Hallo, thank you for the video. It is so much helpful. I have a question about micelle solubilizing the drug in the water. If I have the cmc of the surfactant, the concentration of surfactant being added, the solubility of the drug in the water, and the distribution coefficient of micelle in the water, how could I determine whether the micelle solubilize the drug in the water or not?
The only issue here is because cmc isn't expressed in mole fraction, you've not got the correct answer. You've also not taken into account headgroup dissociation - you've used the equation for a nonionic surfactant for an anionic one, which would be OK in a high electrolyte concentration (probably) but not in just water. Need to use dG = (2-a) RT ln X(cmc) where a is dissociation (0.4 for SDS under these conditions to 1 sf), and X(cmc) is mole fraction, so 8.2 x 10^-3 M / 55.5 M ~ 1.5 x 10^-4 [where 55.5 is concentration of water in 1L water i.e. 1000/18].
I would like to know if you can help me with one question. How I calculate the entropy and the enthalpy from the following values to c.m.c of a non-ionic surfactant in water with temperatures as follows: Temperature (°C) 15 20 25 30 40 c.m.c. (mmol dm-3) 21.9 20.8 19.9 19.1 17.8
Similar to this th-cam.com/video/ZflSRRoKNbo/w-d-xo.html but notice that now you will use deltaG=RTlnCmc, so the sign of slope and y-intercept need to be the opposite of the eq in the video.
Simple and excellent explanation. Thank you very much for it.
Hallo, thank you for the video. It is so much helpful. I have a question about micelle solubilizing the drug in the water. If I have the cmc of the surfactant, the concentration of surfactant being added, the solubility of the drug in the water, and the distribution coefficient of micelle in the water, how could I determine whether the micelle solubilize the drug in the water or not?
The only issue here is because cmc isn't expressed in mole fraction, you've not got the correct answer. You've also not taken into account headgroup dissociation - you've used the equation for a nonionic surfactant for an anionic one, which would be OK in a high electrolyte concentration (probably) but not in just water. Need to use dG = (2-a) RT ln X(cmc) where a is dissociation (0.4 for SDS under these conditions to 1 sf), and X(cmc) is mole fraction, so 8.2 x 10^-3 M / 55.5 M ~ 1.5 x 10^-4 [where 55.5 is concentration of water in 1L water i.e. 1000/18].
I would like to know if you can help me with one question.
How I calculate the entropy and the enthalpy from the following values to c.m.c of a non-ionic surfactant in water with temperatures as follows:
Temperature (°C) 15 20 25 30 40
c.m.c. (mmol dm-3) 21.9 20.8 19.9 19.1 17.8
If you have solve it kindly Help me please
I also need it
Similar to this th-cam.com/video/ZflSRRoKNbo/w-d-xo.html but notice that now you will use deltaG=RTlnCmc, so the sign of slope and y-intercept need to be the opposite of the eq in the video.