Breonna Barker is so smart and so grounded. What a skill or talent to be able explain complex ideas in such a way that even I can understand it. I can't image what a gift she is to her students.
Dickson!! ‼️‼️‼️‼️‼️💛💛💛💛💛💛💛 Welcome back! Prayers and blessings and good wishes for you always! 🕯🙏 I have started downloading and listening to some of your urban agriculture podcast. Thank you for everything, Dickson.
On the right side, I really appreciate what you guys do, all of you, bringing your expertise to informing the public about viruses, the kind that make you sick.
I know this is about monkey pox today, but I have to bring up something that has troubled me for some time. The New York Times publishes coronavirus maps of the world. One map shows vaccination rates, the other shows ongoing infections. Almost all areas of the world show at least moderate vaccination rates, and varying infection rates amongst various populations. Africa is the glaring exception. The map shows virtually no vaccinations across the continent, yet the infection map shows virtually no infection. Either Africans have some innate mutation that protects them from covid-19 or the entire continent is being neglected almost entirely in terms of treatment for covid 9. Sadly I have to believe it is the latter.
That’s just what data gaps do to maps. There’s a good explainer on this phenomenon in Biotech and Bioinformatics with Prof Greg on the May 14 interview.
19:20 to 19:35 "...because we swallow mucus and it passes through." I'm not sure that's how most of the antigen gets to the stool at these late stages. Short-lived intestinal goblet cells, for example, grow their own SARS-CoV-2 virions months out from acute infection, completely independently from airway infection, without much cytopathic effect. There's usually not much detectable stuff going on in the airway after a few months (so there's not much to swallow). The MUC2+ intestinal goblet cells probably aren't collecting debris from anywhere else. I'm baffled why Vincent would say this or why Rich and Brianne didn't correct him (they are clearly both aware of the immunoEM results for MUC2+ intestinal goblet cells).
somewhat related 19:35 "the question is whether the virus can replicate in the intestine" Yes, but plaque assays are a notoriously insensitive method to determine this. As you know, other viruses that are known to be replication competent and infectious in tissues still fail to be cultured for an array of murky reasons (some get outcompeted by other irrelevant viruses, sometimes a virus may rely on exploiting specific transient cell-cell interactions that are common in vivo). Successful plaque assay attempts are sometimes just as surprising, so method error is huge. When short-lived cells have a steadily low level of viral proteins detected by half a dozen other methods, and overall trends in affinity maturation suggest an ongoing infection, it's clear that the specialized plaque assay methodology may need decades of work to catch up. It shouldn't be holding everyone back or gaslighting other lines of thought. Why not mention that generating a productive infection in one cell type may require a variety of different cell types to be co-cultured?
The human organism and its interactions with an external pathogen is so complex that there is no way to accurately predict what is going to happen. It’s a dynamic system, always shifting ……
I think discussions on viruses in Asian & African nations are now emerging . These have been around for a while. In fact we had a time 3-4 yrs ago where kids were getting foot & mouth diseases in India. It’s a wake up call for one half of the world about what goes on in the other half .
May be elderly have lower body temperature? and lower capacity to increase IT. If SARS COV2 are temperature senzitive ? theoreticaly low body temperature can be a rysk factor for SARS COV2 infection
Community Immunity is a term that reminds us that part of immunity in a population is dependent on the behavior and actions of community members. Things like participation in vaccination, curtailing droplet spread, dispersal of and dilution of aerosols with ventilation and air purification would effect the amount of virus in air that people are sharing, and impact how frequently people get infected or sick. We may, as community members have more ability to shape population immunity or community immunity than we would think. The public may have a higher expectation about the durability of immunity and herd immunity or community immunity than is actual.
While most scientists I know are open to frank discussion and debate of their subject matter, the basic problem with how the public has interfaced with "Science" through this pandemic is that the "political scientists" dictated to rather than educated the public. People know when they aren't being told the whole story. We also needed more actual studies and less "because I said so."
There was no whole story to be told because the studies weren't done yet because that took time, and we still are learning. What was important up to now were the public health measures, extreme as they were in some cases, because we had to buy time to complete the studies, which as we see are ongoing yet. Of course the public didn't know the whole story - no one knew the whole story. And we still don't. The public health measures saved lives at a critical time, no doubt about it.
Do you know what studies are being done on covid19 infection in correlation of destruction of the lymphatic system? I have no lymphatic uptake now from my neck to my breats and have lymphademia in that area which is quite unusual and causing major lymphangitis infections closing off my airway
If(?)SARS COV2 better replicate at low tissue temperature (see a clue of that at TWiV Nr 659 at min29) may be interferon increase body temperature rapidly and high body temperature mitigate SARS COV2 infection?
Some of this is incorrect. eg this is a West African strain with a MR of 1% whereas the other main African strain has a MR of 10%. The genomic sequence has been released by a Portuguese researcher.
Fantastic Sunday watch!! I just came in from feeding ‘my’ birds…peanuts in the shell, black oil sunflower seeds, walnut suet, a birdseed mix on a gorgeously cool *(for DFW Texas) am | afternoon! Thank you guys for being super awesome!! I appreciate the abundant and reliable information! Enjoy the rest of your weekend everyone!
Fascinating and informative. Re the discussions about herd immunity and how the info provided by the CDC about Covid is confusing - I learned from Dr. Dean Edel decades ago that science is always evolving, and we need to be ready to change our conclusions as more knowledge is obtained. Nothing is black and white. We have seen our government create a safe, effective vaccine in 1/10 the time it used to take, a phenomenal accomplishment. I am blessed to live in the U.S.
May be interferon are the first factor that increase body temperature in viral infection? May be analgezic antipiretic drugs can mitigate efect of interferon and must be avoided in SARS COV2 infection?
@@troy530 He is a veterinarian, has never published any research about vaccines, and calls it a quite harmless virus. Ref: The Doomsday Prophecy of Dr. Geert Vanden Bossche
@@christopherrobinson7541 I’ve seen you post that before but you never state why you don’t think he’s credible. His pra’dyktions thus far have been spot on.
Growing plants off Earth: The astronauts might be able to add something, but probable will need to add elements, and microbes from Earth (so special selected and studied Earth topsoil to seed the culture).
Breonna Barker is so smart and so grounded. What a skill or talent to be able explain complex ideas in such a way that even I can understand it. I can't image what a gift she is to her students.
You can tell Brianna loves her work. She's has a very positive and cheerful disposition.
I think for long videos like this it would be good to use TH-cam's chapter system where we can skip ahead to named sections
We all love TWIV. And TWIM, TWIN, TWIP-the whole lot.
This episode of TWiV reminded me of the old adage: The more you learn, the less you know. I would be curious to learn if I have those autoantibodies.
Dickson!! ‼️‼️‼️‼️‼️💛💛💛💛💛💛💛 Welcome back! Prayers and blessings and good wishes for you always! 🕯🙏 I have started downloading and listening to some of your urban agriculture podcast. Thank you for everything, Dickson.
On the right side, I really appreciate what you guys do, all of you, bringing your expertise to informing the public about viruses, the kind that make you sick.
Arquimides story ...would put the medal 🏅 in water check the density . Congratulation on the recognition of your lab discovery and hard work
I know this is about monkey pox today, but I have to bring up something that has troubled me for some time. The New York Times publishes coronavirus maps of the world. One map shows vaccination rates, the other shows ongoing infections. Almost all areas of the world show at least moderate vaccination rates, and varying infection rates amongst various populations. Africa is the glaring exception. The map shows virtually no vaccinations across the continent, yet the infection map shows virtually no infection. Either Africans have some innate mutation that protects them from covid-19 or the entire continent is being neglected almost entirely in terms of treatment for covid 9. Sadly I have to believe it is the latter.
That’s just what data gaps do to maps. There’s a good explainer on this phenomenon in Biotech and Bioinformatics with Prof Greg on the May 14 interview.
And the age of the African population.
Congratulations on the medal Vincent!
19:20 to 19:35
"...because we swallow mucus and it passes through."
I'm not sure that's how most of the antigen gets to the stool at these late stages. Short-lived intestinal goblet cells, for example, grow their own SARS-CoV-2 virions months out from acute infection, completely independently from airway infection, without much cytopathic effect. There's usually not much detectable stuff going on in the airway after a few months (so there's not much to swallow). The MUC2+ intestinal goblet cells probably aren't collecting debris from anywhere else. I'm baffled why Vincent would say this or why Rich and Brianne didn't correct him (they are clearly both aware of the immunoEM results for MUC2+ intestinal goblet cells).
somewhat related
19:35
"the question is whether the virus can replicate in the intestine"
Yes, but plaque assays are a notoriously insensitive method to determine this. As you know, other viruses that are known to be replication competent and infectious in tissues still fail to be cultured for an array of murky reasons (some get outcompeted by other irrelevant viruses, sometimes a virus may rely on exploiting specific transient cell-cell interactions that are common in vivo). Successful plaque assay attempts are sometimes just as surprising, so method error is huge. When short-lived cells have a steadily low level of viral proteins detected by half a dozen other methods, and overall trends in affinity maturation suggest an ongoing infection, it's clear that the specialized plaque assay methodology may need decades of work to catch up. It shouldn't be holding everyone back or gaslighting other lines of thought.
Why not mention that generating a productive infection in one cell type may require a variety of different cell types to be co-cultured?
Very, very interesting and informative. Thank you team!!!
Nice to see Dixon. Did anyone else see him on CBS Sunday Morning this week?
I missed it. Here is a link to the segment
th-cam.com/video/JixDaIoJrAI/w-d-xo.html
Thank you TWiV!
The human organism and its interactions with an external pathogen is so complex that there is no way to accurately predict what is going to happen.
It’s a dynamic system, always shifting ……
Thank you! Always such a pleasure to listen to your knowledge ♥️
Having Vincent and Rich together in the Incubator causes the energy levels to fly off the scale!⚡️ 👤II&E🍄🔜TWIX!👍🏼
Congratulations Vincent 🙏💙🦋😇
Love you people!
To travel across Texas from Texarkana to El Paso would be about 38 hours traveling time on the interstate system (excluding stops on side trips).
I think discussions on viruses in Asian & African nations are now emerging . These have been around for a while. In fact we had a time 3-4 yrs ago where kids were getting foot & mouth diseases in India. It’s a wake up call for one half of the world about what goes on in the other half .
Dear Prof Vincent, do you hv detailed lecture about Monkeypox?
Very interesting. Thank you.
Brianne looks so pretty! Great TWIV as alway!
Discussions regarding autoimmune antibodies have been ongoing for almost 2 years.
May be elderly have lower body temperature? and lower capacity to increase IT.
If SARS COV2 are temperature senzitive ? theoreticaly low body temperature can be a rysk factor for SARS COV2 infection
Community Immunity is a term that reminds us that part of immunity in a population is dependent on the behavior and actions of community members. Things like participation in vaccination, curtailing droplet spread, dispersal of and dilution of aerosols with ventilation and air purification would effect the amount of virus in air that people are sharing, and impact how frequently people get infected or sick. We may, as community members have more ability to shape population immunity or community immunity than we would think. The public may have a higher expectation about the durability of immunity and herd immunity or community immunity than is actual.
Uh nothing showing…
While most scientists I know are open to frank discussion and debate of their subject matter, the basic problem with how the public has interfaced with "Science" through this pandemic is that the "political scientists" dictated to rather than educated the public. People know when they aren't being told the whole story. We also needed more actual studies and less "because I said so."
There was no whole story to be told because the studies weren't done yet because that took time, and we still are learning. What was important up to now were the public health measures, extreme as they were in some cases, because we had to buy time to complete the studies, which as we see are ongoing yet. Of course the public didn't know the whole story - no one knew the whole story. And we still don't. The public health measures saved lives at a critical time, no doubt about it.
Do you know what studies are being done on covid19 infection in correlation of destruction of the lymphatic system? I have no lymphatic uptake now from my neck to my breats and have lymphademia in that area which is quite unusual and causing major lymphangitis infections closing off my airway
👍👍👍👍👍Great Episode!!! ❤❤❤❤❤I want to make a painting for that nice empty spot on you right!!!🥰🥰😉😉😘
If(?)SARS COV2 better replicate at low tissue temperature (see a clue of that at TWiV Nr 659 at min29) may be interferon increase body temperature rapidly and high body temperature mitigate SARS COV2 infection?
Love this panel all very interesting thank ye for counting this and coming into our ordinary lives
Some of this is incorrect. eg this is a West African strain with a MR of 1% whereas the other main African strain has a MR of 10%. The genomic sequence has been released by a Portuguese researcher.
Fantastic Sunday watch!! I just came in from feeding ‘my’ birds…peanuts in the shell, black oil sunflower seeds, walnut suet, a birdseed mix on a gorgeously cool *(for DFW Texas) am | afternoon!
Thank you guys for being super awesome!! I appreciate the abundant and reliable information! Enjoy the rest of your weekend everyone!
Could this be transmitted on toilet paper? Crap changed when charmin said 6=24 rolls
Fascinating and informative. Re the discussions about herd immunity and how the info provided by the CDC about Covid is confusing - I learned from Dr. Dean Edel decades ago that science is always evolving, and we need to be ready to change our conclusions as more knowledge is obtained. Nothing is black and white. We have seen our government create a safe, effective vaccine in 1/10 the time it used to take, a phenomenal accomplishment. I am blessed to live in the U.S.
It’s in Spain Portugal Italy Canada and the USA Uk also
May be interferon are the first factor that increase body temperature in viral infection?
May be analgezic antipiretic drugs can mitigate efect of interferon and must be avoided in SARS COV2 infection?
some interesting points by Prof Despommier - actually biologists do not make and use 'laws', like physicists do
Geert Vanden Bossche breaks it down as to why the vasilated have something to worry about
Bossche is not a credible source.
@@troy530 He is a veterinarian, has never published any research about vaccines, and calls it a quite harmless virus.
Ref: The Doomsday Prophecy of Dr. Geert Vanden Bossche
@@christopherrobinson7541 I’ve seen you post that before but you never state why you don’t think he’s credible. His pra’dyktions thus far have been spot on.
@@troy530 Did he predict a tropism shift in BA1, MPro cleaving NEMO, or macrophage infection? No? Then who cares.
@@minRef We’ll all know soon enough if he’s right.
Growing plants off Earth: The astronauts might be able to add something, but probable will need to add elements, and microbes from Earth (so special selected and studied Earth topsoil to seed the culture).
Working now.
Vincent's lecture in Zurich
chab.ethz.ch/forschung/institute-und-laboratorien/LPC/ernst-lecture.html
It Is now on TH-cam where the streaming goes smoother.