So i think of Hypothalamus as the director, Pituitary as the manager, and Adrenal as the staff. Director orders manager, and the manager walks to the employee office tells them to release cortisol. Never gonna forget again.
@neuroscientifically challenged............. Thank you very much for all of your videos......... Almost after three weeks.... Now there is a new video.......makes life easy..... Have a nice day
Love your videos! Watching a few now to supplement the dense literature review I've been doing in preparation for a talk on the relationship between nutrition and mental health. Thanks for this resource!
Haven't had time to read the papers but would I be wrong in assuming this negative feedback modulating the stress response of the hippocampus/hypothalamus is in part responsible for the so,ewhat spontaneous cessation of craving and drinking behaviors of opioids, alcohol, cocaine, and recently more?
The best way to remember what goes on in the adrenal cortex is the acronym “salt, sugar and sex. The deeper you go, the better it gets. Aldosterone, cortisol and testosterone. The medulla makes norepinephrine and epinephrine.
Hi! Thank you for this! Are there any videos going into more detail on the negative feedback mechanism, specifically the binding of cortisol to the MRs and GRs?
Props for url in the video, that is almost cranio (QAeBKRaNri0) :D I love these videos. Studying and simulating 'life' as chess in Python; feasibility of the classical min-max and pruning algo to be used for optimizing life choices, and stumbling upon stress, action theory and all the good stuff.
3 years later I graduated and got an A in the neuroscience class I needed your channel for at stony Brook! so thank you so much for your content!!! 😂❤️
Unfortunately, I don't have much in that area. I do have a video on oxytocin: th-cam.com/video/tLc9fQd58bg/w-d-xo.html and one on the hypothalamus & pituitary gland: th-cam.com/video/TVhm2rBGhB0/w-d-xo.html along with the HPA axis video.
ı heard the cortizol itself can trigger the hpa axis making the stress response a loop in terms of depression or anxiety disorders. ı could not make the connection. :(
Hi, I'm not very familiar with this but I would expect that it could involve exogenous glucocorticoids binding to glucocorticoid receptors and acting as a negative feedback signal to suppress the HPA axis. In other words, when there are high levels of cortisol in the blood, the cortisol binds to glucocorticoid receptors in areas like the hypothalamus and hippocampus and creates a signal that shuts off the hormone cascade (outlined in the video) that normally leads to the production of cortisol. Shutting off this hormone cascade acts to keep cortisol levels from getting too high. I would assume that exogenous glucocorticoids could bind to these same receptors and "trick" the HPA axis into thinking it needed to decrease hormone secretion, thus leading to HPA suppression.
I do not have a background in biology - I am apologizing for the question that I am going to ask - so the negative feedback loop is created when the cortisol is too high and the pituitary gland and hypothalamus shut off? so the body cannot respond to stress?
The negative feedback loop is intended to shut the response off when the desired effect has been achieved. In other words, the goal of the HPA axis response is to increase cortisol levels in the blood. When that has been achieved, and the stressor is no longer present, then the initial response can be shut off. It's similar to a thermostat. When the desired temperature has been reached, the heat shuts off.
Thank you for the great video! Can I use your HPA-axis video in my schoolwork? I would translate it in to finnish and show for my classmates. Kind regards, Henna
what is the point of knowing any of this ? Theres little to no way to reset the HPA axis with pharmakinetics or drugs. There are no tests or scans to identify a disregulated HPA axis. These videos are pretty useless to be quite frank.
The best 2 minute explanation of the HPA-axis I've ever seen!
out of the total of 1 video i have seen on HPA-axis i would say this one is the best
So i think of Hypothalamus as the director, Pituitary as the manager, and Adrenal as the staff. Director orders manager, and the manager walks to the employee office tells them to release cortisol. Never gonna forget again.
Good
and cortisol level is high( staff is up set with too much overloading working ) yelling at director to shutting off stress - negative feedback.
Wow 🎉🎉
@@kc-ss7szNice..
😅😅, you simplify better👍👍
as a psych student, I was struggling to understand this in my Emotions class. This video just cleared up all confusion. THANK YOU
As a neuroscience undergrad, these videos are SO helpful. Thank you so much!
as a highschool student having to give a presentation on the cause of phobias, this video is really helpful XD
For a Biochemist Ph D - this is a true pleasure watching you doing this. Great Talent! Become a Prof. of Biochemistry!
Thank you! I am a prof, just not of biochemistry. My department is biobehavioral health, which is like health psychology.
Biochemistry saves lives.
Didn't know I had a second nut sack in my brain, you learn something new everyday!
Edit: Thank you for the video.
lol
I am French, and it's been two weeks I've been looking for this video! Thank you so much!
Love the video! Major help for my nursing exam on the endocrine system in 2 days
The best video to explain HPA axis , thank you very much 😊
Wow, I normally don't react or comment on videos, but your channel is greatly underappreciated! Thanks for the great videos!
Woah. Great job again man. I just got a bit lost the last 5 seconds but I will read the transcript to clarify :) THANKS BUDDY!!!
@neuroscientifically challenged............. Thank you very much for all of your videos......... Almost after three weeks.... Now there is a new video.......makes life easy..... Have a nice day
This was perfect, clear and concise. Thank you!
Bro your two minutes videos are blessing for us students
Big help! The best explanation I've seen! Thank you so much!
Thank you very much for the knowledge about the hpa axis.❤
This is exactly how it is in my book...more short and detailed actually...thanks
Just what is required and nothing else, nice work there! Thanks :)
Love your videos! Watching a few now to supplement the dense literature review I've been doing in preparation for a talk on the relationship between nutrition and mental health. Thanks for this resource!
Haven't had time to read the papers but would I be wrong in assuming this negative feedback modulating the stress response of the hippocampus/hypothalamus is in part responsible for the so,ewhat spontaneous cessation of craving and drinking behaviors of opioids, alcohol, cocaine, and recently more?
Thank you! this is very educational and its only 2 minutes!
Just amazing! summed up all of my confusing notes
Nice video. How about making it 3 minutes so you could finish that last thought.
Interesting!! 👍🏼 I love learning about the brain.💕
Short and to the point, thanks
It’s Good explanation about HPA-Axis. Thank you so much
Appreciate the information. I agree with the comment about finishing the last thought!
Have you made a video on how Glucocortisoid treatment affects the HPA Axis and how that affects the body and how we feel?
Horrible. Lisa of cognition. Sleeping all the time.
Thank you so much! Very clear and helpful. Great channel. Subscribed!
Advance Patho FNP student here. Thanks for this. :D
The best way to remember what goes on in the adrenal cortex is the acronym “salt, sugar and sex. The deeper you go, the better it gets. Aldosterone, cortisol and testosterone. The medulla makes norepinephrine and epinephrine.
Awesome. Short and sweet.
Wow u helped me a lot👏👏👏
This is amazing. Thank you
very good , thank you , please keep making videos ! love u so much !
I love you too.
Very nice. I could not have done it better myself. Keith
I'm listening to this on repeat before a test
OK but how do we fix HP A-axis dysfunction and doesn't the thyroid tie in with this as well
Hi! Thank you for this!
Are there any videos going into more detail on the negative feedback mechanism, specifically the binding of cortisol to the MRs and GRs?
you are a life saverrrr
Thank you so much!!!! Great video
Props for url in the video, that is almost cranio (QAeBKRaNri0) :D I love these videos. Studying and simulating 'life' as chess in Python; feasibility of the classical min-max and pruning algo to be used for optimizing life choices, and stumbling upon stress, action theory and all the good stuff.
Good explanation ❤❤ thanx alot
Thank you so much for this!
Excellent.
Nicely explained
Very informative. Thank you
short and precise
Thank you for this
just to be specific, he is talking about the anterior pituitary gland. there is a different mechanism for posterior pituitary
Thanks helps a lot 😅
Awesome 👏
That was way simpler than I thought it was thank you so much!! ❤️❤️
3 years later I graduated and got an A in the neuroscience class I needed your channel for at stony Brook! so thank you so much for your content!!! 😂❤️
Do u have pdf so I can cite you. Very well explained, thank you so much 💓 🙏 😊 ❤️. God bless u always
You're the best
Do you have anything on behavioral endocrinology?
Unfortunately, I don't have much in that area. I do have a video on oxytocin: th-cam.com/video/tLc9fQd58bg/w-d-xo.html and one on the hypothalamus & pituitary gland: th-cam.com/video/TVhm2rBGhB0/w-d-xo.html along with the HPA axis video.
Your videos helped a lot when I took neuroscience last year so thank you
@@Christina-eh4pq You're welcome! I'm glad they were helpful!
ı heard the cortizol itself can trigger the hpa axis making the stress response a loop in terms of depression or anxiety disorders. ı could not make the connection. :(
Thanks!
Thanks! Can you explain how glucocorticoid use, as in asthma, can lead to HPA suppression?
Hi, I'm not very familiar with this but I would expect that it could involve exogenous glucocorticoids binding to glucocorticoid receptors and acting as a negative feedback signal to suppress the HPA axis. In other words, when there are high levels of cortisol in the blood, the cortisol binds to glucocorticoid receptors in areas like the hypothalamus and hippocampus and creates a signal that shuts off the hormone cascade (outlined in the video) that normally leads to the production of cortisol. Shutting off this hormone cascade acts to keep cortisol levels from getting too high. I would assume that exogenous glucocorticoids could bind to these same receptors and "trick" the HPA axis into thinking it needed to decrease hormone secretion, thus leading to HPA suppression.
How can we repair this system?
Korean red ginseng extract
Use it
Find a good source
Best for this IMO
what will happen to right adrenal cortex if let adrenal cortex has benign tumor? will both side will be affected incase one side is affected ?
😍😍 Thank u so much
Great job
But l am wondering which would be short and long loop😢😢😢
So how do we fix this negative feedback mechanism? please help
Great explanation, can I share this on IG?
Sure!
I do not have a background in biology - I am apologizing for the question that I am going to ask - so the negative feedback loop is created when the cortisol is too high and the pituitary gland and hypothalamus shut off? so the body cannot respond to stress?
The negative feedback loop is intended to shut the response off when the desired effect has been achieved. In other words, the goal of the HPA axis response is to increase cortisol levels in the blood. When that has been achieved, and the stressor is no longer present, then the initial response can be shut off. It's similar to a thermostat. When the desired temperature has been reached, the heat shuts off.
@@neurochallenged Cannot thank you enough! very very clear! thank you for taking the time to respond to me -
What happened, wenn the feedback is not happened? What is the homeostasis role hier?
thank you veryyyyyyyyyyyyyyyyy much
Thank you!
Thank you for the great video! Can I use your HPA-axis video in my schoolwork? I would translate it in to finnish and show for my classmates. Kind regards, Henna
Sure, thanks for checking!
I know I need help here... my Nutrionist says the caffeine ( it’s survival for me) is what’s causing a lot of HPA axis problems.... true?
If I was to reference your video, do you have a name I can put down or do you hide your name intentionally?
My name is Marc Dingman.
THANK YOU
Thank you
What can be done if a person has a disrupted HPA axis??
How do I cite you as a source in APA?
What software are you using to make these?
Videoscribe
Thanks! Happy I got a response from you, I'm currently in a Neuroscience course and your channel is very well known. ;)
Great to hear! Good luck in your studies!
Haha thanks! We've been assigned a media task to demonstrate a topic. Our topic is "The neurological basis of Autism Spectrum Disorder"
That's a tough one---complex and not much consensus. You won't see me attempting to summarize that in 2 minutes. Good luck!
Got to be positive vs negative feedback loops next? :p
thnx
shoutout that boi sam gosling
Great but the pituitary gland looks like a nut sac
Nat Well
ily
m
what is the point of knowing any of this ? Theres little to no way to reset the HPA axis with pharmakinetics or drugs. There are no tests or scans to identify a disregulated HPA axis. These videos are pretty useless to be quite frank.