going to make from this?
And i don't know... but i 'm "like sure...." the IA have an idea on certain process... in years of study all data collected then inserted in various IA... FOR SURE various "TIPS" go out. And happy about this... IA have, if used well... all benefits for all mankind and many other.
They cured cancer before GTA6 😭
LOL! Btw, man reached moon faster than F-35 fighter program managed to delive, do u kno? So, such "modern" next level inefficiency is today's norm it seems.
@@aniksamiurrahman6365 I think the weight of progress of our next generation is on our shoulders. We should take responsibility and inspire others. Room for Creativity and fierce competition is a dire need for our World. I think we could soon be in such a condition where there would be a huge boost of productivity due to long term saturation and all decades old research coming to fruition. 👍🏻
Please hurry up my dad is stage 2
I wish your dad good health. I hope you're doing okay.
We are rushing 🕴️
I like first trials
I am Legend ☠️
Amazing video and information. However, the sound effects may be the most triggering and annoying thing I've seen. Why the f would you have them in there?
Can bacteriophages or what their name was kill cancer?
Bacteriophages are viruses that kill bacteria
No, bacteriophages are viruses which attack bacteria. Hence their Name, which is greek for "eating bacteria".
Bacteriophages can be used against bacterial infections, a type of therapy that was investigated in the Soviet Union, today research is still done in Georgia (the country, not the US state) as far as I know.
@@christoffussenegger9377 they meant macrophage
@@christoffussenegger9377 they can target specific cells or something so it would make sense if you could get the most common DNA in the cancer and make the bacteriophages inject self destruct or become normal human cell DNA from the human in the cancer cells.
Edit: Just writing this right after I sent this. You seem to know more about this topic than me but the idea of an organism like phages is very powerful. They could make diseases go extinct as a contagious vaccine but they could be terrible bio weapons. Phages can probably be improved in some way but the idea of them is very useful for someone in the future.
*Blue Lobster Jumpscare.*
Starting price will be 10 million
That's amazing, these vaccines can't come soon enough!
Be ready for a $100 milliin debt that ur descendants will carry on till the year 4024.
Nature is focussing a lot on cancer these days. There was once a video about using nanotechnology to fight cancer.
The 💉 had nanotechnology in it. It’s considered a g e n e therapy. Sorry my comments get deleted. Just look up scientific papers on it.
@@shayalynn No, it's not gene therapy, which is the use of genetic material to treat disease. RNA is not genetic material in humans.
Seriously, don't be a fool. You'll never hear about the stuff that works from the establishment.
Inertia.
it would be hotter than anything if my cancer could bust
Although they're a minority, seeing negative comments surprises me because I expect people who are interested enough to click on this video would have learned basic molecular/cellular biology and immunology.
I'm not encouraging blind faith in the technology outlined in this vid, as nothing is certain yet as per the trials, but if it works it'd be revolutionary! Very excited about the possibilities of human medicine! Peace
Some of these treatments are literally just begging auto immunity to happen 💀 3:13 Wouldn't other cells break and liberate THEIR proteins to be read by our immune system? Sounds risky
Agree, any knowledge and understanding is very important. The normal process is 3:20 mark; Radiation kills cells and eaten cells should produce antibodies through the steps described in the video. But that does not guarentee a robust cancer auto immune reaction where the body actually attacks cancer cells. Normal Immunity process leaves live cells alone, it doesnt attack live cells. Hence the sceptical reactions
In order to work you must specifically target the "eat me" and "dont eat me" expression in cancer cells, like PDL1 expression using PDL1 inhibitor. Like startrek Voyager "shield down"
So a very sophisticated combination of interventions is needed and then standardized through phase I, II,III which unfortunately takes years.
That's totes cooj yo
A moderna advertisement.
thank you. glad to see not everyone here is falling for this propaganda
2007 i am legend
The last approach wouldn't work because radiotherapy affects the capacity of the body to produce immune cells. However, the first approaches look promising!
exciting :)
Will they be "safe and effective" like a certain other recent vax ?
what are the chances of accidentally training the immune system to target healthy cells?
mmmh hmmm
This is what Australian company Imugene is doing.
Why not vaccinate before cancer diagnosis as preventative measure?
Because it will be targeted at the specific cancer you happen to get
Yeah I guess it's because there can be very many different cancers (so barcodes, as shown here), and each different one will need different vaccine setting, so trying to guess what cancer you'll get later is like injecting yourself with a random disease vaccine by just guessing you'll get it and not others later in life.
Wouldn't work for the personalised ones. The video mentions that the non-personalised ones didn't turn out to work as well as expected, but if we can develop working vaccines to common cancers which don't need to be tailored to each specific person's cancer then preventative immunizations could presumably be an option.
:)
Let me guess, graphine oxide?
👏🏼❤️
U can have all
Every one of the negative commenters will be singing a different tune when this saves their lives or that of a loved one.
oh yeah..?? like covid vacc?? no thanks, nature cures all if u do it right, and u do it BEFORE u reach a critical stage...
Dear, scientists. I love what you're doing.......respectfully..........hurry up, pretty please?
Why our government doesn't throw everything behind medical endeavors is beyond me.
Because as unfortunate as it is there two reasons. One they make more money people being sick and relying on medicine to survive. Two they need people to die to keep population lower. That's the world we live in enjoy it. It's also everything else in life.
No way no how!
RIP your majesty
I feel so existed!!!
Click bait
Just hope it's not so costly that only the well to do can afford it 🤞
No one would pay for it. The cure would be free and required
No one would pay for it. The cure would be free and required
Anti vaxxers gonna love this
Dr. Nicholas Klehr was pioneering a method like this about 20 years ago. His work was viciously suppressed and he, himself, was ridiculed, probably because the method was very simple and inexpensive, so that no profit could be made from it.
Profit can be made even if something is cheap to make what the hell are you talking about.
Cancer vaccine, HERE WE COME!
God may help those who help themselves. So do scientists to those who can't by themselves!
No way they are coming when the lobby is there to just… not let that happen. Or maybe they will charge a lot for it?
Rich people die of cancer all the time, and most of the people in power aren't that rich.
Or maybe they don’t work.. so they’ll still not lose future profits from cancer patients.
In vitro vitamin c
كلش كذب مشفنا والو
a lot of this sounds just like the vaccines UCLA has developed, and working to get approved in the U.K.
“The cure for cancer benefits no one”
- Umbrella
Hopefully antivaxxers will refuse these vaccines. Darwin ftw.
I too was thinking that Darwinism will weed out the antivaxxers in regards to this.
Please explain the "mysterious" excess death that keep rising in highly vaxxed countries after the pandemic...
Cancer is not the same as a flu.
You seem to be assuming they'll do more good than harm. Is there any reason to believe that?
I thought the antivaxxers were all already dead from the virus?
Nonsense
More vaccines, more money for big pharma. Cancer could be cured but it would stop the gravey train.
Silly comment. Do you really think there are humans who could 'cure cancer' but don't want to? This is just conspiracy nonsense.
Hope the lab team is careful as to not disappear under mysterious circunstances, as always... 😮💨
Right, an mRNA 'vaccine' for cancer. What could possibly go wrong 😕 ?
Everything
The problem is....the mRNA has no shut off mechanism...youre newly programmed DNA just keeps on doing what its doing, forever. Thats...a big, big problem.
@@rpscorp9457 that’s not how any of it works blud
Great TH-cam censored my comment when I mentioned the truth about Moderna
All comments are erased if are about injured and deads after doses. I am one of the injured...
Cool, just add it to the water
As long as they get placebo controlled safety trials like all other medicines....
they will....cancer treatment is probably one of the most funded medical research topic so far
Why should there not?
Nobody, scientists included, would take it seriously if they weren't.
Of course they will do placebo controlled safety trials, how can you think they won't do this? But before the mass production they'll switch the process completely aka "bite and switch"
Like all other medicines...
If only all other medicines were tested carefully. This is bo longer the case.