It’s in the blood: a test for Alzheimer’s Disease | Dr Lesley Cheng | TEDxMelbourne
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- เผยแพร่เมื่อ 29 ส.ค. 2016
- Lesley's ground breaking research is a milestone for not only degenerative diseases but health conditions of all types. It's a step towards personalised medicine. Get a glimpse of the future of medicine
Lesley’s work at on Molecular Science involves developing a blood test for the early detection of brain conditions such as Alzheimer’s Disease. She uses basic science, automation, Next-Generation technologies and big data to profile hidden genetic material called "exosomes". Research applications are not limited to disease diagnosis and may be used to understand healthy ageing, develop new therapies and improve health.
This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at ted.com/tedx
Role of biomarkers - There are several widely investigated biomarkers for the molecular and degenerative process of AD that can be supportive of a diagnosis of AD but are not yet recommended for routine diagnostic purposes (table 2) [12]. Such testing can add incremental confidence to a clinical diagnosis of AD, however, and can be useful in certain circumstances, including early-onset dementia and atypical presentations of AD in which the differential diagnosis includes other non-amyloid neurodegenerative diseases such as FTD.
Molecular biomarkers of Aβ protein deposition include:
●Low cerebrospinal fluid (CSF) Aβ42 (or Aβ42:Aβ40 ratio)
●Positive amyloid PET imaging using one of the amyloid PET tracers
Biomarkers of tau deposition (a key component of neurofibrillary tangles) include:
●Increased CSF total tau and phospho-tau
●Tau PET imaging using flortaucipir F-18
In addition to these molecular biomarkers, there are several topographic or neurodegenerative biomarkers used to assess the downstream brain changes that correlate with the regional distribution of neuronal dysfunction and eventual neuronal death associated with AD [150]. These include medial temporal lobe atrophy on MRI and reduced glucose metabolism in the temporoparietal regions on FDG-PET.
Thanks so much. Hope the test is available now.
Early diagnosis is no doubt is a great advancement. It is not just talk but a motivation and hope as well. Fingers crossed for treatment by ultrasound methods
I wonder what had developed since this was recorded? Fascinating work!
Seriously!
What is this test called? My mother was afflicted... and I'm at the age that she was becoming dependent.
My sister has Parkinson's... but so far, I am vigorous, creative, and healthy....
HSV-1 and HSV-2 has been linked to Alzheimer's. After days of awful headaches I already feel less sharp after being exposed. This came after a week of back and neck pain, and shooting pains in arms and legs. Count yourself lucky as I suspect this disease causes a lot of problems people experience as they get older.
Superb...
Thanks for your clear description of the process. Straight to the point..Very exciting time. Can our GP do the blood test.
The name of the test would be helpful
Yes! NAME PLEASE?
We live longer "as an average of population, not overall'. Just 60 years ago as a person surviving to your 80s you would likely survive to 100.The average comes from illnesses at a younger age like infections.
And yet, to my knowledge, the test is still not available..
I looked on the internet and among several companies it is estimated the blood test to be available this year (2022) or 2023.
I found this on the internet:
“The pharmaceutical company Eli Lilly, could distinguish Alzheimer's disease from other neurodegenerative disorders by elevated levels of p-tau217 - and with high accuracy (between 89 and 98 percent). That degree of precision is similar to that of positron emission tomography (PET) imaging and cerebrospinal fluid tests, and superior to other blood tests.
In individuals with a gene causing Alzheimer's disease, higher levels of p-tau217 were detectable 20 years before symptom onset.
"Even though it's not a cure, [this test] would be a huge step forward,” says Sarah Lenz Lock, senior vice president for policy and brain health at AARP and executive director of the AARP-founded Global Council on Brain Health. “I have heard from so many families struggling to get an answer as to what's wrong. Patients and families could really use this to help them plan and cope. This is great news. It puts us on the right path to improve care and help people better manage this chronic disease sooner.”
Blood test could be available in two years
Oskar Hansson, M.D., a researcher from Sweden's Lund University and corresponding author on the JAMA study, says it will likely be another two years before the blood test that he and his colleagues studied is available in doctors’ offices. (Other research groups are testing and developing p-tau217 blood tests as well. Some also presented their findings at AAIC 2020.)
Once there, however, he and Reiman see it being used by specialists to help diagnose individuals experiencing memory problems, and eventually, by primary care physicians as a screening tool - especially if more preventive therapies or interventions for Alzheimer's disease become available.”
What us the name of test in collection manual please. ?
I think it is p-tau217. See my post above
Nearly forgot to watch this.
It’s 2022, the numbers are rising here in USA, I’m caregiver to these patients, wow, it’s spreading and they’re more kinds of Dementia/Alzheimer’s then I can count .
God said do not eat from the tree of life or you will surely die.
Life is in the blood, the second you consume it, death begins inside you.
Shakalaka boom boom
Tortuous gap between title and content. So frustrating
Stop eating so much meat
First
nothing new, just talk, we need to hear cures.
yeah lot of talk and no substance just some DNA mumbo at the end and without correlation to the subject boring rambling
The direful train advisably appear because spring methodologically disappear with a absurd sound. mixed, fluffy print
If you want to relieve the symptoms of Alzheimer's or dementia disease take an eyebrow tweezers and remove the hair follicles from the patients hands, feet, and wrists. This should have an immediate effect on their well being.
What?
@@perfectscotty I second that...wtf??
Sounds like a Scientologist
All flesh consumers, will go madd before dying if they live long enough.