Gene therapy part 1 : basics of gene therapy

Gene therapy explained. This gene therapy lecture explains the basic principles of gene therapy shomusbiology.w...
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Gene therapy is the use of DNA as a pharmaceutical agent to treat disease. It derives its name from the idea that DNA can be used to supplement or alter genes within an individual's cells as a therapy to treat disease. The most common form of gene therapy involves using DNA that encodes a functional, therapeutic gene to replace a mutated gene. Other forms involve directly correcting a mutation, or using DNA that encodes a therapeutic protein drug (rather than a natural human gene) to provide treatment. In gene therapy, DNA that encodes a therapeutic protein is packaged within a "vector", which is used to get the DNA inside cells within the body. Once inside, the DNA becomes expressed by the cell machinery, resulting in the production of therapeutic protein, which in turn treats the patient's disease.
Gene therapy was first conceptualized in 1972, with the authors urging caution before commencing gene therapy studies in humans.[1] The first FDA-approved gene therapy experiment in the United States occurred in 1990, when Ashanti DeSilva was treated for ADA-SCID.[2] Since then, over 1,700 clinical trials have been conducted using a number of techniques for gene therapy.[3]
Although early clinical failures led many to dismiss gene therapy as over-hyped, clinical successes since 2006 have bolstered new optimism in the promise of gene therapy. These include successful treatment of patients with the retinal disease Leber's congenital amaurosis,[4][5][6][7] X-linked SCID,[8] ADA-SCID,[9] adrenoleukodystrophy,[10] chronic lymphocytic leukemia (CLL),[11] acute lymphocytic leukemia (ALL),[12] multiple myeloma[13] and Parkinson's disease.[14] These recent clinical successes have led to a renewed interest in gene therapy, with several articles in scientific and popular publications calling for continued investment in the field.[15][16]
In 2012, Glybera became the first gene therapy treatment to be approved for clinical use in either Europe or the United States after its endorsement by the European Commission.[17][18] Source of the article published in description is Wikipedia. I am sharing their material. Copyright by original content developers of Wikipedia.
Link- en.wikipedia.or...

[@sarangas8688]

Very very useful sir
But rather than slide presentation, yours white board explanation is very clear 😘😘

[@shomusbiologyofficial]

Thank you

[@professionalkids1742]

S sir

[@dr.ushaghimire1790]

Very nice explanation Shomu.! But Your white board presentation is far more Better and enjoyable as compared to powerpoint presentation.! However, This is also understandable.! Just a feedback.! Don’t take it negatively.! 🙏🙏 Your are the reason I passed my entire Masters ❤ Hearfelt Gratitude 🙏 ❤❤❤

[@shomusbiologyofficial]

Thank you. I stick to my usual board presentation mode

[@AsimDas-ke3li]

দাদা আপনার ক্লাস খুবই হেল্পফুল।😍

[@shomusbiologyofficial]

Thank you

[@juniorjeketera4275]

Pronounce words as it is Sir but it is very clear thank you

[@ankitanaik1705]

Sir, am requesting to can you explain cell and gene therapy

[@bharathsiva5189]

Thanks sir

[@theepicone1174]

Thank-u chomu bro for such a amazing content

[@shomusbiologyofficial]

You're welcome

[@diksha4942]

Parkinson's disease can be cured through gene therapy??
Plz reply me bcoz i have chosen this disease for my assignment on any disease which can be cured through gene therapy .

[@dananjanibandara3029]

Thank you for the great teaching!!!!!

[@shomusbiologyofficial]

Youre welcome

[@JD-nw8cu]

How it is possible to fix gene one by one of all cells of our body

[@shomusbiologyofficial]

Under experimentation and gene therapy didnd work well in most of the cases

[@sangitamondal7108]

Thanks

[@immigrantworld4899]

When is gene therapy for color blindness avaible? I think it is the most soght gene therapy on this planet. It affected over 300 million people and we lost our dreams and we also have been waiting for it for so long time. It was claimed that could cure red green color blindness in monkey in 2009, but till know we dont have clue when it is approved in human trials. Contact lenses or glasess is useless to correct our vision. We hope you proffessors, doctors, biologists and all of medicine expertises., please give us a miracle and spirit when we open our eyes in every morning🙏🙏🙏😭

[@hinasaleem9684]

Sir where's part second
🙄

[@amarmali1195]

Where treatment india ,reply please

[@thisisron7994]

Make the video again ....

[@PinkiSharma-fl9hz]

boxes which are popping up are really irritating.

[@totalfootballke8299]

Pinki Sharma keep calm and get the facts

[@razinshaikh7808]

Please sir can you make this video again

[@shomusbiologyofficial]

Okay

[@knowledgejunction1643]

🌟🌟

[@maizajamil6431]

Plz improve your pronunciation

[@arogyamitra9]

Thanks sir

[@shomusbiologyofficial]

You're welcome

[@arogyamitra9]

@@shomusbiologyofficial when I read gene therapy I can't understand anything but when I saw your presentation sir I understand easily thanks sir

[@ashwanibabbar8828]

Thanks