Colchicine, Cancer and the Flame Lily (Gloriosa superba)
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- เผยแพร่เมื่อ 10 ก.ย. 2024
- In this, the third episode of our ongoing series on the extraordinary Flame Lily (Gloriosa superba), Gus talks us through some of the medicinal applications of the plant's roots and tubers. Specifically he focuses on the compound colchicine, found in the tuber. Colchicine is already FDA-approved in the treatment of gout, but is currently being explored for its anti-cancer activity. Join us as we delve deeper into the medicinal uses of the Flame Lily.
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For more on the use of colchicine in the treatment of cancer, see:
Lu Y, Chen J, Xiao M, et al. An overview of tubulin inhibitors that interact with the colchicine binding site. Pharm Res 2012; 29:2943-2971
Lin ZY, Wu CC, Chuang YH, et al. Anti-cancer mechanisms of clinically acceptable colchicine concentrations on hepatocellular carcinoma. Life Sci 2013; 93:323-328.
Bhattacharyya B, Panda D, Gupta S, et al. Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin. Med Res Rev 2008; 28:155-183.
Bhattacharya S, Das A, Datta S, Ganguli A and Chakrabarti G: Colchicine induces autophagy and senescence in lung cancer cells at clinically admissible concentration: potential use of colchicine in combination with autophagy inhibitor in cancer therapy. Tumour Biol 2016.
Huang Z, Xu Y and Peng W: Colchicine induces apoptosis in HT29 human colon cancer cells via the AKT and c-Jun N-terminal kinase signaling pathways. Mol Med Rep 12: 5939-5944, 2015.
G. Sivakumar. Colchicine semisynthetics: chemotherapeutics for cancer?. Curr Med Chem. 2013; 20: 892-898.
Colchicine Significantly Reduces Incident Cancer in Gout Male Patients: A 12-Year Cohort Study Ming-Chun Kuo, Shun-Jen Chang, Ming-Chia Hsieh Medicine (Baltimore) 2015 Dec; 94(50): e1570. Published online 2015 Dec 18.
Colchicine: an ancient drug with novel applications
B. Dasgeb, D. Kornreich, K. McGuinn, L. Okon, I. Brownell, D. L. Sackett Br J Dermatol.
Published in final edited form as: Br J Dermatol. 2018 Feb; 178(2): 350-356. Published online 2018 Jan
Lead Phytochemicals for Anticancer Drug Development
Sukhdev Singh, Bhupender Sharma, Shamsher S. Kanwar, Ashok Kumar Front Plant Sci. 2016; 7: 1667. Published online 2016
Anticancer Activity of Natural Compounds from Plant and Marine Environment Anna Lichota, Krzysztof Gwozdzinski
Int J Mol Sci. 2018 Nov; 19(11): 3533. Published online 2018
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Insane how you dont have more recognition. Your videos are so professional and I love that you put references in description. Keep it up!!!
I appreciate that!
Yes! I think so too
I love your content sir
I'll never see Colchicine the same. Thanks for that tidbit.
Colchicine inhibits proliferation of colon cancer cells
As shown in Fig. 1, colchicine significantly inhibited the proliferation of HT-29 cells when the cells were treated with >20 μg/ml colchicine, compared with the control, and the cell viability decreased significantly in a dose-dependent manner.
Amazing medicine to control over active immune system
Thanks for sharing that!
Hello there. I came across this video. thanks for the nice deep dive into the Flame lily. I am A PhD Candidate studying plant biology (with a focus on natural products). I like your description of Clchocine's mode of action. I hope you don't find it rude but I have included a simplification and analogy on how it works (i use it to explain to my students sometimes) 1:47 translation: colchicine acts like a wrench in a chain making the chromosomes go to one or the other daughter 'cells'. Normally the tubulin acts like a chain to pull apart and split the chromosome sets evenly between the two cells. Think kind of like a Christmas cracker where normally both people pull and it snaps (chromosome separation). When colchicine is in the mix it's like when two people pull, but one of the handles gets cut off. in this case, one person is left with a whole cracker (both sets of chromosomes). mind you this really only scratches the surface.
This video was very cool for me. As I am sure you can relate to, there is just something to seeing a plant in its natural habitat, and watching a deep dive into an interesting plant is always fun!
As a random side note, if you come across any members of the Nepeta genus, I would watch that video (i only just found your channel not sure if you've done a video on them.
Wow, thanks for this amazing input. That's really helpful for people to have a better understanding of the way Colchicine works. Much appreciated!
We don't have any indigenous Nepeta in this region, although we do have quite a few others plants in the Lamiaceae family. A particularly interesting one is Hoslundia opposita, which has a wide range of traditional medicinal uses from from the treatment of cataracts, abdominal pain, diarrhoea, sore throat and epilepsy through to snakebite, live disease, mental disturbance and the driving away of evil spirits. A useful plant to be carrying in your pocket then!
@@AfricanPlantHunter never heard of Hoslundia opposita... wow they look so cool weird! i am sure you can relate but i am like, " wow you look like Nepeta cataria only very much not!" (translation you just made me nerd out for a bit so thank you!). My only problem, it doesn't look like seeds are easy to come by in my area (but where there is a will there is a way). thanks for the recommendation (i went straight to google scholar and found some awesome work!)
I was curious about Nepeta in your area because I was working on a literature review on north African Nepeta (pretty much the Mediterranean and parts of Ethiopia). I hadn't found much about nepeta from your neck of the woods which was why I asked (research can only take you so far and all that).
Thanks for everything! ill keep watching and enjoying if you keep the vids coming!
Happy to have been the cause of a nerd out moment. My favourite kinds of moment! I'll keep the vids coming, I promise!
Colchine is actually there as a pharmaceutical drug.
Indeed it is!
Thank you very informative, keep it coming!!!!
Hi there, do you have any videos on how to separate and harvest rhizomes for propagation of more flame lilly plants?? Thank you for a cool video!
Not yet, but thanks for the suggestion!
Love your videos. Shame I'm only finding them now. Was going to propagate Gloriosa here in the UK last year but chickened out knowing the potential risk. Think I 'overthought' it when I threw the bulbs away. Beautiful flowers. Might just give it a go again though the growing season here is so short....the background there makes me wistful...home 😭😭😭
Yes, I agree you probably were overthinking it. Try it this year and see what happens. And remember, home's not going anywhere. Just sitting patiently, waiting for your return.
How poisonous is this plant and what are the symptoms? 🤔
Thanks for the address, Gus! Do you do B and B?