When Will MS Be Cured?
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- เผยแพร่เมื่อ 8 ก.ค. 2024
- A commenter by the name of "CT" asked me when I think MS will be cured. This video explains where I think we stand in terms of a cure for MS and speculate about the future. There are a few nuances including exactly what is meant by "cure." A cure for some or a cure for everyone with MS? Cessation of relapses? Cessation of disability progression? Control of symptoms? Recovery of long-standing disability?
Selected Sources:
Tysabri observational program showed that 34.4% had CDI ⩾2.0 points: journals.sagepub.com/doi/10.1...
Mesenchymal stem cell-derived neural progenitors in progressive MS: Two-year follow-up of a phase I study by Dr. Saud Sadiq: pubmed.ncbi.nlm.nih.gov/33277...
Comment or ask questions below! I would be happy to answer!
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My book "Resilience in the Face of Multiple Sclerosis" on Amazon: www.amazon.com/dp/B07WP7H5LK
Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
Follow me on twitter: / brandon_beaber
Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link: • Video T
he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information. - วิทยาศาสตร์และเทคโนโลยี
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I’m receiving Tysabri monthly treatments, I say as long as it will STOP the insidious damage I feel my body may be able to heal itself God willing. 🙏
Hopefully Tysabri works well for you Annette.
Great video. Tremendous progress has been made. Lots of room to go obviously but really incredible progress thus far in this field has been made
Thank you for this video dr. Beaber! It is optimistic and your explanation makes it seem very plausible. It will be so interesting to see what the future brings.
I'm glad you enjoyed it Marie :)
Thank you so much for replying to my previous comment and making a video to answer my question! I didn't realize that you posted this video so I guess I'm gonna subscribe because your videos give me so much hope!
:)
Thanks for the interesting update as usual! I hope doctors in the future will continue to improve the integrated approach in treating MS, because I believe lifestyle, diet and mindset play a big part in dealing with this disease, always alongside the right DMT.
I agree that lifestyle is important. Hopefully we will get more definitive evidence on this in the future.
Watching this video two years after it came out. I was diagnosed with RRMS in March. Your optimism as an experienced MS-specialised neurologist is particularly valuable to me, thank you!
My biggest hope is for remyelinating and/or axonal-regeneration therapies to be approved sometime in the foreseeable future, because they could prove useful for all forms of MS, and for many other demyelinating diseases as well. Breakthroughs in those areas could be life-changing for millions of people as a result.
Thank you Doctor... Hearing this from you gives me great hope... 🙏🙏🙏
This video gave me hope. I’m 46 with aggressive PPMS diagnosed 2.5 years ago
Thankyou for another informative video Dr.
I'm glad you liked it Robert.
Lots of great advancements being made! Such good news.
Indeed. BTW, I did make the video "10 surprising facts about MS" to be published 4/28. I cited you at the end of the video.
So appropriate 🙄
@@DrBrandonBeaber thanks Dr. B!!
This may be one of your best videos!!
Thanks Rob :) I accidentally forgot to turn my speakers off which led to horrible sound quality, and I was too lazy to refilm it. Content trumps production value I suppose.
@@DrBrandonBeaber Didn't notice because your content made me very optimistic. Thanks for this!
@@DrBrandonBeaber All good, dr. Beaber! I didn't notice any sound problems.
@@freethinkeralways Good. Perhaps I've become a sound snob.
@@robwegner :)
Thanks doctor and please more videos like this.
Sure thing. Is there any specific topic you would suggest?
I'm 54 so given my age, I know a healthy lifestyle, positive attitude and Tysabri are about all I will presently get as far as a "cure". I hope there will be some nuance in care/cure that will benefit me in the future, but I'm not betting on it. I am hopeful for younger people with MS and those not yet dx'd, to have a better outcome. That being said, I am grateful for the care I receive now and the options of meds etc we MS'ers currently have vs. even 20-30 years ago.
HSCT is much better than Tysabri.
@@amydascalos3964 HSCT might be much better, but is not an option for me, or I imagine most people. No one in my personal circle of friends and family, could afford to go to Mexico or elsewhere, to pay for this procedure.
@@klburke yes..I know...most all take loans...the govt. should do it as it's cheaper than dmt's
@@amydascalos3964 Great point. Wouldn't that be awesome if the gov't paid for it!
I also hope even if I will not get a super cure pill(even though right now I am benign), my kids who are at high risk of getting it will have it.
extremely informative...thank you doctor
Thanks
Please put subtitles on "Nerve Pain Treatment Explained by Neurologist" . Thanks for the video!
Okay. I put them in the description.
Thanks for the concise explanation and thanks for not selling dreams, and instead being honest and realistic.
I'm glad you enjoyed it Yunus.
For me with frequent attacks it was cessation of most severe attacks that allowed recovery. Started Betaseron lottery #230. Leave toxic relationship, which btw was another hurdle. So I am much better, however I’m the type refuses to give up. Last neuro visit prescribed AFO, cane and pt. Turned out no drop foot as problem was hip and knee spasticity causing gait disturbances. Then to find PT who could see real problem. Long road, but I fight. Thanks. Btw you’re looking good.
Thanks Carolyn. Keep fighting.
yes...most neuros don't know this..it's not leg weakness..but spasticity...@6:30..th-cam.com/video/aMcazVftpaA/w-d-xo.html
all the videos... th-cam.com/channels/VLi3JmSusOe45zJxZw0E9w.htmlvideos
Thank you for this. Hope is ALWAYS A GOOD THING. I am interested in the gold nanoparticle trials underway. I have heard MS researchers say the have seen some mice with EAE vastly improve after going through some of these trials. Very exciting. I'm a 50yo male doing my best to stay out of a wheelchair, but it's getting harder and harder to do. Dxd 28 years ago.
Hey Andrew, as a young male in your position, could I ask you a few questions about how MS has affected you?
@@Captaincrunch235 sure
Hi Dr. Excellent videos..
I was diagnosed with MS 2 years ago. Recently, I was diagnosed with neurocardiogenic syncope (cardioinhibitory and vassodepressor types), POTS and AV block grade 3. All that lead to a pacemaker last week.
Neuro and cardiologist now think that "maybe" I never had MS.
I'm trying to look up for information and both conditions can produce bands and lessions. So, how can i be sure? Any good source of information where i can check that or reported cases similar to mine?
They both told me to suspend treatment as they believed interferon made my heart worse.
Mitocondrial failure 2:41 grabbed my attention!
How can I best tend to Mitochondrial health?
i'm 58, Going for non myeloabletive HSCT for PPMS (EDSS maybe 3) Aug28, 2023.
I'm hoping for the best but want to do all I can mentally physically in preparation and post HSCT.
Dr. Beaber, whatever happens with my HSCT this summer, I'll be forever grateful for you walking the walk, living up to your Hippocratic oath!
Cure is a loaded word, I guess I’m jaded this morning, cause I went to bed with my leg muscles locked in that spasticity, J&J vaccine I was scheduled to get is on hold, and the remyelination trial I was part of isn’t going to phase 3.
I kind of just want to stop using the word Cure all together. I have a medicine that stops my progression. I have hope to get involved in another remyelination trial, because my specialist is looking ahead to the next one.
I am heartened by what my specialist said, that she will only be concentrating on restorative medicine and medicine to help more progressive forms of MS. That is where I would like to see the research going. There are so many people on that gradual decline, and they need better medicines to stop it. Thanks Dr. Beaber. 🧡🙏🏼
I am pleased to see that a lot of pharmaceutical companies seem to be laying down big dollars to pursue these products even though there is no guarantee of success.
Hi, great video. I have been having symptoms for 1-2 years. Off and on. Recently I had a brain, c spine, thoracic, lumbar and sacral MRI spine. Scanned with 1.5 Tesla without contrast. All came back normal with no evidence of lesions of demyelination. My dad has MS. I wonder if the scan was strong enough or if something was missed or if this is all in my head now, what do you think or should I rule out MS? Thanks
Hi Dr. Beaber. Love you channel and commentaries. Can you comment on SOT therapy for EBV and its potential for curing of MS ? Thanks a lot.
Very good question sir
What are your thoughts on going from Ocrevus back to Copaxone?
Thx Dr - Example Diabetes
1950s - Diabetes also meant amputation of Limbs, Now ~70 years later, variety of tablets/injection there to treat and keep it under control - Still no "cure" after 70 years. Best we can hope is a slew of treatment to "control" MS in our lifetime
In this regard, seeing how fast Experts formulated a mRNA vaccine for Corona virus, gives me hope if some medication makes you avoid EB virus' effect
They are also tryibg to make mrna vaccine against ms
Have had MS since I was 10 yrs old now I'm 62 yrs old. I've resisted all drugs except for Minocycline which staved off many exacerbations. Now I'm desperate and have chosen to try Rituximab and am looking forward to treatment at Kaiser San Rafael, thanks for your feedback. Mark
Best of luck to you Mark.
Hi Doctor, I liked what you said at the beginning of the video, it depends on your defination of "cure". I dont think the world will be erraticated of MS, but what we may see is the ability to stop the progression of the discovered disease. I am very interested in re-mylination and would love to get on a Canadian trial for that type of drug, however I dont expect my current symptons to disappear. In all honesty I didnt feel like I had MS until I started taking Tecfidera, it seemed to tell my body that I had MS and oh look here are the symptons you have regarding that....along with all the side effects that come from that drug. Im hoping to feel better on Kesimpta but that is just a hope, the goal is not to get worse. If I can keep what I have left working correctly until I die then to me that's the cure. Look you have MS, we can stop it from getting worse by taking this drug and maybe with another drug added in I may just feel better. Thank you for sharing, I appreciate your you tube channel.
Thanks for the comment. I am sure many people with MS would be happy enough to prevent progression of the disease and live with their current symptoms.
Doctor Beaber, have you heard about Trehalose use in treating ms? Sone researches show it is connected with autophagy process - bad cell recycling or so.
Hello. What are you doing? I want to ask you a question, therefore: a good friend of mine who has MS like me has been suffering from a very painful problem for a few months, which he thought was trigeminal neuralgia, but when he went to treat it he was told that it is not so. He also went to many dentists and was told that he had no problems with his teeth. He is currently on Aubagio, he was on Betaseron before and was changed because he had active lesions. He recently had an MRI and had active lesions again. What do you think he would have? PS: it hurts to say that someone cut him alive with a knife.
Thanks again Dr, really helpful these updates. I'm about to see my Dr about whether I go for Tysabri or Ocrevus. I'm only 34 and my desire to improve my EDSS from 4.5 to around 3 (enjoyable life) is the most important, would you recommend Tysabri if you were me? I wish I could book an appointment with you online but Im currently in England UK and don't know if Im allowed to see you :(
"desire to improve my EDSS from 4.5 to around 3 (enjoyable life)"...pretty much the only treatment that can do this is hsct...when you have mri inflammation.
I can't give you personal medical advice, but in my opinion, Tysabri and Ocrevus are approximately equal in efficacy. Ocrevus has better evidence for primary progressive MS (the ORATORIO trial).
So sorry... I was diagnosed at 34 as well & my first series of attacks were vicious 🥺 No steroids or other treatments could slow the process... I thought I was dying..
@@bnice2all I guess this would be up to the prescriber. Whether or not ocrevus increases the risk of breast cancer is controversial.
What do you think about „ocrelizumab“ . Im 21 and I’ve been diagnosed with MS 4 month ago and my doctor suggested me to start with this Medikament.
I can't give you medical advice here, but I do have a video on Ocrevus: th-cam.com/video/mCVVvq7Aov0/w-d-xo.html
You can find her on youtube also many testimonys of people she helped
Hope dies last; waiting patiently is wise.
I don’t agree. Don’t wait. Act now. Save your own life before MS robs you of it. Almost ever HSCT veteran will tell you the one regret they have is not doing it SOONER!
@@brandi_whine So True...hsct doesn't always work but alot of time it does.
@@amydascalos3964 HSCT success is a function of time/disease progression. The earlier the better!
The “panacea” question. Doctors hit walls with care dealing with insurance, family members, the patient, and their own bias All health issues need a logical course of RX and a compliant patient. It’s also the responsibility of the patient to be disciplined enough to live better mentally, emotionally, and physically.
Tough question to answer black and white
This is indeed a very difficult question to answer in black and white.
can we massage our scalp /head on ms ?
Always keep the faith!!
I'll never stop trying to heal myself and other pwMS!!
I'll continue to make advocacy and lobbying that the best treatments are available 1st line (if a neurologist prescribes)
A neurologist will never prescribe HSCT. That’s a lot of patients who no longer need a neurologist afterwards!
@@brandi_whine most old school neuros will agree with you! Now we have neuros like Dr Brandon Beaber, Aaron Boster, Gavin Giovannoni... keep the faith in your body
@@pedrodacostapinto I have great faith in my body - I am living proof it works
It is going to be when they develop a way to fix and correct the microbiome.
Hey Doc, what are the chances of someone in their 30s being diagnosed with PPMS off the bat?
I lived with Herpes virus for very long time till I meet Dr Ogbona on TH-cam who helped me get rid of it with his herbal medication
Providing one doesn't indulge in addictions. 33% better than none.
It’s hard to see the full spectrum. I can’t find information on wether some people with very active inflammation and high relapse rate can go into remission for many years after starting treatment, I mention this only because you stated that some people after therapy stop having relapses. It would be nice to know the best case scenario and worse case scenario and everything in between, even though it’s variable in each individual. Even my friends dad , when I asked him about how his dad is doing he said “oh yeah he had ms when he was younger” didn’t get what he meant by that. I’m on orcrevus now and I haven’t had an attack in 2 years 🙏🏼
I'm not exactly sure what you are asking, but many people with active inflammation and a high relapse rate go into remission and are stable after starting treatment.
@@DrBrandonBeaber sorry my auto correct went a little haywire. In short, is it possible to halt ms and stay in remission for many years without activity after starting treatment? I’m 34 now and I was diagnosed at 33, I’ve been told to stay on orcrevus until I get closer to my 40s and that my immune system should calm down more as I age.. Allegedly. The reason I ask is because I had a bunch of attacks in the beginning... I was really into the gym at the time not sure if that some how protected me but most attacks I recovered 100% from but I had a really bad one that didn’t recover in my vestibular nerve and brainstem was inflamed, I got double vision which recovered 100% but the dizzy spells are my residual damage that I just have to live with for now. I have hopes that one day they can reverse that but hey it is what it is. I’m just asking because I’m hoping that I don’t pile on a bunch more symptoms on top of what I already have. Thanks again for all your videos, i binge every night before I go to sleep lol
Even when there is no relapse ms is causing abnormal brain loss..but sometimes it takes 1..2..or 3 decades for the damage to show up...this is called secondary progressive ms.
Do you think a 'cure' could come in the form of a vaccine for EBV?
Yes..Moderna has an EBV vaccine
Do you think diet may have an effect on MS as well?
Yes. I have a playlist on nutrition and multiple sclerosis you may like: th-cam.com/video/Cey5muWJBs0/w-d-xo.html
@@DrBrandonBeaber thoughts on the carnivore diet?
@@hilcho I haven't seen much data on the carnivore diet in MS.
@@DrBrandonBeaber its mostly anecdotal now but I can say after 2 weeks the feeling and dexterity has greatly improved on my left side. I have relapsing/remitting ms.
I just don't want to keep getting worse
What about stem cells
When the proteins that cause MS will be discovered
When they find out was causes it.
I’m not so sure about a “cure“, I think the biggest possibility is in prevention. The problem is people won’t be willing to accept the preventative measures until they get sick.
A lot of the preventative measures that we could take could fight off other things as well.
Perhaps EBV immunization could prevent MS in the future.
@@DrBrandonBeaber
I don’t know anything about that I do believe that our food chain contaminated, and we add a lot of extra things to our food for preservatives, to make them look better or for other reasons.
Our junk food world is going to catch up to us. Even so called healthy foods aren’t even so good for us.
I struggle a lot now because it shouldn’t be as hard as it is to eat healthy.
Then you’ll get their product such as beauty products, toothpaste soaps, shampoos,… They all have things in them that we are putting on or in our bodies that are detrimental to our health. They certainly seemed effect some people more than others..
I think if we can avoid getting many of these diseases or illnesses will put us above the curve rather than trying to fight them off once we get them.
Of course, I’m assuming a lot of things.
Swank diet has been proven to prevent family members of PwMS from developing MS
I'm not aware of any basis to this claim other than perhaps anecdotal evidence, but I am going to do a few videos on the Swank diet within the next few months.
@@DrBrandonBeaber
I think diet is a big key with a lot of issues. The problem is knowing which diet is right. I don’t believe that there is one diet for everyone.
Eating properly is a lot harder than taking a pill, so many people would probably choose the latter.
I don't see how they can come up with a vaccine for covid so quick without even ACCIDENTALLY finding one for MS. I feel like (and i know it doesnt make sense, I dont have the biology background to explain it) but I just feel like there's some type of correlation between a covid vaccine and finding a vaccine of SOME SORTS for MS. come back to this comment in june 2022 *manifesting this idea*
There was an article back in January which got a ton of press about using the lipid nanoparticle technology to make an mRNA Vaccine for Multiple Sclerosis: science.sciencemag.org/content/371/6525/145 I made a video about the article as well: th-cam.com/video/ML700hPtJmI/w-d-xo.html
@@DrBrandonBeaber that's what I thought I seen in a twitter article before but then I couldn't find anything on it again once it got lost in the covid vaccine news. I'll look more into this. Thank you Dr. Beaber!
@@MMSL.Brionn I'll definitely make a video if there is any update to this.
@@DrBrandonBeaber splendid! I'm sure it'll be great, as usual lol
@@DrBrandonBeaber I have asked Biogen. They said the trials probably will begin in 2 years.
HSCT is as close as you get. I’m almost 6 years out.
Awesome...1.5 years out...really seeing improvements now.
@@amydascalos3964 so great! That’s about when I started to too! Congratulations!
Where did you get HSCT done?
@@Captaincrunch235 Northwestern Memorial in Chicago
@@brandi_whine oooph I would love to but I heard Dr. Burt isn’t conducting them anymore and essentially cancelled them indefinitely until his however long sabbatical is
I'm pretty keen for a doctor to prescribe me clemastine and metformin, what's the worst that can happen? yolo
:) Well...both of these drugs have potential side effects, but there are doctors who prescribe clemastine for MS. It's just unproven.
@@DrBrandonBeaber Thanks Dr Beaber, I hope to find a Doctor which will go the extra mile and give me the choice of using metformin and clemastine given their potential side effects. It is quite possible that the potential rewards far outweigh the risks.
@@pelletey Know someone who tried it..didn't stop her progression..Dr. Robin Franklin put out false hope w/this..look into hsct
@@amydascalos3964 False hope seems a bit harsh for something which is still in trial phase? Didn't they know it was still unproven? HSCT is dealing with the inflamation not remyelination.
@@pelletey she and her dr. went to talk and so she tried it th-cam.com/video/VgHi4JjKVwA/w-d-xo.html
She also has had ms for 30yrs ps I'm just a dump white guy with ms looking for help but let's she's right wouldn't chemo kill parasites? and that explain why some people in chemo get better? That's just a thought
They do. Chemo wipes out your immune system and kills off MS. My wife had it done with HSCT Gary. Big PHARMA doesn't want this in the US and Canada my friend. Watch Living Proof with Matt Embry for starters. On Amazon Prime
How is she doing now?
@@garybroaddus1847
I had it and am doing good...progression stopped...chemo kills bcells and tcells that drive disease.
NVG 291 is coming soon.
I will likely do a video about it.
@@DrBrandonBeaber i would like to see a video on this doc, i think it looks very promising, but needs some years of research still. If i'm not mistaken is the only " drug" that repairs neurological damage for several neurological diseases.
MSCT, artificial nerve fibers, and Neuralink seem like the best routes by far.
do you think they will put a big price tag on a "cure" for MS? and by "cure" i mean one injection and it regulates your immune system for life.
If an approved pharmaceutical formulation could consistently cure MS, there is no doubt in my mind the price tag would be a 7 figure amount.
Good video. At least when you do your videos. I don’t get the impression that big pharma have you in their pocket.
The only reason I watch. 👊
No financial conflict of interest with pharma, but we all have our own biases.
Yeah, I was born too early 🤷♀️
Well...You could have been born earlier and had no access to disease modifying therapies whatsoever. Like I said, we will likely see some significant developments in the short run even if they aren't outright "cures."
Selma Blair seems fine but I ain't got the money for her treatment
The cure is hsct....
Reading about Elon Musk's Neuralink looks like a pretty cool way to “cure” MS symptoms. If it can make a monkey play pong like that, I would think it could help people walk again with more research. Then again, I don’t know if folks would be rushing to get a chip in their brain 😬.
I guarantee there will be enough volunteers.
MS is a horrible disease, my Mother died from it back in 1982, I watched my Mom suffer so inhumanly from this disease. I really hope they find a cure. 😢