Adjuvant therapy for high-risk melanoma

Jason J. Luke, MD, FACP, University of Pittsburgh, Pittsburgh, PA, discusses adjuvant therapy for high-risk melanoma. Approved treatments include PD-1 and BRAF inhibitors for stage 3 melanoma. Recent research has shown that stage 2 patients are at a similar level of risk of 5- and 10-year survival to stage 3 patients. KEYNOTE-716 has led the way for PD-1, BRAF, and MEK inhibitors being used in adjuvant therapy for patients with stage 2 melanoma. Dr Luke recommends that future research focuses on how to refine and increase the benefit of adjuvant treatment for these patient populations. This interview took place at the European Society for Medical Oncology (ESMO) 2021 congress.