Pharmacology - ANTIVIRAL DRUGS (MADE EASY)

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Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do not destroy their target pathogen; instead they inhibit their development. This pharmacology lecture discusses the replication cycle of selected viruses such as influenza, HIV (human immunodeficiency virus), hepatitis B & C, herpes virus, as well as mechanism of action of drugs used in treatment of infections caused by these pathogens. Drugs mentioned include: Anti-influenza agents: M2 ion channel inhibitors - Amantadine, Rimantadine; Endonuclease inhibitor - Baloxavir; Neuraminidase inhibitors - Oseltamivir, Peramivir, Zanamivir; Anti-HIV agents: Entry inhibitors - Enfuvirtide, Maraviroc, Ibalizumab; Nucleoside reverse transcriptase inhibitors (NRTIs) - Abacavir, Emtricitabine, Lamivudine, Tenofovir, Zidovudine; Non-nucleoside reverse transcriptase inhibitors (NNRTIs) - Doravirine, Efavirenz, Etravirine, Nevirapine, Rilpivirine; Integrase inhibitors - Dolutegravir, Raltegravir; Protease inhibitors - Atazanavir, Darunavir, Fosamprenavir, Ritonavir, Saquinavir, Tipranavir; Anti-hepatitis B agents: Nucleoside/Nucleotide analogues - Entecavir, Lamivudine, Adefovir, Telbivudine, Tenofovir; Anti-hepatitis C agents: NS3/4A protease inhibitors - Boceprevir, Glecaprevir, Grazoprevir, Paritaprevir, Simeprevir, Telaprevir, Voxilaprevir; NS5A inhibitors - Daclatasvir, Elbasvir, Ledipasvir, Ombitasvir, Pibrentasvir, Velpatasvir; NS5B polymerase inhibitors - Dasabuvir, Sofosbuvir; PEGylated interferons α-2a and α-2b, Ribavirin; Anti-herpes agents: Acyclovir, Ganciclovir, Penciclovir, Valacyclovir, Valganciclovir, Famciclovir.
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References/source of selected illustrations:
commons.wikimedia.org/wiki/Fi...
commons.wikimedia.org/wiki/Fi...
doi.org/10.3389/fimmu.2017.00436
00:00 Intro
00:34 Anti-influenza drugs
03:41 Anti-HIV drugs
08:21 Anti-hepatitis B drugs
10:34 Anti-hepatitis C drugs
13:25 Anti-herpes drugs

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Hi, I watched all your videos and they helped me a lot in learning pharmacology. Could you please make one video about immunosupressants? Really appreciated!!!

[@shanyapandey5247]

Yes...plz make a video on immunosuppressants.

[@strife2504]

thank you so much for making this video. antivirals are really annoying for me and i really really needed this video i pray for you to be safe from covid and all sickness and hope you keep giving us your amazing way of teaching us pharmacology
thank you again

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[@elibaied4093]

Great video, and thanks for putting it together. One thing I did notice was you stated that ganciclovir is phosphorylated by viral thymidine kinase. While TK acts on acyclovir/valacyclovir it does not act on ganciclovir. A different viral kinase is in play here. This is why in acyclovir resistance (most commonly due to absent or decreased activity of viral TK) ganciclovir will remain active and an option for treatment of HSV and VZV. Thanks again for putting together this video. It was a good review

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Great video thx , a small thing i wanna mention here is that M2 ion channel inhibitors are only effective against influenza A , beside these drugs are associated with rapid emergence of drug resistant isolates of influenza A

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Please make a video for immunosuppressants

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Hello Sir ! When will a short lecture on Antimalarial Drugs upload?

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Kindly upload a video on antianginal drugs also

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