Same. There's something so unique with Mecaline. I never did it's pure form, but I did 5 peyote buttons. I felt sick at first, but as soon as the sickness faded, I never felt more at peace. Very hard to explain, but I totally felt "one with the earth" hahaha (I know, total cliche, but it's true!) It was pure bliss, pure love, pure "understanding" (of course, I probably looked stupid, but I felt the most amazing beautiful connection) very little visuals. Mescaline doesn't really cause any visuals (other than waves or vibrations) but the body high (emotional perception) is unreal.. just unreal... I wish Mescaline was more popular, it's simply amazing, no words can really describe it!! Peace out from Arizona!
@@octomondo5270 My experience with Mescaline in 1971 was similar. I was a sophomore in college then and after Easter break, I dropped out. In effect, I pursued answers about it in religion. After my journey in Buddhism and Hinduism, I settled for Christianity, viz. the Gospel.
Opiates don't bind to dopamine receptors, yet they're very addictive - they work via opioid receptors, which in turn causes a cascade effect and the release of things like endorphins, dopamine, etc. There's a certain ceiling dose before one overdoses, or opioid receptors become flooded and there's no room/receptor cites left for more drugs to bind to (that's how narcan works). Yet Heroin is very much addictive under the right circumstances with the right demographic (people who are suffering, physically or mentally). People like opioids because they are agonists of the mu-opioid pathway, which is what provides the euphoria and pain relief; after binding to the mu-opioid receptors, there's a cascade effect where other neurotransmitters are then released (like dopamine, or possibly gaba, or even glutamate which has an antidepressant effect when released via opioid pathways). Which leads into Ketamine (a great, safe painkiller when used properly, as well as great for reducing depression and suicidal urges in part due to its affects on glutamate), which is considered a psychedelic - it's a dissociative though, not a hallucinogen. Despite not coming from the poppy plant, it is an opiate (if it came from the poppy plant it would be an opiOID), and it works by binding to the kappa opioid receptors, which are also known for their pain-killing-analgesic effect, but cause disassociation. Despite not binding to the the mu-opioid (or dopamine) receptors or being as euphoric as something like heroin, for some people, that's their drug of choice and addiction. Addiction has nothing to do with what pathways are activated; Benzos for example bind to GABA receptors which are found throughout the body, and they're highly addictive to some people. The release or presence of more GABA, and relief from stress itself, can be euphoric and causes dopamine to be released - it's a cascade effect, the drug itself does not bind to dopamine receptors. The only drugs I know that directly affect dopamine receptor cites that are commonly used are things like meth or crack/cocaine. If you Google "Meth/Cocaine fMRI vs control", you will see how long-term meth or cocaine use damages the brain and dopamine receptor cites. There's also a difference between a "psychological" addiction and a "physical addiction". I am one semester away from graduating as a neuropsychology major, so I don't know everything, but how drugs/medications affect and interact with the brain/CNS, as well as how childhood development affects the brain, are my areas of study. I hope I helped give you a better understanding of addiction and some things to use as branches for you to do your own research off of. It is possible to become addicted to literally anything if the circumstances are right from food, the internet, your phone, gambling, sex, heroin, lsd, shrooms, Xanax, anything really. It's all about genetics, personal Mesosystems, what we went through and experienced as our CNS and brain developed, as well as our morals, values, traditions, what's available to us, and who's around us etc. Addiction is very complex and it isn't as simple as a drug releasing dopamine, and that's it, you're hooked. Be well!
extremely interesting video. I am very interested in the ideas you are talking about. where can I start for a base level of understanding how cells in the brain and body interact. thank you
Hi there, I'm not the person who made this video, but if you are more interested in a broad level understanding of the interactions between neurons in the brain and body, I would highly recommend lectures on neuropsychology. If you are looking to focus more on the specific chemical compositions of different molecules and their effects on neuronal communication, neurochemistry might be of interest to you. The video I have linked below appears to be a good summary of many broad concepts related to neurons and their communication. While it might not be the flashiest or most interesting video, it should give a good base to then consume more content related to this topic. th-cam.com/video/-xdl5PT_5fM/w-d-xo.html This stuff is extremely interesting to me, and if you have any other questions feel free to ask me (although I am only a 4th year undergrad in psychology, with a particular interest in neuropsychology, so I am by no means an expert or even advanced in this subject). Below are some of the basics related to neuronal communication that are applicable to this video and the effects of mescaline. This stuff is also covered in depth in the video I linked around the 11 minute mark, but I thought a brief summary might be helpful. In very simplistic terms: - Neurons are the primary communicative cells in the brain. - Neurons communicate with other neurons by forming connections with one another, and information is conveyed via 'action potentials'. - Action potentials are electrical signals in neurons triggered by a collection of various stimuli acting on the neuron, that travel down the Axon of a neuron (a tube looking structure). - Neurons form connections with each other. These connections are called synapses. Synapses are composed by the end of one neuron (terminal button) and the beginning of the next neuron (dendrite). - At the end of an axon is the terminal button. When an electrical signal (action potential) is sent down an axon, neurotransmitters produced by the neuron are released from the terminal button. - These chemicals then bind to receptors on the dendrite. This binding can cause a varitety of effects. But the thing of primary imoprtance is that the binding of neurotransmiters to receptors effects the likelihood of an action potential being fired. - This plus or minus effect on the likelihood of an action potential is why drugs have an effect on us. - Many drugs mimic the role of neurotransmitters, and bind to receptors on the dendrite of a post-synaptic neuron. In this video, the effects of mescaline (which presumably mimics serotonin) were explored. Around the 11 minute mark in the linked video, the concepts that this video discussed (mescaline acting on the receptors of a post-synaptic neuron's dendrites) are explained in broad terms. In the example of this video, mescaline would presumably mimic the role of serotonin (or some other neurotransmitter) and bind to its receptors, increasing or decreasing the likelihood of the neuron firing (action potential), and thus having an effect on the brain. Apologies for any spelling or gramatical errors, I have stayed up far too late.
IMO... Yes, but they don't have the neurogenic effects that psylocybin mushrooms do. Lions mane, however, does and us 100 percent legal. If you have family support and are able to talk about your trauma openly and honestly, the lion's mane alone will work wonders. I am not a doctor or even very bright. I hope you're feeling well today.
Absolutely, I highly recommend that the source of mescaline you should pick is San Pedro, NOT PEYOTE. San Pedro is very smooth in its Healing property’s that are very forgiving regarding its effects. Very MDMA euphoric type feelings realizations it puts all of that ptsd into a better perspective,what and why those events took place. micro doses of San Pedro has been compared MDMA . Evan just a Base line dose is very euphoric... highly serotogenic
Mdma is really what you need for ptsd . On the drug harm scale it actually rates under thc which makes it pretty safe . Just don’t take ecstasy’ because it’s cut with other drugs . And looooots of water before during and after . Mdma will make you feel very good with a serotonin dump and it will make you empathetic specially towards yourself . A deeper understanding of self
@@amandaspear6148 Lions Mane helps with depression, but when I took it daily it completely eliminated my sex drive and overall vitality, which made me depressed in a different way. After about 6 months of daily use I decided it wasn't helping enough to sacrifice my vitality
I've tried all of the classic psychedelic compounds ( LSD, DMT, Psilocybin, and Mescaline) and this is by far my personal favorite.
Why if I may ask..?
Same. There's something so unique with Mecaline. I never did it's pure form, but I did 5 peyote buttons. I felt sick at first, but as soon as the sickness faded, I never felt more at peace. Very hard to explain, but I totally felt "one with the earth" hahaha (I know, total cliche, but it's true!) It was pure bliss, pure love, pure "understanding" (of course, I probably looked stupid, but I felt the most amazing beautiful connection) very little visuals. Mescaline doesn't really cause any visuals (other than waves or vibrations) but the body high (emotional perception) is unreal.. just unreal... I wish Mescaline was more popular, it's simply amazing, no words can really describe it!! Peace out from Arizona!
@@octomondo5270I agree totally. It is such a happy experience. For me it brings back happy childhood memories. Flooding in one after the other.
@@octomondo5270 My experience with Mescaline in 1971 was similar. I was a sophomore in college then and after Easter break, I dropped out. In effect, I pursued answers about it in religion. After my journey in Buddhism and Hinduism, I settled for Christianity, viz. the Gospel.
Is everybody in the ceremonies about to begin....
Eating shrimp on a low dose of mescaline is amazing.
I thought the dopamine pathway was NOT involved in psychedelics. The dopamine pathway, as I have learned, leads to addiction…psychedelics do not.
Opiates don't bind to dopamine receptors, yet they're very addictive - they work via opioid receptors, which in turn causes a cascade effect and the release of things like endorphins, dopamine, etc. There's a certain ceiling dose before one overdoses, or opioid receptors become flooded and there's no room/receptor cites left for more drugs to bind to (that's how narcan works). Yet Heroin is very much addictive under the right circumstances with the right demographic (people who are suffering, physically or mentally).
People like opioids because they are agonists of the mu-opioid pathway, which is what provides the euphoria and pain relief; after binding to the mu-opioid receptors, there's a cascade effect where other neurotransmitters are then released (like dopamine, or possibly gaba, or even glutamate which has an antidepressant effect when released via opioid pathways).
Which leads into Ketamine (a great, safe painkiller when used properly, as well as great for reducing depression and suicidal urges in part due to its affects on glutamate), which is considered a psychedelic - it's a dissociative though, not a hallucinogen. Despite not coming from the poppy plant, it is an opiate (if it came from the poppy plant it would be an opiOID), and it works by binding to the kappa opioid receptors, which are also known for their pain-killing-analgesic effect, but cause disassociation. Despite not binding to the the mu-opioid (or dopamine) receptors or being as euphoric as something like heroin, for some people, that's their drug of choice and addiction.
Addiction has nothing to do with what pathways are activated; Benzos for example bind to GABA receptors which are found throughout the body, and they're highly addictive to some people. The release or presence of more GABA, and relief from stress itself, can be euphoric and causes dopamine to be released - it's a cascade effect, the drug itself does not bind to dopamine receptors.
The only drugs I know that directly affect dopamine receptor cites that are commonly used are things like meth or crack/cocaine. If you Google "Meth/Cocaine fMRI vs control", you will see how long-term meth or cocaine use damages the brain and dopamine receptor cites.
There's also a difference between a "psychological" addiction and a "physical addiction".
I am one semester away from graduating as a neuropsychology major, so I don't know everything, but how drugs/medications affect and interact with the brain/CNS, as well as how childhood development affects the brain, are my areas of study. I hope I helped give you a better understanding of addiction and some things to use as branches for you to do your own research off of.
It is possible to become addicted to literally anything if the circumstances are right from food, the internet, your phone, gambling, sex, heroin, lsd, shrooms, Xanax, anything really. It's all about genetics, personal
Mesosystems, what we went through and experienced as our CNS and brain developed, as well as our morals, values, traditions, what's available to us, and who's around us etc. Addiction is very complex and it isn't as simple as a drug releasing dopamine, and that's it, you're hooked.
Be well!
would you make a video on the models for brain/protein and possible bias ?
that was the most interesting part, thanks !
mescaline masculine its in the name belive wether u want or not
extremely interesting video. I am very interested in the ideas you are talking about. where can I start for a base level of understanding how cells in the brain and body interact.
thank you
Hi there, I'm not the person who made this video, but if you are more interested in a broad level understanding of the interactions between neurons in the brain and body, I would highly recommend lectures on neuropsychology. If you are looking to focus more on the specific chemical compositions of different molecules and their effects on neuronal communication, neurochemistry might be of interest to you. The video I have linked below appears to be a good summary of many broad concepts related to neurons and their communication. While it might not be the flashiest or most interesting video, it should give a good base to then consume more content related to this topic.
th-cam.com/video/-xdl5PT_5fM/w-d-xo.html
This stuff is extremely interesting to me, and if you have any other questions feel free to ask me (although I am only a 4th year undergrad in psychology, with a particular interest in neuropsychology, so I am by no means an expert or even advanced in this subject).
Below are some of the basics related to neuronal communication that are applicable to this video and the effects of mescaline. This stuff is also covered in depth in the video I linked around the 11 minute mark, but I thought a brief summary might be helpful. In very simplistic terms:
- Neurons are the primary communicative cells in the brain.
- Neurons communicate with other neurons by forming connections with one another, and information is conveyed via 'action potentials'.
- Action potentials are electrical signals in neurons triggered by a collection of various stimuli acting on the neuron, that travel down the Axon of a neuron (a tube looking structure).
- Neurons form connections with each other. These connections are called synapses. Synapses are composed by the end of one neuron (terminal button) and the beginning of the next neuron (dendrite).
- At the end of an axon is the terminal button. When an electrical signal (action potential) is sent down an axon, neurotransmitters produced by the neuron are released from the terminal button.
- These chemicals then bind to receptors on the dendrite. This binding can cause a varitety of effects. But the thing of primary imoprtance is that the binding of neurotransmiters to receptors effects the likelihood of an action potential being fired.
- This plus or minus effect on the likelihood of an action potential is why drugs have an effect on us.
- Many drugs mimic the role of neurotransmitters, and bind to receptors on the dendrite of a post-synaptic neuron. In this video, the effects of mescaline (which presumably mimics serotonin) were explored.
Around the 11 minute mark in the linked video, the concepts that this video discussed (mescaline acting on the receptors of a post-synaptic neuron's dendrites) are explained in broad terms. In the example of this video, mescaline would presumably mimic the role of serotonin (or some other neurotransmitter) and bind to its receptors, increasing or decreasing the likelihood of the neuron firing (action potential), and thus having an effect on the brain.
Apologies for any spelling or gramatical errors, I have stayed up far too late.
You have the bottom h3c backwards and i think you ment native Americans and not aboriginals. Great video btw
Would this be ok for ptsd
IMO...
Yes, but they don't have the neurogenic effects that psylocybin mushrooms do.
Lions mane, however, does and us 100 percent legal.
If you have family support and are able to talk about your trauma openly and honestly, the lion's mane alone will work wonders.
I am not a doctor or even very bright.
I hope you're feeling well today.
Absolutely, I highly recommend that the source of mescaline you should pick is San Pedro, NOT PEYOTE. San Pedro is very smooth in its Healing property’s that are very forgiving regarding its effects. Very MDMA euphoric type feelings realizations it puts all of that ptsd into a better perspective,what and why those events took place. micro doses of San Pedro has been compared MDMA . Evan just a Base line dose is very euphoric... highly serotogenic
Mdma is really what you need for ptsd . On the drug harm scale it actually rates under thc which makes it pretty safe . Just don’t take ecstasy’ because it’s cut with other drugs . And looooots of water before during and after . Mdma will make you feel very good with a serotonin dump and it will make you empathetic specially towards yourself . A deeper understanding of self
@@amandaspear6148 Lions Mane helps with depression, but when I took it daily it completely eliminated my sex drive and overall vitality, which made me depressed in a different way. After about 6 months of daily use I decided it wasn't helping enough to sacrifice my vitality
It certainly helped me more then anything else. That's all I can say