I received a single infusion 6 months ago, and cured my treatment resistant depression and anxiety. I had it for 40 years. I have not relapsed - It was a miracle for me.
I'm from the US, and yes, it really does work when administered by a doctor at the proper dose. For most people, unlike standard therapies which fail in most people.
I just completed a protocol of 4 ketamine infusions in 2 weeks period ( dosage 0.5 mg over 45 min. infusion). Ive experienced mind clarity during infusion but was back to my original baseline few hours after. What protocole did they used for you?
70 years of dosing people with antidepressants and this guy admits that we have to some degree playing pachinko with people's brains and hoping for the best...
He discusses NAC here which is what my bipolar daughter was put on 2 1/2 yea ago for severe OCD/intrusive thoughts. It has made a huge difference in her thinking, her depression and her anxiety. It’s been a miracle as she cannot take SSRI’s. Interesting area of progress for these awful illnesses.
Like all medical procedures and medications they effect different people differently. Apparently I was born with a depression gene and as a result I have had lifelong depression. After trying everything available except ECT I tried ketamine infusion. After five infusion treatments I experienced no, none, zero effect.
Have you tried weed (or cbd-) oil? Mdma also helps. (it's not gonna cure you though) Different people have different dosages. You've to try to get the right dosage. Don't get stuck with the recommendations. For example cbd-oil has the recommendation of 2-3 drops a day, or so. If that's not working for you, try 1 drop every 3-5hours. And if that's not working try 2-3 drops every 3-5 hours. It won't hurt you. You can't o.d. on weed/cbd-oil.
Robert Lockwood dude perhaps ... What I did eventually... Was to look for answers in the spiritual aspek of life and I know its sound like a harry potter sci fi storie but the answers lie there...... From childhood upbringing with constant stress to how your life path could be on the wrong side and u should change your lifestyle or job.,... Its the only thing left and its free and its given to us from the creator .... Its what Jesus or buddah lived from and like...
Robert Lockwood, I have been suffering from depression since childhood and my recent episode cost me to spend 4 months in hospital..not that's important but just to let you know a bit of what depression looks like for me so far. I learned recently that I'm part of the 30% of people who dont respond to antidepressant. Last March/April I received 50 sessions of RTMS after completing 5 sessions of ECT (bilateral). As scary as it is, I recommend that you give à try to ECT. Unilateral will cause less short term memory loss. (Bilateral suppose to be more efficient but its definitly more agressive). For my part, unfurtunatly, I could not handle more then 5 sessions has it brought back some PTSD memories, but I dont regret trying. Beside triggering PTSD, I did notice a significant change in my ability to communicate and I felt much less anxious. I have some md friends who are sufferring bout of depression and dont have the time for the trials and errors of antidepressants...so they get few rounds of ECT and their good to go for a significant period of time. I just came back today for a Ketamine Tx (4 infusions in 2 weeks). No miracle for me but I keep learning and at least if I can help someone with my experience it would have worth all this pain. Stay safe :).
Sorry to hear that Robert. I have never tried ketamine but I appreciate you sharing your experience. I have had several unilateral ect. treatments but I can honestly say I wish I never had. I still experience the trauma of the after effects. It was a living nightmare!
There are different pathways that affect anxiety and depression outside of the MAO or NMDA pathways. My daughter has a glutamate kainate pathway anomaly on her the genetic test I ran on her, along with a SERT anomaly, which is the presynaptic serotonin membrane which regulates how rapidly she breaks down serotonin before it gets into the synapse, which would indicate that she would likely have low efficacy for any SSRIs. She is also compound homozygous for the MTHFR Gene which converts folic acid to folate, which is critical for making methyl groups, which regulate serotonin, melatonin, norepinephrine, noradrenaline, glutathione, which is downstream from NAC or n-acetylcysteine which this doctor talked about inmanagement for anxiety. The other factor that has a huge implication for funny people is pyrroles. Hemoglobin is broken down into him and then excreted from the body through our urine. But for some people, they have a genetic anomaly which causes kryptopyrrole circulate in the body to bind with Vitamin B6 and zinc thusly depleting them faster and preventing their use in the brain. Activated B6 or p5p is it critical intermediate in the conversion of tyrosine to dopamine, glutamate to glutamine, hydroxytryptamine to serotonin, homocysteine two sister thionine and cysteine, along with many other extremely important neurochemical regulations. I highly recommend that you Google pyroluria along with glutamate and anxiety. I know that this discussion is on depression, but much of depression has an underlying causation of high levels of stress or inner tension on the body. This often causes significant disruption and sleep pathways which further cripples a person suffering from depression or anxiety. I finally took over my daughter's care as her pediatrician after witnessing the ridiculous lack of care she received from my colleagues. I had a SPECT scan done on her brain, did allergy testing, in a panel that I call my behavioral lab to look at underlying neurochemical and organic acids/amino acid functioning, along with a sleep study, even though she had observable sleep issues apart from mouth breathing. Her genetic test also showed that she was homozygous for the COMT enzyme that rapidly breaks down dopamine in the prefrontal cortex, which is often the chemical diagnosis of ADHD. Really long story just sort of long, after giving her low doses of methylfolate and increasing them slowly over the course of about a week and a half when we therapeutic level at 5mg of methylfolate which is the active form vitamin b9, she started smiling again, for the first time in a long time, oh, and we live in Washington state, and her vitamin D level was 19. It should be in the 50s or 60s, and vitamin D is critical for making serotonin.I guess my point is, that the way psychiatry is practice today is the same way it was practiced in Abraham Lincoln's time. Keep going to a clinic, you tell them but your problems are, they go, I'll s***, try this prescription and follow up in a month. You follow up and you're not feeling better so they increase it and tell you to follow up again in a month. You keep doing that until you're so ridiculously exasperated with the medical community that you start experimenting without a help your "self." As my wife has often said, imagine where my daughter would be if I wasn't her father. oh, I didn't mention it after we did the brain scan and a 3-day evaluation with a psychiatrist, we were told that we needed to take parenting classes, and he prescribed Zoloft for my eight year old daughter that did not suffer from depression, but rather and almost crippling anxiety. And per her genetic test, she very likely would have had poor results are very negative side effects. Get a genetic test, Google great plains laboratory and watch webinars from Doctor William Shaw and you will soon become smarter and almost any general practitioner you will ever see in context of trying to help you with your mental health challenges.
Seems like I would call it (ketamine) as contraindicated in bipolar. (This is not medical advice, it’s a science hypothesis.) I think the only reason they want to do it because it makes psychiatrist feel like real doctors again, and it will eventually be insanely profitable.
Yea...2 weeks of treatment is $ 2000K. And does not last 6 weeks or more. The effect It last only for days. That is a patient said to me. Who can afford it?
![Neurobiological mechanisms of ketamine's therapeutic effect [Prof Gerard Sanacora]](http://i.ytimg.com/vi/_gJ4aKLMvGk/mqdefault.jpg)
I received a single infusion 6 months ago, and cured my treatment resistant depression and anxiety. I had it for 40 years. I have not relapsed - It was a miracle for me.
Wiener Woods where are you from bro does it really helps are you lifted up from depression
I'm from the US, and yes, it really does work when administered by a doctor at the proper dose. For most people, unlike standard therapies which fail in most people.
Can you please give me more details please
I just completed a protocol of 4 ketamine infusions in 2 weeks period ( dosage 0.5 mg over 45 min. infusion). Ive experienced mind clarity during infusion but was back to my original baseline few hours after. What protocole did they used for you?
Who did u go to for your CRPS
70 years of dosing people with antidepressants and this guy admits that we have to some degree playing pachinko with people's brains and hoping for the best...
Next slide.
Thanks for a dopamine burst
He discusses NAC here which is what my bipolar daughter was put on 2 1/2 yea ago for severe OCD/intrusive thoughts. It has made a huge difference in her thinking, her depression and her anxiety. It’s been a miracle as she cannot take SSRI’s. Interesting area of progress for these awful illnesses.
6 years later. Nothing
Same thought here.
Like all medical procedures and medications they effect different people differently. Apparently I was born with a depression gene and as a result I have had lifelong depression. After trying everything available except ECT I tried ketamine infusion. After five infusion treatments I experienced no, none, zero effect.
Have you tried weed (or cbd-) oil? Mdma also helps. (it's not gonna cure you though) Different people have different dosages. You've to try to get the right dosage. Don't get stuck with the recommendations. For example cbd-oil has the recommendation of 2-3 drops a day, or so. If that's not working for you, try 1 drop every 3-5hours. And if that's not working try 2-3 drops every 3-5 hours. It won't hurt you. You can't o.d. on weed/cbd-oil.
Robert Lockwood dude perhaps ... What I did eventually... Was to look for answers in the spiritual aspek of life and I know its sound like a harry potter sci fi storie but the answers lie there...... From childhood upbringing with constant stress to how your life path could be on the wrong side and u should change your lifestyle or job.,... Its the only thing left and its free and its given to us from the creator .... Its what Jesus or buddah lived from and like...
Robert Lockwood, I have been suffering from depression since childhood and my recent episode cost me to spend 4 months in hospital..not that's important but just to let you know a bit of what depression looks like for me so far. I learned recently that I'm part of the 30% of people who dont respond to antidepressant. Last March/April I received 50 sessions of RTMS after completing 5 sessions of ECT (bilateral). As scary as it is, I recommend that you give à try to ECT. Unilateral will cause less short term memory loss. (Bilateral suppose to be more efficient but its definitly more agressive). For my part, unfurtunatly, I could not handle more then 5 sessions has it brought back some PTSD memories, but I dont regret trying. Beside triggering PTSD, I did notice a significant change in my ability to communicate and I felt much less anxious. I have some md friends who are sufferring bout of depression and dont have the time for the trials and errors of antidepressants...so they get few rounds of ECT and their good to go for a significant period of time. I just came back today for a Ketamine Tx (4 infusions in 2 weeks). No miracle for me but I keep learning and at least if I can help someone with my experience it would have worth all this pain. Stay safe :).
Sorry to hear that Robert. I have never tried ketamine but I appreciate you sharing your experience. I have had several unilateral ect. treatments but I can honestly say I wish I never had. I still experience the trauma of the after effects. It was a living nightmare!
There are different pathways that affect anxiety and depression outside of the MAO or NMDA pathways. My daughter has a glutamate kainate pathway anomaly on her the genetic test I ran on her, along with a SERT anomaly, which is the presynaptic serotonin membrane which regulates how rapidly she breaks down serotonin before it gets into the synapse, which would indicate that she would likely have low efficacy for any SSRIs. She is also compound homozygous for the MTHFR Gene which converts folic acid to folate, which is critical for making methyl groups, which regulate serotonin, melatonin, norepinephrine, noradrenaline, glutathione, which is downstream from NAC or n-acetylcysteine which this doctor talked about inmanagement for anxiety. The other factor that has a huge implication for funny people is pyrroles. Hemoglobin is broken down into him and then excreted from the body through our urine. But for some people, they have a genetic anomaly which causes kryptopyrrole circulate in the body to bind with Vitamin B6 and zinc thusly depleting them faster and preventing their use in the brain. Activated B6 or p5p is it critical intermediate in the conversion of tyrosine to dopamine, glutamate to glutamine, hydroxytryptamine to serotonin, homocysteine two sister thionine and cysteine, along with many other extremely important neurochemical regulations. I highly recommend that you Google pyroluria along with glutamate and anxiety. I know that this discussion is on depression, but much of depression has an underlying causation of high levels of stress or inner tension on the body. This often causes significant disruption and sleep pathways which further cripples a person suffering from depression or anxiety.
I finally took over my daughter's care as her pediatrician after witnessing the ridiculous lack of care she received from my colleagues. I had a SPECT scan done on her brain, did allergy testing, in a panel that I call my behavioral lab to look at underlying neurochemical and organic acids/amino acid functioning, along with a sleep study, even though she had observable sleep issues apart from mouth breathing. Her genetic test also showed that she was homozygous for the COMT enzyme that rapidly breaks down dopamine in the prefrontal cortex, which is often the chemical diagnosis of ADHD.
Really long story just sort of long, after giving her low doses of methylfolate and increasing them slowly over the course of about a week and a half when we therapeutic level at 5mg of methylfolate which is the active form vitamin b9, she started smiling again, for the first time in a long time, oh, and we live in Washington state, and her vitamin D level was 19. It should be in the 50s or 60s, and vitamin D is critical for making serotonin.I guess my point is, that the way psychiatry is practice today is the same way it was practiced in Abraham Lincoln's time. Keep going to a clinic, you tell them but your problems are, they go, I'll s***, try this prescription and follow up in a month. You follow up and you're not feeling better so they increase it and tell you to follow up again in a month. You keep doing that until you're so ridiculously exasperated with the medical community that you start experimenting without a help your "self." As my wife has often said, imagine where my daughter would be if I wasn't her father. oh, I didn't mention it after we did the brain scan and a 3-day evaluation with a psychiatrist, we were told that we needed to take parenting classes, and he prescribed Zoloft for my eight year old daughter that did not suffer from depression, but rather and almost crippling anxiety. And per her genetic test, she very likely would have had poor results are very negative side effects.
Get a genetic test, Google great plains laboratory and watch webinars from Doctor William Shaw and you will soon become smarter and almost any general practitioner you will ever see in context of trying to help you with your mental health challenges.
Seems like I would call it (ketamine) as contraindicated in bipolar. (This is not medical advice, it’s a science hypothesis.)
I think the only reason they want to do it because it makes psychiatrist feel like real doctors again, and it will eventually be insanely profitable.
Yea...2 weeks of treatment is $ 2000K. And does not last 6 weeks or more. The effect It last only for days. That is a patient said to me. Who can afford it?
wrong.
2,000,000?!!
I heard its more like 35 eur a gram ;)
Check out Spravato
What this treatment in india
I am in Australia & i am getting in 2 weeks
Man I am so happy I don't have a suicide disorder. Like holy crap...
It's not fun because depression is not fun, and it is the cause.
V