I however would have liked if they mentioned a bit of how stem cells are being used to cure aging. Some deep conversations happening at the healthspan discord server (discord.gg/ftSbffu) I'm just overwhelmed that aging might actually be cured soon.
Great lecture! Thank you teacher 😊 Using the blackboard was really nice. Power points are getting boring. I could understand everything! Really helpful, thanks for posting.
I am 18 years old and I am in the final stage of secondary school. I am not exaggerating when I say that this is the best lecture I have ever seen in my entire life. What very excellent information, experiences and explanation. Although I do not know much English, I activated the translation feature. Your teacher is wonderful and the patience is incredible. You should be grateful for having all these tools. What is exciting about This is all 10 ten years ago 😲 I wish I could study with you, Talama. I love biology very much But unfortunately he is not financially capable What is my fault? I was born from a poor family and a poor country like Iraq. I wish I had been born in a European country so that I could achieve my dreams because my passion never ends. Stay well and sincere thanks and appreciation to you❤❤
I'm a really hugh fan of MIT OPENCOURSEWARE. I find it very informative, very useful, and the professor's explain it so it's easy to understand. God bless MIT OPENCOURSEWARE and thank you for sharing 🙏
"DESPITE THE HYPE; DESPITE THE COVER OF TIME MAGAZINE;AND THE FRONT PAGE OF EVERY NEWSPAPER ACROSS THE WORLD ; STEM CELLS ARE NORMALLY FOUND IN OUR BODIES" Loved the statement......😎
Dr. Sive's a wonderful teaching biologist. To more effectively use time -- to answer student questions, for example -- I would allow students to access notes and screen images to their phones, tablets and/or laptops.
I like how the school known for technology, hence Massachusetts Institute of Technology, knows when too much technology is too much. So, they shun PowerPoint in favor of good 'ol chalkboards. Now THAT is smart.
No they wouldn't. A differentiated cell is at the complete other end if the process. An embryonic stem cell is totally undifferentiated, hence why it's called a totipotent stem cell.
Regarding the stem cells from URINE obtained after urination: HOW MANY TYPE OF STEM CELLS CAN WE FIND IN THAT URINE ? We can find only USCs ( urine stem cells ) or we can find also other stem cells ? . Is there any public protocol to separate if there are many types than USCs? Thank you.
I may have missed something here but she stated that there might be non compatibility issues with the embryonic stem cells and a none 'genetic' (wrong word I know!) match, which is understandable, but how did it work with the hairless mice? Any responses please keep as simple as possible I've just started researching this and am yet to get into full swing. Thanks!
The hairless, or we call them nude mice, have been engineered so that they have an extremely defective immune system, almost no immune system at all. Therefore, they do not have any issues of rejection. Rejection of foreign materials from our bodies is based on the fact that our immune system can recognize self vs non-self (by way of antibodies and cell surface receptors - these protein molecules are like feelers that will touch all the things that enter your body, and check if they belong to you. They can signal other immune cells to mount an attack on any foreign matters, because it could be dangerous. This is why our immune system can eliminate bacteria and viral infections from our bodies most of the time). The immune system recognizes cells from another person as being foreign, because those cells will have a different genome, thus making proteins that are slightly different from our own. Therefore, if a person has an organ transplant, the recipient's immune system will try to attack the donor organ thinking it is foreign and bad. That's why transplant patients need to taken immunosuppressant drugs to keep their own immune system from destroying the donated organ - which then at the same time makes the transplant recipient more susceptible to infections and getting sick. Now you see, that nude mouse has no immune system, so there is no 'security team' to recognize foreign matter, so there is no issue of rejection. This ended up longer than I anticipated... hope it is helpful.
Oooo yes that makes sense, I didn't know about the nude mice being engineered to have a defective immune system, good to know for future ponderings and will also stop me asking silly questions. Thank you very much!
Would love to see a follow-up that addresses the Problems and carry's forward to today...some 3 years forward. As she says...the promise of the future that is in most cases being advanced outside of the US.
(On Tuesday of January 24, 2023). In the Matter of Biology and Stem Cells (Embryologic Non-Differentiated Hematopoietic Cells, With Homeostatic Functions of Repairing and Healing. Nice, Precise and Highly Theoretical. Potency (Totipotency [Zygote], Pluripotency [Bone Marrow Cell], Multipotent (Lymphoid Progenitor) All the way to the Commitment Absolutely of a Cell); 2) Fate is the number of Possible Axes to a Cell; Determination to Total Differentiation; Stem Cells with their Self-Renewing Capacity Have the Potential of Being Therapeutic (Bone Marrow Transplantation, Skin Cell Transplantation [Burn and Repairing with a Skin Graft]); Stem Cells (SC) Assay or Technique Therein: 1) Radio isotopic Chase 2) Florescence Activated Cell Sorting (FACS) via Sorting of Cells Via Cytological Markers ((mAbs with Radio isotopic Tags), And Laser Detectors of the Tags (Apheresis) and Computer Analysis and Deflection Assortment; 3) Repopulation Assays (BMT) for Hematopoietic Stem Cells; 4) Dilution Assay; 5) In Vitro Induction Assay (For SC Potency) with Proliferation Factors (Cytokines, Growth Factors [GFs]); 6 Embryo Incorporation (With Radio Labels and In Vitro Inoculation); 7) Stem Cell Regulation and the Notion Of Niche: 1) Quiescent SC (Cytokine and Chemokine Signals) or G0 Cells (Cell Cycle Allusion); 2) Environmental Control and/or Chemical Ecology of Cell-Cell Interaction; 3) Bulge (Collection of SC for a Hair Follicle [Basal Cells of Epithelium SC Potency]) and Niche Cells (Dermal Papillae Cells) Regulation or Control Thereof SC; 4) Therapeutics involving SCs: 1) Infusion (Intravenous Inoculation or Release) of SC for Healing and Repairing Capability (Function of SC upon Full Development or Adult Stage); 2) Embryonic SC (Variation of Potency but Zygotic SC are Omnipotent/Totipotent) And Further Segregation and Culturing of Select Pluripotent SC (Embryonic Excision Modality); 3) Ethics and Moral Considerations; 4) Induced Pluripotent Stem Cells (iPSCs)or (IPS Cells) where a Reversing of Potency Via Yamanaka Factors (Transcription Factors of Four Types or Even Less); 5) (iPS) Therapeutics and The Ethical Barrier of Embryo Irreverence or Destruction for Mere Therapeutic (Single Use Disposal) is less a Matter of Consideration and shows Promising (Perhaps the Most Ever) Beneficial And Medicinal Potential; PhD Hazel Sive is an extraordinary Biologist (Geneticist). Heil!
The s.c. can replace some damaged tissue. As I am aware people with ADHD have some problems with under-expression of dopaminergic neurons, so they need extra stimulation. Maybe, in the future will be possible to replace part or the whole nucleus accumbens, which is responsible for "feeling happy" and the reward system.
Let's talk about one of the biggest advances in bio-technology ever ... but we'll use technology from 100 years ago to explain it. Why does she need to write all of this on a chalkboard? Why not a projector with slides ... or at least markers? Much easier than writing with chalk. She could cover so much more material in the allotted time if we weren't watching her write everything while she is facing the chalkboard. It should be more like a TEDtalk where she speaks to and engages the audience while the show behind her is secondary to the discussion and does not require her full attention.
the lecture is interesting but too old model way of teaching which disturb her in writing on the board, can someone lend her a projector and a remote controler to save some time?
Wow, I’m amazed at how amazing her board writing is. Just beautiful!!
I like the old school way of writing on the board.
I however would have liked if they mentioned a bit of how stem cells are being used to cure aging. Some deep conversations happening at the healthspan discord server (discord.gg/ftSbffu) I'm just overwhelmed that aging might actually be cured soon.
Me too. However it also distracts me with ASMR---making me feel sleepy.
Her kind of axiomatic approach to the topic combined with the blackboard makes it feel like a math lecture. Good stuff!
Foregen wants to regenerate male foreskin with all specialized structures, if you want to know more about it : www.foregen.org
She does too. She writes so hard to make that sound.
The explanation is simply lovely. I can't thank the professor enough. Thanks for this excellent lecture.
Damn such good teaching quality at MiT people who go there are lucky
Great lecture! Thank you teacher 😊 Using the blackboard was really nice. Power points are getting boring. I could understand everything! Really helpful, thanks for posting.
I am 18 years old and I am in the final stage of secondary school. I am not exaggerating when I say that this is the best lecture I have ever seen in my entire life. What very excellent information, experiences and explanation. Although I do not know much English, I activated the translation feature. Your teacher is wonderful and the patience is incredible. You should be grateful for having all these tools. What is exciting about This is all 10 ten years ago 😲 I wish I could study with you, Talama. I love biology very much But unfortunately he is not financially capable What is my fault? I was born from a poor family and a poor country like Iraq. I wish I had been born in a European country so that I could achieve my dreams because my passion never ends. Stay well and sincere thanks and appreciation to you❤❤
My professors use PowerPoint and i haaaate it ! This so much better ..
agreed 100% can follow everything and take screen shots
Great content delivery! Succintly laid out the main points with very relevant examples.
I'm a really hugh fan of MIT OPENCOURSEWARE. I find it very informative, very useful, and the professor's explain it so it's easy to understand. God bless MIT OPENCOURSEWARE and thank you for sharing 🙏
32:52 regulating stem cell fate by the niche (surrounding cells)
"DESPITE THE HYPE; DESPITE THE COVER OF TIME MAGAZINE;AND THE FRONT PAGE OF EVERY NEWSPAPER ACROSS THE WORLD ; STEM CELLS ARE NORMALLY FOUND IN OUR BODIES"
Loved the statement......😎
Thank you, you have just made my Christmas revision that much easier. Many thanks
can anyone alongwith me, take a moment to acknowledge the beauty in maam’s handwriting and presentation❤
Absolutely loved every single minute of the lecture!
Wow, it's a really nice video that's healing. Thank you so much for your wonderful performance
Dr. Sive's a wonderful teaching biologist. To more effectively use time -- to answer student questions, for example -- I would allow students to access notes and screen images to their phones, tablets and/or laptops.
Excellent Lecture. Thank you very much :).
High dose chemo with stem cell transplant for MS at University of Michigan, AnnArbor, MI
Thank you, Professor!
The rubber ducks are a nice touch
I like how the school known for technology, hence Massachusetts Institute of Technology, knows when too much technology is too much. So, they shun PowerPoint in favor of good 'ol chalkboards. Now THAT is smart.
is there a difference between differentiated and committed?
yes, differentiated cells would be the earliest stage of a stem cell; embryonic
No they wouldn't. A differentiated cell is at the complete other end if the process. An embryonic stem cell is totally undifferentiated, hence why it's called a totipotent stem cell.
An embryonic stem cell is pluripotent not totipotent, as it can't make trophectoderm/placenta
Good lecture, its kind of funny how this is now counted as general knowledge and is teached at colleges when just 10 years ago this was Uni stuff
Very beautiful handwriting and so is the organization and explanation
Regarding the stem cells from URINE obtained after urination: HOW MANY TYPE OF STEM CELLS CAN WE FIND IN THAT URINE ? We can find only USCs ( urine stem cells ) or we can find also other stem cells ? . Is there any public protocol to separate if there are many types than USCs? Thank you.
This seams to be from quite solid days !
Very nice explanation of topic and using all relevant examples. Improved my knowledge thanks a lot!
Great teacher, great lecture!
Hey Amelia
Hhheeeeeyyyyyyy
The 7 layers also promit
On body in small intestin
محاضره غنيه جدا و محتواها قيم 🌺
100%
Body activates everytime cell processes to active forward when
great lessons. thank you!
Wow what an amazing lecture! Thank you so much!
Does anyone know where I can get more courses like this about stem cells? Thanks a lot!
I may have missed something here but she stated that there might be non compatibility issues with the embryonic stem cells and a none 'genetic' (wrong word I know!) match, which is understandable, but how did it work with the hairless mice? Any responses please keep as simple as possible I've just started researching this and am yet to get into full swing. Thanks!
The hairless, or we call them nude mice, have been engineered so that they have an extremely defective immune system, almost no immune system at all. Therefore, they do not have any issues of rejection. Rejection of foreign materials from our bodies is based on the fact that our immune system can recognize self vs non-self (by way of antibodies and cell surface receptors - these protein molecules are like feelers that will touch all the things that enter your body, and check if they belong to you. They can signal other immune cells to mount an attack on any foreign matters, because it could be dangerous. This is why our immune system can eliminate bacteria and viral infections from our bodies most of the time). The immune system recognizes cells from another person as being foreign, because those cells will have a different genome, thus making proteins that are slightly different from our own. Therefore, if a person has an organ transplant, the recipient's immune system will try to attack the donor organ thinking it is foreign and bad. That's why transplant patients need to taken immunosuppressant drugs to keep their own immune system from destroying the donated organ - which then at the same time makes the transplant recipient more susceptible to infections and getting sick. Now you see, that nude mouse has no immune system, so there is no 'security team' to recognize foreign matter, so there is no issue of rejection.
This ended up longer than I anticipated... hope it is helpful.
Oooo yes that makes sense, I didn't know about the nude mice being engineered to have a defective immune system, good to know for future ponderings and will also stop me asking silly questions.
Thank you very much!
Would love to see a follow-up that addresses the Problems and carry's forward to today...some 3 years forward. As she says...the promise of the future that is in most cases being advanced outside of the US.
Excellent idea Jack. That is an important piece of the puzzle that doesn't get enough attention unfortunately.
6:00 Now there are 1.960.000 hits on Google news.
Excellent lecture, I was intrigued the entire time
Teachers at MIT must be advised to write in the board. I don’t see this often in biology classes
Great professor great teacher 😀😀
In what experiment were they artificially found. LCD chain conveyer please I got no rna cycle brain is leaking synius
Interesting video. How do you feel about mesenchymal stem cells therapy?
Thank you very much Madam. The lecture is very helpful
(On Tuesday of January 24, 2023). In the Matter of Biology and Stem Cells (Embryologic Non-Differentiated Hematopoietic Cells, With Homeostatic Functions of Repairing and Healing. Nice, Precise and Highly Theoretical. Potency (Totipotency [Zygote], Pluripotency [Bone Marrow Cell], Multipotent (Lymphoid Progenitor) All the way to the Commitment Absolutely of a Cell); 2) Fate is the number of Possible Axes to a Cell; Determination to Total Differentiation; Stem Cells with their Self-Renewing Capacity Have the Potential of Being Therapeutic (Bone Marrow Transplantation, Skin Cell Transplantation [Burn and Repairing with a Skin Graft]); Stem Cells (SC) Assay or Technique Therein: 1) Radio isotopic Chase 2) Florescence Activated Cell Sorting (FACS) via Sorting of Cells Via Cytological Markers ((mAbs with Radio isotopic Tags), And Laser Detectors of the Tags (Apheresis) and Computer Analysis and Deflection Assortment; 3) Repopulation Assays (BMT) for Hematopoietic Stem Cells; 4) Dilution Assay; 5) In Vitro Induction Assay (For SC Potency) with Proliferation Factors (Cytokines, Growth Factors [GFs]); 6 Embryo Incorporation (With Radio Labels and In Vitro Inoculation); 7) Stem Cell Regulation and the Notion Of Niche: 1) Quiescent SC (Cytokine and Chemokine Signals) or G0 Cells (Cell Cycle Allusion); 2) Environmental Control and/or Chemical Ecology of Cell-Cell Interaction; 3) Bulge (Collection of SC for a Hair Follicle [Basal Cells of Epithelium SC Potency]) and Niche Cells (Dermal Papillae Cells) Regulation or Control Thereof SC; 4) Therapeutics involving SCs: 1) Infusion (Intravenous Inoculation or Release) of SC for Healing and Repairing Capability (Function of SC upon Full Development or Adult Stage); 2) Embryonic SC (Variation of Potency but Zygotic SC are Omnipotent/Totipotent) And Further Segregation and Culturing of Select Pluripotent SC (Embryonic Excision Modality); 3) Ethics and Moral Considerations; 4) Induced Pluripotent Stem Cells (iPSCs)or (IPS Cells) where a Reversing of Potency Via Yamanaka Factors (Transcription Factors of Four Types or Even Less); 5) (iPS) Therapeutics and The Ethical Barrier of Embryo Irreverence or Destruction for Mere Therapeutic (Single Use Disposal) is less a Matter of Consideration and shows Promising (Perhaps the Most Ever) Beneficial And Medicinal Potential; PhD Hazel Sive is an extraordinary Biologist (Geneticist). Heil!
Beautiful lecture thank you!
What happens when u inject the wrong sc ?
superb professor!
Tqsm mam nice explaination 🤩🥳✨🙏🙏
All good info much appreciated
beautifully explained thank you ....
I love her course!
A VERY GOOD CLASS
Which is the answe is
r to powas as vone morrowh
She has the most frustrating G's
Her G's have been winding me up for the whole lecture!
excellent teacher
LOVE THIS VIDEO
How about HECS or mouse stem cells. Or IPs
44:20
Excellent lecture
22:43
I need to know what she puts in her coffee, then perhaps I’ll divulge into the complexities of stem cells..
Maam's handwriting grabs more attention than the topic...
Thanks ❤️🤍
Can stem cells help adhd for 8 year od and a 15 years old
The s.c. can replace some damaged tissue. As I am aware people with ADHD have some problems with under-expression of dopaminergic neurons, so they need extra stimulation. Maybe, in the future will be possible to replace part or the whole nucleus accumbens, which is responsible for "feeling happy" and the reward system.
I can't believe its available for free 😮
I loved it, thank you
For stem cells therapy, cancer, sickle cell, cataract, glycouma, diabetic,autism,infertility, click 👇👇
I really like this!
thank you so much
Amazing lecture by amazing teacher ❤❤❤❤❤❤❤❤❤❤❤ can i get pdf please reply 😊😊😊😊😊😊😊❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤
Course materials are on MIT OpenCourseWare at: ocw.mit.edu/7-013S11.
Best wishes on your studies!
indeed nice teacher.
Wowwww!!! Thanks! 👏👏👏
720i is so jarring after getting used to 720p
This is helpful ❤️🤍
Thank you!!!!!
Tnqs ma'am
WHAT ABOUT PEOPLE THAT GET STEM CELL THERAPY TO HEAL THEIR OWN BODY
38:50
Blackboards and chalk? How retro.
Can someone answer my question: How many kinds of adult stem cells exist??
perfect
thnks
just how many blackboards are there!damn!
She’s a machine with that chalk
Nice
Top Notch
Why is MIT so expensive yet the university campus is the worst
I like how she writes down whole sentences on the board. I guess MIT has really low expectations of their students.
Let's talk about one of the biggest advances in bio-technology ever ... but we'll use technology from 100 years ago to explain it. Why does she need to write all of this on a chalkboard? Why not a projector with slides ... or at least markers? Much easier than writing with chalk. She could cover so much more material in the allotted time if we weren't watching her write everything while she is facing the chalkboard. It should be more like a TEDtalk where she speaks to and engages the audience while the show behind her is secondary to the discussion and does not require her full attention.
is MIT looks like ITT a for-profit technical institute ?
I hate math but i love bio
Well now I can pass my exams.
She has an accent. Where is she from?
South Africa
madagascar
+Avenue X at Cicero She sounds Australian
Türkçe altyazalı olsaydı yada ayarlarda Türkçe ayarı olsaydı
🙏🙏🙏🙏🙏🙏🙏🌹🌹🌹🌹🌹🌹😊😊😊😊😊excellentl
we need to share this because i dont whant to die.
and i need some green wiskers jk
nice vid
the lecture is interesting but too old model way of teaching which disturb her in writing on the board, can someone lend her a projector and a remote controler to save some time?
Run this at 2x speed to plow through her agonizing chalking
seriously?
HA
J