Vitamin D & CV Events: Mendelian Randomization - Dr. Stephen Burgess (Cambridge (UK)

Based upon his large-scale data from the UK Biobank, EPIC-CVD, VitDSC, Copenhagen City Heart Study (CCHS) and Copenhagen General Population Study (CGPS), which have been published in Lancet Diabetes Endocrinology in early 2024, Dr. Burgess discusses whether or not individuals with low vitamin D plasma levels are at higher risk for cardiovascular events and all-cause death.
Dr. Burgess is a medical statistician at the University of Cambridge, whose main area of research is causal inference and specifically methods for Mendelian randomization: the use of genetic variants to understand whether putative risk factors are causally related to specific disease outcomes.
The interview was recorded on June 24th, 2024.
Moderators: Prof. Dr. Dr. Stephan Schirmer (Kaiserslautern, Germany), Prof. Dr. Florian Custodis (Saarbrücken, Germany) and Prof. Dr. Gunnar Heine (Frankfurt, Germany).
Articles discussed:
Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses.
Emerging Risk Factors Collaboration/EPIC-CVD/Vitamin D Studies Collaboration
Lancet Diabetes Endocrinol 2024
doi: 10.1016/S2213-8587(23)00287-5
Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease.
Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, Gibson H, Gordon D, Copeland T, D'Agostino D, Friedenberg G, Ridge C, Bubes V, Giovannucci EL, Willett WC, Buring JE; VITAL Research Group
N Engl J Med 2019
doi: 10.1056/NEJMoa1809944
Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial.
Hahn J, Cook NR, Alexander EK, Friedman S, Walter J, Bubes V, Kotler G, Lee IM, Manson JE, Costenbader KH.
BMJ 2022
doi: 10.1136/bmj-2021-066452
Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial.
Costenbader KH, Cook NR, Lee IM, Hahn J, Walter J, Bubes V, Kotler G, Yang N, Friedman S, Alexander EK, Manson JE
Arthritis Rheumatol 2024
doi: 10.1002/art.42811
Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline.
Demay MB, Pittas AG, Bikle DD, Diab DL, Kiely ME, Lazaretti-Castro M, Lips P, Mitchell DM, Murad MH, Powers S, Rao SD, Scragg R, Tayek JA, Valent AM, Walsh JME, McCartney CR.
J Clin Endocrinol Metab 2024
doi: 10.1210/clinem/dgae290