Oxygen Hemoglobin Dissociation Curve
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- เผยแพร่เมื่อ 10 ก.ค. 2024
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Explanation of the physiology of the oxygen-hemaglobin dissociation curve, with a discussion of it's clinical relevance.
i was so confused before this video but now i completely understand thank you so much you just saved my butt for my Anatomy and Physiology final
Thank you for the feedback Bethany! Glad you found it helpful!
I'm a nurse and I'm ok with him saying that. i mean, why would someone watch this video if not to learn the content. and if you got the content elsewhere, u wouldn't need this video. he breaks the info down simple for one to understand with a basic medical knowledge. so yea, I'm super grateful for this video.
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Mr, Wolf I’m currently pursuing my second Master’s in Sports Sciences in Ukraine. The job you’re doing is fantastic and inspiring. Thanks God that I know English otherwise I would be deprived of the opportunity to learn using your video lectures. Thanks a lot.
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AWESOME-- I now understand this concept better than I ever have.. actually, I never really understood it at all. Thanks!
Thanks Rachael for the kind words! More lessons on the way!
Thanks very much Andrew. I understood your explanation much better than any lecture I attended whilst at Uni! Much appreciated..
Thanks Lynda for the positive feedback!
Best explanation on the internet :) Thanks man.
Appreciate the feedback Naterv. Glad you found the lesson helpful!
Thank you very much for making these wonderful videos and taking the time to make them avaliable for people to view!
Thanks Dave for watching!
Thank you for the video - very helpful to understand. Much better than how my textbook explained it.
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I am so grateful for your presentations! So many concepts that I have been at loss with, have become crystal clear! Thank you, thank you!
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You really know how to teach. Every other teacher just assume that people understand this by a fast explination. This video made me understand though! :D
Thanks Joran for the encouraging words!
oh my god...ANDREW! IM SO ABSOLUTELY GRATEFUL TO HAVE FOUND YOUR CHANNEL!-- Ive been so frustrated in my RT course because i can't grasp the concepts my BOOORING teacher is trying to powerpoint into my brain. And by the grace of YOU, and 25 minutes, i'm learning it! thank you thank you so much for doing these videos on partial pressures, and association curves and etc etc etc. You're just an angel! THANKS SO MUCH!
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There are actually about 250 million hemoglobin molecules per red blood cell. Which I find pretty insane! Great video. Thanks a lot for taking the time to explain this!
Thank you for watching!
All of your lectures are amazing! Thank you for making nursing school easier by providing another reference in addition to my lectures and textbook. Thank you, Thank you, Thank you!!!
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People like u sir r necessary for students ....whole world...... tq so much
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Thank you soooo much! I'm a first year anesthesia and intensive care resident and I have been trying to really understand this since med school (and I finally did!)
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You are amazing, Im RT student, my professor muffled through on this topic, but you made it clear. Thanks.
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Thank you very much! Excellent explanations, I actually understand more now. I have watched several videos on this subject and this one is the best so far.
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Thank you so much! You did a great job explaining and making it very understandable!! This really helps me as I am a student nurse!!
Thanks Sara for watching the lesson. Glad you found it helpful.
very good lecture very good correlation to the clinical aspect! Thank you!
Thank you for watching!
thank you so much
this video is very good now i know more information about tissue supply ,cynosis , or loss of hemoglobin
you are just an angel.... G
en-telling
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Thank you so much!! Most helpful and understandable explanation yet!!
You’re welcome Mahima. Glad you found it helpful!
thank you so much! Makes so much sense now after your explanation.
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Nice explanation. So good even the doctors I work with would understand it.
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Thank YOU for this video!
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EXCELLENT! Thank you so much. great video
You’re welcome Dwayne. Glad you found it helpful!
honstley, i wish you were my professer
you really helped me alot understanding most of the respiratory phsyio
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Fantastic tutorial, thank you!
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thank you so much for the discussion. i was able to understand it clearly and easier! :)
Glad to hear that Akee. Thanks for watching.
thanks a lot for your efforts
Thank you so much for watching!
What a fantastic video ! thank you so much !
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This make soooooo much more sense now. Thank you! The McCance textbook did such a poor job of explaining the curve and did not even mention BPG. Now I understand!
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I LOVE YOU!! OMG, it finally all made sense! THANK YOU!
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Thanks, the video is considerably informative.
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You are the BEST, thank you Sir.
Thank you for the feedback Khalid! Glad you found it helpful!
great presentation... thank you!
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Thank you so much for this video, I just had an AHAH moment! I get this whole process now!
Thanks Tara for watching. We love the "ahah moments!"
Do you have any videos on Pharmacology (ADME- Absorption, Distribution, Metabolism, Excretion)?
Hi there Reverse Light! Dr. Wolf and the rest of the team here at Health Ed Solutions will be releasing new content weekly starting very soon :)
Thank you very much...it helped me a lot
Thanks for watching. Glad it was helpful.
So one should not administer oksygen to the septic patient in the case?
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So helpful. Thanks so much!
Glad you found it helpful!
thank you very much,
very helpful.
Thank you for watching and glad the video was helpful!
Thank you for this!
You’re welcome StefinEG. Glad you found it helpful!
Hi, these are great videos on respiratory/pulmonary pathophysiology. I'm currently studying paramedicine and these are a massive help. One questing regarding the above video, does this mean that a R) shift is the bodies way of adapting to states where the tissue needs more oxygen but still has a constant PO2 level and when the tissues need for O2 returns to normal, the curve will move L) back to its normal position?
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this is especially difficult for nurse in particular to understand? No other profession has a difficult time learning this? I am wondering where the statistics are that show this?
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THANK YOU SO MUCH!
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Finally I understand! Completely missed the point in med school for some reason
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This was brilliantly presented, thank you so much!
Can you explain what the "60/90" rule for COPD patients refers to - I know it's related to where they hit this curve, but I'm not sure what the use was of hearing about this "rule." Perhaps it doesn't matter if I understand what you explained in this video - but I'd still like to know/understand what my instructor might have meant by that.
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Hey Andrew would it be right in saying at the cellular level undergoing cellular respiration it is more acidic and at other area like the lungs it is more alkalosis?
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are there any situations where it would make sense to shift this oxyheoglobin dis curve to the right in a patient whit hypoxia to insure better oxygen delivery?
Im thinking for example of a patient with bad O2 sats because of Pneumonia for example, and he s also acidotic, to NOT treat the acidosis or even render him acidotic?? You could treat some of the symptoms of acidosis like hyperkalemia but leave the pH low...
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Thank you.
Thank you for watching!
Thanks for the video, great explanation. One question, were (paramedic students) always told to be careful when administering oxygen to a COPD patient as they could have a negative reaction since they are used to the lower amounts, so why does it affect them just from getting more oxygen, you touch on it with BPG but I am still confused, does the oxygen become more tightly bound making the tissues potentially hypoxic?
Thanks for the question. We will ask Dr. Wolf and see what he says!
I understand the concept of why loose binding would allow the tissue to be saturated easier given a low PO2, but I am a little confused. So at 20:55 you refer to the yellow circle, what's happening on the tissue side, can you explain why those numbers are good? Is it because of what you said earlier at 4:55, that the saturation on the tissue side is around 80%? Thank you, Mr. Wolf.
+Andrew Wolf Sorry, this topic is entirely new to me, maybe I am looking too much into the graph you drew, and should just stick to the basic concept that you explained very well. What I wanted clarification on was the yellow circle you drew at 20:00. Why would that yellow circle, that encompasses the tissue O2sat on the curve, communicate to me that everything is ok with the patient? In your response you wrote "sufficient oxygen for aerobic metabolism" what number range would be sufficient enough for aerobic metabolism? Again thanks a million for the video, and more so for the responding.
Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!
This video does a wonderful job of explaining how acidosis, an increase in temp and BPG casues a shift to the right = looser binding of O2, which improves O2 delivery to the tissue. It seems to me that a looser binding of O2 would also mean that fewer O2 is picked up from the lungs and carried to the tissue making the net effect of a shift to the right neutral. Does the higher concentrations of O2 near the lungs and decreased O2 in the tissue make this a net positve for O2 delivery?
Thanks for the question. We will ask Dr. Wolf and see what he says!
Very helpful video. You make a good point that we tend to fixate clinically on pulse oximeter readings. Could you do a video on the validity/confounders in this technology(ie. nail polish, poor perfusion, motion artifact, etc)? My pet peeve is folks documenting SaO2 without documenting FIO2. That's almost worse than not knowing the SaO2 at all. Thanks
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Andrew i'm a little confused. when someone is hypoxic they become acidotic, so i would expect the curve to shift right as you explained, causing a looser binding so that the available oxygen unloads better. But what if the cause of the hypoxia is CO poisoning where the tighter binding and not allowing the oxygen to unload, isn't that a left shift associated with alkalosis ? thanks again.... I love these videos..
Thanks for the question Brian! We have passed this along to the Health Ed Solutions medical review team.
may ask please..what's hang dory when mentioned in minute 16.20? is medical term?
Thanks for the question. We will ask Dr. Wolf and see what he says!
I love the way you say capillary :')
Thanks Anna. We will let Dr. Wolf know :)
Hi. Can you please explain how sickle cell disease will affect the curve?
Hi Mira, we will ask Dr. Wolf and see what he says!
You rock!!! THANK YOU!
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Thank you so much o.o really helpful :)
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The Lecture was very helpful...But i have a question...Can u relate the Oxygen dissociation curve with heme biosynthesis? Thank u
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thank you sir for replying..so i can understood...Cynosis means as well the tissue is not well supplied with oxygen i mean that oxygen particles is not loose of hemglobin to supply tissue..what i meant by my qs i can use cynosis i good sign if the tissue supplied by oxygen even if the o2 sat is low? another qs plz why the lungs doesn't work independantly from the heart and the other way is true?what the physiologic reason behind dat? at least it would work till the residual volume used up?
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Mr. Wolff. I am a nursing instructor. With the school closures we have been forced online. I am seeking permission to use your videos for some of my classes. Thank you for your consideration.
Hi Lisa, no worries. We will be rolling out new lessons soon. Keep watching, we appreciate the support!
What happens when people at high altitudes come down to normal levels? Is their breathing and O2 delivery effected?
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Interesting... I had always just assumed that since RBC don't have mitochondria that they didn't do glycolysis and got the 23BPG from the tissues. It makes sense that they are doing glycolysis without oxidative phosphorylation. So, are they also producing lactic acid or is too much oxygen always around?
Thanks for the question. We will ask Dr. Wolf and see what he says!
very useful
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amazing. thank u so much for explaining all of this! i was so confused reading my med surg book but you make everything SO clear
Thank you Elleily. We are glad you found the video useful!
but how would explain cyanosis? as long as you said if the level of oxygen in
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what happens in a foetus of a mother with pneumonia? how can this be explained using the curve?
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thanks for uploading... nice acadamic stuff...i value ur vedios always.. 1 ques sir... how does it become 110mmhg (pa02) in normal individual since alveolar pAo2 is about 100mmhg (21% 02 alvelar gas equation).. shudnt it be 100mmhg or bit low
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i was expecting an answer from you....... anyhow chief thanx alot ;)
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❤️❤️
So doc what about LOW CO2? Could you discuss how over ventilation with BIPAP can mess with CO2 levels during sleeping hours in a way that is not helpful?
Thanks for the question. We will ask Dr. Wolf and see what he says!
where would a patient with pickwikan disease be. please
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would you please explain this concept in fetal physiology ?
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Thank you, got A- in the exam
Thanks for your feedback and glad you ACED it!
Righty loosey, lefty tighty lol
Thanks for watching!
You lost me at, "one of the things that makes it difficult, for particularly nurses, to understand...."
I am an ICU nurse. I don't claim to know much of anything. However, I do have a rudimentary understanding of the O2-Hgb curve and often find myself prompting interventions in relation to this curve to individuals in possession of an MD.
+Andrew Wolf
I took this statement to refer to the fact that RNs are often the ones to take an SaO2 measurement using a finger Sat probe, so it is easy to get distracted by that when considering interventions r/t O2 Sat overall.
As an RN training to become an NP I found this video (as with MANY of your other videos) very helpful with gaining a deeper understanding as to what is going on at a tissue level! And never once have felt that you were 'talking down' to nurses :)
Thank you!
Thanks for your feedback!
Appreciate the kind words!
This sounds like you don't advocate for treating low oxygen saturation.
Thanks for watching Carrie!
This video has the ability to be good... but u pause and break way to much, it's distacting
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