Thank you for explanation But why is it indicated to give H2 Blockers in AKI rather than PPI to prevent GI bleeding due to inc serum urea if Cimetididine causes Inc in S.Creatinine levels ?
Thanks but I have a Question Why dobwe say the amount of Urea increases in the Blood in case of AKI because of the reduction of filtration , when at a normal state it will come back to the blood anyway through Absorption ?!
Good question. Although we normally filter 100% of urea from blood into nephron and then reabsorb the urea in the nephron, we do not reabsorb ALL 100% of it. Normally 20-50% of urea ends up being excreted out in urine, which is why our blood urea nitrogen levels normally do not rise as high as they do in AKI(how urea is normally handled is explained more in detail at bottom). In the case of AKI, AKI causes reduction of filtration that leads to less than 100% of urea from blood filtered into nephron, which means more urea will bypass filtration and remain in blood, leading to increased blood urea levels. The reduced filtration will also lead to less urea excretion in nephron due to there being less urea in the nephron from lack of filtration. Hope this helps! Normal urea handling(can google "urea handling" if you want to confirm my info) 100% of urea is normally filtered, 50% of that filtered urea reabsorbed in proximal tubule, 0-30% reabsorbed in medullary collecting duct, 20-50% excreted out in urine.
@Naj Nahar you seem to know this, ~ a month ago my creatinine was 0.95 and my BUN was off the charts on the low end (6). they had it highlighted in red. are my #s good or bad? no one ever got back to me to explain the test results. i'm male, more than 90% of the time my systolic is 100 to 110 and over 90% of the time my diastolic is under 75
I like your straightforward animation.
Thank you. I’ll have to watch when I’m not tired do I can absorb this better. You last It out so well.
Just Amazing work Donev❤
Thank you! That was very helpful.
Absolute carnage of explanation....😳😎
Very Informative! Thank you
Thank you! Great video
excellent ......
informative in such a palatable way
Thank you!
GREAT ONE🥰🥰
THANK YOOOOOU, that was really helpful!!❤️
Thank you so much!
Thank you so much
Thanks for clearing with good concepts
So nice of you
Thanks for the wonderful video😸!!!!
Glad you liked it Emily
Thank you very much
GREAT !!!❤❤❤
very helpful and meany valuable points.
Thank you
Wow wow ❤❤❤
Thanks alot keep going
Thank you 🌷
You’re Very welcome
Thank you for explanation
But why is it indicated to give H2 Blockers in AKI rather than PPI to prevent GI bleeding due to inc serum urea if Cimetididine causes Inc in S.Creatinine levels ?
Thank youu
Thank you so much
I used to be so confused
But now it’s clear to me
🌹 🌹 ❤️
Thank you so much that was helpful
Glad it helped
Thanks 🙏 sir
So what does it mean, having normal BUN levels but elevated serum creatinine?
So wonderful im thankful
Glad it was helpful 😀
@@physiopathopharmaco4190 💕💖
Good very good
Thanks but I have a Question
Why dobwe say the amount of Urea increases in the Blood in case of AKI because of the reduction of filtration , when at a normal state it will come back to the blood anyway through Absorption ?!
Good question. Although we normally filter 100% of urea from blood into nephron and then reabsorb the urea in the nephron, we do not reabsorb ALL 100% of it. Normally 20-50% of urea ends up being excreted out in urine, which is why our blood urea nitrogen levels normally do not rise as high as they do in AKI(how urea is normally handled is explained more in detail at bottom).
In the case of AKI, AKI causes reduction of filtration that leads to less than 100% of urea from blood filtered into nephron, which means more urea will bypass filtration and remain in blood, leading to increased blood urea levels. The reduced filtration will also lead to less urea excretion in nephron due to there being less urea in the nephron from lack of filtration.
Hope this helps!
Normal urea handling(can google "urea handling" if you want to confirm my info)
100% of urea is normally filtered, 50% of that filtered urea reabsorbed in proximal tubule, 0-30% reabsorbed in medullary collecting duct, 20-50% excreted out in urine.
Sir i alwys remains confuse about acid base imbalance and compensation
Wt exactly happen in this
Plz make one video related to this
Sir...so if you have high creatinin lile point 3.
Can we reduce it until normal..? How to do it..? Very thank you..
👏🏻👏🏻👏🏻
Can somebody explain why bun : creatinine ratio is >20 in pre renal an d post renal aki but
Thanks for the video but why are the doctors holding swords? 😂
Just for the fun of it
Tq
why is my cr clearance is always high in my blood test and the creatinine is in the low side?
@Naj Nahar you seem to know this, ~ a month ago my creatinine was 0.95 and my BUN was off the charts on the low end (6). they had it highlighted in red. are my #s good or bad? no one ever got back to me to explain the test results. i'm male, more than 90% of the time my systolic is 100 to 110 and over 90% of the time my diastolic is under 75
My creatinine level is good but urea is high what should i do
thank you so much!!!!
You’re very welcome Nurul - all the best to you.
how can I contact with you my dear ? I have an offer
Yes, it’s pathovideo@gmail.com
Awesome video
Glad it was helpful
thank you ^^
Your Welcome
Please ANYBODY help me understand why my BUN Creatinine is HIGH: 26 and my Creatinine is LOW: 0.47
You are probably dehydrated.
The storage form of creatine is creatine phosphate. True/False
True
A low BUN-to-creatinine ratio 5.7
I believe the arrows in the animation are backwards for reabsorption and secretion.
How is BUN is the amount of urea in blood when normal values of BUN and Blood urea are different? Your video is misleading.
Yes, it should have been said that BUN reflects the amount of urea in the blood.