Memory and Information Storage in the Brain: A Molecular Perspective | Brandon Woods | TEDxBoston
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- เผยแพร่เมื่อ 8 ก.ค. 2024
- Have you ever wondered how memories are formed, and how memory arises from the information rich context of our surroundings? For deep exploration into the cellular and molecular mechanisms that process and store information in the brain, neuroscientist Brandon J. Woods has prepared a succinct, yet compelling talk for your intellectual entertainment and enrichment. Through Brandon’s passion for molecular biology, and his unique talents to inspire and communicate, he is certain to provide you with an educationally motivating experience that will consume your curiosity for the wonders of memory formation and neuroscience.
Biology,Brain,Cognitive Science,DNA,Genetics,Human Body,Information,Intelligence,Memory,Molecular Biology,Neuroscience,Psychology,Science As a neuroscientist at Harvard Medical School and a multi-talent, Brandon’s career lies at an intersection of science, music, film, writing, and education. Consequently, his life story is about pushing the boundary of what is possible. For him, neuroscience is more than a set of principals arising from data backed premises. Rather, neuroscience is a discipline that we can come to appreciate and apply in our daily lives as we reach for our dreams. www.brandonjwoods.com This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx
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Jargon and more jargon; I am illuminated by your eloquence!!
Gatekeeping at its best keep up the good work brother!
How is this gatekeeping bruh. Did Elmo learn a new word?
Well done! InspireD!
Applaudable👏👏
Again, these are all theories and we don’t have the technology to prove this. The reality can possibly be something completely different. But people have to produce some theories so that they can be investigated if it does make sense or not. Some theories might take 100s of years to be proven or rejected.
The reality is, today nobody understands how it works and until it is fully understood, then we will take it purely unexplainable miracle.
Also think about dangers and risks associated fully understanding memory process. And this is another topic of TedX talk 😊
I think this is the most fascinating area of research to date. It builds on almost every physical and mathematical idea we’ve ever produced as a society in one single concept: miRNA’s. Neuroplasticity may explain the organization of information, but it doesn’t explain the physical existence of it. Also, informational structures don’t explain concepts like consciousness, or more abstract ideas regarding the brain. Micro RNA’s might give us a new perspective on these long argued ideas about existence and the human condition. Im agnostic but bless this man for his plain and easily accessible presentation of the idea on micro RNAs. Accessibility is a huge part of spreading information and sparking interests because of our understanding of temporal difference learning, in which rewards that are closer in the future matter much more than rewards further away. The short and intuitive explanation given helps people get into these ideas in science and flourish within their fields of research. Again, bless this man 😁
Great work my brother🏆🏆🏆
OK, synaptic activity is important in storing and retrieving information. But, what biochemical changes make up a memory? I'm not aware of any variety of biochemical changes that occur at a synapse which may play a part in transmitting colors, music, analytical data, experiences, etc. Is it the same old molecules that transmit touch and smell? What chemicals store the variety of stimuli that make up a complex stored thought? If I watch the Beatles perform, for example, what stores the music, the lyrics, the volume intensity, the noises of the crowd, etc.? Do we know if it is stored chemically, or is it stored with microelectronics or is there some combination of both? And, what else might be involved? Anatomy of the brain and the interconnecting pathways are certainly important to understand, but I think we're ready to understand so much more. I feel it is as though we are at the start of the industrial revolution in understanding memory. Someone now needs to discover memory's cotton gin, so to speak.
I was thinking of this in terms of color and came up with a possibility. I have a background in coding so I will use that as an analogy. The retina processes information received via stimulation of the cones and rods held within it. It could be that the neurons have the ability to store the order at which the cones and rods are sending information to the brain. You could see it as 1 & 0 where 1 is a cone and 0 is a rod. I am oversimplifying it but if you imagine how the colors are generated on our monitors with the use of RGB where a certain intensity intensity of red, green and blue average out to show us a specific colour. I am making the assumption here that there is a gap between each time a cone or rod sends information down the optic nerve of course. So essentially if the neurons would be able to store the order and number of impulses sent from each cone and rod found in the retina it could reproduce this by firing this sequence again within the brain mimicking the "colour". Please take it with a grain of salt though, just my spur of the moment thought experiment.
@@TheMarkrafter Thanks for sharing your thoughts on this process. Let's take your comment one step further. When a rod and cone are stimulated to recognize the color blue, for example, is that a totally electrical activity inside those two cells (rod and cone), or are there also chemicals temporarily forming inside that nerve as it moves the information along to the next nerve cell so it can be interpreted as blue? Then, how is that information sent across a nerve junction (synapse) on its way to the brain for further interpretation and storage? There simply can't be enough different synapse chemicals instantly formed to move things along so quickly. And where is the defect in a person's eye who happens to be red/green colorblind and cannot "see" blue, but he interprets this color as being grey? For me, that question is a good place for me to begin my understanding of memory. At the synapse the "blue" information being transferred is sent via chemicals to the new nerve cell which now needs to quickly get that information to the brain. That second nerve may be three feet long, so rapid chemical transfer would be out of the question. It would be too slow. So, it received the "blue" code chemically, moved it three feet thru this nerve cell electrically, then it needs to be converted back to a chemical response to transfer this "blue code" across a new synapse to a brain stem nerve cell. And, all this happens in an instant. It's beginning to sound a lot like "magic", not biology.
Ever advancing on the frontier of memory research! Invent a device to recall and project our distant past memories onto a screen before I die please.
At 3:29 he claims that the mechanism of how memories are stored in the brain is the modification of synaptic structures. At first that sounds impressive, but is it true? I'm sceptical about that claim, does anybody know of a reliable source (e.g. a recent scientific paper) which confirms that? Or research which refutes this assertion?
I'm not a neuroscientist, but it's partly true what he's saying. He's saying memories are stored by how the brain is configured to be connected. Based on how neurons are connected, a stimulation will pass through specific areas of the brain resulting in a specific output. So, if it's configured a different way, you will get a different output.
The other part is the stimulation- the origin and the duration (type and intensity). A brain can be configured a particular way, but if the person is unable to transmit the signal well, it will result in a different output.
Yes, it’s simply amazing how this process of organising energy into a synaptic morphology happened just by chance. Go figure !!
Does adrenalin affect the process of memory creation? In particular, does adrenalin speed up this process, so that recall appears to run at a slower rate because more detail has been stored?
1-Adrenaline is rarely released alone, it is mostly released during the stress response. There is evidence linking acute stress with increased memory retention. That is, when rats are faced with spatial navigation tests they tend to learn it faster if they receive a brief shock right after an association trial. This effect is reversed when stress becomes chronic (p.s. This may be due to different receptors involved in acute VS sustained stress, e.g.mineralocorticoid vs glucocorticoid) However, because other chemicals are released during stress in addition to adrenaline, it's difficult to isolate its effects.
2- I think it's unlikely that the process of changes in gene expression during memory formation would be speeded up by adrenaline. First of all, adrenaline acts mostly as a hormone and not really as a neuroactive substance. Secondly, when it does act on the brain, it targets extracellular receptors, and only influences gene expression indirectly through g protein complexes. However, it is likely that intracellular processes are altered by increased extracellular adrenaline, and that might in turn lead to changes to memory formation.
@@kingofking245Thanks for the coherent answer 😊.
I ask, as you mention that adrenaline release increase attention. The memories are supposed to be accurate? in that phase?
Like, supposedly, I show you 12 different numbers, because of adrenaline you remember the 12 of them because of increase attention, and like 8 without adrenaline as the attention is not as good.
Am I getting this right?
This might also means adrenaline wouldn't really play a huge role of the attention is as good as it can be.
very well spoken!
❤️
May be evolution find a way to give more prefferance to emotion associated memory because it facilitates survival better
Why haven't we looked for chemical imprints on the cells because it could be transferred
Wow! What a word salad!
It's in the water of the ECM
Jhonson?
Mr. Dobolina... Mr. Bob Dobolina.
1
.🦁
I love the autism corner of the internet
meow
I want to translate an Arabic how
Isn’t the correct answer to that ‘rhetorical’ question No?
How memories are stored and retrieved in case of a person with split personality disorder 🙄🙄
Weird ryt
What does this mean?
@@maxbrandmeyer5388
Person with personality disorder somehow recalls different memories for the same thing. It seems like of you do have personality disorder, you might not be able to develop memories smoothly.
Like let's say you eat cabbage and a tomato. One of your personality might like cabbage and the other might like tomato. Both the personalities have different preferences, favorites. How come you taste things differently? Which ends up the two different personalities have very different favorite foods?
The storage of the memories (neural structure) has to be physically at different locations. The question still lingers, how does personality difference create literally two different, physical, neuronal structure in the same brain?!
The question is relevant to the video as the video is talking about how the "physical storage" of memory grows and the limitations of it.
I thought will Smith is explaining it from MIB 😂😂😂😂
Maaaaan... you should be a politician. You talked a lot but gave absolutely no insight into the brain-information-storage that this title announced.
Exactly!
I felt the same and I was disappointed. I wonder how in the same neurons can be saved multiple informations. Can the neuron fire each axon terminal as the neuron "wants" i.e. according the data . Then it should know which one and why