You had me at "Serotonin is not the happiness molecule". I'm the killjoy that always follows that statement up with "Huh.. I guess that means it's the PUKING molecule too". It doesn't make me popular.
Absolutely love your channel, i have read some interesting things about the effects of music and nostalgia on a psychedelic experience, perhaps that could be a topic of another video.
Hi Manesh - awesome video with solid science of therapeutics. Quick Question - (Perhaps I need to watch the video Part 1 again to understand the molecular distribution of the effect psychedelics has on on receptor more specifically S2a.) My question: If LSD creates a "overflow" of glutamate to come extent which results in disorganized regulation/modulation of neurons, would this result in too much upregulation of excitatory neurons and create a stress response such as anxiety?
Hey Manesh, came across you on the Big Truth Podcast. Watched your fMRI in 10 mins video and absolutely loved it. I hope you become a prominent personality in this subject as you've already got dibs on the best name! If I could offer some technical advice, the audio in these two serotonin 2A receptor videos seems to be hitting the upper limit at times and causing a noticeable "buzz". I believe you can avoid this by turning the audio volume down when editing. I'm sure these little things will get ironed out as you grow and the quality of your videos improves. Best of luck and keep it up!
Hey man, very much appreciated! And yes you're right that the audio isn't ideal here. One of the main issues is that the room I record in is very spacious and creates a lot of reverb, which is a pain to deal with and involves compromise. In any case, always looking to to improve - cheers!
great video, thanks a lot!! One question: Near death experiences can shape peoples lives and their perspectives, sometimes shifting them into a more positive and thankful direction. Could this be due to the 5-HT2A receptor?
Excellent presentation. Thank you. In regards to one of your latter points about the psychedelic experience possibly bringing up fearful memories, it seems (in the case of psychedelic-assisted psychotherapy) that the traing of the therapist is paramount to the success of the therapy. That being said, are there any books or training programs that you recommend to therapists that hope to deliver this type of service to their clients?
Does microdosing activate 1A in a degree needed to boost self discipline a little bit? I mean if it’s an inhibitory receptor so it would be easier to stop eating sugar or something like that while microdosing ?
Hey, you have a great channel, I love your work and the way how you explain topics! Could you share your thoughts about DMT as a neurotransmitter? Cheers!
Apart from the essential importance of context (set and setting), there's the idea that challenging/fearful experiences which might be really uncomfortable in the moment can very possibly lead to positive outcomes (greater well--being, reduced anxiety, etc.) down the line. This is the point that short-term and long-term effects can be very different or even opposite. (Although, certainly, having an extremely fearful experience without proper support or resolution can very possibly lead to lasting negative effects - hence the importance of undergoing the experience in a therapeutic context or with a trained and reliable shaman/guide/facilitator).
I have this concept of that the brain tends to reach homeostasis, I mean that leads to reduce the receptors of x if x is often present over the normal.(what makes u tolerant to drugs). Could then happend that with microdosing (for example) that u are increasing always the A2 response (becouse the psicodelic works like an agonist of serotonina on the A2 receptors) the neurons would start producing less A2 receptors for reaching that basal state, and in consequence you would have less A2 response in absence of the substance??
Bro, can you make a video or at least answer here by text and advice me some neuroscience books? I’ve quit university cuz I wanna learn for by myself not spending lots of money to pay for university. I wanna buy books and read read read and write. So, tell me please the most cool books?)
This might be one of the best break downs of serotonin and how it works in the body I've ever heard!
Thank you!!
You had me at "Serotonin is not the happiness molecule". I'm the killjoy that always follows that statement up with "Huh.. I guess that means it's the PUKING molecule too". It doesn't make me popular.
Extremely amazing channel!
Very good job! 🎉
Absolutely love your channel, i have read some interesting things about the effects of music and nostalgia on a psychedelic experience, perhaps that could be a topic of another video.
these two videos have taught me more abut phycadelics than ive ever learn thank you so much we have to get your videos seen.
incredibly clear ✨ thank u sooo very much🫶
Thank you for the time spent researching and filming! 🙏 This series is helpful!
Hi Manesh - awesome video with solid science of therapeutics. Quick Question - (Perhaps I need to watch the video Part 1 again to understand the molecular distribution of the effect psychedelics has on on receptor more specifically S2a.) My question: If LSD creates a "overflow" of glutamate to come extent which results in disorganized regulation/modulation of neurons, would this result in too much upregulation of excitatory neurons and create a stress response such as anxiety?
Brilliant. Incredibly clear and informative. Would love to see you make vids on other major neurotransmitters and receptor families!
My favourite channel. Thanks for the knolwedge
this.is. amazing !!! thanks i love brains and i still learned a lot
Great overview. Thank you.
This was great, thanks!
Hi! Could you talk about the mechanism of atypical antipsychotics vs psychedelics on 5HT2a receptors? Thanks, I really love your channel!
Hey Manesh, came across you on the Big Truth Podcast. Watched your fMRI in 10 mins video and absolutely loved it. I hope you become a prominent personality in this subject as you've already got dibs on the best name! If I could offer some technical advice, the audio in these two serotonin 2A receptor videos seems to be hitting the upper limit at times and causing a noticeable "buzz". I believe you can avoid this by turning the audio volume down when editing. I'm sure these little things will get ironed out as you grow and the quality of your videos improves. Best of luck and keep it up!
Hey man, very much appreciated!
And yes you're right that the audio isn't ideal here. One of the main issues is that the room I record in is very spacious and creates a lot of reverb, which is a pain to deal with and involves compromise. In any case, always looking to to improve - cheers!
great video, thanks a lot!! One question: Near death experiences can shape peoples lives and their perspectives, sometimes shifting them into a more positive and thankful direction. Could this be due to the 5-HT2A receptor?
"Serotonin is NOT the happiness molecule" 😂😂 Thanks for explaining this.
Excellent presentation. Thank you. In regards to one of your latter points about the psychedelic experience possibly bringing up fearful memories, it seems (in the case of psychedelic-assisted psychotherapy) that the traing of the therapist is paramount to the success of the therapy. That being said, are there any books or training programs that you recommend to therapists that hope to deliver this type of service to their clients?
Hey, great video, plenty of in-depth knowledge. Do you know of any supplements that can boost the 1a and 2a receptors?
Thanks 🙏🏻
Does microdosing activate 1A in a degree needed to boost self discipline a little bit? I mean if it’s an inhibitory receptor so it would be easier to stop eating sugar or something like that while microdosing ?
Hey, you have a great channel, I love your work and the way how you explain topics! Could you share your thoughts about DMT as a neurotransmitter? Cheers!
Totally fascinating! Apart from the importance of set and setting, are there other
implications for psychedelic therapy?
Apart from the essential importance of context (set and setting), there's the idea that challenging/fearful experiences which might be really uncomfortable in the moment can very possibly lead to positive outcomes (greater well--being, reduced anxiety, etc.) down the line. This is the point that short-term and long-term effects can be very different or even opposite.
(Although, certainly, having an extremely fearful experience without proper support or resolution can very possibly lead to lasting negative effects - hence the importance of undergoing the experience in a therapeutic context or with a trained and reliable shaman/guide/facilitator).
You're making my brain hurt! ;;;)
I have this concept of that the brain tends to reach homeostasis, I mean that leads to reduce the receptors of x if x is often present over the normal.(what makes u tolerant to drugs). Could then happend that with microdosing (for example) that u are increasing always the A2 response (becouse the psicodelic works like an agonist of serotonina on the A2 receptors) the neurons would start producing less A2 receptors for reaching that basal state, and in consequence you would have less A2 response in absence of the substance??
Hold on, can activation of the 1A receptor help aid in alzheimer’s?
Bro, can you make a video or at least answer here by text and advice me some neuroscience books? I’ve quit university cuz I wanna learn for by myself not spending lots of money to pay for university. I wanna buy books and read read read and write. So, tell me please the most cool books?)
what about the long term effects?