In this episode, we discuss: 0:00:08 - Kellyann’s background, training, and interest in the brain 0:03:33 - A primer on neurodegeneration: different types, prevalences, interventions, and more 0:14:44 - Overview of Parkinson’s disease and neuromuscular disorders including ALS 0:16:26 - Parkinson’s disease: early signs, diagnosis, genetics, causative triggers, and more 0:31:12 - Interventions to delay or avoid Parkinson’s disease, and the role of sleep and anxiety 0:40:26 - The challenge of standardizing early interventions for Parkinson’s disease without a clear biomarker 0:49:22 - Alzheimer’s disease: pathophysiology and the role of the amyloid and tau proteins 0:53:16 - Can PET scans be informative for diagnosing Alzheimer’s disease? 0:59:28 - Tau accumulation in the brain, tau scans, serum biomarkers, and possible early detection of Alzheimer’s disease pathology 1:06:43 - Cognitive testing explained 1:18:55 - The challenge of identifying the stage of the disease and why drugs have not shown efficacy 1:22:23 - The association between hearing loss and dementia 1:26:39 - The relationship between oral health and neurodegenerative diseases 1:29:58 - Genetic risk for Alzheimer’s disease 1:39:17 - What one’s mitochondrial haplotype can reveal about their risk of neurodegenerative disease 1:43:23 - The positive impact of exercise on brain health 1:46:34 - High blood pressure as a risk factor 1:51:22 - Why women are disproportionately affected by Alzheimer’s disease 1:54:14 - Final takeaways: the future of understanding neurodegenerative disease and further reducing risk
should really disclose, as per linkedin, she works for a firm affiliated with the podcast. but will assume it was and I just missed it. to their credit, it seems factual not commercial in topic
Thank you for this. My father was diagnosed with Parkinson’s and the medications make him worse. He started having a tremor immediately after taking psychiatric meds. There is so little guidance for us. The doctor just keeps giving new meds-it’s very discouraging for people who wish to be proactive. This all came to light for us in 2020 after my mom died of pancreatic cancer.
The treatment is to keep moving ,boxing help to focus,sleep,healthy organic food,fasting,no snacking and binging,omega 3 from oily fish like sardines,Mackeral,Wild Salmon,It our toxic environment,air,water,food,plastic ,all this civilized modern life which our body do not know because we are evolved from our ancestors with scarcity ,Keep learning to reverse or slow disease.Prevention is better than cure Arabic proverb(الوقايه خير من العلاج).Learn from traditional cultures basic living.God blessings.
I'm 40, have been acting out my dreams for about 10 years, and grew up on a farm using well water where we and the neighbors use pesticides. I'll be going to the doctors soon!
Supposedly out of 33K views when I listen to this interview but only 766 thumbs up - what's wrong with these views? Excellent talk! Keep up the efforts.
She was clear about avoiding toxic metals through the lifespan, and clear about having good genes. She was clear about good sleep boosting brain function, and poor sleep making brain function worse/damaging the brain. She is also clear about reducing inflammation in the body. You can attack your diet and sleep today, and that will boost your health. They will not reverse current damage that has been done on your basal ganglia, and they will not alter your genetic makeup enough. Ask Michael J. Fox. You know that he has access to the best advice out there, and the ability to act on it. It is in his most recent book. He has lived for 30 years with this disease, and it has continued to progress.
So dancing in my Silver Sneakers classes makes some sense! The relation of music, dance, sound as it relates to exercise is something I’d love to see explored. Thanks for this informative discussion.
It’s very depressing to me that it sounds like almost nothing has changed with Parkinson’s disease since I did my research in medical school. That was in the mid 90s.
#DrDaleBrenesen #DrDonaldLayman #CharlieFoundation #MetabolicMind #metabolicHealthSummit #insulinIQ #DrTerry #collagen #DrJasonFung #DietDt #DominicDagostino #Besteverfoodreviewshow #reindeerherdsman I really believe now that agriculture has really contributed to all current diseases. #Carbohydrates hurt the human body. #ProteinLeverageHyphothesis MACROS in order of importance *FAT *PROTEIN *SALT *MAGNESIUM *POTASSIUM *CALCIUM *seasonal carbs #collagen is made in our bodies when we eat fatty protein and heals burn victims, heals epilepsy, heals cancers, heals osteoporosis, heals diabetic wounds reverses many metabolic conditions.
By far Dr. Peter Attia, this was great information! Dr. Kellann knowledge is so incredibly important! Thank you both for sharing this information and educating the world about these Monster neurological diseases! Hugs~ to you both! Please keep up the great work and please never stop sharing what you have learned! Mj Gignac 🏃♀️
❤I am so thankful to you for all of your efforts...finally! Information that truly educates with in- depth detail. My mother, her twin, and their mother died enduring vascular dementia.....and yes, the worst incremental decline imaginable. My heart hurt at the end of this podcast. I am riveted when listening to your podcasts on ASCVD and Apoe B... I have just discovered your podcasts and feel like a kid on Christmas morning❤❤ Again.....THANK YOU
I wish the role of these issues was included in the discussion: 1. Multiple TBI events (such as in boxing, sports, car accidents) 2. Sleep Apnea 3. Interactions/Side Effects of the merry-go-round of Prescription Drugs given to seniors in this country (most are on at least 5 drugs at any given time, many are on far more)
This otherwise informative discussion dropped the ball when after Niotis alluded to “all the things they can do preventatively once they know someone is apoe4,” Attia didn’t follow up and ask what those preventive measures are. Other than exercise and using a waterpik, listeners are left with no actionable information. Diet? Supplements? Statins? I find this to be a recurring theme in Attia’s podcasts. They are always interesting, and there are always vague allusions to “what he does in his practice with his patients,” but he never gets to specific, actionable items for his listeners. For example, I know he loves statins, but lots of studies show statins are detrimental for cognitive health and, specifically, for alzheimers patients. So, should Apoe4s take statins to lower LDL to the detriment of their cognitive health? Curcumin? Keto diet? DHA supplements? Listeners can’t afford Attia, can’t wait 5 years on the waiting list for Cornell for Niotis, can’t wait 5 years on the waiting list for Richard Isaacson at FAU, and their local doctor is woefully uninformed and simply prescribes aricept and namenda, both of which don’t work. If he really wanted to help people, he would get more to the point with his guests as to what the average person at home should do. I’ve been a big fan of his for years, but have been getting more and more disappointed with his esoteric discussion of issues, his constant vague references to what he does with his patients, and his failure to tell his listeners exactly what it is he is advising his patients to do. This is why Huberman is so popular … detailed lists of actionable items that the listener can implement.
Thats his theme tho he doesnt talk about practical things that much anyways, i dont come to his podcast for practical advice, i go to barbell medicine, tho no one podcast can talk about everything medical
Steve Gaudin, Check out Dale E. Bredesden, MD. He has written a book called.’ The End of Alzheimer’s - The First Program to Prevent and Reverse Cognitive Decline’. It’s a game changer! In all fairness to Peter Attia, Andrew Huberman does not make a living treating patients with that kind of information. We all know it’s the money that makes the world go around.
Many of those topics recovered here, including improving sleep, and exercise. In general lots of movement. this combine with his many other podcasts provides lots of detail background that you seem to be interested in.
I would have liked to know her opinion about a possible metabolic origin of these neurodegenerative diseases and how a ketogenic diet can help in their improvement. Also, what do she think when she hear that these protein plaques are advanced glycation and oxidation end products?
Thank you to for producing some amazing content! Exercise and movement can help so much in maintaining brain health and preventing some of these disorders.
You don't treat patients, do you? I lost count of the formerly active and athletic people who developed Parkinson's and Alzheimer's. Age and genetics are the primary risk factors, not diet and exercise. Tons of heavy flabby people w/o these diseases. Tons of trim and healthy people with them. Those are the most distressed patients. They thought they had done everything right. They often outlived their expiration date on health. Try not to do that yourself.
Yes it does! Physical activity can improve your cognitive health-helping you think, learn, problem-solve, and enjoy an emotional balance. It can improve memory and reduce anxiety or depression.💯
@@Cathy-xi8cb yes man thank you. I don't know whats happening to me. I am a super healthy individual, excercise a tonne, eat healthy, and someday i have good sleep someday not so much but am working on it. Doing all this, i feel like i am loosing my speech, have started slur words a bit, mental maths has become tough, recalling the right word that i want to speak is tough. Dont know what to do anymore.
Life is amazing, so many things have to go just right in order to be healthy and what do we do........... somehow I'm still alive and fairly healthy. I didn't ride my bike this morning and after watching this I feel even more guilty. Use it or lose it.
1:44:46 Exactly why I’m a huge fan of cross country skiing. The sport requires a high level of skill and balance to do well. The movement patterns take years to perfect. The cardio respiratory demands are also off the chart. Elite cross country skiers have some of highest VO2 maxes ever measured.
Yes; Parkinson's patients do report changes in mood and thinking, but they AND THEIR DOCTORS attribute it to aging or life stress. Try living with someone who has developed the cognitive and emotional changes associated with Parkinsons. You are now living with someone mentally ill AND physically ill. It is a nightmare.
If glucose uptake is decreased where there is early neurodegenerative disease (and amyloid buildup is not reliably linked to cognitive degredation) doesn't this suggest that metabolic disfunction is a key aspect of the underlying causality? (Especially in light of the recent uncovering of fraud being involved in key studies thought to have linked protein plaques to dementia.)
Drs. Niotis and Attia, have either of you previously presented any findings on the potential effects corticosteroids have on healthy individuals? Four months ago, I was prescribed prednisone to treat lung and bronchial tube congestion resulting from three weeks of confined exposure to mold toxins. Within ten hours of taking the first 20 milligram tablet I began experiencing, for the first time, neuromuscular issues: balance/equilibrium problems, muscle weakness and slow muscle response in both legs. Within twelve hours, that weakness was present in both arms and shoulders. After completing the prescribed 10-day regimen, physical exhaustion and certain neurological concerns began to manifest. Over the next two months all the symptoms slowly improved. However, that improvement plateaued in early December. Just curious if you've come across this type of reaction to corticosteroids and how they mirror some of the cognitive and neuroplasticity issues discussed in your video. As usual, many thanks for your insightful content.
I had something similar it took me a very long time to figure out. I took 2 prednisone packs at different times 2 years ago. I just found out Corticosteroides deplete magnesium. I was taking magnesium citrate so I did not know I was deficient. I had all sorts of test even MRI and CScam. They never measured my minerals. I was like that for 2 years and getting progressively worse. One day I switched over to magnesium lysinate glycinate drs best high absorption. I took it at night and woke up with no pain I was shocked. I now take 300 mg daily and magnesium cream. I am 100% better. Just start taking it right away. The type of magnesium matters. Glycinate is the one for muscle issues. Also try to get a mineral panel test see if you are low in other minerals like potassium. Corticosteroids may increase the body's loss of magnesium. Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300-400 mg of magnesium per day.
@@moondrop3013 Thanks for commenting. I haven't thought about possible mineral deficiencies as a result of prednisone. I wish that advice had come with the prescription. I have an appointment with a neurologist and will make a point of suggesting a mineral panel. You had a rough time with the magnesium deficiency but glad to hear the glycinate helped. I'll add that to my supplements. NMN has helped with low energy levels. I appreciate you taking time to share your experience. Take care.
@@mac878 If you are magnesium deficient and start taking it you will notice a difference the next day. The magnesium also helps with energy levels, mood, muscle spasms and cramps. It’s only $11 just start taking it.
@@moondrop3013 Good to know. Currently looking for a quality brand and local source before purchasing on Amazon. I'm looking forward to having the same results you've experienced. Thanks again.
@@mac878 It’s been a month since you last posted- for nerdy people like me who read comments and learn a lot can you update your results? Did the magnesium and/or other minerals work?
I listen to these 2 drs and i remembered seeing neurologists early in my traumatic brain injury journey when i have so many sensory symptoms and neuro dysfunction. I could swear the neurologists i saw got their training from maccas cause they seemed to not know how the complex puzzle of the brain works.
What do you mean "APOE4's are immune to the learning effect... learning is not a factor for them?" LOL that seems wrong. No? Richard Isaacson if you see this can you please explain what she's talking about.
Very informative podcast,big fan of drive podcasts.If sensory input is critical,then lack of visual sensory input should cause neurodegeneration earlier in blind people,or in deaf mutism,are there any RCTs in blind,or deaf mute persons on dementia or Alzheimer's causation and progress.
My husband has multiple neurological issues; both physical and brain related. We've seen several neurologist's and basically get nowhere. We are always told "no diagnosis" no treatment and no cure. See you in 6 months. Why even bother to go to these appointments....it is just a total waste of our limited time and energy. My husband has been told he has major neurocognitive disease, stage 4 (according to his gerontologist.) A brief discussion mention Charcot Marie Tooth Disease but a DNA test is needed to determine that (SYMPTOMS: high arches, hammertoes, nerves dying in his legs, wonky gait, falling etc.)
Could gluten’s toxicity extend to the nervous system, producing symptoms identical to classical Parkinson’s disease? A new case study adds to a growing body of research indicating that wheat’s neurotoxicity is greatly underestimated. A remarkable new case report describing the dramatic recovery of a 75-year-old Parkinson’s disease patient after following a 3-month long gluten free diet reveals the need to explore whether there is an increased prevalence of silent or symptomatic celiac disease or non-celiac gluten sensitivity both in those afflicted with Parkinson’s disease and the related multi-factorial neurodegenerative condition known as Parkinsonism.
Idk my mom used to sleep walk. We always had to work hard to wake her up. She did stop doing that for the most part after she healed some trauma. She’s now 75 and no sign of any neurodegeneration. Maybe she’s part of the 10% or maybe it’s more environmental that we understand. But she did smoke for many years, too lol
I acted my dreams out until I started using THC as a teen. I wonder if THC is beneficial for people with parkinson's in their family who act out their dreams. My grandma suffered from parkinsons after misdiagnosis. I'm very health @ 37yo.
Do you have any information on vitamin B6 as a neurotoxin? I have been healing from B6 toxicity…even very low dose of supplementation (under 10mg) causes Serum toxic accumulation for me with tingling feeling in left leg. Neurologist doesn’t have a lot of information other than to stop all B6 supplementation. MRI negative for MS and ALS.
Anecdotally, recently I had a burning sensation on my foot( not painful at all, just oddly hot) that would happen for 5-10 seconds once or twice or three times a day. Had no idea what is was until I eliminated the B complex vitamin I recently started and it went away. I then took one after being away from it for two weeks and the heat came back. Haven’t taken one since and no burning feet. I have “guessing” it is due to the B6 in there.
I am surprised this podcast hasnt interviewed Dr. Dale Bredesen . He has demonstrated reversal of cognitive decline by treating whatever is wrong wirh the body. He assesses for low level inflammation , insulin resistance / diabetes , chronic infection including periodontal, accumulation of toxins, head trauma , decreased blood flow to the brain ,anemia, decreased trophic support( hormones,viamin B12,). He is also looking at other neurodegenerative disease.
We know that those drugs can damage many phases of sleep, and that poor sleep can damage brains. People are taking them to study and to work extra hours. How's that?
How about the NIH's insistence on hypothesis-based research? Even worse, they increasingly ask applicants to list their "probable results" in grant applications. The system is biased against screens to discover new things.
Free flowing and a superb, highly informative episode, thank you both. Pesticides rightly mentioned but sidestepped some of the actual foods impacted - a great shame. Worries maybe about those big businesses defending their pesticide covered products? If so, it’s a shame that intimidation or fear of reprisals from big pharmaceuticals silences us. Otherwise, an excellent collaboration and discussion. :)
@@wildhorses6817 Not my clinical experience. My elderly patients 40 years ago weren't drinking anywhere near the amount of milk and sugar that younger people get in their lattes and other fancy coffee drinks.
You guys should approach Google or Apple and see if they will do the machine learning for the Gene sequencing patterns on the house for the good publicity
Amazing podcast, thank you. With regards to nocturnal hypertension I realise that this is a difficult area to assess but are there any guidelines that can be recommended? For example taking blood pressure just before bed, during any periods of wakefulness at night, first thing on rising?
what we see in medicine are all the older people that fall when they get up hypotensive and dizzy from the effects of drugs. The short-acting drugs make them get up to pee. Expecting drugs to be great solutions for chronic issues is not working.
I take rasagiline and low dosage entecapone to prevent Parkinson's. that is because I abused dopaminergic stimulants during my youth, and I irreversibly damaged/killed millions of my dopamine=producing neurons.
Regarding the link between pronouncing difficult words and (higher) IQ.. any thoughts on the evolutionary biology theory that having a exceptional memory when young, may cause the substantia nigra to burn out when older ( antagonistic pleiotropy). For example Russel Foster ('Why do we sleep') suggests genes involved with sleep (ex. shank2, CHRNA7 , etc) are the same as those involved with schizophrenia and that schizophrenics have unusual synaptic pruning. I understand senescent cells are needed early in development but for some reason they increase in numbers as you age, continuing to function, just not able to divide or die (apoptosis). But if knocking out the autohphagy gene in mice leads to neurodegeneration, any thoughts on using Lithium / rapamycin to manage autophagy/parkinsons? Regarding how using dance/movement may help with Parkinsons, any thoughts on Alex Kerten's Gyro-Kinetic Method . On early detection using the 9 smell tests, does the at-risk person recognize the smell is unable to identify/name it, or do they not recognize it all? In addition to irregular breath, acting out rem sleep, less movement in your dominant hand (less sense on the opposite leg).. I understand insomnia and constipation occur decades before those that will go on to get Parkinson's. Inflammatory bowel disease (IBD) seems also positively (ex. Crohns patients are at a 30% higher risk ). Any thoughts if dysbiosis (increased levels of Akkermansia) may be causal? Also, I understand uric acid acts as an antioxidant/metal chelator , but if levels are too high it is pro-oxidant.. and that Peter likes to use SGLT2 inhibitors / allopurinol to bring uric acid levels to below 5mg/dl. But isn't low uric acid levels also associated with Parkinsons? Interesting point on how the brain doesn't rely on insulin, and yet intranasal insulin injection seems to temporarily alleviate tremor symptoms.. but regarding how high AboB (LDL) is associated with reduced speed of processing, any thoughts on using fat-soluble statins (lipitor/atorvastatin) and their correlation with a decreased risk of Parkinsons? Julie Anderson from the Buck Institute suggests Paraquat exposure, elevated levels of Iron ( or low blood anemia), may all contribute to Parkinson's. Coffee and nicotine, seem to be protective.
Environmental triggers,cellular biology,diagnose 20years before disease appears ,find the cause,no bio markers,prevention is difficult and essential.Histopathology for alpha nuclei n proteins misfolding and cause brain degeneration.physical misfolded proteins inside the cells,common cause is sugar,refined flours,oxidized cholesterol particles trigger inflammation,so impair cellsignalling,autopsy findings to diagnose.Pet scans shows which brain parts ,show hypometabolic ,sugars is less to affected area due to nuerodegenertion,not perfect,does not tell us what proteins and is it part of normal aging process.Amyloid is abnormal but also normal in normal people but needs to clear it.one night no good sleep increase Amyloid 5%.We are ignorant of the brain.philosophical,practical questions.what markers to look at? It should be cognition markers.Scans have a lot of radiation.Every person is different.Take scam tell us about cognitions decline,costly,and radiation.Sleep is powerful tool to clear Amyloid which is present all the time.part 2.
Math, music, movement, etc. all have dominant parts of the brain. Music seems to be the last to go, mathematicians peek and fade in their careers earlier. I noticed my regimented morning routines were indicative of the need for order and efficiency. I can cluster groups of the details but together they create inner calm. It helps to label transitional walking as an activity like walking from room to room. It keeps the cycle of mindfulness. This was REALLY helpful. I also liked CLOSURE routines such as last looks and shutting doors. Now that I am retired I love mental reviews of what I did that day and REFLECTING on my intentions, burnout, noticing CHANGES. (Connect the dots for surprising meaning).
@@Grandma188 I visited a friend who was in the final stage of Alzheimer's last week. The person I knew was gone for the most part; I did speak in a soft voice of pleasant times, and put on some Beatles music, the hallmark of our generation. She has been nonverbal awhile and if there was reaction, it was too subtle for me to understand. I hope it was a good experience for her. She died two nights ago.
If one knows they are at an elevated risk to get a neurodegenerative disease because they have ALS and Parkinson’s in their family and they are an ashkenaszi Jew (asking for a friend ;), am I understanding correctly that the only prevention ideas are various forms of exercise, a waterpik type flosser, and making sure you have quality REM sleep. Have I missed anything else?
@@chandelie4 I know the microbiome is important but I had not heard about it being protective in this instance… would love to hear more. I have been pounding down kombucha and homemade soy yogurt lately….
I would suggest various detoxifying efforts- such as sauna, drinking purified water, being very careful about OTC lotions, soaps, etc., and so on. I'm not an expert but there are definitely books on how to detox. I worked many of these with my mom who was diagnosed with the "toxic" form of Alzheimer's (with a high blood mercury level, and a low zinc/high copper level), and we saw her cognition improve as well as her blood test markers for toxins drop. (Note we were also following a ketogenic diet, balancing nutrients, decreasing stress, increasing sleep, working on exercise, healing her "gut" biome via colostrum and other pre/pro biotic, and having her engage her brain via brainhq. She definitely improved substantially in just a few months, but didn't care for following the rigidity of the interventions we were trying. But given the results I saw in such a short time, I am committed to following many of these guidelines myself to avoid any neurodegenerative diseases later. I did get my DNA tested and noted that I have the dreaded "APOE4" gene, but was very interested in this podcast to learn that the 23&me gene that they test for Parkinson's isn't the only Parkinson's marker. After looking at the more advanced "raw data" from my DNA it turns out that I have several "poor results" on the various other Parkinson's genes- particularly the ones Dr. Niotis mentioned. But I think there's a great deal of reason to be positive- we're in the generational cohort that can be proactive and have reasonable expectations of positive results. Listen to Dr. Attia's podcast with Dr. Isaacson (from about two years ago on Alzheimer's prevention), and get some books on the same topic. These neurodegenerative diseases appear to be very similar and preventative measures that work on one can reasonably be inferred to work on another. Do they all work? Maybe- maybe not, but it doesn't hurt to improve your life (as most of the suggested interventions are things we should be doing anyway) and at worst your data points can help other people in the future while at best they can absolutely help you delay or even prevent the onset of the disease. Good luck!
Look into control of limiting epigenetic risk factors through proper nutrition and anti-stress techniques. Obviously, avoid toxins and pesticides. Like you, I worry about this too. And last, low dose naltrexone seems quite helpful for autoimmune disease in general. It's recommended on some Parkinson's sites.
Peter - do you and Kelly REALLY want to solve this mystery? I have iRBD diagnosed by polysomnogram. I developed the first diet to shut down my dream enactment. Parkinson's is a combination of food - toxins - infections. I have test that point to toxins (environmental, mold, and organic acids) and possible low-level infection. If you REALLY mean what you say, reach out and I will be glad to go over what I have discovered since being diagnosed with iRBD in 2019.
1:16:45 HOLD ON: What the hell was she talking about, “APOE4’s are immune to the ‘learning effect’? they actually don’t learn as well, so you can retest them in 6 months since learning isn’t really a factor to consider for Them?” WTF? Peter can we confirm this lol This woman / that statement is crazy.
If you have cognitive impairment from APOE4-related brain damage, you will not remember the questions, or the answers, to the cognitive functioning tests. In other words, you will not exhibit the learning effect of being initially tested. Hope this is clearer.
@@cjgreene2344 Because AZ is different in presentation from vascular dementia and other dementias. They could have eaten a great diet all their life. Genes will still triumph in the end. AZ presents with strong and early learning and memory issues. The EPOE4 contribution is how AZ is diagnosed, but also with specific deficit constellations. With vascular dementia we see a predominance of executive functioning issues with sparing of a lot of learning impairments until later stages. With Lewy Body we see the motor issues of parkinsons along with the delusions and hallucinations, as well as emotional changes from premorbid life. Hope that helps.
@@Cathy-xi8cb so Chris Hemsworth’s genes will still triumph in the end? (Thor actor - 2 copies E4) Doing everything right? Got it. I’ll let him know he’ll be ‘immune to the learning effect’ later in life despite near perfect epigenetic influences👍🏽
@@cjgreene2344 Genetic influences are the strongest in determining whether you will develop AZD, along with advanced age. This was said early in this presentation, and hasn't changed for decades. We see former Olympic athletes and committed exercisers drooling and wearing diapers in their 90s. And very old people who did everything wrong being gleefully independent as they swan off to Chik-Fil-A.
Sugar, grains and seed oil. Don’t eat that crap. Encourage friends and family not to eat that crap. Then we don’t need to worry much about all these chronic degenerative diseases.
Please make focused list of prevention of nuerodegenerative diseases to safe lives,help lay people.Testing leave it to professionals.What is your audience Then plan your teaching to that audience.Thank you.Time is very precious and too many distractions.Lateral talking without content is superfluous and not productive.
Recap,sleep disturbances 30 years before symptoms.Triggers are autophagy genes not working,toxics like herbicides,water,genes,abnormal movements,slow,Body is asymmetric,right arm not swinging during walking if right handed,breathing patterns,use more non dominant side,orthopedic injuries,neuronal circuits,pay attend to all parts of body.sleep tracking,REM sleep is important for emotions in addition to memory,more anxiety in such patients,light exposure for20-30 minutes early morning to regulate rhythm and hormones including Melatonin.Anxiety is related to Melatonin signalling ,cause or result?.This is part 1 Recap.
you know what is interesting I got home and I cannot listen to your podcast any further. I only listen to you to boost my dopamine( a joke) while walking my dogs or being on the way. Back at home I boost my dopamine by knitting, there is nothing better than that. I knitted over 400 pieces within the last 2 and half years. The good thing about my family is we have really healthy longevity genes. We are outstanding in physics, math and chemistry. Like Johny Nash oh schizophrenia hm which algorythmus is that. I am simply to disinterested now to watch you further, but you are good, your book is surely top, just tomorrow when I walk my dogs, I always learn new stuff walking my dogs, but being at home I want my brain to empty itself. Did someone ever type you so many words as a comment, having nothing to do with the topic? I cannot just knit further, my fingers are getting warm, riboflavin from the science point of view, B vitamins, folate, etc.... but you know where I am now histidin( amino acids) this one is tricky and might or I am pretty much sure the key.... histamine, etc.... glucose, Ph, hemoglobin, etc....
It is very annoying that this intelligent neurologist uses vocal fry , a patronizing tone of voice that detracts from her otherwise clarity of thought and makes it difficult to listen. Provider? What happened to the medical profession? REM behavior disorder can be precipitated by SSRIs. A common mistake, familial is not necessarily genetic .
And I was checked later by the doctor( all different things were measured), As I have already written I am not the only one, the list of patients by one of the clinic is over 6000 patients all proved being ill through the vaccine. Also young people who were healthy before. I was fine with my past, trauma, by being dement, first paralyzed my left side I got set in the past. Short memory damage, eye damage..... I know more than one person with eye damage 2 are blind, I even know someone now suddenly sitting in a wheel chair. Thank you. Also in my case is proved it is the vaccine.
Love her knowledge and their conversation but does anybody think it's odd she hardly looks at Peter? very little eye contact - almost just have to listen to it instead of the watch because it feels uncomfortable.
00:30:00 "Clearly there is something that we are missing..." Yeah enviromental factors and "genetic" aka family habits. Crap carb?? food crap industrial food? crap mitochondrion destroying elmements ?? lack of Deuterium poor electrical signaling??? Start there more crap will come along.
you know what is constantly on my mind watching you you have something that alcoholics have, the control.... well, see this is my algorythms I was more than good in algebra. See maybe you all together measure your brain's own brain leaks. I will comment next t
Unfortunately, many neurodegenerative diseases cannot be prevented. There is a strong genetic component. Take MS for example. There's nothing you can do to avoid getting MS. Same with Parkinson's and let's not mention ALS. There may be ways to lower the risk of Alzheimer's, for example, but there's not much you can do to prevent it. This is why neurology is a depressing specialty; there's little hope you can give your patients other than possibly prescribe meds to mitigate symptoms but you cannot stop the progression.
@@Cathy-xi8cb Yes, I am. But unfortunately a vaccine will do nothing for established MS. The immune system is already primed, to say nothing of reversing existing disability. We have a long way to go.
In this episode, we discuss:
0:00:08 - Kellyann’s background, training, and interest in the brain
0:03:33 - A primer on neurodegeneration: different types, prevalences, interventions, and more
0:14:44 - Overview of Parkinson’s disease and neuromuscular disorders including ALS
0:16:26 - Parkinson’s disease: early signs, diagnosis, genetics, causative triggers, and more
0:31:12 - Interventions to delay or avoid Parkinson’s disease, and the role of sleep and anxiety
0:40:26 - The challenge of standardizing early interventions for Parkinson’s disease without a clear biomarker
0:49:22 - Alzheimer’s disease: pathophysiology and the role of the amyloid and tau proteins
0:53:16 - Can PET scans be informative for diagnosing Alzheimer’s disease?
0:59:28 - Tau accumulation in the brain, tau scans, serum biomarkers, and possible early detection of Alzheimer’s disease pathology
1:06:43 - Cognitive testing explained
1:18:55 - The challenge of identifying the stage of the disease and why drugs have not shown efficacy
1:22:23 - The association between hearing loss and dementia
1:26:39 - The relationship between oral health and neurodegenerative diseases
1:29:58 - Genetic risk for Alzheimer’s disease
1:39:17 - What one’s mitochondrial haplotype can reveal about their risk of neurodegenerative disease
1:43:23 - The positive impact of exercise on brain health
1:46:34 - High blood pressure as a risk factor
1:51:22 - Why women are disproportionately affected by Alzheimer’s disease
1:54:14 - Final takeaways: the future of understanding neurodegenerative disease and further reducing risk
should really disclose, as per linkedin, she works for a firm affiliated with the podcast. but will assume it was and I just missed it. to their credit, it seems factual not commercial in topic
Thank you for this. My father was diagnosed with Parkinson’s and the medications make him worse. He started having a tremor immediately after taking psychiatric meds. There is so little guidance for us. The doctor just keeps giving new meds-it’s very discouraging for people who wish to be proactive. This all came to light for us in 2020 after my mom died of pancreatic cancer.
The treatment is to keep moving ,boxing help to focus,sleep,healthy organic food,fasting,no snacking and binging,omega 3 from oily fish like sardines,Mackeral,Wild Salmon,It our toxic environment,air,water,food,plastic ,all this civilized modern life which our body do not know because we are evolved from our ancestors with scarcity ,Keep learning to reverse or slow disease.Prevention is better than cure Arabic proverb(الوقايه خير من العلاج).Learn from traditional cultures basic living.God blessings.
I'm 40, have been acting out my dreams for about 10 years, and grew up on a farm using well water where we and the neighbors use pesticides. I'll be going to the doctors soon!
Damn.
Good luck...
I would like many more deep dives on neurodegenertative disease. Fantastic episode. Thanks you both a lot!
Supposedly out of 33K views when I listen to this interview but only 766 thumbs up - what's wrong with these views? Excellent talk! Keep up the efforts.
Nice chat wish there was more on prevention/reversal.
She was clear about avoiding toxic metals through the lifespan, and clear about having good genes. She was clear about good sleep boosting brain function, and poor sleep making brain function worse/damaging the brain. She is also clear about reducing inflammation in the body. You can attack your diet and sleep today, and that will boost your health. They will not reverse current damage that has been done on your basal ganglia, and they will not alter your genetic makeup enough. Ask Michael J. Fox. You know that he has access to the best advice out there, and the ability to act on it. It is in his most recent book. He has lived for 30 years with this disease, and it has continued to progress.
So dancing in my Silver Sneakers classes makes some sense! The relation of music, dance, sound as it relates to exercise is something I’d love to see explored. Thanks for this informative discussion.
Peter, this was an outstanding interview: a real collaborative conversation rather than a display of ego. Seriously, kudos!
It’s very depressing to me that it sounds like almost nothing has changed with Parkinson’s disease since I did my research in medical school. That was in the mid 90s.
When something doesn't make sense, is there a hidden agenda?
#DrDaleBrenesen #DrDonaldLayman
#CharlieFoundation
#MetabolicMind
#metabolicHealthSummit
#insulinIQ #DrTerry
#collagen #DrJasonFung
#DietDt #DominicDagostino
#Besteverfoodreviewshow
#reindeerherdsman
I really believe now that agriculture has really contributed to all current diseases. #Carbohydrates hurt the human body.
#ProteinLeverageHyphothesis
MACROS in order of importance
*FAT
*PROTEIN
*SALT
*MAGNESIUM
*POTASSIUM
*CALCIUM
*seasonal carbs
#collagen is made in our bodies when we eat fatty protein and heals burn victims, heals epilepsy, heals cancers, heals osteoporosis, heals diabetic wounds reverses many metabolic conditions.
Did I miss hear you could use 10k lux light for 25 min in the morning and exercise to help prevent it?
VERY DEPRESSING BECAUSE NO PREVENTION OR INTERVENTION
Is it bc it ts ine of the hardest things in the nody to understand, the brain that studies itself
By far Dr. Peter Attia, this was great information! Dr. Kellann knowledge is so incredibly important! Thank you both for sharing this information and educating the world about these Monster neurological diseases! Hugs~ to you both! Please keep up the great work and please never stop sharing what you have learned!
Mj Gignac 🏃♀️
❤I am so thankful to you for all of your efforts...finally! Information that truly educates with in- depth detail.
My mother, her twin, and their mother died enduring vascular dementia.....and yes, the worst incremental decline imaginable. My heart hurt at the end of this podcast. I am riveted when listening to your podcasts on ASCVD and Apoe B...
I have just discovered your podcasts and feel like a kid on Christmas morning❤❤ Again.....THANK YOU
I wish the role of these issues was included in the discussion:
1. Multiple TBI events (such as in boxing, sports, car accidents)
2. Sleep Apnea
3. Interactions/Side Effects of the merry-go-round of Prescription Drugs given to seniors in this country (most are on at least 5 drugs at any given time, many are on far more)
This otherwise informative discussion dropped the ball when after Niotis alluded to “all the things they can do preventatively once they know someone is apoe4,” Attia didn’t follow up and ask what those preventive measures are. Other than exercise and using a waterpik, listeners are left with no actionable information. Diet? Supplements? Statins? I find this to be a recurring theme in Attia’s podcasts. They are always interesting, and there are always vague allusions to “what he does in his practice with his patients,” but he never gets to specific, actionable items for his listeners. For example, I know he loves statins, but lots of studies show statins are detrimental for cognitive health and, specifically, for alzheimers patients. So, should Apoe4s take statins to lower LDL to the detriment of their cognitive health? Curcumin? Keto diet? DHA supplements? Listeners can’t afford Attia, can’t wait 5 years on the waiting list for Cornell for Niotis, can’t wait 5 years on the waiting list for Richard Isaacson at FAU, and their local doctor is woefully uninformed and simply prescribes aricept and namenda, both of which don’t work. If he really wanted to help people, he would get more to the point with his guests as to what the average person at home should do. I’ve been a big fan of his for years, but have been getting more and more disappointed with his esoteric discussion of issues, his constant vague references to what he does with his patients, and his failure to tell his listeners exactly what it is he is advising his patients to do. This is why Huberman is so popular … detailed lists of actionable items that the listener can implement.
Thats his theme tho he doesnt talk about practical things that much anyways, i dont come to his podcast for practical advice, i go to barbell medicine, tho no one podcast can talk about everything medical
Attia also pushed for vaccines specifically the jab. I felt like he was part of the propaganda campaign during the BS lock downs.
Steve Gaudin, Check out Dale E. Bredesden, MD. He has written a book called.’ The End of Alzheimer’s - The First Program to Prevent and Reverse Cognitive Decline’. It’s a game changer!
In all fairness to Peter Attia, Andrew Huberman does not make a living treating patients with that kind of information. We all know it’s the money that makes the world go around.
Many of those topics recovered here, including improving sleep, and exercise. In general lots of movement. this combine with his many other podcasts provides lots of detail background that you seem to be interested in.
Steve, I feel exactly the same 100%. Thanks for expressing it.
I would have liked to know her opinion about a possible metabolic origin of these neurodegenerative diseases and how a ketogenic diet can help in their improvement. Also, what do she think when she hear that these protein plaques are advanced glycation and oxidation end products?
I have RBD, and follow a keto diet. I would really like to know the answer to this question.
Thank you to for producing some amazing content! Exercise and movement can help so much in maintaining brain health and preventing some of these disorders.
You don't treat patients, do you? I lost count of the formerly active and athletic people who developed Parkinson's and Alzheimer's. Age and genetics are the primary risk factors, not diet and exercise. Tons of heavy flabby people w/o these diseases. Tons of trim and healthy people with them. Those are the most distressed patients. They thought they had done everything right. They often outlived their expiration date on health. Try not to do that yourself.
Yes it does! Physical activity can improve your cognitive health-helping you think, learn, problem-solve, and enjoy an emotional balance. It can improve memory and reduce anxiety or depression.💯
@@Cathy-xi8cb yes man thank you. I don't know whats happening to me. I am a super healthy individual, excercise a tonne, eat healthy, and someday i have good sleep someday not so much but am working on it. Doing all this, i feel like i am loosing my speech, have started slur words a bit, mental maths has become tough, recalling the right word that i want to speak is tough. Dont know what to do anymore.
I have post concussion syndrome and I found this so informative. Thank you
Life is amazing, so many things have to go just right in order to be healthy and what do we do........... somehow I'm still alive and fairly healthy. I didn't ride my bike this morning and after watching this I feel even more guilty. Use it or lose it.
1:44:46 Exactly why I’m a huge fan of cross country skiing. The sport requires a high level of skill and balance to do well. The movement patterns take years to perfect. The cardio respiratory demands are also off the chart. Elite cross country skiers have some of highest VO2 maxes ever measured.
I’ve learned how to scramble eggs and brush my teeth with either hand. Based on this video will be a good thing in the long run!
Thanks Peter for a excellent discussion super interesting to me as my wife is suffering from Parkindon’s
Yes; Parkinson's patients do report changes in mood and thinking, but they AND THEIR DOCTORS attribute it to aging or life stress. Try living with someone who has developed the cognitive and emotional changes associated with Parkinsons. You are now living with someone mentally ill AND physically ill. It is a nightmare.
Outstanding podcast and guest. At 27:57 I realized I need to stop playing around on the sofa.
If glucose uptake is decreased where there is early neurodegenerative disease (and amyloid buildup is not reliably linked to cognitive degredation) doesn't this suggest that metabolic disfunction is a key aspect of the underlying causality? (Especially in light of the recent uncovering of fraud being involved in key studies thought to have linked protein plaques to dementia.)
Thank you for another great podcast. I am totally invested in this and watch biopharma daily for positive advancements in Alzeimers Disease.
Continuous bp monitoring would likely show you that the amount of time you spend exercising you are also experiencing elevated blood pressure.
Drs. Niotis and Attia, have either of you previously presented any findings on the potential effects corticosteroids have on healthy individuals? Four months ago, I was prescribed prednisone to treat lung and bronchial tube congestion resulting from three weeks of confined exposure to mold toxins. Within ten hours of taking the first 20 milligram tablet I began experiencing, for the first time, neuromuscular issues: balance/equilibrium problems, muscle weakness and slow muscle response in both legs. Within twelve hours, that weakness was present in both arms and shoulders. After completing the prescribed 10-day regimen, physical exhaustion and certain neurological concerns began to manifest. Over the next two months all the symptoms slowly improved. However, that improvement plateaued in early December. Just curious if you've come across this type of reaction to corticosteroids and how they mirror some of the cognitive and neuroplasticity issues discussed in your video. As usual, many thanks for your insightful content.
I had something similar it took me a very long time to figure out. I took 2 prednisone packs at different times 2 years ago. I just found out Corticosteroides deplete magnesium. I was taking magnesium citrate so I did not know I was deficient. I had all sorts of test even MRI and CScam. They never measured my minerals. I was like that for 2 years and getting progressively worse. One day I switched over to magnesium lysinate glycinate drs best high absorption. I took it at night and woke up with no pain I was shocked. I now take 300 mg daily and magnesium cream. I am 100% better.
Just start taking it right away. The type of magnesium matters. Glycinate is the one for muscle issues. Also try to get a mineral panel test see if you are low in other minerals like potassium.
Corticosteroids may increase the body's loss of magnesium. Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300-400 mg of magnesium per day.
@@moondrop3013 Thanks for commenting. I haven't thought about possible mineral deficiencies as a result of prednisone. I wish that advice had come with the prescription. I have an appointment with a neurologist and will make a point of suggesting a mineral panel. You had a rough time with the magnesium deficiency but glad to hear the glycinate helped. I'll add that to my supplements. NMN has helped with low energy levels. I appreciate you taking time to share your experience. Take care.
@@mac878 If you are magnesium deficient and start taking it you will notice a difference the next day. The magnesium also helps with energy levels, mood, muscle spasms and cramps. It’s only $11 just start taking it.
@@moondrop3013 Good to know. Currently looking for a quality brand and local source before purchasing on Amazon. I'm looking forward to having the same results you've experienced. Thanks again.
@@mac878 It’s been a month since you last posted- for nerdy people like me who read comments and learn a lot can you update your results? Did the magnesium and/or other minerals work?
Peter What causes someone to lose their spinal discs ?
I listen to these 2 drs and i remembered seeing neurologists early in my traumatic brain injury journey when i have so many sensory symptoms and neuro dysfunction.
I could swear the neurologists i saw got their training from maccas cause they seemed to not know how the complex puzzle of the brain works.
YES, Totally useless in my experience after a significant TBI.
I love how he never interrupted her and let her speak. Sometimes men can overpower a conversation and I love that he didn’t do that.
Very interesting and surprising. Thank you.
What do you mean "APOE4's are immune to the learning effect... learning is not a factor for them?" LOL that seems wrong. No? Richard Isaacson if you see this can you please explain what she's talking about.
Very informative podcast,big fan of drive podcasts.If sensory input is critical,then lack of visual sensory input should cause neurodegeneration earlier in blind people,or in deaf mutism,are there any RCTs in blind,or deaf mute persons on dementia or Alzheimer's causation and progress.
My husband has multiple neurological issues; both physical and brain related. We've seen several neurologist's and basically get nowhere. We are always told "no diagnosis" no treatment and no cure. See you in 6 months. Why even bother to go to these appointments....it is just a total waste of our limited time and energy. My husband has been told he has major neurocognitive disease, stage 4 (according to his gerontologist.) A brief discussion mention Charcot Marie Tooth Disease but a DNA test is needed to determine that (SYMPTOMS: high arches, hammertoes, nerves dying in his legs, wonky gait, falling etc.)
Could gluten’s toxicity extend to the nervous system, producing symptoms identical to classical Parkinson’s disease? A new case study adds to a growing body of research indicating that wheat’s neurotoxicity is greatly underestimated. A remarkable new case report describing the dramatic recovery of a 75-year-old Parkinson’s disease patient after following a 3-month long gluten free diet reveals the need to explore whether there is an increased prevalence of silent or symptomatic celiac disease or non-celiac gluten sensitivity both in those afflicted with Parkinson’s disease and the related multi-factorial neurodegenerative condition known as Parkinsonism.
Thank you
Idk my mom used to sleep walk. We always had to work hard to wake her up. She did stop doing that for the most part after she healed some trauma. She’s now 75 and no sign of any neurodegeneration. Maybe she’s part of the 10% or maybe it’s more environmental that we understand. But she did smoke for many years, too lol
I acted my dreams out until I started using THC as a teen. I wonder if THC is beneficial for people with parkinson's in their family who act out their dreams. My grandma suffered from parkinsons after misdiagnosis. I'm very health @ 37yo.
Wow first comment ever! Thank you to Peter Attia for producing some amazing content.
Mr. Attia please try to simplify the episodes titles.
Do you have any information on vitamin B6 as a neurotoxin? I have been healing from B6 toxicity…even very low dose of supplementation (under 10mg) causes Serum toxic accumulation for me with tingling feeling in left leg. Neurologist doesn’t have a lot of information other than to stop all B6 supplementation. MRI negative for MS and ALS.
Anecdotally, recently I had a burning sensation on my foot( not painful at all, just oddly hot) that would happen for 5-10 seconds once or twice or three times a day. Had no idea what is was until I eliminated the B complex vitamin I recently started and it went away. I then took one after being away from it for two weeks and the heat came back. Haven’t taken one since and no burning feet. I have “guessing” it is due to the B6 in there.
I found the section on oral health particularly interesting… off to get a water pik! Bottom line… keep moving!
I am surprised this podcast hasnt interviewed Dr. Dale Bredesen . He has demonstrated reversal of cognitive decline by treating whatever is wrong wirh the body. He assesses for low level inflammation , insulin resistance / diabetes , chronic infection including periodontal, accumulation of toxins, head trauma , decreased blood flow to the brain ,anemia, decreased trophic support( hormones,viamin B12,). He is also looking at other neurodegenerative disease.
Only tangles end up inside the neurons. The plaques are outside.
Amazing!
How does someone become a patient of your practice? Can’t find any info on the web.
How about ADHD and stimulants affecting dopamine?
We know that those drugs can damage many phases of sleep, and that poor sleep can damage brains. People are taking them to study and to work extra hours. How's that?
@@Cathy-xi8cb what if you’re diagnosed and using the lowest dose prescribed once a day. Not abusing it.
How about the NIH's insistence on hypothesis-based research? Even worse, they increasingly ask applicants to list their "probable results" in grant applications. The system is biased against screens to discover new things.
Free flowing and a superb, highly informative episode, thank you both. Pesticides rightly mentioned but sidestepped some of the actual foods impacted - a great shame. Worries maybe about those big businesses defending their pesticide covered products? If so, it’s a shame that intimidation or fear of reprisals from big pharmaceuticals silences us. Otherwise, an excellent collaboration and discussion. :)
19:05 you are correct that is in fact a terrifying fact
Should we all eat more mushrooms?
what about drinking coffee as a way to prevent neurodegenerative syndrome?
The current elderly grew up drinking tons of strong coffee. Watch old movies. Didn't help them much.
@@Cathy-xi8cb Mostly with lots of Sugar and Milk which is The Problem, not the coffee.
@@wildhorses6817 Not my clinical experience. My elderly patients 40 years ago weren't drinking anywhere near the amount of milk and sugar that younger people get in their lattes and other fancy coffee drinks.
You guys should approach Google or Apple and see if they will do the machine learning for the Gene sequencing patterns on the house for the good publicity
Amazing podcast, thank you. With regards to nocturnal hypertension I realise that this is a difficult area to assess but are there any guidelines that can be recommended? For example taking blood pressure just before bed, during any periods of wakefulness at night, first thing on rising?
what we see in medicine are all the older people that fall when they get up hypotensive and dizzy from the effects of drugs. The short-acting drugs make them get up to pee. Expecting drugs to be great solutions for chronic issues is not working.
17:46 😳😳😳 wt* that’s insane 90% predictive???
I take rasagiline and low dosage entecapone to prevent Parkinson's. that is because I abused dopaminergic stimulants during my youth, and I irreversibly damaged/killed millions of my dopamine=producing neurons.
Which ones did you abuse?
Regarding the link between pronouncing difficult words and (higher) IQ.. any thoughts on the evolutionary biology theory that having a exceptional memory when young, may cause the substantia nigra to burn out when older ( antagonistic pleiotropy). For example Russel Foster ('Why do we sleep') suggests genes involved with sleep (ex. shank2, CHRNA7 , etc) are the same as those involved with schizophrenia and that schizophrenics have unusual synaptic pruning.
I understand senescent cells are needed early in development but for some reason they increase in numbers as you age, continuing to function, just not able to divide or die (apoptosis). But if knocking out the autohphagy gene in mice leads to neurodegeneration, any thoughts on using Lithium / rapamycin to manage autophagy/parkinsons?
Regarding how using dance/movement may help with Parkinsons, any thoughts on Alex Kerten's Gyro-Kinetic Method .
On early detection using the 9 smell tests, does the at-risk person recognize the smell is unable to identify/name it, or do they not recognize it all? In addition to irregular breath, acting out rem sleep, less movement in your dominant hand (less sense on the opposite leg).. I understand insomnia and constipation occur decades before those that will go on to get Parkinson's. Inflammatory bowel disease (IBD) seems also positively (ex. Crohns patients are at a 30% higher risk ). Any thoughts if dysbiosis (increased levels of Akkermansia) may be causal?
Also, I understand uric acid acts as an antioxidant/metal chelator , but if levels are too high it is pro-oxidant.. and that Peter likes to use SGLT2 inhibitors / allopurinol to bring uric acid levels to below 5mg/dl. But isn't low uric acid levels also associated with Parkinsons?
Interesting point on how the brain doesn't rely on insulin, and yet intranasal insulin injection seems to temporarily alleviate tremor symptoms.. but regarding how high AboB (LDL) is associated with reduced speed of processing, any thoughts on using fat-soluble statins (lipitor/atorvastatin) and their correlation with a decreased risk of Parkinsons? Julie Anderson from the Buck Institute suggests Paraquat exposure, elevated levels of Iron ( or low blood anemia), may all contribute to Parkinson's. Coffee and nicotine, seem to be protective.
Environmental triggers,cellular biology,diagnose 20years before disease appears ,find the cause,no bio markers,prevention is difficult and essential.Histopathology for alpha nuclei n proteins misfolding and cause brain degeneration.physical misfolded proteins inside the cells,common cause is sugar,refined flours,oxidized cholesterol particles trigger inflammation,so impair cellsignalling,autopsy findings to diagnose.Pet scans shows which brain parts ,show hypometabolic ,sugars is less to affected area due to nuerodegenertion,not perfect,does not tell us what proteins and is it part of normal aging process.Amyloid is abnormal but also normal in normal people but needs to clear it.one night no good sleep increase Amyloid 5%.We are ignorant of the brain.philosophical,practical questions.what markers to look at? It should be cognition markers.Scans have a lot of radiation.Every person is different.Take scam tell us about cognitions decline,costly,and radiation.Sleep is powerful tool to clear Amyloid which is present all the time.part 2.
I also have discovered the possible oral connection to PD
I wonder sometimes if the way a person has organized their minds- the way they think- contributes to some of these diseases.
It seems too prevalent to imagine there is one dominant-enough pattern in the growing afflicted group.
Math, music, movement, etc. all have dominant parts of the brain. Music seems to be the last to go, mathematicians peek and fade in their careers earlier.
I noticed my regimented morning routines were indicative of the need for order and efficiency. I can cluster groups of the details but together they create inner calm.
It helps to label transitional walking as an activity like walking from room to room. It keeps the cycle of mindfulness. This was REALLY helpful. I also liked CLOSURE routines such as last looks and shutting doors.
Now that I am retired I love mental reviews of what I did that day and REFLECTING on my intentions, burnout, noticing CHANGES. (Connect the dots for surprising meaning).
@@Grandma188 I visited a friend who was in the final stage of Alzheimer's last week. The person I knew was gone for the most part; I did speak in a soft voice of pleasant times, and put on some Beatles music, the hallmark of our generation. She has been nonverbal awhile and if there was reaction, it was too subtle for me to understand. I hope it was a good experience for her. She died two nights ago.
Now THIS was a scorched-earth tour de force. Outstanding.
If one knows they are at an elevated risk to get a neurodegenerative disease because they have ALS and Parkinson’s in their family and they are an ashkenaszi Jew (asking for a friend ;), am I understanding correctly that the only prevention ideas are various forms of exercise, a waterpik type flosser, and making sure you have quality REM sleep. Have I missed anything else?
According to this session, I think so.
Not that it was discussed here, but you need to address the microbiome.
@@chandelie4 I know the microbiome is important but I had not heard about it being protective in this instance… would love to hear more. I have been pounding down kombucha and homemade soy yogurt lately….
I would suggest various detoxifying efforts- such as sauna, drinking purified water, being very careful about OTC lotions, soaps, etc., and so on. I'm not an expert but there are definitely books on how to detox. I worked many of these with my mom who was diagnosed with the "toxic" form of Alzheimer's (with a high blood mercury level, and a low zinc/high copper level), and we saw her cognition improve as well as her blood test markers for toxins drop. (Note we were also following a ketogenic diet, balancing nutrients, decreasing stress, increasing sleep, working on exercise, healing her "gut" biome via colostrum and other pre/pro biotic, and having her engage her brain via brainhq. She definitely improved substantially in just a few months, but didn't care for following the rigidity of the interventions we were trying. But given the results I saw in such a short time, I am committed to following many of these guidelines myself to avoid any neurodegenerative diseases later. I did get my DNA tested and noted that I have the dreaded "APOE4" gene, but was very interested in this podcast to learn that the 23&me gene that they test for Parkinson's isn't the only Parkinson's marker. After looking at the more advanced "raw data" from my DNA it turns out that I have several "poor results" on the various other Parkinson's genes- particularly the ones Dr. Niotis mentioned. But I think there's a great deal of reason to be positive- we're in the generational cohort that can be proactive and have reasonable expectations of positive results. Listen to Dr. Attia's podcast with Dr. Isaacson (from about two years ago on Alzheimer's prevention), and get some books on the same topic. These neurodegenerative diseases appear to be very similar and preventative measures that work on one can reasonably be inferred to work on another. Do they all work? Maybe- maybe not, but it doesn't hurt to improve your life (as most of the suggested interventions are things we should be doing anyway) and at worst your data points can help other people in the future while at best they can absolutely help you delay or even prevent the onset of the disease. Good luck!
Look into control of limiting epigenetic risk factors through proper nutrition and anti-stress techniques. Obviously, avoid toxins and pesticides. Like you, I worry about this too. And last, low dose naltrexone seems quite helpful for autoimmune disease in general. It's recommended on some Parkinson's sites.
Almost no discussion of Thiamine deficiency, I see that as a wasted opportunity to spread a message
What message?
@@tuna9919 touché
@@tuna9919 High Dose Thiamine shows promise as part of a regimen to slow the progress of Parkinson's and Parkinsonism
We see it in the ER with drunks all the time. They don't GET the message.
The End of Alzheimers and Surviving Alzheimers details how to treat and recover from neurodegenerative disease.
seems sleeping is important
Peter - do you and Kelly REALLY want to solve this mystery? I have iRBD diagnosed by polysomnogram. I developed the first diet to shut down my dream enactment. Parkinson's is a combination of food - toxins - infections. I have test that point to toxins (environmental, mold, and organic acids) and possible low-level infection. If you REALLY mean what you say, reach out and I will be glad to go over what I have discovered since being diagnosed with iRBD in 2019.
I don't want to be nasty, don't get it wrong, Rich Roll and you are my favorite alcoholics on You Tube
World missing a war !! War give lot of poverty , stress , exercise.. ultimately very good for health a
NEED TO KNOW ABOUT ACNE AND SCAR CAN YOU MAKE A VIDEO ABOUT THAT PLZZ.
MICRONEEDLING
1:16:45 HOLD ON: What the hell was she talking about, “APOE4’s are immune to the ‘learning effect’? they actually don’t learn as well, so you can retest them in 6 months since learning isn’t really a factor to consider for Them?”
WTF? Peter can we confirm this lol
This woman / that statement is crazy.
If you have cognitive impairment from APOE4-related brain damage, you will not remember the questions, or the answers, to the cognitive functioning tests. In other words, you will not exhibit the learning effect of being initially tested. Hope this is clearer.
@@Cathy-xi8cb yes, or anyone with Standard American diet/lifestyle brain damage. Funny how this effect could be singled out as distinctly E4 related.
@@cjgreene2344 Because AZ is different in presentation from vascular dementia and other dementias. They could have eaten a great diet all their life. Genes will still triumph in the end. AZ presents with strong and early learning and memory issues. The EPOE4 contribution is how AZ is diagnosed, but also with specific deficit constellations. With vascular dementia we see a predominance of executive functioning issues with sparing of a lot of learning impairments until later stages. With Lewy Body we see the motor issues of parkinsons along with the delusions and hallucinations, as well as emotional changes from premorbid life. Hope that helps.
@@Cathy-xi8cb so Chris Hemsworth’s genes will still triumph in the end? (Thor actor - 2 copies E4) Doing everything right? Got it. I’ll let him know he’ll be ‘immune to the learning effect’ later in life despite near perfect epigenetic influences👍🏽
@@cjgreene2344 Genetic influences are the strongest in determining whether you will develop AZD, along with advanced age. This was said early in this presentation, and hasn't changed for decades. We see former Olympic athletes and committed exercisers drooling and wearing diapers in their 90s. And very old people who did everything wrong being gleefully independent as they swan off to Chik-Fil-A.
Hey, that plant in the room looks kinda like a nerve branch. As soon as I saw it I thought "dendrite". 😁
Just imagine if commercial pesticides were just isolated natural plant pesticides. 😮😅😢
and the coffee( again it blocked histamine release) plus the milk and so on....
Sugar, grains and seed oil. Don’t eat that crap. Encourage friends and family not to eat that crap. Then we don’t need to worry much about all these chronic degenerative diseases.
Please make focused list of prevention of nuerodegenerative diseases to safe lives,help lay people.Testing leave it to professionals.What is your audience
Then plan your teaching to that audience.Thank you.Time is very precious and too many distractions.Lateral talking without content is superfluous and not productive.
Recap,sleep disturbances 30 years before symptoms.Triggers are autophagy genes not working,toxics like herbicides,water,genes,abnormal movements,slow,Body is asymmetric,right arm not swinging during walking if right handed,breathing patterns,use more non dominant side,orthopedic injuries,neuronal circuits,pay attend to all parts of body.sleep tracking,REM sleep is important for emotions in addition to memory,more anxiety in such patients,light exposure for20-30 minutes early morning to regulate rhythm and hormones including Melatonin.Anxiety is related to Melatonin signalling ,cause or result?.This is part 1 Recap.
you know what is interesting I got home and I cannot listen to your podcast any further. I only listen to you to boost my dopamine( a joke) while walking my dogs or being on the way. Back at home I boost my dopamine by knitting, there is nothing better than that. I knitted over 400 pieces within the last 2 and half years. The good thing about my family is we have really healthy longevity genes. We are outstanding in physics, math and chemistry. Like Johny Nash oh schizophrenia hm which algorythmus is that. I am simply to disinterested now to watch you further, but you are good, your book is surely top, just tomorrow when I walk my dogs, I always learn new stuff walking my dogs, but being at home I want my brain to empty itself. Did someone ever type you so many words as a comment, having nothing to do with the topic? I cannot just knit further, my fingers are getting warm, riboflavin from the science point of view, B vitamins, folate, etc.... but you know where I am now histidin( amino acids) this one is tricky and might or I am pretty much sure the key.... histamine, etc.... glucose, Ph, hemoglobin, etc....
Would have been nice to ask her about the fraud in Alzheimers research.
He sounds sick in this one :(
It is very annoying that this intelligent neurologist uses vocal fry , a patronizing tone of voice that detracts from her otherwise clarity of thought and makes it difficult to listen.
Provider? What happened to the medical profession?
REM behavior disorder can be precipitated by SSRIs.
A common mistake, familial is not necessarily genetic .
And I was checked later by the doctor( all different things were measured), As I have already written I am not the only one, the list of patients by one of the clinic is over 6000 patients all proved being ill through the vaccine. Also young people who were healthy before. I was fine with my past, trauma, by being dement, first paralyzed my left side I got set in the past. Short memory damage, eye damage..... I know more than one person with eye damage 2 are blind, I even know someone now suddenly sitting in a wheel chair. Thank you. Also in my case is proved it is the vaccine.
I never bother about spelling mistakes, may be you make a podcast on dyslexia or loosing the ability to write through trauma
So much less fluff here compared to huberman.
Disagree.
Permaculture to save the world and you can do it yourself
Love her knowledge and their conversation but does anybody think it's odd she hardly looks at Peter? very little eye contact - almost just have to listen to it instead of the watch because it feels uncomfortable.
00:30:00 "Clearly there is something that we are missing..."
Yeah enviromental factors and "genetic" aka family habits. Crap carb?? food crap industrial food? crap mitochondrion destroying elmements ?? lack of Deuterium poor electrical signaling??? Start there more crap will come along.
There's massive sibilance on the guest's mic which makes this unlistenable for my ears, unfortunately
Ten second short or two hours. You’re not giving me much choice here.
you know what is constantly on my mind watching you you have something that alcoholics have, the control.... well, see this is my algorythms I was more than good in algebra. See maybe you all together measure your brain's own brain leaks. I will comment next t
Hate to be that person in the comment section but i cant get over how beautiful she is
She was very hard to listen to. As gravelly and grumbly a voice as I’ve ever seen in a female.
Unfortunately, many neurodegenerative diseases cannot be prevented. There is a strong genetic component. Take MS for example. There's nothing you can do to avoid getting MS. Same with Parkinson's and let's not mention ALS. There may be ways to lower the risk of Alzheimer's, for example, but there's not much you can do to prevent it. This is why neurology is a depressing specialty; there's little hope you can give your patients other than possibly prescribe meds to mitigate symptoms but you cannot stop the progression.
Cool story bro
You must not be aware of the recent studies connecting EB virus with MS. Very hopeful direction.
Have you heard of Dr. Terry Wahl’s?
@@Cathy-xi8cb Yes, I am. But unfortunately a vaccine will do nothing for established MS. The immune system is already primed, to say nothing of reversing existing disability. We have a long way to go.
@@cjgreene2344 Thanks for your stimulating contribution. Muppet.
One things I know for sure I will never enter the USA again, this land is poisoned.