And does heat cause a decarboxylation, because the bond that is broken happen to be the weakest bond in the structure, which is most vulnerable to the addition of heat ? And does claisen condensation always share to involve an OH leaving group or can the leaving groups be of any molecular form ?
Heat does cause the dehydration reaction. Technically I think the reaction with chloride group is a nucleophile addition reaction with the enolate acting as the nucleophile. On the internet it says that a claisen rxn requires an ester
At roughly 5:40, in the most bottom-right of the drawings, you mention that adding a water molecule, or reacting a water molecule with that central carbon to the left of the other central carbonyl carbon (both of these central carbonyl carbons are somewhat electron-deficient I assume) - you then show in the next diagram appearing above it at 5:49, a product that has lost its C-O leaving group (which I guess would be carbon monoxide unless it is meant to be taken as an OH group ?), but that the added group is labelled as ''OH''. My question is twofold - first, we assume that the C-O (or unless it is meant to mean OH) is a relatively stable leaving group, i.e. unreactive ? And second, why is OH added, when H2O was the original addition ? Is there thus a deprotonation event of the water when the water attaches (I assume the oxygen of the water molecule is attaching to this carbonyl carbon and not either of water's hydrogens that is doing the attaching..)
So to be brutally honest, it’s been a couple of years since I took 2nd semester organic chemistry... but if I can recall, the water replaces the c-o because it’s an aqueous solution so the high water concentration creates favorable thermodynamics and a spontaneous negative non-standard state Gibbs free energy pushing that reaction forward..............Also, i realize perhaps I was a bit lazy with my hydrogens and charges when making some of these videos (the earlier ones I was very lazy and regret it).. But technically the amounts of hydrogens on the oxygen is determined by the pH of the solution and most likely there would be a pH where the oxygen was actually negatively charged..
And does heat cause a decarboxylation, because the bond that is broken happen to be the weakest bond in the structure, which is most vulnerable to the addition of heat ?
And does claisen condensation always share to involve an OH leaving group or can the leaving groups be of any molecular form ?
Heat does cause the dehydration reaction. Technically I think the reaction with chloride group is a nucleophile addition reaction with the enolate acting as the nucleophile. On the internet it says that a claisen rxn requires an ester
At roughly 5:40, in the most bottom-right of the drawings, you mention that adding a water molecule, or reacting a water molecule with that central carbon to the left of the other central carbonyl carbon (both of these central carbonyl carbons are somewhat electron-deficient I assume) - you then show in the next diagram appearing above it at 5:49, a product that has lost its C-O leaving group (which I guess would be carbon monoxide unless it is meant to be taken as an OH group ?), but that the added group is labelled as ''OH''.
My question is twofold - first, we assume that the C-O (or unless it is meant to mean OH) is a relatively stable leaving group, i.e. unreactive ?
And second, why is OH added, when H2O was the original addition ? Is there thus a deprotonation event of the water when the water attaches (I assume the oxygen of the water molecule is attaching to this carbonyl carbon and not either of water's hydrogens that is doing the attaching..)
So to be brutally honest, it’s been a couple of years since I took 2nd semester organic chemistry... but if I can recall, the water replaces the c-o because it’s an aqueous solution so the high water concentration creates favorable thermodynamics and a spontaneous negative non-standard state Gibbs free energy pushing that reaction forward..............Also, i realize perhaps I was a bit lazy with my hydrogens and charges when making some of these videos (the earlier ones I was very lazy and regret it).. But technically the amounts of hydrogens on the oxygen is determined by the pH of the solution and most likely there would be a pH where the oxygen was actually negatively charged..
@@sciencesimplified3890 Thanks