See that's interesting. I'm a year shy of earning my PharmD, and the thought of doing an oncology research Master's on the side has tickled my mind over the last couple of years. For me it very much depends on how promising the prospective breakthroughs look over the next couple of decades or so -- can you comment a little bit on this for me as a Cancer Biology major? I would really appreciate it. Thanks.
However, R. Weiberg is the origin of my interest in cancer research (more precisely his "hallmarks of cancer, 2000")+all lab directors should be like him towards their students. Their work on EMT is interesting.
EMT is now well known to be correlated to the production of CSCs. However, something to keep in mind is that EMT might only cause the adoption of SC markers: CD24/CD44, SC gene expression, morphology, but whether the cells themselves are actually stem cells in vitro and in vivo remains to be tested. Something else to think about is if EMT creates stem cells from epithelial breast cancer cells and mesenchymal (not stem) cells from epithelial cells in development, what caused the obvious difference. Where does the parallel end?
Tony Wang Actually, I wonder if you could clarify. Almost any definition of mesenchymal cells includes 'stem' or at least multipotency as a part, so I've always been confused about this distinction between cancer cells having undergone EMT, and CSCs. What's up with that?
I still have a lot to learn+ there are still things I don't get, but to me, "cancer initiating cells" are a consequence (=agressiv evolution) of cancer but definitly not the origin of it. The name they give to these cells is the only new concept but the phenotype of these cells could not have been a mystery for so long...
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Just amazing, how in 1 hr 19 mins I got to know what i was working on for over a month!!
Beautiful informative lecture.Thank you for your book, the biology of Cancer.
amazing, stunning... wow
Actually, I'm graduating this year from Cancer biology Master's and I'm keen to go ahead with a PhD
See that's interesting. I'm a year shy of earning my PharmD, and the thought of doing an oncology research Master's on the side has tickled my mind over the last couple of years. For me it very much depends on how promising the prospective breakthroughs look over the next couple of decades or so -- can you comment a little bit on this for me as a Cancer Biology major? I would really appreciate it. Thanks.
R.Weinberg is a primus inter pares.
However, R. Weiberg is the origin of my interest in cancer research (more precisely his "hallmarks of cancer, 2000")+all lab directors should be like him towards their students.
Their work on EMT is interesting.
How I wished I was taking 7.012 in MIT (though I was so much younger then)
EMT is now well known to be correlated to the production of CSCs. However, something to keep in mind is that EMT might only cause the adoption of SC markers: CD24/CD44, SC gene expression, morphology, but whether the cells themselves are actually stem cells in vitro and in vivo remains to be tested.
Something else to think about is if EMT creates stem cells from epithelial breast cancer cells and mesenchymal (not stem) cells from epithelial cells in development, what caused the obvious difference. Where does the parallel end?
Tony Wang Actually, I wonder if you could clarify. Almost any definition of mesenchymal cells includes 'stem' or at least multipotency as a part, so I've always been confused about this distinction between cancer cells having undergone EMT, and CSCs. What's up with that?
difficult to say if EMT is causative or symptomatic of CSC transformation.
Can someone please provide the link for the research article referred at 07:50 ? The reference mentioned below figure is not readable.
Thank you :)
I still have a lot to learn+ there are still things I don't get, but to me, "cancer initiating cells" are a consequence (=agressiv evolution) of cancer but definitly not the origin of it. The name they give to these cells is the only new concept but the phenotype of these cells could not have been a mystery for so long...
Where can I found the papers swowed ?
seeing this i have got all d symptoms i just wish i die but not of this esp.
Are you currently by any chance a cancer researcher yourself?