So, is an increase in spectrum disorders (i.e. Autism, Asperger's, etc) something to be seen as not only a descriptive reality but one of evolutionary adaptive ability?
The correlation between spectrum disorders and the regions where these duplications occur is not adaptive, but as a result. The causal mechanism is the cellular machinery does not realize there is a duplication, but thinks there is only one copy(the two are too close in the genome) and thus what happens is the section of code in between the two is deleted and the duplication is reversed, destroying the good usable code in between and eliminating one of the copies, one of which was almost always changed from the original version. It is a result from the type of evolutionary outcome rather than a sign of future evolution.
So if Neanderthals Denisovans and modern humans all arise from the same root stock, why is it that we are the only one that shows this genetic profundity?
The both share most of these with us. And that is a bigger question because of it. Why are they so different from modern humans if they share most of these duplications.
The idea that evolution can be measured by some linear analysis of gene similarity is ridiculous. There are three central results of modern genetics and sequencing of the human genome. One is that a large range of human behaviors and diseases have a large heritable component. A second has been the failure to identify specific genetic variations that are responsible for this heritability. The third is the large amount of genetic variation among different Human individuals. An animal cell is an immensely complex biochemical system. There is every reason to expect that small variations to the numbers of different components or their interactions could have large systemic effects. In fact, the physical differences between Chimpanzees and Humans are small. The dramatic difference in human behavior is a complex system property not a difference in the components of the system. It is very likely that the process of evolution largely involved modest quantitative changes in the number, timing, or splice variation of RNA transcripts. Certainly, changes in copy number of genes are one way of producing changes in the number of gene transcripts. But, the overall process of change is much more likely to be the result of large numbers of genetic variations than a few specific ones. The results of human genome sequencing have shown that there are more than thirty million common Human single nucleotide polymorphisms. The average Human expresses some unique combination of over three million of them. To date, there is almost no understanding how any of these SNPs function. My own study of thousand genome data revealed a large amount of population dependent structure in the associations of SNPs expressed by different individuals dnjake.github.io/ . To date the genetics profession does not seem to have recognized this reality or even started to explain its significance. It is certainly likely that copy number variation is a significant factor in Human evolution. But, the prospect for any understanding of the whole process or the relative importance of any particular part seems far beyond any foreseeable future.
I feel that we Homosapien sapiens were to fast of to appear here on earth, the now passed away dr.loyd pye explained what I believe happened to the hominids that were around thousands of years ago we were engineered
So, is an increase in spectrum disorders (i.e. Autism, Asperger's, etc) something to be seen as not only a descriptive reality but one of evolutionary adaptive ability?
The correlation between spectrum disorders and the regions where these duplications occur is not adaptive, but as a result. The causal mechanism is the cellular machinery does not realize there is a duplication, but thinks there is only one copy(the two are too close in the genome) and thus what happens is the section of code in between the two is deleted and the duplication is reversed, destroying the good usable code in between and eliminating one of the copies, one of which was almost always changed from the original version.
It is a result from the type of evolutionary outcome rather than a sign of future evolution.
So if Neanderthals Denisovans and modern humans all arise from the same root stock, why is it that we are the only one that shows this genetic profundity?
The both share most of these with us. And that is a bigger question because of it. Why are they so different from modern humans if they share most of these duplications.
So what did happen about 50,000 yrs ago when we suddenly got critical thinking.
The idea that evolution can be measured by some linear analysis of gene similarity is ridiculous. There are three central results of modern genetics and sequencing of the human genome. One is that a large range of human behaviors and diseases have a large heritable component. A second has been the failure to identify specific genetic variations that are responsible for this heritability. The third is the large amount of genetic variation among different Human individuals. An animal cell is an immensely complex biochemical system. There is every reason to expect that small variations to the numbers of different components or their interactions could have large systemic effects. In fact, the physical differences between Chimpanzees and Humans are small. The dramatic difference in human behavior is a complex system property not a difference in the components of the system. It is very likely that the process of evolution largely involved modest quantitative changes in the number, timing, or splice variation of RNA transcripts. Certainly, changes in copy number of genes are one way of producing changes in the number of gene transcripts. But, the overall process of change is much more likely to be the result of large numbers of genetic variations than a few specific ones. The results of human genome sequencing have shown that there are more than thirty million common Human single nucleotide polymorphisms. The average Human expresses some unique combination of over three million of them. To date, there is almost no understanding how any of these SNPs function. My own study of thousand genome data revealed a large amount of population dependent structure in the associations of SNPs expressed by different individuals dnjake.github.io/ . To date the genetics profession does not seem to have recognized this reality or even started to explain its significance. It is certainly likely that copy number variation is a significant factor in Human evolution. But, the prospect for any understanding of the whole process or the relative importance of any particular part seems far beyond any foreseeable future.
There are lots of genome wide association studys linking snps to diseases. Timing of RNA splicing would be a regulatory change.
I understood nothing. NOTHING! ! Because I don't speak English
I feel that we Homosapien sapiens were to fast of to appear here on earth, the now passed away dr.loyd pye explained what I believe happened to the hominids that were around thousands of years ago we were engineered