Medical School Pathology: Pathophysiology of Myelin Disorders

This video for medical students covers the pathophysiology, clinical features and morphologic findings of demyelinating (e.g., multiple sclerosis) and dysmyelinating (e.g., the leukodystrophies) disorders. Krabbe disease, metachromatic leukodystrophy and adrenoleukodystrophy are discussed.

[@LEARNING-MEDICAL-EDUCATION]

does MS involve cranial nerve nuclei and cranial nerves. i think they are part of PNS, so, MS wont involve cranial nerve nuclei and cranial nerves

[@moshesadofsky9429]

Can students interpret why the plaque in MS stands out so nicely in MRI imaging? Remember what this technique reveals. In classic radiology the bright white in an image would be radio-dense. Often calcium or bone. But in MRI, the method is sensitive to changes in Hydrogen and its environment (Technically, relaxation time) . Water and fats (like myelin sheaths) are strongly imaged. But it is a computer generated image, and the white/black is chosen as a setting. It could be reversed.

[@PathologyCentral]

Thank you so much for this informative addition to the narrative, Dr. Sadofsky! As always, you are illuminating!!