In this episode, we discuss: 0:00:08 - Tommy’s professional work, unique skill sets, and interests 0:03:27 - Age-related decline in cognitive function and memory 0:19:58 - Improving brain function with the right level and type of demand 0:32:57 - Formula 1 as a model for how to perform under high cognitive demand and how to increase multitasking capacity 0:39:54 - Advice for the person reaching middle life looking to mitigate cognitive decline 0:48:42 - Tasks and activities that support and improve cognitive function 0:53:25 - Neuropathology of Alzheimer’s disease: exploring the role of amyloid and tau proteins 1:11:48 - Why Tommy believes dementia research funding should be focused on environmental and lifestyle-based risk factors 1:15:57 - Benefits of lowering homocysteine and boosting omega-3’s, and evidence-based supplements that support cognitive function 1:29:40 - A unifying theory of dementia 1:33:29 - How muscular strength can help with both the prevention and survivability of dementia 1:39:24 - Head injuries: comparing concussions against traumatic brain injuries (TBIs), mitigating the damage after an incident, and the long-term management of head injuries 1:58:33 - Is hyperbaric oxygen treatment helpful after a TBI? 2:03:07 - Supplements that aid recovery from a TBI: creatine, DHA, and choline 2:12:16 - Demands faced by F1 drivers, and testing interventions to improve their performance
As a 57 y/o female, I have been an athlete off and on throughout life. I let life get in the way a few years and gained a few pounds and became "sedentary" yet busy in life. I noticed a scary drop off in cognitive function despite still eating a healthy diet. It was far too many healthy carbs. I made a conscious change last year to become a fat burner and get back to peak fitness and a diet lifestyle change. I had kids later and they are still teens, so I want to extend both my lifespan and health span. I have noticed an incredible reversal in the declines I was seeing both physically (muscle mass, strength) and cognitively. I do think that removal of carbs and sugar really has made a huge difference. Even when I was an athlete in the past, I still had brain fog now and then and aches and pains. I can honestly say my brain and body work far better on ketones. I am getting comments constantly about how young and fit I look now and people mistake me for 10-15 years younger than I really am. 😊
That's wonderful to hear about the positive changes you've experienced in your physical and cognitive health through your lifestyle changes. It's great that you made a conscious decision to become a fat burner and focus on a healthier diet and fitness regimen. Many studies have shown the potential benefits of reducing carbohydrates and sugar intake, and it's encouraging to hear that it has made a significant difference for you. Improved muscle mass, strength, cognitive function, and a more youthful appearance are all fantastic outcomes.
My mother was diagnosed with early onset around 41 years old. She stayed with us until 76. None of my siblings or myself have any signs of this thankfully. When I was younger and had an MRI for some eye problems, the woman in the room told me that I have plaque on my brain. Im on a strict no carb diet, exercise, and keep learning to protect my brain and body.
Peter asked what memories are. Here's a brief summary of what neuroscience research has discovered: Memories are patterns of activity in networks of hundreds or thousands of neurons, often distributed across distant brain regions. Different brain areas are activated to process perceptual inputs (e.g., the visual cortex processes visual inputs, the auditory cortex processes auditory inputs, the somatosensory cortex processes inputs from other parts of the body, and the motor cortex is activated to execute movement). The hippocampus binds these separate activated neural networks over time to form connected, narrative memories that can be consciously recalled. Without an intact and well-functioning hippocampus, implicit memories can be formed, that is, learning that can be demonstrated through priming, skills, or other methods. The cerebellum is recruited to bind neural networks involved in the learning of procedural memories (such as riding a bicycle). In short, memories consist of consolidated neural networks that are often distributed across brain areas. Retrieving those memories involves reactivating those networks. Denise Cummins, PhD, Professor Adjunct of Psychology and Neuroscience, University of Colorado-Boulder
I haven't watched this yet, but I'm really looking forward to it. I listen to all Dr Attia's podcasts and Tommy Wood's work on cognitive demand changed the way I exercise. Should be a good discussion.
I know just one case is not significant, but my mother in law had incredible grip strength and yet developed dementia in her last months. The reason I am positive she never lost her grip strength is that we were trying to pry a metal chair from her hands, which she was trying to throw at the window in one of her sundowning episodes.
An underrated part of this story is perhaps clogging of the veins and arteries to the head head(internal jugular vein stenosis, etc). Because too much narrow focus on molecul-level could cloud the view of what happens to the "pipes" to the head and perhaps what happens to the pipes inside the head especially over longer term. FYI, still not fully recovered after head /neck injuries in 2019-20.
Can you please do an episode on MS? I know you have said it’s one of the worst things that can happen to someone.. but I have it and I would like to hope that I can still live a normal life if possible. Any insights would be appreciated. Thanks for all your amazing work 🙏
I have several friends and clients with MS who are doing extremely well in their 50s, 60s, 70s, you would hardly know they have health conditions at all (just for perspective, of course there are loads of completely opposite scenarios))
Not news to anyone in rehab that head injury predisposes you to cognitive impairment immediately and going forward. At all. Cannot tell you how many older patients have histories of head injury from sport, from alcoholic events, car accidents, etc. And how hard we work to teach our own families that you want to avoid smacking your head at all times. All times. Unless you are eager to wear a diaper, to forget how to get home, or to lose your job and your health insurance.
The litany of concussions , out of control ADHD and my being " a traditional Catholic extremist, deplorable and MAGA terrorists" I need to watch this. Thank you for the professional recommendation and laudable comments ref the aforementioned video.
I am on the Bredesen protocol which includes Brain Hq. I was happy to hear Tommy Wood say it has the most research backing it up. When is Dr Bredesen coming on this podcast? I would like to hear more about BHRT for women who already have existing cardiovascular disease. I had close to 50% plaque in both carotid arteries at 52 and the Bredesen protocol is saying I need to be on BHRT. I am 58 and have never been on it. They do not believe in the critical timing hypothesis.
Anedoctal n=1: I was involved in a serious MVA 30 years ago, someone T-boned my car running a red light going about 40 mph. I woke up 3 hours later in the ER.....having absolutely no memory of impact, extraction, transport or subsequent actions of the ER staff. I had already had full body xrays and several CT scans that essentially showed I was fine. I remember being very upset they had cut my brand new sweater and favorite jeans off my body when I came too, but not upset to learn my head had broken the driver side window and I still had glass in my hair. They kept me overnight for observation and discharged me the next morning telling me to take it easy for awhile. No other instructions. I happened to be in 3rd year med school at the time and I took a week off and slept. I took some homeopathic Arnica and I also got several acupuncture treatments (wish I knew what points they needled or what "syndrome" they were treating but I remember it seemed to really help bring me back into my body.) Long story short: I essentially considered it over, more hassle dealing with the loss of my car. Only recently did I consider I might be at increased risk for dementia, but so far so good at 62...I still feel very sharp cognitively. I am APOE3/3 so that likely helped. I am very interested in photobiomodulation for TBI, and surprised Peter did not ask about this. My husband is APOE4/4 and all the men in his family die of dementia, so we are considering getting a Vielight device (see their YT channel) which has some solid research behind it for PTSD, Anxiety, TBI.
Peter & Tommy - Thanks for this conversation. Incredibly valuable. Hey might you be able to clarify your recommendation for Vitamin B/Omega-3 doses that one might take to work towards lowering homocysteine and boosing omegas as you suggest? You mention at 1:20:45 that you recommend 1-2gm/day of DHA but I don't believe that you made a specific recomendation for Methyl Folate, Methyl B12, Vitamin B6 dose/frequency. It would be super helpful if you could please fill in this part of the picture for us if possible (apologies if you did mention this elsewhere in the conversation and i missed it). Love your work guys! thank you!
Thank you very much for sharing your insights and wisdoms filled videos !! Scientific and educational intelligent !! Outstanding !! Greetings from California … I wish you and folks and all good health, success and happiness !! Much Love ✌️😎💕
One thing I've never heard mentioned by anyone is the declining ability to tolerate foreign accents because decoding them is getting more laborious as we age. I can no longer enjoy Indian, British or Aussie movies because listening to thick accents is now tedious work for me. I don't think it's my hearing per se, which has not otherwise changed, just my need to process and decode the different inflections, pronunciations, and rhythms. Is this a sign of cognitive decline or am I just getting "sound selective" and lazy-brained?
Please consider trying the "Forbrain" device to improve your auditory processing. You could also get a hearing aid because this is one of the behavioral "clues" of hearing loss.
@@dianed4190 Yes; I am licensed to perform auditory treatment/therapy. You need someone licensed in your state or country to evaluate you because there are risks of DIY treatment. Get your hearing tested first because if you have lost the ability to hear high frequency sounds that could explain a ton. Most languages change their accents on vowels and alter the consonant combos and people speaking English with an accent retain many of their native speaker patterns. If you have high frequency hearing loss, you are losing more "clues" to decipher what they are saying. Forbrain will not work as well for you if you have hearing loss. Address that first.
I recently (April 2023) suffered a severe concussion resulting in a break at C5-C6 with a spinal cord contusion. ACDF surgery 6/23, obviously some PCS symptoms, including noticeable cognitive impairment. The second major, and seemingly, worsening symptom is light sensitivity. My mother also passed away, unexpectedly after open heart, between the injury and my surgery, so anything but low stress. I do fast 20 hours a day, adore LMNT (2/day), and practice numerous other “Huberman” recommendations, 2 year fan. Long set-up I know, but complicated situation. I was taking 5 grams of creatine daily, but since seeing this episode I increased that to 20-25 grams divided into 2 doses (taken with m LMNT). I know I am just an N of 1 but the difference is significant! Are there any other suggestions, even anecdotal, to would recommend. I’m a 52 year old female, 5’4” 105-110lbs. I am currently still off but my career requires high execution function. Thanks in advance!
I'm having difficulty understanding the relationship between age and dementia. Why is it some people,perhaps most, do not become demented as they age. Perhaps dementia is more related to food choices or other diseases. This relating of cognitive decline to age alone is rather "old school".
good Morning Peter, i watched most videos and i bay your book, i want ask you, about older adults , my husband 80 years old me 69 what you recommend about exercises and supplements? 🙏
The return of sane Peter! He even mentioned ^ApoB alone is not sufficient for ASCVD. No comments about people making up side effects of statins :) Great discussion about supplements and stuff that is ready and OTC to very likely prevent AD as well as possibly reduce risk of Mild TBI. Always great to hear from Tommy Wood!
In this episode, we discuss:
0:00:08 - Tommy’s professional work, unique skill sets, and interests
0:03:27 - Age-related decline in cognitive function and memory
0:19:58 - Improving brain function with the right level and type of demand
0:32:57 - Formula 1 as a model for how to perform under high cognitive demand and how to increase multitasking capacity
0:39:54 - Advice for the person reaching middle life looking to mitigate cognitive decline
0:48:42 - Tasks and activities that support and improve cognitive function
0:53:25 - Neuropathology of Alzheimer’s disease: exploring the role of amyloid and tau proteins
1:11:48 - Why Tommy believes dementia research funding should be focused on environmental and lifestyle-based risk factors
1:15:57 - Benefits of lowering homocysteine and boosting omega-3’s, and evidence-based supplements that support cognitive function
1:29:40 - A unifying theory of dementia
1:33:29 - How muscular strength can help with both the prevention and survivability of dementia
1:39:24 - Head injuries: comparing concussions against traumatic brain injuries (TBIs), mitigating the damage after an incident, and the long-term management of head injuries
1:58:33 - Is hyperbaric oxygen treatment helpful after a TBI?
2:03:07 - Supplements that aid recovery from a TBI: creatine, DHA, and choline
2:12:16 - Demands faced by F1 drivers, and testing interventions to improve their performance
As a 57 y/o female, I have been an athlete off and on throughout life. I let life get in the way a few years and gained a few pounds and became "sedentary" yet busy in life. I noticed a scary drop off in cognitive function despite still eating a healthy diet. It was far too many healthy carbs.
I made a conscious change last year to become a fat burner and get back to peak fitness and a diet lifestyle change.
I had kids later and they are still teens, so I want to extend both my lifespan and health span.
I have noticed an incredible reversal in the declines I was seeing both physically (muscle mass, strength) and cognitively. I do think that removal of carbs and sugar really has made a huge difference.
Even when I was an athlete in the past, I still had brain fog now and then and aches and pains. I can honestly say my brain and body work far better on ketones.
I am getting comments constantly about how young and fit I look now and people mistake me for 10-15 years younger than I really am. 😊
That's wonderful to hear about the positive changes you've experienced in your physical and cognitive health through your lifestyle changes. It's great that you made a conscious decision to become a fat burner and focus on a healthier diet and fitness regimen. Many studies have shown the potential benefits of reducing carbohydrates and sugar intake, and it's encouraging to hear that it has made a significant difference for you. Improved muscle mass, strength, cognitive function, and a more youthful appearance are all fantastic outcomes.
My mother was diagnosed with early onset around 41 years old. She stayed with us until 76. None of my siblings or myself have any signs of this thankfully. When I was younger and had an MRI for some eye problems, the woman in the room told me that I have plaque on my brain. Im on a strict no carb diet, exercise, and keep learning to protect my brain and body.
Peter asked what memories are. Here's a brief summary of what neuroscience research has discovered: Memories are patterns of activity in networks of hundreds or thousands of neurons, often distributed across distant brain regions. Different brain areas are activated to process perceptual inputs (e.g., the visual cortex processes visual inputs, the auditory cortex processes auditory inputs, the somatosensory cortex processes inputs from other parts of the body, and the motor cortex is activated to execute movement). The hippocampus binds these separate activated neural networks over time to form connected, narrative memories that can be consciously recalled. Without an intact and well-functioning hippocampus, implicit memories can be formed, that is, learning that can be demonstrated through priming, skills, or other methods. The cerebellum is recruited to bind neural networks involved in the learning of procedural memories (such as riding a bicycle). In short, memories consist of consolidated neural networks that are often distributed across brain areas. Retrieving those memories involves reactivating those networks. Denise Cummins, PhD, Professor Adjunct of Psychology and Neuroscience, University of Colorado-Boulder
Yes that is the current consensus.
Of course what is aware of those memories is a complete mystery
What moves neurons btw?
I haven't watched this yet, but I'm really looking forward to it. I listen to all Dr Attia's podcasts and Tommy Wood's work on cognitive demand changed the way I exercise. Should be a good discussion.
I know just one case is not significant, but my mother in law had incredible grip strength and yet developed dementia in her last months. The reason I am positive she never lost her grip strength is that we were trying to pry a metal chair from her hands, which she was trying to throw at the window in one of her sundowning episodes.
I would love to see a conversation between you and Dr. Daniel Amen. I think it would be incredible! Love you both!
An underrated part of this story is perhaps clogging of the veins and arteries to the head head(internal jugular vein stenosis, etc). Because too much narrow focus on molecul-level could cloud the view of what happens to the "pipes" to the head and perhaps what happens to the pipes inside the head especially over longer term. FYI, still not fully recovered after head /neck injuries in 2019-20.
Can you please do an episode on MS? I know you have said it’s one of the worst things that can happen to someone.. but I have it and I would like to hope that I can still live a normal life if possible. Any insights would be appreciated. Thanks for all your amazing work 🙏
I have several friends and clients with MS who are doing extremely well in their 50s, 60s, 70s, you would hardly know they have health conditions at all
(just for perspective, of course there are loads of completely opposite scenarios))
Not news to anyone in rehab that head injury predisposes you to cognitive impairment immediately and going forward. At all. Cannot tell you how many older patients have histories of head injury from sport, from alcoholic events, car accidents, etc. And how hard we work to teach our own families that you want to avoid smacking your head at all times. All times. Unless you are eager to wear a diaper, to forget how to get home, or to lose your job and your health insurance.
The litany of concussions , out of control ADHD and my being " a traditional Catholic extremist, deplorable and MAGA terrorists" I need to watch this. Thank you for the professional recommendation and laudable comments ref the aforementioned video.
I am on the Bredesen protocol which includes Brain Hq. I was happy to hear Tommy Wood say it has the most research backing it up. When is Dr Bredesen coming on this podcast? I would like to hear more about BHRT for women who already have existing cardiovascular disease. I had close to 50% plaque in both carotid arteries at 52 and the Bredesen protocol is saying I need to be on BHRT. I am 58 and have never been on it. They do not believe in the critical timing hypothesis.
Among soooo many valuable points, i absolutely love the dog chipping in to the discussion !
Anedoctal n=1: I was involved in a serious MVA 30 years ago, someone T-boned my car running a red light going about 40 mph. I woke up 3 hours later in the ER.....having absolutely no memory of impact, extraction, transport or subsequent actions of the ER staff. I had already had full body xrays and several CT scans that essentially showed I was fine. I remember being very upset they had cut my brand new sweater and favorite jeans off my body when I came too, but not upset to learn my head had broken the driver side window and I still had glass in my hair. They kept me overnight for observation and discharged me the next morning telling me to take it easy for awhile. No other instructions. I happened to be in 3rd year med school at the time and I took a week off and slept. I took some homeopathic Arnica and I also got several acupuncture treatments (wish I knew what points they needled or what "syndrome" they were treating but I remember it seemed to really help bring me back into my body.) Long story short: I essentially considered it over, more hassle dealing with the loss of my car. Only recently did I consider I might be at increased risk for dementia, but so far so good at 62...I still feel very sharp cognitively. I am APOE3/3 so that likely helped.
I am very interested in photobiomodulation for TBI, and surprised Peter did not ask about this. My husband is APOE4/4 and all the men in his family die of dementia, so we are considering getting a Vielight device (see their YT channel) which has some solid research behind it for PTSD, Anxiety, TBI.
Great interview, thanks
Supplements Dr. Peter Attia takes:
1. Methyl Folate
2. DHA
3. EPA
4. Methyl B 12
5. Vitamin B6
+ 5-7 more that were not mentioned in the video
What was the company he uses for these please
Jarrow is one
@@paigedavis7191
Carlson
Nordic naturals
Jarrow
Pure encapsulation
Thorne.
What are the other 5-7 he takes not mentioned in video?
Tommy Wood is jacked!
If one already has Lewy Body Dementia would supplementing with DHA and Vit B’s help to slow down progression or are these only for prevention?
1:34:00 dementia and srrength
Peter & Tommy - Thanks for this conversation. Incredibly valuable. Hey might you be able to clarify your recommendation for Vitamin B/Omega-3 doses that one might take to work towards lowering homocysteine and boosing omegas as you suggest? You mention at 1:20:45 that you recommend 1-2gm/day of DHA but I don't believe that you made a specific recomendation for Methyl Folate, Methyl B12, Vitamin B6 dose/frequency. It would be super helpful if you could please fill in this part of the picture for us if possible (apologies if you did mention this elsewhere in the conversation and i missed it).
Love your work guys!
thank you!
Thank you very much for sharing your insights and wisdoms filled videos !! Scientific and educational intelligent !! Outstanding !!
Greetings from California … I wish you and folks and all good health, success and happiness !! Much Love ✌️😎💕
One thing I've never heard mentioned by anyone is the declining ability to tolerate foreign accents because decoding them is getting more laborious as we age.
I can no longer enjoy Indian, British or Aussie movies because listening to thick accents is now tedious work for me. I don't think it's my hearing per se, which has not otherwise changed, just my need to process and decode the different inflections, pronunciations, and rhythms. Is this a sign of cognitive decline or am I just getting "sound selective" and lazy-brained?
Please consider trying the "Forbrain" device to improve your auditory processing. You could also get a hearing aid because this is one of the behavioral "clues" of hearing loss.
@@Cathy-xi8cb Are you a physician or medical practitioner? I will look into it, thanks.
@@dianed4190 Yes; I am licensed to perform auditory treatment/therapy. You need someone licensed in your state or country to evaluate you because there are risks of DIY treatment. Get your hearing tested first because if you have lost the ability to hear high frequency sounds that could explain a ton. Most languages change their accents on vowels and alter the consonant combos and people speaking English with an accent retain many of their native speaker patterns. If you have high frequency hearing loss, you are losing more "clues" to decipher what they are saying. Forbrain will not work as well for you if you have hearing loss. Address that first.
This is a really good episode. Great interview
Excellent discussion! Thanks!
Combining Omega 3 and vitmain B drops chance of AD by 20% @ 1:22:30.
I recently (April 2023) suffered a severe concussion resulting in a break at C5-C6 with a spinal cord contusion. ACDF surgery 6/23, obviously some PCS symptoms, including noticeable cognitive impairment. The second major, and seemingly, worsening symptom is light sensitivity.
My mother also passed away, unexpectedly after open heart, between the injury and my surgery, so anything but low stress. I do fast 20 hours a day, adore LMNT (2/day), and practice numerous other “Huberman” recommendations, 2 year fan. Long set-up I know, but complicated situation.
I was taking 5 grams of creatine daily, but since seeing this episode I increased that to 20-25 grams divided into 2 doses (taken with m LMNT).
I know I am just an N of 1 but the difference is significant! Are there any other suggestions, even anecdotal, to would recommend. I’m a 52 year old female, 5’4” 105-110lbs. I am currently still off but my career requires high execution function.
Thanks in advance!
What are your thoughts on the Q-Collar to help with Concussions.
I'm having difficulty understanding the relationship between age and dementia. Why is it some people,perhaps most, do not become demented as they age. Perhaps dementia is more related to food choices or other diseases. This relating of cognitive decline to age alone is rather "old school".
good Morning Peter, i watched most videos and i bay your book, i want ask you, about older adults , my husband 80 years old me 69 what you recommend about exercises and supplements? 🙏
The return of sane Peter! He even mentioned ^ApoB alone is not sufficient for ASCVD. No comments about people making up side effects of statins :) Great discussion about supplements and stuff that is ready and OTC to very likely prevent AD as well as possibly reduce risk of Mild TBI. Always great to hear from Tommy Wood!
Memory is bio electric distributed across the body?!..
Brain 🧠
Tommy who? The link to the full podcast is broken.
Tommy Wood, M.D., Ph.D
Tommy Wood
Lmao
I would delete the podcast and reload it. That should fix it.
Tommy Wood survived a bite from a Fer de Lance snake while in Costa Rica.
1:39:20
1:42:51