The first complete map of every neuron in an adult fly brain.
ฝัง
- เผยแพร่เมื่อ 1 พ.ย. 2024
- The first wiring diagram of every neuron in an adult brain and the 50 million connections between them has been produced for a fruit fly.
This landmark achievement has been conducted by the FlyWire Consortium, a large international collaboration including researchers from the University of Cambridge, the MRC Laboratory of Molecular Biology in Cambridge, Princeton University, and the University of Vermont.
The researchers say the whole fly brain map is a key first step to completing larger brains. Since the fruit fly is a common tool in research, its brain map can be used to advance our understanding of how neural circuits work.
Dr Gregory Jefferis, from the University of Cambridge and the MRC Laboratory of Molecular Biology, one of the co-leaders of the research, said: “If we want to understand how the brain works, we need a mechanistic understanding of how all the neurons fit together and let you think. For most brains we have no idea how these networks function.
“Flies can do all kinds of complicated things like walk, fly, navigate, and the males sing to the females. Brain wiring diagrams are a first step towards understanding everything we’re interested in - how we control our movement, answer the telephone, or recognise a friend.”
References
Schlegel, P. et al: Whole-brain annotation and multi-connectome cell typing of Drosophila. Nature, Oct 2024. DOI: 10.1038/s41586-024-07686-5
Dorkenwald, S. et al: Neuronal wiring diagram of an adult brain. Nature, Oct 2024. DOI: 10.1038/s41586-024-07558-y
![🔴 ฟุตบอลแชมป์กีฬา 7HD แชมเปียน คัพ 2024 [รอบรองชนะเลิศ]](http://i.ytimg.com/vi/zPm8ClLVhoE/mqdefault.jpg)
fruit fly source code leaked
Every copy of a fruit fly is personalized
@@chamber_hiro256 😱😱😱🪰🪰🪰
You wouldn't download a fruit fly
If fruit, go, else, sad
fly.exe
How far science has come...i remember reading when they mapped 1% of a mouse's neurons and I thought "this is huge".
Mice have ~70 million neurons while a fly has ~130,000
@@ian_mcbridethe video says the fly has 50 million
@@aFerrn no, 50 million connections
@@ian_mcbride Imagine 20 years from now having hyper realistic simulations of animals and possibly humans, I think that would be pretty cool
1% of a mouse's brain has more neurons than a fruit fly, but this is still a very big accomplishment
This is actually crazy…
Mapping brains could help us in insane amounts medically but also in literally every field, this could help computing by showing how to make extremely small neural networks for computers, and how to make parts of computers extremely small or simple.
One step closer to The New World Order and chips in the brain Millions must listen..
… Or what is likely going to happen is people will find a way to construct patterns of their neural maps to target psychological functions more precisely, furthering the algorithmization of our modern world. With every step forward modern science takes, corporatization takes 2 steps back.
Not reading all that
@@leothelion8796It’s one sentence lil man.
Bro really said: "🤓"
I love you, Martha. Please, come back. They're my kids too... I need to see them
Is there already an API to use flies brain and control it ?
Evil pfp
@@herethere5637 they’re glowing
@@manny27392 Light mode user common L 😂😂😂
I hate your profile pic. The black line on it made me think there was a hair
@@TaylorfromPapaLouie same lmaoo
maybe im dumb but i feel like this should be a bigger deal than just some random youtube video with 30k views
Quite often the large public misses on major scientific breakthroughs because the large public is dum
Most people are focused with stuff like Mr beast and the trans phobia shit instead of this
eh
viewing this video is cool but for the vast majority of people, whether we see it or not is utterly irrelevant.
@@whwhwhhwhhhwhdldkjdsnsjsks6544 Still, I'm amazed this isn't all over the news. This is an absurdly huge accomplishment that could be the ground work for truly revolutionary work.
50years from now. The regular house fly brain… has been mapped.
Everyone at that point: 🤯 this changes everything!
this is so huge, yall dont realise the potential this has
Yeah bro we can create high computing supercomputers using this tech
@@soyanshumohapatra exactly. The ones at the top daydream of the day they'll be able to achieve transhumanism in its perfection by developing cyborgs. They'll combine a genetically modified super human brain with a superchip specifically designed for AGI. And boom...
@@zasta7 bro I was just joking I don't know what are you talking about; I just made up some theory
@@soyanshumohapatra me too lol
@@zasta7 😂😂🤣
We got a map of a fly's brain before the map of gta 6
😭
Not the map we needed, but we get what we effin deserve anyway
You funny thing
OH MAH GOD BRO I LEGIT SEE THIS TYPA COMMENT IN EVERY FRICKIN VIDEO I CLICK, GET ORIGINAL BRUH
On the bright side: Now they can put a realistic fly in GTA 6!
Wow, time sure flies like an arrow! Thanks to this research, we may finally understand why fruit flies like bananas....
reading " 'fruit' flies like bananas " gave me a chuckle lol
But will science ever explain why kids love the taste of Cinnamon Toast Crunch?
@@ilikeceral3 sweet cronch be bussin
This is great
What? I don't get it. Fruit flies put their eggs on fruits, because their larvae eat fruits. How is that not known?
One step closer to human neuron mapping
Ainda precisamos aprender a fazer esse mapa "in vivo", sem fatiar o cérebro
One step on a path with infintely many steps, means nothing 😂
@@peamutbubber cmon dude, don't clean up our dreams😅
I’ll finally get to know where my gay thoughts come from.
@@wana2dmaxmax233The Devil
cross section view rotates perfectly so you can't see it
You already rotated the model once. Just let us see the entire cross-section animation please.
0:21 that picture of nikocado
GET OUT
I'm fucking done bruh 💀
Vro.
…
NO
This is the most civilized comment section I've ever seen.
I agree. Never have i ever seen a comment section so tame
The comment right above you makes "yo mama" joke
Skibidi rizz ligma aah yo mama sussy bababooey
Yes. It's uncomfortable. Let's start an argument. I'll go first. "This video shows the wonder of God's creation."
@@Fordnan How can you argue with something so indisputably true
Hopefully this gets us one step closer to solving neural damages/diseases and even make way for full-fledged cybernetic enhancements (perhaps the latter is less of a priority than the former).
If that means they could actually re-wire my brain so I’m not autistic anymore that would be amazing
fck the last one
@@sopwithhannah2401 same but with ADHD.
@@sopwithhannah2401 So real
@@Valgween I have adhd too, it would be so lovely to actually be able to function and get things done lol
if the connectome of a fruitfly is this large..... i cant imagine how long it'll take to make one for a human. has to be massive.
for sure… fruit fly is about 150000 neurons and ours is 100 billion
The word “connectome” in your message was just blue and a small magnifying glass symbol in the top-right of it, when I tapped on it it took me to a youtube search for the word.
I was going to ask how you did that but it doesn’t look like it’s there anymore once I backed out of the search.
@@pixerhp Just TH-cam things. That wasn't the commenter's doing.
3
I'm sure advanced algorithms forged by using this research should help with that... grandiose task.
Can it run doom?
Honestly, putting a house fly in virtual Doom sounds like such blatant disregard for ethics. And I love it.
@@4.0.4 they cause diseases
That would be admitting that living organisms, including humans, are indeed computers and have no soul
Can it play Bad Apple?
@@4.0.4 Flies don’t contribute to society
It looks immensely complicated even for such a relatively simple creature.
Yup! They had millions of years to develop such complexity.
brains are just awesome like that
a neuron is equivalent to about
1,000 transistors, so a cellphone's
10,000,000,000 transistors is about a fifth as many as the fly's
50,000,000 neurons, which is equivalent to about
50,000,000,000 transistors; for scale, a human brain has about
86,000,000,000 neurons, equivalent to about
86,000,000,000,000 transistors
@@LeastNationalistPolebillions*
@@smalinwhere did you get that a neuron is equivalent to that many transistors? If you really want to make a comparison, neurons are like analog "transistors" that handle signals of varying degrees and not just on/off like binary digital transistors. But claiming a 1:1000 ratio sounds like nonsense.
Well camberige if you need a volunteer to map every neuron in my brain count me in. It would be easy; I am only running on 2. Hey this could potentialy help with my two brain cells actually start communicating with each other.
Exactly, I've already mapped my brain out. The current version is just a dot but it might become 2 due to my advanced levels of genius.
@@aggravatedassaultduck Damn, that would mean that you would increase your neuron count by 100%
im running on 1
Where is the part that tells the fly "try to land on this guy's nose while he carries heavy stuff with both of his hands"
All of it
Do you even realise how you think?
Brain is a thing composed of neurons and the firing of neurotransmitters make different kind of imaginations
_It is so unbelievably cool if you think about it_
Can you name 5 off the top of your head and the main pathway they operate in and what they do?
Then some people believe in reincarnation and souls and life forces.😂. It's all brain
@@blazer9547 yeah bro that's so like crazy how people are such fool
@@ValidatingUsername what are you trying to say? I don't know that much English so can you explain in simple language
@@soyanshumohapatrahe probably isn't a native too, as we can only deduce what he tried to say. I think he tried to be a smartass and ask the guy who commented how his brain works. Don't know why tho
One step closer to steaming Rick roll on Brain
*streaming
@@FazedSoulu has got Rick rolled
@@mason228x jokes on you, I love rick roll. Lmao 🤣
My favorite part of the past where you see the slices, then you go behind the brain and lose all of the potential beauty of what you were showing us
I have been waiting my whole life for this moment😂❤! TY
To see the wiring diagram of a fruit flys' brain?
@@MuhammedAasilto see a full wiring diagram of a brain. Some steps behind human brain driagram
@@pedroantonio5031 The guy didnt say he wanted to see that. He said he waited his whole life for _this._ This being what is shown in the video.
@@MuhammedAasil might not be so literal though.
@@Derpalerpa Guy didn't leave much room for anything else. It's not like "this moment" has, for now, any further implications that are guaranteed and extremely far reaching, such that they will further cause OP to be so excited.
Was not expecting fruity pebbles in the fruitful brain, but makes sense 0:28
They finally mapped your moms brain 🤯
meanie :(
MY MOM HAS A BEAUTIFUL BRANE AND YOU SHOULD REPECT IT
As a Millennial from the days of og COD lobbies all I have to say is this...
Proud of you bro! 😂 🥂
@@saccorhytus But does she run Doom? 🤔
Sonovabich, I laughed harder than I should
Oh, you’re a neurologist? Name every fruit fly neuron.
Quite the jump from fully mapping a nematode's neural network
poo
Fun fact: they used ai to help with the mapping of the regions of the brain. Way better use than wasting literally an ocean on ai image slop
Nothing will top the AI Mario video where he becomes a doctor and saves Luigi from a life-threatening disease after he slips on a banana peel.
This is just my best friend's brain scan
Crazy how I'm studying about DTI's and Brain Mapping and this just drops.
Brain trying to understand brain: 🗿
This bout to be the next meme candidate
Finally! You had no idea how long I've been waiting for this (I have no idea this was even a thing).
a whole new meaning to fly by wire
Now can you take that map, and create a simulated representation of a house fly with house fly behavior, or a computer chip version of it? Or is the way a brain is “wired” fundamentally different than we can simulate or construct?
Nice! Halfway to all species!
It’s amazing just how small flies are with a brain that is so complex. Life is truly fascinating.
Oxford has been real quiet since this dropped🔥
Could they stimulate the mapping of the brain by simulating sensory signals, and if so, would the mapping technically become conscious?
A Fly Swatter can obliterate it within nonoseconds.
"From the surface to the intricate neuroal network to the FlyWire connectone to the stunning 3D detail"🗣🗣🗣🔥🔥🔥🔥🔥
"to control our movement, answer the telephone, or recognize a friend"
That sounds so quaint, like an example Feynman would give.
I wonder, it doesn't seem like that many neurons. You could probably run a fly Matrix with a single gaming GPU. It's wild to imagine, at some point it might be a small pet, then a larger one, and then....
more importantly can we run doom on the fly
@@Valgween I assume this research means you can replicate a fly's brain in a computer, not the other way around.
@@4.0.4 yes I know what I meant is that I wonder if the map is going to give us enough knowledge to figure out whether or not the Flies brain has enough processing power to run Doom
@@Valgween I don't think you could even store Doom, let alone run it. Consider that nobody managed to store Doom on an LLM yet (I'm aware of the diffusion model one, it's not really the game either)
It looks cool. That looks really cool.
It could explain why they keep running into the wall whenever the door is wide open.
One step closer to the human connectome project
And two for the human instrumentality project
@@thetas-soundsAtleast I'll get to jack off to ramiel in person 😮💨
One and a half to get in the damn robot
Adapted from xkcd 2977:
"Finally, a map of EVERY neuron!"
Y'all this is huge, I dont realize the potential this has
what if even the scientist dont. ther inventor of the transistor perhaps never imagined the internet.
SOMA when?
We should probably start backing up our brains, just in case
Eclipse Phase RPG
Everyone has a brain digitalizer im the cortex for "backup"
Im more amazed by the fact that an insect even has a brain.
Congrats! How was that mapped though, and how long? 50 million connections for that tiny brain. Wow.
Now compare that to 86 billion neurons (2,000 times more than the fly) for a human brain.
We've come a long way but we've got a long way to go
@@andreybushev3020The neurons are the easy part. It’s the hundred trillion connections between them all that will be tricky.
The brain was the size of a pinhead, and they used a thin razor blade to slice it like 3000 times in thinner slices! Then used AI to connect all those tiny neurones together and make a 3d image
@@rarra world's most expensive carpaccio
@@andreybushev3020 and the most disgusting
I wonder if this is going to be like how mapping the entire human genome took a really long time at first but now we can get it done for multiple people within a week…
"there's a fly in my robot"
I swear we've had this for a while, I'm waiting for the mouse brain.
When you see something as seemingly insignificant as a fly, pause and recognize that all life is extraordinary. We often shrink it down to words and thoughts that barely touch the true wonder of reality. And if you ever feel insignificant yourself, remember: you are infinitely complex. Just by existing, you're one of the most remarkable things in the universe.
Brains wondering how a brain. Such a brain classic
We can finally make a simulation of a bunch of flies in a virtual box, exciting!
if you were to do that your pc would be melting with 249k+ neurons all firing
yeah I don't think you can just "run a simulation" of the whole brain like that
@@AsherKadmiel not really, a high end GPU can process billions of neurons with decent speed, at least artificial ones.
@@4.0.4 Any data on that or did you pulled that out of thin air?
Having a connectome is not enough for simulating brain. There are still the biochemical environment of the neurons, dendritic properties, external input, synaptic weight and plasticity, temporal dynamics and the 50 other things we don't know about yet.
the only computer bug you should never delete
It's nice to see how intricate its innards are, hard to get an idea of that when I smash them into pulp.
i was scrolling youtube at night and when this popped up in my feed i thought a real fly landed on my phone i genuinely freaked out
I have also done a long-term clinical study on fruit flies. Well for the last 3 months since I last cleaned my dishes.
Fruit flies are very adept at avoiding being squashed with fast slaps, either with one hand against a hard surface or between two hands. Much more so than mosquitoes in my experience.
I am looking forward to how this willl advance in 10 years
Nothing
It's very exciting! A key step to understanding the human brain
damnn, it'd eventually have a huge impact on studying nueral connectivity, great work
Beautiful work of the most intelligent people on this planet, surely it won't be a subject of funding the project by big conglomerates so they can use it to make more money in the future, am I right?
0:26 those solid colored cords hanging out the back fascinating they Look awfully familiar 😮
And yet, the flies are dumber than a box of rocks-
I guess size matters after all.
@@yusufcoskun7914 butt
@@yusufcoskun7914 eh, crows are pretty smart
as a fly im offended
that fly has more brain cells than me 💀
underrated video
This is an early but major step toward the singularity
i wanna come back to this video a few years from now and see what cool inventions people will be talking about in the comments that came from this
Behold: the most unoptimized computer to successfully exist
Ok, may I have the instruction set for a fly brain please?
does this mean we can now perfectly predict fruitfly behavior exactly? if so this is HUGE news and im excited
The colors are chosen like confetti, is that just for illustrative purposes or does each color have its own name or effect? thank you
all of that just to get vaporized by a funny tennis racket
Off topic: To people saying computers can't be conscious/intelligent: Computers can simulate our brains, our brains are conscious, hence, computers can simulate consciousness.
Simulating consciousness doesnt make it conscious
@@Joe-dy7bb Sure it does. At least in a way that the sum of neurons in our brain is conscious. Coz they do exactly the same - run the software we call consciousness. By saying computer is conscious, I mean it contains consciousness, in a way our brain contains consciousness.
No. It doesn't. Youre dumb and youre playing on semantics
Under materialism you're absolutely correct. If one argues that conscious is an emergent property of physical processes, as most science currently presumes, it only follows that any physical process would be able to create a conscious being. While I don't fully subscribe to the idea that physical processes alone generate conscious observers, it's something we have to consider and quite frankly scares me to think about.
@@Joe-dy7bb i mean, if the brain can be broken down into basic insignificant elements, then if you took the same materials and formed a direct replica of that brain, wouldn't it be conscious as well?
This is gonna be a meme material accelerated x100 I swear
Can they also simulate it working?
Now make a fly from scratch
Does this mean we can precisely simulate a fly behavior? Or build a fly brain anew?
I freakin love science over here !
are the dentritic connections and specialised cells noted?
babe wake up, new step towards freezing conciousness just dropped
So we could fully simulate fly behaviour using this map and simulated electrical impulses?
Nice music. Sounds like the Bladerunner soundtrack.
why am I watching this at night and why is it interesting????
Another W for Drosophila melanogaster
Complete mapping of fly brain…my life is now complete
The fly brain scan situation is crazy!
Where can I download it
I'm gonna upload Silverhand's engram on that fruit fly
Oh no, I slapped one recently and now I see how magnificent and complicated even such a small and annoying creature is😭
Can we simulate it completely then?
Cool!
Well guys, it’s been a good run.
Let's be honest, it wasn't
It will continue to be an even better run
@@harmoney-tk5wd
Good men, create good times
Good times create greater men
This did this with a little worm like a decade ago so I wouldn't worry
TH-cam is a crazy place. I just watched the kia soul hamster commercial right before this.
okay this is actually so cool
0:39 aw hell naw 😂😂😂
wut
😏
@@trainersview the neurussy
If there's a hole.....
?
so now if we put that into simulation software, we've built a matrix, correct?
Would love if you guys would post the doi in the description
Done!
@@cambridgeuniversity Thank you very much for listening to feedback. Much appreciated! Will look into the doi now :) would be great if that keeps being the standard for future videos
How do i apply to FlyWire Consortium and become a fly specialist
Grow a beard and grab a hard cover book, easy