So very clear and WONDERFUL ANALOGIES--what better way to show antigen recognition and binding than lovers? And the tides in Nova Scotia representing the ebb and flow of the immune response. And all the incidental references to the diseases that are explained by immune overstimulation or exhaustion. What a brilliant and Renaissance man. I need to view this many more times. THANK YOU for making this available
I wonder how Dr. Looney feels about having highest number of views of all channel videos, including more than Dr. Esselstyn (my hero!). I wish both the best.
at 5:05 he mention how t cells get activated in the lymphatics, but a predominant amount of t cells get activated in the thymus and mTECs. I think some treg cells get activated in the periphery such as the lymphatics.
No, they don't permanently release cytokines. That is why you have CTLA-4 to down regulate the response along with IL-10 and TGF-beta. It is a HIGHLY regulated system. However, there are times it does go wrong.
+Eva Gold This is from Robbins textbook: The requirement for CD4 binding explains the selective tropism of the virus for CD4+ T cells and other CD4+ cells, particularly monocytes/macrophages and dendritic cells. Binding to CD4 is not sufficient for infection, however.
Activation energy for any and every cell in the body needs to be monitored and controlled to prevent excessive photon and quantum radiation from passing through or onto the body.
![BOWKYLION - ส่วนต่าง (do it without me) [Official MV]](http://i.ytimg.com/vi/7x-pwcMopzE/mqdefault.jpg)
I just needed to link everything together and this lecture helped me with that, very simple and clear, thank you!!
This video helps a lot! Thank you Dr.John Looney
Seriously well put together video. Top notch!
OMG, TY for this!!!! It summed up perfectly what I needed to understand!!!
Excellent lecture presentation! Thank you!!
Amazing explanation. Clear and informative!
dr. John is a real boss, respect
Thank you for the time to explain this material so well.
So very clear and WONDERFUL ANALOGIES--what better way to show antigen recognition and binding than lovers? And the tides in Nova Scotia representing the ebb and flow of the immune response. And all the incidental references to the diseases that are explained by immune overstimulation or exhaustion. What a brilliant and Renaissance man. I need to view this many more times. THANK YOU for making this available
Very well explained. Helped me to study all these modern therapies like PD1 and CTLA Inhibitors. Thanks!
What an ammazing topic.....This lecture ROCKS!!!
Thank you so much for the great lecture!
Awesome summary and nice examples from culture or nature to keep some point in mind thank you!
A great lecture, thank you so much!
Very helpful, thank you very much!
Excellent! Thank you so much!
Very detailed and well explained
Great explanation!
You save my life tonight, so much thank you
Lol
thanks a lot sir for explaining it all so nicely....
Great job, thank you very much!!
Thank you for this.
Thnk you! Great repetition material!
It was a very good lecture. Thank you sir.
well done! thanks Dr!
This video really help out a lot
great video. really clear and moves really well into what it can mean for future developments. explains why its interesting haha, thanks
GREAT JOB! thanks a lot!
Thanks, it helps a lot.
Excellent talk
This is a fantastic class. Everything explained. The secret of check point inhibitor in oncology revealed
Thank you!
Thanks for this.
Ure so much better at explaining this than my lecturer was. Thank you so much
I watch Twiv (This week in virology) podcast and these mechanisms are discussed a lot. This is very easy to watch, and interesting thanks.
TWIV is good too!
Awesome talk
Very good lecture, thank you !
ayy ;)
thank you!
I wonder how Dr. Looney feels about having highest number of views of all channel videos, including more than Dr. Esselstyn (my hero!). I wish both the best.
Nice talk
this is really helful
fantastic!
Excellent Talk..... Very very clear concepts..!!!
Rashmi Vinayak I thought it was very very very clear, not very very clear, didn’t give it enough credit
Lasers can be used to identify materials that are coorelated with shredding and heating settings on recycling systems.
Gracias , me queda la idea de la complejidad del sistema inmune
Great Talk! Different components of innate and adaptive immunity have been put together in a clear and articulate manner!
Thanks😊
Thankyu very much
Good lecturer
Nice video
It is primarily explanation but we need to connect that with the clinically associated explanation
beautiful
Thanks
I feel that I grasped this better and with ease than the lectures my professor gave through out the whole semester
Love it
A very good explanation but how is a picture of a person indicating HIV
amazing
thanks
I need the conctact with this doctor please.
at 5:05 he mention how t cells get activated in the lymphatics, but a predominant amount of t cells get activated in the thymus and mTECs. I think some treg cells get activated in the periphery such as the lymphatics.
I wish you could help those with celiac disease surely
I am curious about the radioactively contaminated water that Japan is trying to discharge.
This dude has a stellar mustache though, props to him hahaha
Good
How can I download these videos of interest???????
help!!!
Solomon Do you go on google and search how! You’re a smart one! (Sarcasm fully intended)
do activated t-cells PERMANENTLY release Cytokines even though no antigen binds to its T-Cell-receptor???
No, they don't permanently release cytokines. That is why you have CTLA-4 to down regulate the response along with IL-10 and TGF-beta. It is a HIGHLY regulated system. However, there are times it does go wrong.
how do activated T cells know where to go after they have been activated in the lymph node?
chemokines secreted by dendritics cells lead the way towards the infected tissue.
by chemokines ofc
what about infected Mph and DC? Can they make a presentation antigen for T CD8 ? Are there MHC I on DC and Mph or just only MHC II ? Thank you
+Gukan Sakthivel Thank you for answer!
Other one thing surprise me: is it really APC have CD4? For what it?
+Eva Gold thank you ! but very often i read about the HIV infects all CD4+ cells =APC !
+Eva Gold No No CD4 cells are T cell CD8 cells are T cells too both are T cells ! HIV infects T cells!
+kugan svoid Thank you! But why everywhere written about HIV 1 infects Mph by way CD 4 and CCR5?
+Eva Gold
This is from Robbins textbook:
The requirement for CD4 binding explains the selective tropism of the virus
for CD4+ T cells and other CD4+ cells, particularly monocytes/macrophages and dendritic cells.
Binding to CD4 is not sufficient for infection, however.
💗
chemokines!!
Activation energy for any and every cell in the body needs to be monitored and controlled to prevent excessive photon and quantum radiation from passing through or onto the body.
Creatine prevents exhaustion
Good